CRISPR Screening and Acetaldehyde Tolerance; Systems Toxicology for Predicting Renal Toxicity; and More Featured in May 2019 Toxicological Sciences
Issue Also Contains Papers on Polyaromatic Hydrocarbons and Endocrine Effects on Testicular Gap Junctions and Vincristine-Induced Atresia in Ovarian Follicles
Newswise — In the May 2019 issue, Toxicological Sciences features papers on CRISPR screening and acetaldehyde tolerance; systems toxicology for predicting renal toxicity; polycyclic aromatic hydrocarbons (PAHs) and endocrine effects on testicular gap junctions; and vincristine-induced atresia in ovarian follicles. There also are open access papers on intercellular communication in acetaminophen-induced pericentral necrosis and the evaluation of genes involved in non-genotoxic carcinogenesis.
Highlights of Toxicological Sciences Volume 169, Issue 1 include:
- Editor’s Highlight: Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde
- Editor’s Highlight: A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro
- Editor’s Highlight: Polycyclic Aromatic Hydrocarbons and Endocrine Disruption: Role of Testicular Gap Junctional Intercellular Communication and Connexins
- Editor’s Highlight: Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice
- Open Access: Propagation of Pericentral Necrosis During Acetaminophen-Induced Liver Injury: Evidence for Early Interhepatocyte Communication and Information Exchange
- Open Access: Expression Characteristics of Genes Hypermethylated and Downregulated in Rat Liver Specific to Nongenotoxic Hepatocarcinogens
Toxicological Sciences is the official journal of the Society of Toxicology (SOT), a professional and scholarly organization of more than 8,000 scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the United States and abroad.