Newswise — MINNEAPOLIS – The cost of brand-name drugs for epilepsy increased by 277% from 2010 to 2018, according to a study published in the June 15, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. The cost of generic drugs for epilepsy decreased by 42% over the same period.

Brand-name drugs made up 79% of epilepsy drug costs even though they made up only 14% of pills, according to the study of people on Medicare.

“The costs for brand-name antiseizure medications have consistently increased since 2010, particularly boosted by increased prescriptions for the drug lacosamide in addition to a steep increase in the cost per pill, with brand-name drugs costing 10 times more than their generic counterparts,” said study author Samuel Waller Terman, MD, MS, of the University of Michigan, and a member of the American Academy of Neurology. “Previous studies have shown that drugs are the most expensive part of neurologic care, and antiseizure drugs were the second highest category of costs among drugs prescribed by neurologists.”

For the study, researchers looked at records for a random sample of 20% of Medicare beneficiaries with coverage from 2008 to 2018. There were 77,000 to 133,000 people with epilepsy each year.

The cost of brand-name drugs rose from $2,800 per year in 2008 to $10,700 per year in 2018, while the cost of generic drugs decreased from $800 to $460 during that time.

An increased number of prescriptions for the drug lacosamide was responsible for 45% of the total increase in brand-name costs, Terman said.

Brand-name drugs represented a smaller proportion of pills over time, from 56% in 2008 to 14% in 2018. Terman said the decrease in prescriptions for brand-name drugs over time likely corresponded to the increasing availability of generic equivalents. He noted that the expiration of the patent for lacosamide in March 2022 and other changes will affect prescribing patterns.

Many new drugs for epilepsy have been introduced in the last several decades. Doctors must tailor the drug selection to the individual, and there is no single best drug. Many drugs for epilepsy can have interactions with other drugs as well as side effects such as cognitive problems.

The study found that use of epilepsy drugs introduced earlier, called first-generation drugs, as well as enzyme-inducing drugs with many drug interactions, decreased from 2008 to 2018.

“Doctors should consider the societal cost when judging whether the increased expense of brand-name drugs is worth the possible benefits,” Terman said. “While newer generation drugs have potential advantages such as limited drug interactions and different side effect profiles, there have been conflicting studies on whether they are cost effective.”

A limitation of the study was that only Medicare prescription claims were included, so the results may not apply to a younger population with private insurance.

The study received no direct funding.

Independent of this study, Terman is the recipient of the 2021 Susan S. Spencer Clinical Research Training Scholarship in Epilepsy from the American Epilepsy Society, Epilepsy Foundation and the American Brain Foundation in collaboration with the American Academy of Neurology. Study authors Chun C. Lin, PhD, MBA, and Brian C. Callaghan, MD, MS, and a Fellow of the American Academy of Neurology, have also received funding from the American Academy of Neurology.

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The American Academy of Neurology is the world’s largest association of neurologists and neuroscience professionals, with over 38,000 members. The AAN is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, concussion, Parkinson’s disease and epilepsy.

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