Newswise — September 6, 2019 – Patients found unconscious after a prolonged period of time – typically due to opioid overdose – are at risk of developing a serious complication called compartment syndrome, reports a study in the September 4, 2019 issue of The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer.

"Patients who are 'found down' following an opiate overdose with crush injuries resulting in compartment syndrome have a high surgical complication rate and poor recovery of function," according to the paper by Eric Swart, MD, and colleagues of University of Massachusetts, Worcester. Their study provides orthopaedic surgeons with needed guidance on the management of this emerging complication.

Many Surgical Procedures, Poor Outcomes in Patients with 'Found Down' Compartment Syndrome

Compartment syndrome occurs when there is excessive pressure in a muscle space enclosed by tough, fibrous tissue called fascia. If pressure becomes severe, emergency surgical treatment (fasciotomy) is needed to prevent permanent damage to the muscle tissue. Compartment syndrome is most common following fracture of an arm or leg.

Dr. Swart and colleagues review 30 cases of compartment syndrome as a result of muscle crush injuries in patients found unconscious after a prolonged period of immobility. Nearly all of the patients were "found down" as a result of some type of overdose, most frequently heroin. Dr. Swart and coauthors note that their hospital serves an area with high rates of opioid overdose and heroin use.

In most cases, it was unclear how long the patients (24 men and six women) had been unconscious and immobile, although evidence suggested the time down was longer than 24 hours for many of them. Compartment syndrome was most common in the leg, thigh, and/or buttocks, followed by the arm and hand.

All but five of the patients underwent fasciotomy, with an average of 4.2 surgical procedures per patient. Postoperative complications were common, including infections in 20 percent of patients and amputations in 12 percent. Most patients had muscle that appeared nonviable at the time of the first surgical procedure, although some of these patients eventually regained muscle function.

Patients who had complete neurological deficits at initial examination had little or no return of function after surgery. In contrast, 70 percent of those who initially had partial neurological deficits regained some function. Common laboratory tests couldn't predict which patients would regain function.

Initial examination was complicated in the 12 patients who were initially "unexaminable" because of unconsciousness or airway intubation. This group had mixed outcomes, with only a few patients regaining function. Across all 30 cases, the average length of hospital stay was 3 weeks.

This study is not the first to report on crush injuries/compartment syndrome in patients who are "found down." However, most previous studies have been isolated case reports, providing little guidance for patient management.

This article shows high rates of severe functional defects in "found down" patients with compartment syndrome, for whom "operative intervention carries a high risk profile," Dr. Swart and colleagues write. They note that this group of patients may have more in common with those who have delayed-presentation muscle crush injuries (such as earthquake victims), rather than trauma patients. The authors conclude: "It is our hope that these data can help surgeons to make treatment decisions that can maximize return of function while minimizing unnecessary comorbidity of this complex and increasingly prevalent problem."

Click here to read "Found Down” Compartment Syndrome"

DOI: 10.2106/JBJS.18.01307


About The Journal of Bone & Joint Surgery

The Journal of Bone & Joint Surgery (JBJS) has been the most valued source of information for orthopaedic surgeons and researchers for over 125 years and is the gold standard in peer-reviewed scientific information in the field. A core journal and essential reading for general as well as specialist orthopaedic surgeons worldwide, The Journal publishes evidence-based research to enhance the quality of care for orthopaedic patients. Standards of excellence and high quality are maintained in everything we do, from the science of the content published to the customer service we provide. JBJS is an independent, non-profit journal.

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