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Article ID: 712838

On The Way to Fighting Staph Infections With The Body’s Immune System

Johns Hopkins Medicine

Researchers have gained a greater understanding of the biology of staphylococcus skin infections in mice and how the mouse immune system mobilizes to fight them. A study appears this week in the Proceedings of the National Academy of Sciences of the United States of America. Community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) typically causes skin infections but can spread throughout the body to cause invasive infections such as sepsis, and possibly death.

Released:
15-May-2019 9:00 AM EDT
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  • Embargo expired:
    15-May-2019 9:00 AM EDT

Article ID: 712523

Researchers Identify New Therapeutic Target for Metastatic Prostate Cancer

The Rockefeller University Press

Researchers in New York have found that treating human prostate cancer cells with a drug that targets a protein called PHLPP2 may prevent the cancer cells from spreading to other organs in the body. The study, which will be published May 15 in the Journal of Cell Biology, reveals that inhibiting PHLPP2 lowered the levels of MYC, an oncogenic protein that causes many different types of cancer that cannot be targeted by conventional drug therapies.

Released:
8-May-2019 9:00 AM EDT
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Article ID: 712856

Potential Targeted Treatment for Acute Myeloid Leukemia Identified

Sanford Burnham Prebys Medical Discovery Institute

Scientists from Sanford Burnham Prebys have shown that a protein called BMI1 is a promising drug target for an AML subtype in which two normally separate genes, CALM and AF10, fuse together. The findings, published in Experimental Hematology, provide a rationale for evaluating a BMl1-inhibiting drug that is currently in clinical development for solid tumors.

Released:
15-May-2019 8:00 AM EDT
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Article ID: 712828

Johns Hopkins Researchers Find Widely “Inconsistent” Use of Antibodies in Lab Experiments

Johns Hopkins Medicine

Scientists at the Johns Hopkins Kimmel Center say they have affirmed widespread inconsistencies in the use of a common laboratory procedure called immunohistochemical staining, and say the variations are making many laboratory experiments unreliable.

Released:
15-May-2019 8:00 AM EDT
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  • Embargo expired:
    14-May-2019 5:00 PM EDT

Article ID: 712719

Species facing climate change could find help in odd place: urban environments

Tufts University

Research shows animals move faster through ‘low quality’ habitats (fulfilling a minimum of resources for survival) – evidence that could change the way conservationists think about managing urban landscapes to help species move in response to climate change. The study provides a framework for definitive action to help preserve many species at risk

Released:
10-May-2019 1:05 PM EDT
  • Embargo expired:
    14-May-2019 11:00 AM EDT

Article ID: 712552

Pitt Study Finds Direct Oxidative Stress Damage Shortens Telomeres

Health Sciences at the University of Pittsburgh

First causal evidence that oxidative stress works directly on telomeres to speed cellular aging

Released:
8-May-2019 10:05 AM EDT
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Article ID: 712800

Brain Changes Linked With Alzheimer’s Years Before Symptoms Appear

Johns Hopkins Medicine

**Note to journalists: Michael Miller, Ph.D., will discuss this research at the Johns Hopkins Science Writers’ Boot Camp on June 10 at the National Press Club in Washington, D.C. Learn more and register for the free, daylong immersion in topics about mental health and addiction.

Released:
14-May-2019 10:00 AM EDT
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Article ID: 712786

Earlier, More Frequent Removal of Some Pancreatic Cysts May Decrease Cancer Risk for Some Patients

Johns Hopkins Medicine

By analyzing medical records of 901 adults who had surgery for a certain type of precancerous pancreatic cyst, researchers at Johns Hopkins Medicine and The Karolinska Institute in Sweden have updated parameters for an anatomical “marker” that can tell more precisely if these cysts are likely to develop into lethal pancreatic cancers.

Released:
14-May-2019 9:00 AM EDT
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Article ID: 712785

Conquering Cancer’s Infamous KRAS Mutation

Sanford Burnham Prebys Medical Discovery Institute

Scientists from Sanford Burnham Prebys and PHusis Therapeutics have shown that a compound called PHT-7.3 shrinks KRAS-driven tumors in mice. In contrast to directly targeting mutant KRAS, the potential drug candidate targets the protein’s partner in crime: the cellular scaffold to which mutated KRAS attaches. The study was published in Cancer Research.

Released:
14-May-2019 8:00 AM EDT
  • Embargo expired:
    14-May-2019 5:00 AM EDT

Article ID: 712801

Study: Treats Might Mask Animal Intelligence

Johns Hopkins University

Rewards are necessary for learning, but may actually mask true knowledge, finds a new Johns Hopkins University study with rodents and ferrets.

Released:
13-May-2019 5:05 PM EDT

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