Cedars-Sinai investigators have identified a genetic variant that increases people’s risk of developing perianal Crohn’s disease, the most debilitating manifestation of Crohn’s disease.
A new study from researchers at Cummings School of Veterinary Medicine at Tufts University and Tufts Medical Center reports that heart tissue obtained through organ donations from dogs dying of other causes are a promising platform for testing cancer drug toxicity, offering scientists a new alternative.
Researchers at the Icahn School of Medicine at Mount Sinai have demonstrated in a preclinical study a potential new therapeutic approach to treating the most common form of lung cancer. The strategy involves inhibiting the immune-system molecule TREM2 while enhancing natural killer cells (the so-called protectors of the immune system). It was described in the April 20 online issue of Nature Immunology.
ASBMB emphasizes the importance of preserving research from scientists supported by the NIH, NSF and DOE during debt-ceiling deal
University of Pittsburgh researchers developed a novel approach that promoted bone regeneration in mice without implantation of bone tissue or biomaterials.
In people with no thinking and memory problems, a simple test may predict the risk of developing cognitive impairment years later, according to a study published in the April 19, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The National Institutes of Health trial to evaluate the mpox (previously known as monkeypox) vaccine JYNNEOS has now entered the next stage and is studying the immune responses to and the safety of the vaccine in adolescents. The George Washington University is one of 18 clinical trial sites across the United States that have launched this stage testing the JYNNEOS vaccine.
Researchers have identified a strong association between prevalence of prescription stimulant therapy for attention-deficit/hyperactivity disorder (ADHD) and rates of prescription stimulant misuse (taken in a way other than as directed by a clinician) by students in middle and high schools.
A recent Houston Methodist study may offer some guidance on when certain populations should get their next booster. A research team of computational medicine and data scientists from the Houston Methodist Research Institute predicted the immune response to COVID-19 vaccines with a math model they developed, and also found that current CDC dosing intervals may require customization to protect all individuals alike.
Modeling study estimates menu calorie labelling may prevent at least 28,000 obesity-associated cancer cases and 16,700 cancer deaths over a lifetime, saving a combined $2.8 billion in net healthcare and societal costs.
Vitamin D deficiency could be the reason African American men experience more aggressive prostate cancer at a younger age compared with European American men, new research from Cedars-Sinai Cancer suggests.
U.S. middle and high schools with the most students taking prescription stimulants to treat ADHD also had, overall, the highest percentage of students who misused prescription stimulants within the past year.
Type 2 diabetes (T2D) is surging among U.S. children. The number of youths under age 20 living with the disease has nearly doubled between 2001 and 2017, and yet—aside from increases in childhood obesity—the reasons for this disturbing increase are not clear. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH), has awarded the Children’s Hospital at Montefiore (CHAM) and Albert Einstein College of Medicine a six-year, $4.1 million grant to identify the biological and social factors that cause children and adolescents to develop the condition.
A UC Davis study is the first to report on a material transfer mechanism from cells, known as oligodendrocytes, to neurons in the brain of a mouse model. This discovery opens new possibilities for understanding brain maturation and finding treatments for many neurological conditions.
When a person reads a sentence, two distinct networks in the brain are activated, working together to integrate the meanings of the individual words to obtain more complex, higher-order meaning, according to a study at UTHealth Houston.
A new study led by researchers at The University of Texas MD Anderson Cancer Center discovered that co-occurring mutations in three tumor suppressor genes – KEAP1, SMARCA4 and CDKN2A – are linked with poor clinical outcomes in patients with KRAS G12C-mutant non-small cell lung cancer (NSCLC) treated with the KRAS G12C inhibitors adagrasib or sotorasib.
Researchers have made huge strides in ensuring that red blood cell substitutes – or artificial blood – are able to work safely and effectively when transfused into the bloodstream.
Discovery of a gene in multiple mammalian species could pave the way for a highly effective, reversible and non-hormonal male contraceptive for humans and animals.
A researcher from Wayne State University’s Department of Biological Sciences has received a five-year, $1.95 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to identify mechanisms that regulate inositol synthesis in mammalian cells and determine the cellular consequences of inositol depletion.
In November 2022, the National Institute of Allergy and Infectious Diseases (NIAID) co-hosted a virtual workshop on the importance and challenges of developing mucosal vaccines for SARS-COV-2. The highlights of this workshop have now been published as a report in npj Vaccines.
Scientists have traced the origin of a unique protein key to vertebrate’s camera-like vision back 500 million years. Their analysis of more than 900 genomes across the tree of life revealed that the protein came through horizontal gene transfer from foreign bacterial genes.
Houston Methodist nanomedicine researchers have found a way to tame pancreatic cancer - one of the most aggressive and difficult to treat cancers - by delivering immunotherapy directly into the tumor with a device that is smaller than a grain of rice.
A new, $1.8 million Florida State University study funded by the National Institutes of Health will examine the role adiponectin plays in the circulatory system of aging adults and how exercise affects its influence on vascular health. The research aims to offer more insight into how exercise brings benefits and explore how adiponectin can potentially be used for treatment.
An international coalition of biomedical researchers co-led by Alexander Bick, MD, PhD, at Vanderbilt University Medical Center has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients’ risk of blood cancer. The technique, called PACER, led to the identification of a gene that, when activated, drives clonal expansion.
New research from the McKelvey School of Engineering at Washington University in St. Louis has found that cancer cells can sense a layer of cells beneath the top collagen layer on which they normally travel, while normal cells cannot.
Studies have shown that Mexican Americans have worse outcomes after a stroke than non-Hispanic white Americans. A new study looks at whether the language Mexican American people speak is linked to how well they recover after a stroke. The study is published in the April 12, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology
New technologies that can capture subtle changes in a patient’s voice may help physicians diagnose cognitive impairment and Alzheimer’s disease before symptoms begin to show, according to a UT Southwestern Medical Center researcher who led a study published in the Alzheimer’s Association publication Diagnosis, Assessment & Disease Monitoring.
Dopamine, a brain chemical long associated with pleasure, motivation and reward-seeking, also appears to play an important role in why exercise and other physical efforts feel “easy” to some people and exhausting to others, according to results of a study of people with Parkinson’s disease led by Johns Hopkins Medicine researchers. Parkinson’s disease is marked by a loss of dopamine-producing cells in the brain over time.
Investigators from Cedars-Sinai Cancer are collaborating on a streamlined clinical trial design in a study called Pragmatica-Lung.
UC San Diego scientists find a protein associated with liver cancer may actually be the key to protecting against it. By blocking ferroptosis, a form of liver cell death, the protein prevents liver damage and its progression to cancer.
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Researchers reporting in ACS Central Science have developed a new testing platform that encapsulates B cells — some of the most important components of the immune system — into miniature “organoids” to make vaccine screening quicker and greatly reduce the number of animals needed for testing.
Sleep is one of the most essential human activities — so essential, in fact, that if we don’t get enough sleep for even one night, we may struggle to think, react, and otherwise make it through the day. Yet, despite its importance for function and survival, scientists still don’t fully understand how sleep works.
A study published April 11 in the Journal of the American Medical Association (JAMA) evaluated two drugs that act on the renin-angiotensin system (RAS) as potential treatments for severe COVID-19. Severe acute respiratory syndrome coronavirus2 (SARS-CoV-2), the virus that causes COVID-19, enters pulmonary and myocardial cells through binding of its spike protein to the human angiotensin-converting enzyme 2 (ACE2). ACE2 is a vital enzyme that controls blood pressure and blood flow to multiple organs, including the lungs, heart and kidneys.
De acordo com uma pesquisa conduzida pela Aliança para Ensaios Clínicos em Oncologia e o Centro de Câncer da Mayo Clinic, pacientes com diversos tumores em um seio podem ser capazes de evitar uma mastectomia se os tumores puderem ser removidos enquanto uma quantidade suficiente de tecido mamário puder ser preservada.
قد تتمكن النساء المصابات بأورام متعددة في أحد الثديين من تجنب استئصاله إذا أمكن استئصال هذه الأورام مع الاحتفاظ بأنسجة ثدي كافية، وذلك وفقًا لبحث قاده التحالف الطبي للتجارب السريرية في علم الأورام ومركز مايو كلينك الشامل للسرطان.
De acuerdo con la investigación dirigida por la Alianza para Ensayos Clínicos en Oncología y el Centro Oncológico Integral de Mayo Clinic, las pacientes que tengan varios tumores en una sola mama podrían evitar una mastectomía si los tumores se pueden extraer dejando bastante tejido mamario.
St. Jude Children’s Research Hospital scientists developed a combination therapy for a leukemia subtype harboring rearrangements in the KMT2A gene. The approach overcomes the cancer’s drug resistance, without adding toxicity. The study appears in Proceedings of the National Academy of Science.
Mutations in our genes can lead to severe problems, like colon or liver cancer. But cancer is very complex. Mutations in the same genes can lead to different subtypes of tumors in different people. Currently, scientists don’t have a good way to produce such tumor subtypes for study in the lab.
Research led by scientists at UCLA Jonsson Comprehensive Cancer Center found that responses to a type of immunotherapy called PD-1 checkpoint blockade in patients with advanced melanoma depended on whether or not they had previously received another immunotherapy – CTLA-4 blockade – as well as other factors.
UNC School of Medicine scientists demonstrated that stimulating a brain region called Supramammilary nucleus (SuM) located in the hypothalamus effectively enhanced adult-born neurons in the otherwise impaired Alzheimer’s brains of mice.
Brain development follows a newly identified, non-uniform developmental sequence rendering youth to environmental impacts through adolescence.
University of Michigan receives $71M NIH grant to advance clinical & translational science
Alagille syndrome, a genetic disease estimated to affect 1 in 30,000 individuals, is caused by mutations in the gene JAG1 in most cases. The mutations affect multiple organs including the liver where it often results in cholestasis, a condition in which the flow of bile from the liver stops or slows, leading to bile buildup that in time causes liver damage.
Acute myeloid leukemia (AML) is an aggressive blood cancer that causes uncontrolled accumulation of white blood cells. Because of the poor outcomes of this disease, researchers across the globe have been on the hunt for new ways to treat AML, while preserving normal blood development.
A regulatory class of human T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity, according to a new study led by Children’s Hospital of Philadelphia (CHOP). The findings, published today in Science Immunology, could pave the way for new treatments for autoimmune diseases that target the immune system selectively.
A team of scientists at the Medical University of South Carolina (MUSC) has identified a stress-regulated gene that plays a role in the link between long-term stress and a common type of depressive behavior in mice.
People with Alzheimer’s disease develop defects in cognitive functions like memory as well as problems with noncognitive functions that can lead to anxiety and depression.
The University of Texas at El Paso will undertake potentially transformative research on how specific risk factors promote pancreatic cancer development with support from a $1 million grant from the National Institutes of Health’s National Cancer Institute.
A new machine learning model that estimates optimal treatment timing for sepsis could pave the way for support tools that help physicians personalize treatment decisions at the patient bedside, researchers say.
A new study from UCLA researchers finds sex-specific brain signals that appear to confirm that different drivers lead men and women to develop obesity.
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