Reducing levels of a spliceosome-associated factor, SYF2, attenuates TDP-43 pathology in models of diverse forms of ALS. Therefore, these findings by Linares et al. indicate that SYF2 suppression may function as a broadly acting therapeutic strategy
Reducing levels of a spliceosome-associated factor, SYF2, attenuates TDP-43 pathology in models of diverse forms of ALS. Therefore, these findings by Linares et al. indicate that SYF2 suppression may function as a broadly acting therapeutic strategy
Chen and colleagues demonstrate that human brain organoids can integrate structurally and functionally with the injured adult mammalian brain. Organoid grafts connect synaptically with the rat brain and adopt the function of the visual cortex. These
Throughout an organism’s life, the activity of niche signals fluctuates due to injury, and stem cells need to respond accordingly. Klein and colleagues found that during high Wnt activity observed in intestinal regeneration, niche canonical WNT lig
Sebert, Gachet et al. analyzed longitudinal data from patients with Fanconi anemia, a rare inherited DNA-repair disease. They provided genomic and functional insights into MDM4-driven p53 response modulation yielding clonal hematopoiesis and precedi
The utilization of iPSC technologies to model neurological diseases in vitro is challenging due to the inherent tendency of neurons to aggregate and their immature profile. Kiskinis and colleagues developed artificial extracellular matrix biomimetic
Reducing levels of a spliceosome-associated factor, SYF2, attenuates TDP-43 pathology in models of diverse forms of ALS. Therefore, these findings by Linares et al. indicate that SYF2 suppression may function as a broadly acting therapeutic strategy
The maturation of human induced pluripotent stem cell (hiPSC)-derived neurons in 2D is dependent upon cell attachment, spreading, and pathfinding across a biomaterial substrate. In this issue of Cell Stem Cell, Álvarez et al.1 demonstrate that high
The generation of donor-derived induced pluripotent stem cells (iPSCs) for allogeneic transplantation is a major challenge in regenerative medicine. Yoshida et al. now report on the establishment of an HLA-homozygous haplobank of iPSCs that covers a
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.
Irvine, Calif., Jan. 30, 2023 — Combating Alzheimer’s and other neurodegenerative diseases by inserting healthy new immune cells into the brain has taken a leap toward reality. Neuroscientists at the University of California, Irvine and the University of Pennsylvania have found a way to safely thwart the brain’s resistance to them, vaulting a key hurdle in the quest.
BACKGROUNDThe therapeutic effects of various stem cells in acute liver failure (ALF) have been demonstrated in preclinical studies. However, the specific type of stem cells with the highest therapeutic potential has not been determined. AIMTo
Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have illuminated how treatments for multiple myeloma and other aggressive blood cancers can lead to future malignancies, called therapy-related myeloid neoplasms (tMNs).
In a new study using a rat model of Crohn’s disease, a biodegradable hydrogel composite loaded with stem cells, developed by Johns Hopkins Medicine researchers, in a collaborative effort with the Whiting School of Engineering, has shown significant success in treating perianal fistulas (PAF) — one of the many complications of Crohn’s disease.
根据一项妙佑医疗国际(Mayo Clinic)的真实世界证据研究，将再生医学应用于常见的肩关节手术可能会对部分患者的后续修复手术需求产生影响。
إن تطبيق الطب التجديدي على إحدى جراحات الكتف الشائعة قد يكون له تأثيرٌ على الحاجة إلى جراحة مراجعة للمتابعة بالنسبة لبعض المرضى، وفقًا لدراسة مايو كلينك ذات الأدلة الواقعية. حيث حلل باحثو
Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a custom-built application to automate determination of engraftment, a key outcome after hematopoietic stem cell transplant (HSCT). The application supersedes a tedious manual process and at the same time substantially improves accuracy of reported hematopoietic cell transplant engraftments.
Rockville, Md.—The Association for Research in Vision and Ophthalmology (ARVO) Foundation congratulates Miguel Flores-Bellver, PhD, recipient of the 2023 Bert M. Glaser, MD Award for Innovative Research in Retina. The award recognizes an early-career investigator who has made a novel discovery that impacted the understanding and/or treatment of a retinal disease or condition.
UC San Diego researchers describe how pancreatic cancer stem cells leverage a protein in a family of proteins that normally suppress tumors to instead do the opposite, boosting their resistance to conventional treatments and spurring growth.
UC San Diego researchers identify mutation that causes excessive folding in human brain’s wrinkly cerebral cortex, resulting in diminished cognitive function.
The Stem Cell and Bone Marrow Transplant Program at Cedars-Sinai Cancer was recently recognized with two important hallmarks of quality: official accreditation for CAR T-cell therapy, and a third year in a row ranking among the top adult bone marrow transplant programs in the U.S.
A new study led by Cedars-Sinai and the University of California, San Francisco (UCSF), has determined that altering a cellular process can lead stem cells—cells from which other cells in the body develop—to die or regenerate.
Researchers have uncovered sphingolipid accumulation as a new mechanism that affects ageing. Ceramides, the best-known class of sphingolipids, accumulate in aged muscle, impairing its function while also affecting functional capacity in older adults.
Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4), an adoptive T cell receptor (TCR) therapy targeting the MAGE-A4 cancer antigen, achieved clinically significant results for patients with multiple solid tumor types in a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.
Most cells have a pretty normal life: they’re born, they grow, they get old, and they die. But the Benjamin Buttons of the cellular world can go from old to young again in the right context.
Cheng et al. delineate a comprehensive m6A landscape during acute myeloid leukemia (AML) development and identify PRMT6, regulated by IGF2BP2, acting as a key for leukemia stem cell maintenance by restraining MFSD2A expression and docosahexaenoic ac
Chemical modifications of RNA are regulated by a series of readers, writers, and erasers that dictate gene expression. Two new studies in Cell Stem Cell1,2 identify roles for the N6-methyladenosine (m6A) methyltransferase METTL16 and the m6A reader I
By generating a multiomic cell atlas of embryonic human lungs and establishing a human tip progenitor cell organoid culture system, two recent studies demonstrated the exciting research advances in human lung development.
Serrano et al. used human iPSC-derived cardiomyocytes and deep learning data analysis to establish an in vitro safety margin that predicts clinical proarrhythmic effects of drugs. Their platform shows high accuracy in identifying risky drugs as wel
Organoids provide a platform for recapitulating and exploring development, and synthetic biology offers a toolbox to genetically manipulate cell communication, adhesion, and even cell fate. Using modular synthetic biology tools in organoids will impr
Editors’ note: The Ogawa-Yamanaka Stem Cell Prize recognizes groundbreaking work in translational regenerative medicine using reprogrammed cells. The prize is supported by Gladstone Institutes, in partnership with Cell Press. This article features
While many animals can completely repair injured tissues, the mammalian heart possesses limited regenerative capabilities. Yan and Cigliola et al. show that AAV-mediated, zebrafish-derived tissue regeneration enhancer elements (TREEs) can direct pro
(Cell Stem Cell 26, 657–674; May 7, 2020)
Deng and colleagues identify METTL16, an m6A writer, as a strong dependency in AML. METTL16 exerts its tumor-promoting role by altering the abundance of m6A-regulated proteins, BCAT1 and BCAT2, and rewiring BCAA metabolism in AML.
Building tissues and organs is one of the most complex and important tasks that cells must accomplish during embryogenesis.
Retinal cells grown from stem cells can reach out and connect with neighbors, according to a new study, completing a “handshake” that may show the cells are ready for trials in humans with degenerative eye disorders.Over a decade ago, researchers from the University of Wisconsin–Madison developed a way to grow organized clusters of cells, called organoids, that resemble the retina, the light-sensitive tissue at the back of the eye.
Researchers from Rutgers Cancer Institute of New Jersey, the state’s leading cancer program and only National Cancer Institute-designated Comprehensive Cancer Center, together with RWJBarnabas Health, in collaboration with investigators from MD Anderson Cancer Center, discovered a novel triple immunotherapy combination, targeting checkpoints on both T cells and myeloid suppressor cells, that dramatically improved anti-tumor responses by reprogramming the tumor microenvironment in preclinical models of PDAC.
Researchers at Queen Mary University of London have shown that zebrafish can provide genetic baz1b clues to the evolution of social behaviours in humans and domesticated species.
Studying mice, researchers at Washington University School of Medicine in St. Louis have found that proteins made by stem cells to help regenerate the cornea may become new targets for treating and preventing injuries to the cornea related to dry eye disease. When eyes are dry, the cornea is more susceptible to injury.
Porpiglia and colleagues identify a dysfunctional CD47hi muscle stem cell (MuSC) subset in aged mice, which arises from increased U1 snRNA-driven CD47 alternative polyadenylation. CD47hi MuSCs trigger deleterious thrombospondin-1/CD47 signaling. A th
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.
BACKGROUNDIschemic stroke is a condition in which an occluded blood vessel interrupts blood flow to the brain and causes irreversible neuronal cell death. Transplantation of regenerative stem cells has been proposed as a novel therapy to restor
BACKGROUNDSpermatogonial stem cells (SSCs) are the origin of male spermatogenesis, which can reconstruct germ cell lineage in mice. However, the application of SSCs for male fertility restoration is hindered due to the unclear mechanisms of pro
BACKGROUNDThere is still no consensus on which concentration of mesenchymal stem cells (MSCs) to use for promoting fracture healing in a rat model of long bone fracture. AIMTo assess the optimal concentration of MSCs for promoting fracture hea
Intervertebral disc degeneration is the main cause of low back pain. In the past 20 years, the injection of mesenchymal stromal cells (MSCs) into the nucleus pulposus of the degenerative disc has become the main approach for the treatment of lo
Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases. The research team from the National Eye Institute (NEI), part of the National Institutes of Health, printed a combination of cells that form the outer blood-retina barrier—eye tissue that supports the retina's light-sensing photoreceptors. The technique provides a theoretically unlimited supply of patient-derived tissue to study degenerative retinal diseases such as age-related macular degeneration (AMD).
In people with active secondary progressive multiple sclerosis (MS), hematopoietic stem cell transplants may delay disability longer than some other MS medications, according to a study published in the December 21, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study involved autologous hematopoietic stem cell transplants, which use healthy blood stem cells from a person’s own body to replace diseased cells.
New data show the University of Chicago Medicine's David and Etta Jonas Center for Cellular Therapy has the highest one-year survival rate in Illinois for adults undergoing blood and bone marrow stem cell transplants. UChicago Medicine had an 80% one-year survival rate among adult stem cell patients, according to the latest statistics released in mid-December by the Center for International Blood & Marrow Transplant Research (CIBMTR).
Less than three years after joining the Cedars-Sinai Cancer faculty, hematologist-oncologists Justin Darrah, MD, and Akil Merchant, MD, are pioneering new research and bringing a new, comprehensive set of treatment options to patients in the recently established Lymphoma Program.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right
