Newswise — In the May 2019 issue, Toxicological Sciences features papers on CRISPR screening and acetaldehyde tolerance; systems toxicology for predicting renal toxicity; polycyclic aromatic hydrocarbons (PAHs) and endocrine effects on testicular gap junctions; and vincristine-induced atresia in ovarian follicles. There also are open access papers on intercellular communication in acetaminophen-induced pericentral necrosis and the evaluation of genes involved in non-genotoxic carcinogenesis.

Highlights of Toxicological Sciences Volume 169, Issue 1 include:

• Editor’s Highlight: Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde
• Editor’s Highlight: A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro
• Editor’s Highlight: Polycyclic Aromatic Hydrocarbons and Endocrine Disruption: Role of Testicular Gap Junctional Intercellular Communication and Connexins
• Editor’s Highlight: Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice
• Open Access: Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange
• Open Access: Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens

Toxicological Sciences is the official journal of the Society of Toxicology (SOT), a professional and scholarly organization of more than 8,000 scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the United States and abroad.

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