Focus: Hidden - Ohio

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It takes an “A” team to make headway against glioblastoma, a highly aggressive type of brain cancer. Glioblastoma is the most common type of malignant brain tumor in adults. In addition to the caliber of the researchers involved, in this case “A” also stands for atlas. A key member of the team, Jill S. Barnholtz-Sloan, PhD, Sally S. Morley Designated Professor in Brain Tumor Research at Case Western Reserve University School of Medicine, and approximately 80 other internationally renowned neurologists, bioinformaticians, and pathologists from the United States and India recently published details of the Ivy Glioblastoma Atlas in Science.

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Case Western Reserve University School of Medicine researchers have synthesized the first artificial human prion, a dramatic development in efforts to combat a devastating form of brain disease that has so far eluded treatment and a cure. The new findings are published in Nature Communications.

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Good teamwork begins with a cup of coffee for everyone, a new study suggests. Researchers found that people gave more positive reviews for their group’s performance on a task – and their own contribution – if they drank caffeinated coffee beforehand.

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An experimental drug that blocks abnormal neural communication after spinal cord injury could one day be the key to improving quality of life by improving bladder function, new research suggests.

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At the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, researchers from Cleveland Clinic Cancer Center will present data from several new studies, including a prospective clinical trial examining non-small cell lung cancer cells’ response to immunotherapy; research on germline testing for melanoma; and interim results from a study testing a vaccine for glioblastoma.

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Researchers have devised a magnetic control system to make tiny DNA-based robots move on demand--;and much faster than recently possible.

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More than half of high school baseball pitchers report experiencing pain in their throwing arms during the season. To better understand the cause of these injuries, researchers at The Ohio State University Wexner Medical Center conducted a new study to determine when and why overuse injuries are occurring.

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Detecting patterns is an important part of how humans learn and make decisions. Now, researchers have seen what is happening in people’s brains as they first find patterns in information they are presented.

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A strong social network could be the key to preserving memory. New research from The Ohio State University found that mice housed in groups had better memories and healthier brains than animals that lived in pairs.

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New Cleveland Clinic research shows for the first time that ibrutinib, an FDA-approved drug for lymphoma and leukemia, may also help treat the most common – and deadliest – type of brain tumor. The findings, published in Science Translational Medicine, offer hope that the drug may one day be used in patients with glioblastoma and improve poor survival rates.

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A Bowling Green State University microbiology team played an important role in a scientific discovery about alcohol benefitting fungus farming in beetles. The beetle research, headed by an entomologist Christopher Ranger of USDA-ARS, discovered that alcohol, specifically ethanol, is important for the beetles’ food production, and part of the logic for their attraction to alcohol.

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The Nationwide Foundation today announced a new $10 million gift for the Nationwide Foundation Pediatric Innovation Fund at Nationwide Children’s Hospital to help accelerate the most promising research and clinical discoveries at Nationwide Children’s.

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University Hospitals in Cleveland receives grants to support its Workforce Development programs that helps residents from Cleveland's inner city gain employment at the health system's main campus, University Hospitals Cleveland Medical Center.

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You’ve got a full hour until your next meeting. But you probably won’t make the most of that time, new research suggests. In a series of eight studies, both in the lab and real life, researchers found that free time seems shorter to people when it comes before a task or appointment on their calendar.

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Black infants born prematurely are at higher risk for recurrent wheezing. This condition can cause the baby discomfort and is a risk factor for developing asthma later in life. In a study published in the Journal of the American Medical Association, a UH Rainbow Babies & Children’s Hospital physician researcher found black preterm infants experienced a significant decrease in recurrent wheezing with sustained supplementation of vitamin D.

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New research from The Ohio State University has found that young people with subtle hearing loss – the kind they aren’t even aware of – are putting demands on their brains that typically wouldn’t be seen until later in life.

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A study led by scientists at Cincinnati Children’s reveals one mechanism involved in regulating when nephron formation ends. If translated to clinical practice years from now, the result could be reduced need for kidney transplants and fewer deaths from kidney disease.

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a new study from researchers at Nationwide Children’s Hospital and collaborators published today in JAMA Pediatrics shows that racial disparities in suicide rates are age-related. Specifically, suicide rates for black children aged 5-12 were roughly two times higher than those of similarly-aged white children.

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Researchers at Case Western Reserve University found 45 percent of victims were at high risk for homicide and severe assault, in a one-year assessment

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A new study conducted by the Center for Injury Research and Policy and the Central Ohio Poison Center at Nationwide Children’s Hospital found that there were more than 156,000 calls to US Poison Control Centers regarding exposures to attention-deficit hyperactivity disorder medications among children and adolescents 19 years of age and younger from January 2000 through December 2014, averaging 200 calls each week or 29 calls per day.

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A team of aw students prevailed in a federal lawsuit arguing that an Ohio inmate should be allowed to keep his dreadlocks, protecting his religious freedom.

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Scientists from The Ohio State University compared three popular pitcher brands’ ability to clear dangerous microcystins from tap water. They found that while one did an excellent job, other pitchers allowed the toxins – which appear during harmful algal blooms (HABs) – to escape the filter and drop into the drinking water.

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Its name may playfully give homage to a 1980s video arcade game, but the technology on board The Ohio State University’s first satellite -- the CubeRRT -- could be vital for Earth science missions into the future. It is scheduled for launch on May 20.

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Researchers from Case Western Reserve University School of Medicine have discovered how unusually long strands of RNA help colon cancer cells avoid death, allowing unregulated growth. Unlike other RNAs, the intriguing strands do not appear to encode proteins and are termed “long non-coding RNAs” or “lincRNAs.”A new study showed some lincRNAs could be targeted by drug developers to halt colon cancer.

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Announcement of Case Western Reserve University and PAVmed signing a license agreement to commercialize EsoCheck technology which combines a non-invasive, cell-sampling device with highly accurate DNA biomarkers to detect Barrett's Esophagus. University Hospitals in Cleveland will implement use of the technology.

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Many studies have shown that both minority and women scientists face disadvantages in reaching the highest levels of their careers. So it would make sense that minority women would face a “double bind” that would particularly disadvantage them. But a new study suggests that minority women actually face a “one-and-a-half bind."

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Scientists exploring how to tame random gene fluctuations as the embryos that become our bodies start to form have identified a control switch in the vertebrate segmentation clock of developing zebrafish. The researchers report in Cell Reports their findings could uncover methods for modulating genetic signals to prevent birth defects or cancers rooted at the earliest stages of development.

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Corporate programs aimed at offsetting the negative societal impacts caused by their profit-seeking tend to devalue the very people they intend to help.

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A recently identified pig virus can readily find its way into laboratory-cultured cells of people and other species, a discovery that raises concerns about the potential for outbreaks that threaten human and animal health.

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The most common heart medications may get an assist from nitric oxide circulating in the body, according to a new study out of Case Western Reserve University School of Medicine. Researchers showed that nitric oxide may help commonly used heart drugs maximize their benefits while improving heart function. In turn, the study found nitric oxide deficiencies could underlie heart failure while tilting drug effects toward more harmful pathways and side effects.

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Researchers at The Ohio State University Wexner Medical Center are exploring how small changes in the nasal cavity impact airflow and quality of life.

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Researchers tissue-engineered human pancreatic islets in a laboratory that develop a circulatory system, secrete hormones like insulin and successfully treat sudden-onset type 1 diabetes in transplanted mice. In a study published by Cell Reports, the scientists use a new bioengineering process they developed called a self-condensation cell culture. The technology helps nudge medical science closer to one day growing human organ tissues from a person’s own cells for regenerative therapy

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By federal law passed in 1975, children with intellectual disabilities are supposed to spend as much time as possible in general education classrooms.But a new study suggests that progress toward that goal has stalled.

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The new 122,000-square-foot, three-story Neurosciences Center provides a highly collaborative environment for clinical care, research and academic services related to neurological disorders and diseases.

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Bacterial toxins can wreak mass havoc within cells by shutting down multiple essential functions at once, a new study has found. The discovery could one day open the door to exploring better ways to fight life-threatening infections.

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A poll of Ohio registered voters conducted by the Community Research Institute at Baldwin Wallace University finds that many are still undecided about who they will vote for in Ohio’s May 8 primary. The survey of 811 voters was conducted April 24 – May 2.

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A poll of Ohio registered voters conducted by the Community Research Institute at Baldwin Wallace University finds that many are still undecided about who they will vote for in Ohio’s May 8 primary. The survey of 811 voters was conducted April 24 – May 2.

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By studying a rare liver disease called Alagille syndrome, scientists discovered the mechanism behind a form of tissue regeneration that may someday reduce the need for organ transplants. Researchers report in Nature that when disease or injury causes a shortage in one type of liver cell, the organ can instruct another type of liver cell to change identities to provide replacement supplies. The findings one day may lead to a viable treatment for human disease.

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New research led by investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center suggests that the location of immune cells in the body determines whether they help or harm the development of heart disease. The study supports the view that the immune system directly impacts heart failure—still the leading cause of death for men and women in the United States.

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Announcing that national and international nominations are sought for 2019 Harrington Prize for Innovation in Medicine, honoring a physician-scientist who has moved science forward with achievements notable for innovation, creativity and the potential for clinical application.

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When you’re waiting in a busy restaurant or doctor’s office, it may matter whether the tables, light fixtures and other objects are round or square. In a laboratory study, researchers found the shape of physical objects in a service business affected customer satisfaction, depending on how crowded the business was in the experimental scenarios.

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The power of exercise to boost metabolism could arise from a fat molecule with an unexpected source. In a new study, a lipid released from fat, or lipokine, produced by brown fat was shown to surge in the bloodstream after exercise.

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Researchers mapped critical brain-to-spinal cord nerve connections that drive voluntary movement in forelimbs, a development that scientists say allows them to start looking for specific repair strategies. The study is an important step toward one day rehabilitating motor circuits to help motor function recover after an injury or disease damages the central nervous system, the scientists report in Cell Reports.