The July 2020 issue of the journal Disease of the Colon and Rectum is out! Take a look at the editor's top picks.


Title: International Organization for the Study of IBD Recommendations for Surgery in Patients With IBD During the Coronavirus Disease 2019 Pandemic

Description: We aimed to summarize our recommendations from international high-volume IBD centers at epicenters of COVID-19 to avoid morbidity and mortality of patients with IBD during pandemic-imposed limits on nonelective surgery. Our discussion with our patients and our colleagues about balancing unknown risks against known morbidity and mortality should be transparent. Preparation for initial surges or resurgences should include a multidisciplinary approach and the engagement of surgical leadership early in the development. We hope our experience encourages proactive nuanced planning for surgical management across the globe.


Title: Mesenchymal Stem Cell Therapy Can Transcend Perianal Crohn’s Disease: How Colorectal Surgeons Can Help in the Coronavirus Disease 2019 Crisis

Description: Although we are not certain of the clinical efficacy of MSCs for COVID-19, there are significant data demonstrating safety. Without alternative therapeutic options in ventilated patients, MSCs offer a promising treatment alternative that targets diminishing the cytokine storm and resultant immune cell infiltrate. Even if MSCs effectively treat 50% of patients, we have won. The application of novel therapeutics should not be confined to any particular field or disease states. If we can apply what we have learned to alternative pathologies, we can expand our horizons as colorectal surgeons and put our specialty in the middle of the fight against COVID-19.


Title: Prioritizing Access to Surgical Care During the Coronavirus Pandemic

Description: The Coronavirus pandemic currently presents unique challenges to almost all health care systems. Although the ability to care for acutely ill patients with Coronavirus Disease 2019 (Covid-19) must be the ultimate priority, surgeons of all subspecialties have nevertheless been faced with a series of clinical and ethical dilemmas relating to management of patients without (or at least not suspected of having) Covid-19, who continue to require surgery with various degrees of clinical urgency

Manuscript Number: 19-303

Title: HIV-Infected Patients With Anal Cancer Precursors: Clinicopathological Characteristics and Human Papillomavirus Subtype Distribution

Video Creator: Yuxin Liu, M.D., Ph.D. • Keith M. Sigel, M.D., Ph.D. • William Westra, M.D. Melissa R. Gitman, M.D., M.P.H. • Wenxin Zheng, M.D. • Michael M. Gaisa, M.D., Ph.D.4

Description: Nearly all people living with HIV and anal high-grade squamous intraepithelial lesions test positive for high-risk human papillomavirus on anal swabs; negative results may be due to sampling error, L1-based polymerase chain reaction assay, or human papillomavirus types not captured by standard clinical assays. Patients who have human papillomavirus 16-positive anal high-grade squamous intraepithelial lesions are indistinguishable from others based on demographic and clinical characteristics, underscoring the potential role of human papillomavirus testing for anal cancer screening.

Manuscript Number: 19-121

Title: Patient-Reported Bowel Function in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy After Neoadjuvant Therapy: A Case–Control Study

Video Creator: Felipe F. Quezada-Diaz, M.D. • J. Joshua Smith, M.D., Ph.D.  •  Rosa M. Jimenez-Rodriguez, M.D., Ph.D. • Isaac Wasserman, M.P.H. • Emmanouil P. Pappou, M.D., Ph.D. • Sujata Patil, Ph.D. • Iris H. Wei, M.D. • Garrett M. Nash, M.D., M.P.H. • Jose G. Guillem, M.D., M.P.H. • Martin R. Weiser, M.D.  • Philip B. Paty, M.D. • Julio Garcia-Aguilar, M.D., Ph.D.

Description: A watch-and-wait strategy correlated with overall better bowel function when compared with sphincter-preserving surgery using a comprehensive validated bowel dysfunction tool.

Manuscript Number: 19-463


Title: Increasing Incidence of Young-Onset Colorectal Carcinoma: A 3-Country Population Analysis

Video Creator: Timothy J. Chittleborough, M.B.B.S., D.Med.Sc., F.R.A.C.S. • Ida Gutlic  • John F. Pearson, Ph.D. • Angus Watson, B.Sc., M.B.Ch.B., F.R.C.S.(Ed.), F.R.C.S. (Gen. Surg.) •Lesley A. Bhatti, B.Sc.(Hons.) Dip. Biotech., M.Sc.  • Pamela Buchwald, M.D., Ph.D., E.B.S.Q. Coloproctology  • John D. Potter, M.B.B.S., Ph.D.  •  Christopher Wakeman, B.Sc., M.B.Ch.B., M.Med.Sci., F.R.A.C.S.  • Tim Eglinton, M.B.Ch.B., M.Med.Sc., F.R.A.C.S.  •  Frank Frizelle, M.B.Ch.B., M.Med.Sc., F.R.A.C.S.

Description:   This study shows an increase in young onset rectal carcinoma in 3 national populations; this observation may provide a focus for looking at the role of environmental influences on the etiology of this increase and therefore to explore strategies for prevention.

Manuscript Number: 19-815


Title: Family History Is Associated With Recurrent Diverticulitis After an Episode of Diverticulitis Managed Nonoperatively

Video Creator: Turki Almalki, M.D. • Richard Garfinkle, M.D.1 • Elizabeth Kmiotek, M.D., MSc.  •  Vincent Pelsser, M.D. • Pietro Bonaffini, M.D. • Caroline Reinhold, M.D., MSc.  • Petro Yousef, M.D.• Nancy Morin, M.D., FRCSC  •  Carol-Ann Vasilevsky, M.D. •  A. Sender Liberman, M.D., B.Sc. • Marylise Boutros, M.D.

Description:  Patients with a positive family history of diverticulitis are at higher risk for recurrent diverticulitis and complicated recurrences.

Manuscript Number: 19-254


Title: Colon and Rectal Surgery Robotic Training Programs: An Evaluation of Gender Disparities

Video Creator: Katherine E. Foley, M.D. • Kevin M. Izquierdo, M.D. • Madrigal G. von Muchow, B.A. • Amir L. Bastawrous, M.D., M.B.A. • Robert K. Cleary, M.D. • Mark K. Soliman, M.D. •

Description:   There is gender disparity in robotic operative experience in colon and rectal surgery training programs with less opportunity for console participation and less opportunity to complete total mesorectal excisions for female trainees. This trend should be highlighted and further evaluated to resolve this disparity.  

Manuscript Number: 19-396


Title: Quality of Colonoscopy: A Comparison Between Gastroenterologists and Nongastroenterologists


Video Creator: Sujit Muthukuru, M.D. • Mohammad Alomari, M.D.1 • Ruchi Bisen, M.D.  •  Malav P. Parikh, M.D. • Laith Al Momani, M.D.3 • Muhammad Talal Sarmini, M.D.  • Rocio Lopez, M.S. • Shamant Muthukuru, M.S. • Prashanthi N. Thota, M.D.  • Madhusudhan R. Sanaka, M.D.6

Description: In this study, only gastroenterologists met the currently accepted overall and sex-specific adenoma detection rate benchmarks. They also outperformed nongastroenterologists in many other nonestablished quality metrics.


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Disease of the Colon and Rectum, July 2020