Differential expression of COL19A1 in amyotrophic lateral sclerosis.

Abstract: Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of COL19A1, encoding collagen type XIX alpha 1 chain, in the skeletal muscle of patients with ALS. COL19A1 was also differentially expressed in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. COL19A1 transcript was present at significantly higher levels in ALS patient skeletal muscle as compared to control skeletal muscle. These analyses will begin to define the transcriptional landscape of ALS.