Newswise — PHILADELPHIA – About one in three Americans have high blood pressure, called hypertension, but only about half of them have their condition under control. A major factor is that many do not consistently take their medications for the condition, which leads to poor health outcomes such as heart attack or stroke. Researchers from Penn Medicine tested new tactics, including text messaging and remote monitoring via an electronic pill bottle, to see if they might affect blood pressure levels. They found that while each method did appear to keep medication adherence high, neither method appeared to drive down blood pressure levels. These findings were published in the Journal of General Internal Medicine.

“We had experience with electronic pill bottles to monitor adherence in the past, but they were expensive and sometimes technically challenging to administer to patients,” said the study’s lead author, Shivan Mehta, MD, MBA, associate chief innovation officer at Penn Medicine and an assistant professor of Medicine. “For this study, we hypothesized that bidirectional — two-way, conversational — text messaging could have similar functionality but with better user experience. However, we did not see a difference in blood pressure for either method.”

Nearly 150 patients who take medication for their high blood pressure across four Philadelphia primary care practices participated in the study. They were split into three groups: one that received standard of care, another group was mailed an electronic pill bottle that monitored their medication adherence, and the  third group that received automated text messages asking about medication adherence. Groups two and three also received daily text messaging prompting them to take their medications.

The electronic pill bottles recorded every time they were opened and transmitted that data to the  researchers using Penn Medicine’s Way to Health automated technology platform. Each day, participants received one of two text messages: One congratulating them for taking their medication the previous day (if the bottle detected being opened), or another acknowledging that they didn’t take their medication the previous day (if the bottle was not opened). Both messages featured a reminder to take the medication that day.

Participants using two-way text messaging were asked — also via Way to Health — to respond “yes” or “no” to whether they took their medication. Automated messages also either congratulated them for taking their medication the day before or acknowledged that they hadn’t. Adherence to medication was found to be high among the study’s participants, both hovering near 80 percent. Despite the extra methods employed, the researchers found that both blood pressure levels and rates of adherence to blood pressure medication remained similar to patients in the control group – those who didn’t have the electronic pill bottles or the texting. 

The blood pressure levels might not have been improved because adherence levels didn’t increase enough, Mehta explained. It’s also possible that the patients may have needed higher doses of their medications or new medications.

There are also a few other ways that patient outcomes could be influenced by leveraging new insights from behavioral economics. For instance, Mehta is already testing out the social support factor in a new trial that also offered blood pressure cuffs and remote monitoring to 250 patients. Additionally, the new study has built in “nudges” for clinicians to consider dose escalation or additional medications among their hypertension patients.

Authors on this paper in addition to Mehta include senior author David A. Asch, MD, MBA; Kevin G. Volpp, MD, PhD; Andrea B. Troxel, ScD; Susan C. Day, MD; Raymond Lim; Noora Marcus; Laurie Norton; and Sophie Anderson.


Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation’s first medical school) and the University of Pennsylvania Health System, which together form a $7.8 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $405 million awarded in the 2017 fiscal year.

The University of Pennsylvania Health System’s patient care facilities include: The Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center -- which are recognized as one of the nation’s top “Honor Roll” hospitals by U.S. News & World Report -- Chester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation’s first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine, and Princeton House Behavioral Health, a leading provider of highly skilled and compassionate behavioral healthcare.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2017, Penn Medicine provided more than $500 million to benefit our community.