Feature Channels: Alzheimer's and Dementia

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Newswise: Poor Sense of Smell Linked to Increased Risk of Depression in Older Adults
Released: 26-Jun-2023 10:00 AM EDT
Poor Sense of Smell Linked to Increased Risk of Depression in Older Adults
Johns Hopkins Medicine

In a study that followed more than 2,000 community-dwelling older adults over eight years, researchers at Johns Hopkins Medicine say they have significant new evidence of a link between decreased sense of smell and risk of developing late-life depression.

Released: 23-Jun-2023 4:05 PM EDT
Women with common heart rhythm disorder have faster cognitive decline than men
European Society of Cardiology

Women with atrial fibrillation progress more rapidly to cognitive impairment and dementia than men with the heart rhythm condition, according to research presented today at ACNAP 2023, a scientific congress of the European Society of Cardiology (ESC)1 and published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

Newswise: Stem cell model of human brain development suggests embryonic origins of Alzheimer’s disease
Released: 22-Jun-2023 4:05 PM EDT
Stem cell model of human brain development suggests embryonic origins of Alzheimer’s disease
International Society for Stem Cell Research

Alzheimer's disease (AD) mainly affects the older population. Recent research found early disease signs in cell culture models of early human brain development, raising the possibility that the disease has its origins much earlier in life, possibly during embryogenesis – the formation and development of an embryo.

Newswise: New Findings Show Mitochondrial DNA Fragments in Blood as Important Biomarkers for Aging and Inflammation
Released: 21-Jun-2023 10:00 AM EDT
New Findings Show Mitochondrial DNA Fragments in Blood as Important Biomarkers for Aging and Inflammation
Johns Hopkins Medicine

In an eight-year study of more than 600 community-dwelling older adults, Johns Hopkins Medicine researchers say they have further linked levels of cell-free DNA (DNA fragments resulting from cell death) circulating in the blood to chronic inflammation and frailty.

Released: 20-Jun-2023 10:05 AM EDT
Veravas Launches Groundbreaking VeraBIND Technology for Ultra-Sensitive Assays and Matrix Free Sample Analysis
Veravas, Inc

Today, Veravas, a leading innovator in clinical diagnostics, announced the launch of its groundbreaking VeraBIND™ (Biomarker Isolation and N-richment for Detection) technology

   
20-Jun-2023 8:00 AM EDT
Walkable Neighborhoods Help Adults Socialize, Increase Community
University of California San Diego

Adults who live in walkable neighborhoods are more likely to socialize and have a stronger sense of community, report researchers at the UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science.

   
Released: 16-Jun-2023 7:25 PM EDT
Significant correlation found between vitreous human biomarkers and Alzheimer’s disease
Boston Medical Center

New research from Boston Medical Center found a significant correlation between biomarkers in the vitreous humor of the eye and pathologically confirmed cases of Alzheimer’s disease (AD) and Chronic Traumatic Encephalopathy (CTE) in post-mortem brain and eye tissue.

Newswise: Scientists develop universal donor stem cell therapy to treat degenerative brain diseases in a preclinical study
Released: 15-Jun-2023 5:10 PM EDT
Scientists develop universal donor stem cell therapy to treat degenerative brain diseases in a preclinical study
City of Hope

Scientists at City of Hope have developed universal donor stem cells that could one day provide lifesaving therapy to children with lethal brain conditions, such as Canavan disease, as well as to people with other degenerative diseases, such as Alzheimer’s and multiple sclerosis.

Released: 15-Jun-2023 4:35 PM EDT
UC Irvine to lead multi-institutional study of single-cell vulnerabilities to Alzheimer’s disease
University of California, Irvine

The University of California, Irvine has received a five-year, $10 million grant from the National Institutes of Health to lead a multi-institutional study of specific brain cell vulnerabilities to abnormal tau protein deposits in regions affected in the early stages of Alzheimer’s disease.

12-Jun-2023 6:35 PM EDT
Altered gut bacteria may be early sign of Alzheimer’s disease
Washington University in St. Louis

Alzheimer’s disease causes changes to the brain that begin two decades or more before symptoms appear. A study by researchers at Washington University School of Medicine in St. Louis reveals that the bacteria that live in the gut also change before Alzheimer’s symptoms arise, a discovery that could lead to diagnostics or treatments for Alzheimer’s disease that target the gut microbiome.

Released: 13-Jun-2023 11:40 AM EDT
Potential Improvement of Learning and Memory in Down Syndrome
Alzheimer's Center at Temple University Lewis Katz School of Medicine

A new approach could enhance memory and learning in individuals with Down syndrome by stabilizing a key component in the body's protein sorting system called the retromer complex.

Released: 12-Jun-2023 2:45 PM EDT
AAN Submits National Coverage Determination Reconsideration Request to CMS
American Academy of Neurology (AAN)

The American Academy of Neurology (AAN), the world’s largest association of neurologists and neuroscience professionals, has submitted a Formal National Coverage Determination (NCD) Reconsideration Request to the Centers for Medicare & Medicaid Services (CMS) regarding the existing national coverage determination on Monoclonal Antibodies Directed Against Amyloid for the Treatment of Alzheimer’s Disease, including the new therapy lecanemab.

Newswise: Researchers to Explore Potential of New Treatment Against Vascular Dementia
Released: 8-Jun-2023 5:20 PM EDT
Researchers to Explore Potential of New Treatment Against Vascular Dementia
University of Texas at El Paso

Researchers from The University of Texas at El Paso’s School of Pharmacy will explore the viability of a new treatment for vascular dementia, thanks to a $2.2 million grant from the National Institutes of Health National Institute of Neurological Disorders and Stroke.

Released: 7-Jun-2023 3:15 PM EDT
Looking deeper with adaptive six-dimensional nanoscopy
Washington University in St. Louis

Matthew Lew, an associate professor of electrical and systems engineering at the McKelvey School of Engineering at Washington University in St. Louis, has received a five-year $2 million Maximizing Investigators’ Research Award (MIRA) from the National Institutes of Health (NIH) to support his ongoing work to improve microscopic imaging techniques.

Released: 7-Jun-2023 12:30 PM EDT
Research Group Calls for Consensus, Collaboration to Improve Understanding of how Infections Drive Alzheimer’s
Philadelphia College of Osteopathic Medicine

A research consortium, including a Philadelphia College of Osteopathic Medicine neuroscientist and his research coordinator, are calling for a consensus on how scientists identify and evaluate how infections contribute to or cause cognitive impairment and dementias, including Alzheimer’s disease.

Released: 6-Jun-2023 1:35 PM EDT
National Sports Brain Bank launches with pledges of brain donations from Hall of Famer Bettis, more
University of Pittsburgh

Pitt unveils National Sports Brain Bank to track patients with contact-sports backgrounds; Steelers legends Jerome Bettis, Merril Hoge pledge brains and participation in innovative program.

Released: 6-Jun-2023 12:55 PM EDT
Nursing home dementia residents’ care linked to majority presence, UC Irvine-led study finds
University of California, Irvine

The quality of care for nursing home residents with Alzheimer’s disease and related dementias is best when they are in the majority, but most facilities also accommodate a heterogeneous population, where specialized staff training is limited, according to a study led by the University of California, Irvine.

Released: 5-Jun-2023 8:00 AM EDT
Mount Sinai Experts Present Research at SLEEP 2023
Mount Sinai Health System

Sleep medicine experts from the Mount Sinai Health System are presenting new research at SLEEP 2023, the 37th annual meeting of the Associated Professional Sleep Societies running until June 7 in Indianapolis.

Newswise: May Research Highlights
Released: 2-Jun-2023 3:05 AM EDT
May Research Highlights
Cedars-Sinai

A roundup of the latest medical discoveries and faculty news at Cedars-Sinai in May 2023.

30-May-2023 10:30 AM EDT
Deep-brain stimulation during sleep strengthens memory
University of California, Los Angeles (UCLA), Health Sciences

This study provides provides the first physiological evidence from inside the human brain supporting the dominant scientific theory on how the brain consolidates memory during sleep. Further, deep-brain stimulation during a critical time in the sleep cycle appeared to improve memory consolidation.

Released: 1-Jun-2023 10:40 AM EDT
Too Much of Anything Isn’t Good For Your Health: Why You Should Stop Binge Watching To Maintain Your Brain Health
Hackensack Meridian Health

Experts available on the correlation between binge watching television and dementia later in life

26-May-2023 4:00 PM EDT
What Is the Relationship Between Sleep Apnea and Brain Volume?
American Academy of Neurology (AAN)

Studies have shown that sleep apnea is related to an increased risk of dementia. A new study looks at the relationship between sleep apnea and brain volume. The study is published in the May 31, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Released: 29-May-2023 5:05 PM EDT
The Search For Alzheimer's Disease Biomarkers
Alzheimer's Center at Temple University Lewis Katz School of Medicine

A biomarker is a characteristic that can be measured and evaluated as an indicator of normal biological processes, pathogenetic processes, or pharmacologic responses to a therapeutic intervention. In the context of Alzheimer’s disease (AD), an AD biomarker indicates the presence or progression of the disease that may be altered by drug treatment, thereby demonstrating that it is hitting its target. Today, all clinical trials for Alzheimer’s disease utilize biomarkers of some form to assess whether the drug is actually affecting the disease in the brain.

Released: 29-May-2023 4:50 PM EDT
Katz School of Medicine opens Alzheimer’s Center
Alzheimer's Center at Temple University Lewis Katz School of Medicine

The Lewis Katz School of Medicine created the Alzheimer’s Center at Temple from funds donated by Board of Trustees member Phil Richards earlier this month. Richards’s gift created the center and established the Scott Richards North Star Charitable Foundation Chair for Alzheimer’s Research.

Released: 29-May-2023 4:05 PM EDT
Can Music Help Patients with Alzheimer's Disease?
Alzheimer's Center at Temple University Lewis Katz School of Medicine

Did you know that music might be able to connect you with your family members affected by Alzheimer's disease (AD) in a way that words cannot? Many studies have shown that music can evoke a response or a memory in people with Alzheimer's Disease.

Released: 29-May-2023 3:30 PM EDT
Medications to avoid for a patient with Alzheimer’s disease
Alzheimer's Center at Temple University Lewis Katz School of Medicine

The risk of side effects can rise if drugs are taken for conditions other than Alzheimer's disease (AD) treatment. Some sedatives and antidepressants can deteriorate cognitive function, make people drowsy and confused, and worsen cognitive impairment, which increases the risk of falls.

Released: 29-May-2023 3:20 PM EDT
Mechanism Underlying Alzheimer-Like Damage in the Brain of Patients with Down Syndrome
Alzheimer's Center at Temple University Lewis Katz School of Medicine

Alzheimer-like changes – marked by the build-up of harmful amyloid and tau proteins – occur in the brain in Down syndrome has been unclear. But now, in new research, scientists at the Lewis Katz School of Medicine at Temple University show that reduced efficiency of a key protein transport system is partly to blame.

Newswise: Diagnosing Alzheimer's Disease: Neuro-Psychological and Memory Testing
Released: 29-May-2023 3:05 PM EDT
Diagnosing Alzheimer's Disease: Neuro-Psychological and Memory Testing
Alzheimer's Center at Temple University Lewis Katz School of Medicine

Diagnosing Alzheimer's disease (AD) is a complex process that doesn't rely on a single test.

Released: 29-May-2023 2:55 PM EDT
Alzheimer's Center at Temple Awarded $3.8 Million from Pennsylvania Department of Health to Lead Collaborative Investigation into Vascular Risk Factors in Dementia
Alzheimer's Center at Temple University Lewis Katz School of Medicine

Alzheimer's disease is the most common form of dementia in the elderly. Memory loss and difficulty thinking worsen progressively, with some patients eventually becoming delusional, disoriented, and vulnerable to mood swings and depression. Finding ways to slow or reverse this progression, or even prevent symptoms from developing in the first place, are major goals in Alzheimer's research.

Released: 29-May-2023 2:45 PM EDT
Cognitive Changes in Normal Aging
Alzheimer's Center at Temple University Lewis Katz School of Medicine

People may endure cognitive changes as they get older, including forgetfulness and a loss of their capacity for multitasking or concentration. Although these changes are typical, they can be upsetting for elderly people.

Released: 29-May-2023 2:05 PM EDT
Common Myths about Alzheimer’s disease
Alzheimer's Center at Temple University Lewis Katz School of Medicine

Alzheimer's disease is a debilitating condition that affects millions of people around the world, but there is also a lot of misinformation about it. One of the most common myths is that memory loss is a natural part of aging.

Newswise: Alzheimer’s Drug Development Pipeline: Promising Therapies, Pharma Investment Drive Momentum in Clinical Trials
Released: 25-May-2023 12:45 PM EDT
Alzheimer’s Drug Development Pipeline: Promising Therapies, Pharma Investment Drive Momentum in Clinical Trials
University of Nevada, Las Vegas (UNLV)

According to the newly released “Alzheimer’s Disease Drug Development Pipeline: 2023,” there are currently 187 clinical trials in the Alzheimer’s drug development pipeline – the most ever on record. This momentum is driven in part by greater investment from the pharma industry and a bump in biologic therapies – particularly monoclonal antibodies – that were central to the success of both recent FDA-approved drugs. The annual report spots trends in clinical trial design and outcome measures, and also investigate the types of agents and biological targets that are being pursued.

Newswise: Managing epilepsy in older adults
Released: 25-May-2023 11:05 AM EDT
Managing epilepsy in older adults
International League Against Epilepsy

What special considerations must physicians make when managing epilepsy in older adults? Who is considered an “older adult,” anyway? Dr. Anca Arbune interviews two authors of a recent critical review by an ILAE task force.

19-May-2023 4:10 PM EDT
Does Having Alzheimer’s Genes Increase Your Risk of Epilepsy?
American Academy of Neurology (AAN)

People with a genetic predisposition for Alzheimer’s disease may have an increased risk of epilepsy and people with a certain type of epilepsy may have an increased risk of developing Alzheimer’s disease, according to a study published in the May 24, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Newswise: New UCI-led research shows people who live to be 90+ with superior thinking skills are resilient to Alzheimer’s pathology in their brains
Released: 24-May-2023 2:20 PM EDT
New UCI-led research shows people who live to be 90+ with superior thinking skills are resilient to Alzheimer’s pathology in their brains
University of California, Irvine

A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer’s patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems.

Released: 24-May-2023 12:25 PM EDT
Case study reveals potentially lethal side effects of lecanemab for treatment of Alzheimer's disease
IOS Press

In a noteworthy case study published in the Journal of Alzheimer’s Disease investigators report autopsy findings in a 65-year-old woman with Alzheimer’s disease (AD) who received three open label infusions of the experimental anti-amyloid beta (Aβ) antibody drug lecanemab.

Released: 24-May-2023 10:05 AM EDT
Rensselaer Researchers Find New Potential Drug Target for Alzheimer’s Disease
Rensselaer Polytechnic Institute (RPI)

Chunyu Wang, Ph.D., professor of biological sciences at Rensselaer Polytechnic Institute, has added to his body of research on Alzheimer’s disease with significant findings in Angewandte Chemie.Together with his team, which includes first author and Rensselaer doctoral student Dylan Mah, Wang performed the most comprehensive study to date of the interactions between ApoE, or Apolipoprotein E, and heparan sulfate (HS).

Newswise: Scientists at Wake Forest University School of Medicine Discover Metabolic Sensor May Play Role in Alzheimer’s Disease
Released: 22-May-2023 1:05 PM EDT
Scientists at Wake Forest University School of Medicine Discover Metabolic Sensor May Play Role in Alzheimer’s Disease
Wake Forest University School of Medicine

Scientists at Wake Forest University School of Medicine have uncovered a novel mechanism that shows increased sugar intake and elevations in blood glucose are sufficient to cause amyloid plaque buildup in the brain, which increases the risk of Alzheimer’s disease.

Newswise: Study: Blood Vessel Damage Could Be an Alzheimer’s Driver
Released: 19-May-2023 8:05 PM EDT
Study: Blood Vessel Damage Could Be an Alzheimer’s Driver
Cedars-Sinai

Blood vessel abnormalities in the eye are a major factor in the progression of Alzheimer’s disease, according to research from Cedars-Sinai investigators published in the peer-reviewed journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

Released: 17-May-2023 12:55 PM EDT
Higher blood sugar linked to faster loss of brain power in stroke survivors
Michigan Medicine - University of Michigan

Surviving a stroke can bring many long-term effects – including a much higher risk of dementia. But a study suggests that blood sugar may play a key role in that risk.

Newswise: Insight into brain’s waste clearing system may shed light on brain diseases
Released: 16-May-2023 2:35 PM EDT
Insight into brain’s waste clearing system may shed light on brain diseases
Washington University in St. Louis

Impairments in the lymphatic system may contribute to brain diseases, such as neurodegenerative diseases and stroke. Researchers have found a noninvasive and nonpharmaceutical method to influence glymphatic transport using focused ultrasound, opening the opportunity to use the method to further study brain diseases and brain function.

Newswise: Immune cells of the brain are not all the same – new research could open novel therapeutic pathways
Released: 15-May-2023 12:05 PM EDT
Immune cells of the brain are not all the same – new research could open novel therapeutic pathways
University of Helsinki

A recent study published in Nature Neuroscience indicates that, contrary to common belief, the immune cells of the brain, known as microglia, are not all the same.

Newswise: Having dementia and reduction in social participation are associated with increased depression and anxiety during the COVID-19 pandemic
Released: 11-May-2023 7:40 PM EDT
Having dementia and reduction in social participation are associated with increased depression and anxiety during the COVID-19 pandemic
IOS Press

An increased risk of depression and anxiety among US older adults with dementia and poor activity participation has been demonstrated through an analysis of data from the National Health and Aging Trends Study (NHATS), a nationally representative population-based study.

Newswise: Brain-Belly Connection: Gut Health May Influence Likelihood of Developing Alzheimer’s
Released: 11-May-2023 3:50 PM EDT
Brain-Belly Connection: Gut Health May Influence Likelihood of Developing Alzheimer’s
University of Nevada, Las Vegas (UNLV)

UNLV study pinpoints 10 bacterial groups associated with Alzheimer’s disease, provides new insights into the relationship between gut makeup and dementia.



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