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Newswise: New Synthesis Strategy Speeds Identification of Simpler Versions of a Natural Product

Article ID: 711816

New Synthesis Strategy Speeds Identification of Simpler Versions of a Natural Product

Baylor University

A new chemical synthesis strategy to harvest rich information found in natural products has led to identifying simpler derivatives with potential to selectively protect neurons -- important for such diseases as Alzheimer’s -- or to prevent the immune system from rejecting organ transplants.

Released:
24-Apr-2019 11:30 AM EDT
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Article ID: 711811

A New Clue in the Mystery of ALS, Frontotemporal Dementia

Michigan Medicine - University of Michigan

Michigan Medicine (University of Michigan) researchers identify a potential therapeutic target for neurodegenerative conditions ALS and frontotemporal dementia, using animal models.

Released:
23-Apr-2019 5:05 PM EDT
Newswise: Researchers Propose New Theory on Alzheimer's, Amyloid Connection

Article ID: 711713

Researchers Propose New Theory on Alzheimer's, Amyloid Connection

Florida Atlantic University

“Is amyloid precursor protein the mastermind behind Alzheimer’s or is it just an accomplice?” Researchers devised a multi-functional reporter for amyloid precursor protein and tracked its localization and mobility, noticing a strange association between the protein and cholesterol that resides in the cell membrane of synapses. With cholesterol’s broad involvement in almost all aspects of neurons’ life, they propose a new theory on the amyloid precursor protein connection in AD, especially in the surface of those tiny synapses, which triggers neurodegeneration.

Released:
23-Apr-2019 9:00 AM EDT
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  • Embargo expired:
    17-Apr-2019 4:00 PM EDT

Article ID: 711237

Brain Stimulation Shows Promise for Understanding Memory Decline in Older Adults

American Academy of Neurology (AAN)

In a small, pilot study, a non-invasive device that uses magnetic fields to stimulate nerve cells in the brain was associated with temporary improvements in age-related memory loss in older people, according to a study published in the April 17, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Released:
12-Apr-2019 11:05 AM EDT
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  • Embargo expired:
    15-Apr-2019 3:00 PM EDT

Article ID: 711279

Synthetic Peptide Can Inhibit Toxicity, Aggregation of Protein in Alzheimer's Disease

University of Washington

A team led by researchers at the University of Washington has developed synthetic peptides that target and inhibit the small, toxic protein aggregates that are thought to trigger Alzheimer's disease.

Released:
12-Apr-2019 4:05 PM EDT
Newswise: Rutgers Scientists Discover New Role for Sensory Signals in the Brain

Article ID: 711072

Rutgers Scientists Discover New Role for Sensory Signals in the Brain

Rutgers University-New Brunswick

Learning how to tie a shoe or shoot a basketball isn’t easy, but the brain somehow integrates sensory signals that are critical to coordinating movements so you can get it right. Now, Rutgers scientists have discovered that sensory signals in the brain’s cerebral cortex, which plays a key role in controlling movement and other functions, have a different pattern of connections between nerve cells and different effects on behavior than motor signals. The motor area of the cortex sends signals to stimulate muscles.

Released:
11-Apr-2019 11:00 AM EDT
Newswise: Caregiving Not As Bad For Your Health As Once Thought, Study Says

Article ID: 710991

Caregiving Not As Bad For Your Health As Once Thought, Study Says

Johns Hopkins Medicine

For decades, articles in research journals and the popular press alike have reported that being a family caregiver takes a toll on a person’s health, boosting levels of inflammation and weakening the function of the immune system. Now, after analyzing 30 papers on the levels of immune and inflammatory molecules in caregivers, Johns Hopkins researchers say the link has been overstated and the association is extremely small. Caregiver stress explains less than 1 percent of the variability in immune and inflammation biomarkers, they report. Their new meta-analysis was published March 10 in The Gerontologist.

Released:
10-Apr-2019 11:00 AM EDT

Article ID: 711005

Scientists create molecular tool to remove toxic protein from neuronal models of dementia

Massachusetts General Hospital

Harnessing a probe used to image the brain in diagnosing Alzheimer's disease and related forms of dementia, scientists at Dana-Farber Cancer Institute and Massachusetts General Hospital (MGH) have successfully cleared patient-derived brain cells of an abnormal protein associated with dementia and other neurogenerative disorders.

Released:
9-Apr-2019 11:05 AM EDT

Article ID: 711006

Study explores how technology can help prompt positive memories for people with depression

Massachusetts General Hospital

Researchers have provided a crucial first step towards understanding how computing technology could be used to help people with depression remember happy memories.

Released:
9-Apr-2019 11:05 AM EDT

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