Curated News: Cell (journal)

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Newswise: Splicing Deregulation Detected and Targeted in Type of Childhood Leukemia
Released: 7-Mar-2023 12:30 PM EST
Splicing Deregulation Detected and Targeted in Type of Childhood Leukemia
University of California San Diego

UC San Diego researchers delve deep into the unknown cause of pediatric acute myeloid leukemia to identify a gene splicing dysregulation and potential target for treating the disease, which often becomes treatment-resistant.

Released: 2-Mar-2023 2:15 PM EST
How Gut Microbes Help Mend Damaged Muscles
Harvard Medical School

Now, in a surprising new discovery, Harvard Medical School researchers have found that a class of regulatory T cells (Tregs) made in the gut play a role in repairing injured muscles and mending damaged livers. In an even more unexpected twist, the researchers found that gut microbes fuel the production of Tregs, which act as immune healers that go on patrol around the body and respond to distress signals from distant sites of injury.

Released: 2-Mar-2023 8:00 AM EST
U.S. birds’ Eastern, Western behavior patterns are polar opposites
Ohio State University

Avian functional diversity patterns in the Western U.S., where species and functional richness are both highest during the breeding season, are the polar opposite of what is seen in the East, where functional diversity is lowest when species richness is high, according to new research.

Newswise: New testing approach diagnoses COVID-19 with near-perfect accuracy
Released: 27-Feb-2023 5:25 PM EST
New testing approach diagnoses COVID-19 with near-perfect accuracy
Simons Foundation

By inspecting the body’s immune response at a molecular level, a research team has developed a new way to test patients for COVID-19.

Newswise: Tiny new climbing robot was inspired by geckos and inchworms
Released: 27-Feb-2023 1:10 PM EST
Tiny new climbing robot was inspired by geckos and inchworms
University of Waterloo

A tiny robot that could one day help doctors perform surgery was inspired by the incredible gripping ability of geckos and the efficient locomotion of inchworms.

Released: 23-Feb-2023 7:30 PM EST
Psyllium fiber protects against colitis by activating bile acid sensor, biomedical sciences researchers find
Georgia State University

Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a new study by researchers in the Institute for Biomedical Sciences at Georgia State University.

Released: 22-Feb-2023 12:10 PM EST
New research reveals possible COVID vaccine blood clot connection
Flinders University

A new Australian study led by SAHMRI and Flinders University has uncovered fundamental differences in how the AstraZeneca and Pfizer COVID-19 vaccines impact the immune system.

Newswise: First Stem Cells From a Bat Species Known to Harbor SARS-CoV-2 Could Shed Light on Virus Survival and Molecular Adaptability
14-Feb-2023 11:00 AM EST
First Stem Cells From a Bat Species Known to Harbor SARS-CoV-2 Could Shed Light on Virus Survival and Molecular Adaptability
Mount Sinai Health System

Researchers from the Icahn School of Medicine at Mount Sinai have generated the first induced pluripotent stem cells (iPSCs) from bats, gaining valuable insights into the close relationship between bats and viruses.

Newswise: Researchers Map Mosquito Cells That May Help the Insects Choose Tastiest Humans
Released: 21-Feb-2023 10:00 AM EST
Researchers Map Mosquito Cells That May Help the Insects Choose Tastiest Humans
Johns Hopkins Medicine

In a bid to understand why mosquitoes may be more attracted to one human than another, Johns Hopkins Medicine researchers say they have mapped specialized receptors on the insects’ nerve cells that are able to fine-tune their ability to detect particularly “welcoming” odors in human skin.

Newswise: Uncovering the traits of Japan’s dual ancestry: New research reveals historical regional mix and genetic predispositions to obesity and asthma
Released: 20-Feb-2023 2:10 PM EST
Uncovering the traits of Japan’s dual ancestry: New research reveals historical regional mix and genetic predispositions to obesity and asthma
University of Tokyo

Regional differences in the spread of Japan’s two main ancestral groups have been revealed, thanks to new research at the University of Tokyo. Japanese people are generally thought to descend from two main groups: Jomon hunter-gatherers and immigrant farmers from continental East Asia.

Newswise: Evolution: Miniproteins appeared “from nowhere”
Released: 17-Feb-2023 3:40 PM EST
Evolution: Miniproteins appeared “from nowhere”
Max Delbrück Center for Molecular Medicine in the Helmholtz Association

Every biologist knows that small structures can sometimes have a big impact: Millions of signaling molecules, hormones, and other biomolecules are bustling around in our cells and tissues, playing a leading role in many of the key processes occurring in our bodies.

   
Newswise: Engineered wood grows stronger while trapping carbon dioxide
Released: 16-Feb-2023 1:35 PM EST
Engineered wood grows stronger while trapping carbon dioxide
Rice University

Rice University scientists have figured out a way to engineer wood to trap carbon dioxide through a potentially scalable, energy-efficient process that also makes the material stronger for use in construction.

Newswise: Small Molecule Drug Reverses ADAR1-induced Cancer Stem Cell Cloning Capacity
Released: 16-Feb-2023 12:35 PM EST
Small Molecule Drug Reverses ADAR1-induced Cancer Stem Cell Cloning Capacity
University of California San Diego

UC San Diego researchers report that a late-stage, pre-clinical small molecule inhibitor reverses malignant hyper-editing by a protein that promotes silencing of the immune response, metastasis and therapeutic resistance in 20 different cancer types.

Newswise: Hijacking our cells’ enzymes to eliminate disease-causing proteins
Released: 15-Feb-2023 4:35 PM EST
Hijacking our cells’ enzymes to eliminate disease-causing proteins
University of Illinois Chicago

The researchers looked at a ubiquitin ligase enzyme named FBXL2, known to degrade proteins at various cellular membrane compartments. They found that by attaching or detaching a fat molecule or lipid to FBXL2 — a process called palmitoylation and de-palmitoylation — they could direct where the FBXL2 went. They also discovered that in order to travel in the aqueous cellular environment for the delivery of lipid-modified FBXL2 to membrane compartments, it used a trafficking protein called PDE6D, which is known to shield the lipid modifications.

Released: 15-Feb-2023 4:05 PM EST
Bionic fingers create 3D maps of human tissue, electronics, and other complex objects
Cell Press

What if, instead of using X-rays or ultrasound, we could use touch to image the insides of human bodies and electronic devices?

   
Newswise: Insect bite marks show first fossil evidence for plants’ leaves folding up at night
Released: 15-Feb-2023 3:35 PM EST
Insect bite marks show first fossil evidence for plants’ leaves folding up at night
Cell Press

Plants can move in ways that might surprise you. Some of them even show “sleep movements,” folding or raising their leaves each night before opening them again the next day.

Newswise: New compound that withstands extreme heat and electricity could lead to next-generation energy storage devices
Released: 15-Feb-2023 11:15 AM EST
New compound that withstands extreme heat and electricity could lead to next-generation energy storage devices
Lawrence Berkeley National Laboratory

Society’s growing demand for high-voltage electrical technologies—including pulsed power systems, cars and electrified aircraft, and renewable energy applications—requires a new generation of capacitors that store and deliver large amounts of energy under intense thermal and electrical conditions. Researchers at Lawrence Berkeley National Laboratory and Scripps Research have now developed a new polymer-based device that efficiently handles record amounts of energy while withstanding extreme temperatures and electric fields.

Newswise: Alternate-day fasting a good option for patients with fatty liver disease
Released: 14-Feb-2023 5:15 PM EST
Alternate-day fasting a good option for patients with fatty liver disease
University of Illinois Chicago

Nutrition researchers studied 80 people with nonalcoholic fatty liver disease and found that those who followed an alternate-day fasting diet and exercised were able to improve their health. In Cell Metabolism, the researchers report that over a period of three months people in the intervention saw increased insulin sensitivity and decreased liver fat, weight and ALT, or alanine transaminase enzymes, which are markers for liver disease.

Released: 14-Feb-2023 5:00 PM EST
Grassroots effort champions inclusive language in science
University of British Columbia

A new grassroots effort—announced this month in Trends in Ecology and Evolution—is calling for a reevaluation of some terminology used in ecology and evolutionary biology (EEB) to make it more inclusive and precise.

Newswise: A molecular ticket to ride: St. Jude scientists capture the cellular train that enables transport in cilia
Released: 13-Feb-2023 11:00 AM EST
A molecular ticket to ride: St. Jude scientists capture the cellular train that enables transport in cilia
St. Jude Children's Research Hospital

Scientists at St. Jude Children’s Research Hospital solved the 3D structure of a protein in cilia, an organelle important to many diseases at nearly ten times the resolution of previous efforts.

Newswise: Lung cancer study finds new target for treatment resistance after EGFR inhibitors
10-Feb-2023 5:00 PM EST
Lung cancer study finds new target for treatment resistance after EGFR inhibitors
University of Texas MD Anderson Cancer Center

Researchers at The University of Texas MD Anderson Cancer Center have identified CD70 as being highly expressed on drug-resistant cancer cells in EGFR-mutant non-small cell lung cancer (NSCLC), highlighting a novel therapeutic target that could be used to eliminate resistant cells remaining after treatment with commonly used EGFR tyrosine kinase inhibitors (TKIs). The study published today in Cancer Cell.

   
Released: 10-Feb-2023 8:10 PM EST
'Natural killer' immune cells can modify tissue inflammation: study
Monash University

Melbourne researchers have improved our understanding of how the immune system is regulated to prevent disease, identifying a previously unknown role of ‘natural killer’ (NK) immune cells.

Newswise: Cockatoos know to bring along multiple tools when they fish for cashews
Released: 10-Feb-2023 8:05 PM EST
Cockatoos know to bring along multiple tools when they fish for cashews
Cell Press

Goffin’s cockatoos have been added to the short list of non-human animals that use and transport toolsets.

Newswise: Large-Scale Generation of Muscle-Controlling Nerve Cells From ALS Patients
Released: 9-Feb-2023 3:05 PM EST
Large-Scale Generation of Muscle-Controlling Nerve Cells From ALS Patients
Cedars-Sinai

A new Cedars-Sinai study in collaboration with the University of California, Irvine (UCI) and the Answer ALS consortium has examined the expression of thousands of genes in stem cell generated motor neurons that are known to die in patients with amyotrophic lateral sclerosis, a fatal neurological disorder known as ALS or Lou Gehrig's disease.

Released: 8-Feb-2023 6:00 PM EST
Microbiome disturbances reported as signature of chronic fatigue syndrome/myalgic encephalomyelitis
Columbia University, Mailman School of Public Health

New research reveals differences in the gut microbiomes of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) compared to those of healthy controls.

Newswise: A new understanding of reptile coloration
Released: 3-Feb-2023 7:20 PM EST
A new understanding of reptile coloration
McGill University

Snakes and mice don’t look alike. But much of what we know about skin coloration and patterning in vertebrates generally, including in snakes, is based on lab mice.

Newswise: UT Southwestern researchers discover gene regulation mechanism
Released: 3-Feb-2023 1:20 PM EST
UT Southwestern researchers discover gene regulation mechanism
UT Southwestern Medical Center

UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery. The findings, reported in Cell, could lead to new ways of controlling gene regulation and may one day lead to new treatments for a broad array of diseases.

Newswise: Why lung cancer doesn’t respond well to immunotherapy
Released: 3-Feb-2023 12:45 PM EST
Why lung cancer doesn’t respond well to immunotherapy
Massachusetts Institute of Technology (MIT)

Immunotherapy — drug treatment that stimulates the immune system to attack tumors — works well against some types of cancer, but it has shown mixed success against lung cancer.

Newswise: Evolution of wheat spikes since the Neolithic revolution
Released: 2-Feb-2023 7:20 PM EST
Evolution of wheat spikes since the Neolithic revolution
Universidad De Barcelona

Around 12,000 years ago, the Neolithic revolution radically changed the economy, diet and structure of the first human societies in the Fertile Crescent of the Near East.

Newswise: Establishing cell lines to improve iPSC research
Released: 2-Feb-2023 7:15 PM EST
Establishing cell lines to improve iPSC research
Jackson Laboratory

iPSC lines have become essential for determining the underlying genetic drivers of human disease.

   
Newswise: How to make hydrogels more injectable
Released: 31-Jan-2023 7:45 PM EST
How to make hydrogels more injectable
Massachusetts Institute of Technology (MIT)

Gel-like materials that can be injected into the body hold great potential to heal injured tissues or manufacture entirely new tissues.

Newswise: LJI scientists uncover the structure and function of Inmazeb, the first FDA-approved drug for Ebola virus infection
Released: 30-Jan-2023 4:30 PM EST
LJI scientists uncover the structure and function of Inmazeb, the first FDA-approved drug for Ebola virus infection
La Jolla Institute for Immunology

Inmazeb (REGN-EB3), developed by Regeneron, is a three-antibody cocktail designed to target the Ebola virus glycoprotein. The drug was first approved for clinical use in October 2020, but its exact mechanism of action has remained unclear.

   
Newswise: Understanding long-term changes in the synapses between the hypothalamus and hippocampus
Released: 30-Jan-2023 4:15 PM EST
Understanding long-term changes in the synapses between the hypothalamus and hippocampus
Doshisha University

The complexity of the human brain is unparalleled. Fortunately, thanks to constant progress in neuroscience over the past decades, we have started to make some sense of the human brain.

Released: 27-Jan-2023 3:40 PM EST
When bugs swipe left
Washington University in St. Louis

Vinegar flies use pheromones to ensure that they court and mate with members of the same species. As new fly species split off from a common ancestor, but continue to share the same environment, they need a way to rapidly diversify their pheromones to suppress inter-species mating. New research identifies a link between the genetic instructions for the production and perception of sex pheromones.

Released: 27-Jan-2023 1:15 PM EST
Tool to predict the impact of diets on cancerous & healthy cells
Francis Crick Institute

Researchers at the Francis Crick Institute and King’s College London have created a tool to predict the effects of different diets on both cancerous cells and healthy cells.

Newswise: Keys to Making Immunotherapy Work Against Pancreatic Cancer Found in Tumor Microenvironment
Released: 26-Jan-2023 10:00 AM EST
Keys to Making Immunotherapy Work Against Pancreatic Cancer Found in Tumor Microenvironment
Johns Hopkins Medicine

A new study that analyzed the tumor microenvironment of pancreatic cancer revealed the cause of tumor cell resistance to immunotherapy and resulted in new treatment strategies.

Newswise: Researchers Unravel Why Episodes of Low Blood Sugar Worsen Eye Disease in People with Diabetes
Released: 26-Jan-2023 9:00 AM EST
Researchers Unravel Why Episodes of Low Blood Sugar Worsen Eye Disease in People with Diabetes
Johns Hopkins Medicine

People with diabetes who experience periods of low blood sugar — a common occurrence in those new to blood sugar management — are more likely to have worsening diabetic eye disease. Now, researchers at Johns Hopkins Medicine say they have linked such low blood sugar levels with a molecular pathway that is turned on in oxygen-starved cells in the eye.

Newswise: Chatterboxes: FSU researcher develops new model that shows how bacteria communicate
Released: 25-Jan-2023 4:40 PM EST
Chatterboxes: FSU researcher develops new model that shows how bacteria communicate
Florida State University

In new research published by Biophysical Reports, researchers from Florida State University and Cleveland State University lay out a mathematical model that explains how bacteria communicate within a larger ecosystem. By understanding how this process works, researchers can predict what actions might elicit certain environmental responses from a bacterial community.

Newswise: Special Vascular Cells Adjust Blood Flow in Brain Capillaries Based on Local Energy Needs
Released: 25-Jan-2023 11:35 AM EST
Special Vascular Cells Adjust Blood Flow in Brain Capillaries Based on Local Energy Needs
University of Maryland School of Medicine

University of Maryland School of Medicine’s researchers have discovered that a certain type of cell that sits on top of the brain’s smallest blood vessels senses when their brain region needs energy. When glucose levels are low, these cells signal blood vessels to dilate, increasing the blood flow regionally and allowing more energy to fuel that part of the brain.

Newswise: Forests face fierce threats from multiple industries, not just agricultural expansion
Released: 20-Jan-2023 6:40 PM EST
Forests face fierce threats from multiple industries, not just agricultural expansion
Cell Press

Intact forests are important climate regulators and harbors of biodiversity, but they are rapidly disappearing.

Newswise: Collision risk and habitat loss: Wind turbines in forests impair threatened bat species
Released: 20-Jan-2023 4:05 PM EST
Collision risk and habitat loss: Wind turbines in forests impair threatened bat species
Leibniz Institute for Zoo and Wildlife Research (IZW)

In order to meet climate protection goals, renewable energies are booming – often wind power.

Newswise: An Unprecedented Look at Colorectal Cancer
13-Jan-2023 3:20 PM EST
An Unprecedented Look at Colorectal Cancer
Harvard Medical School

Researchers are building detailed maps of colorectal cancer to better understand the dynamics of the disease

Newswise: Harnessing solar energy: new method improves readings of double-sided panels
Released: 18-Jan-2023 6:30 PM EST
Harnessing solar energy: new method improves readings of double-sided panels
University of Ottawa

A leading laboratory in photonics and renewable energy at the University of Ottawa has developed a new method for measuring the solar energy produced by bifacial solar panels, the double-sided solar technology which is expected to meet increased global energy demands moving forward.

Newswise: Scientists Publish New Findings in Quest to Build a Better Opioid
Released: 18-Jan-2023 5:00 PM EST
Scientists Publish New Findings in Quest to Build a Better Opioid
University of North Carolina School of Medicine

This basic scientific research provides a comprehensive structural framework that should help drug developers rationally design safer drugs to relieve severe pain.

Newswise: Salmonella exposure a risk for colon cancer
Released: 17-Jan-2023 4:45 PM EST
Salmonella exposure a risk for colon cancer
University of Illinois Chicago

Researchers studied human colon cancer tissue samples and animal models and found that exposure to salmonella was linked with colon cancers that developed earlier and grew larger.

Newswise: Durable SARS-CoV-2 antibodies bind to two viral targets at once
Released: 17-Jan-2023 4:20 PM EST
Durable SARS-CoV-2 antibodies bind to two viral targets at once
La Jolla Institute for Immunology

A new study led by scientists at La Jolla Institute for Immunology (LJI) shows how ideal antibodies against SARS-CoV-2 hit their marks. Now scientists are looking at how we might harness their power in new antibody therapeutics and even more effective COVID-19 vaccines.

   
Released: 17-Jan-2023 1:40 PM EST
UC Irvine, UCLA researchers identify new therapeutic approach to prevent ARDS
University of California, Irvine

A novel peptide designed by University of California, Irvine researchers has been found to suppress the damaging lung inflammation seen in acute respiratory distress syndrome, or ARDS. Their study, which appears in iScience, describes the first specific treatment designed to prevent the deadly disease, which can appear in patients with severe lung injury from infections with bacteria and viruses, like pneumonia, flu, respiratory syncytial virus (RSV) and COVID-19.

Newswise: Using paleogenomics to elucidate 10,000 years of immune system evolution
Released: 13-Jan-2023 5:40 PM EST
Using paleogenomics to elucidate 10,000 years of immune system evolution
Institut Pasteur

Scientists from the Institut Pasteur, Université Paris Cité, the CNRS and the Collège de France have used paleogenomics to trace 10,000 years of human immune system evolution.

   
Newswise: Evolution of uniquely human DNA was a balancing act, study concludes
Released: 13-Jan-2023 4:00 PM EST
Evolution of uniquely human DNA was a balancing act, study concludes
Gladstone Institutes

Humans and chimpanzees differ in only one percent of their DNA. Human accelerated regions (HARs) are parts of the genome with an unexpected amount of these differences.

Newswise: Scientists Identify How a Biological Pathway Leads Stem Cells to Die or Regenerate
Released: 13-Jan-2023 12:55 PM EST
Scientists Identify How a Biological Pathway Leads Stem Cells to Die or Regenerate
Cedars-Sinai

A new study led by Cedars-Sinai and the University of California, San Francisco (UCSF), has determined that altering a cellular process can lead stem cells—cells from which other cells in the body develop—to die or regenerate.



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