RARG variant predictive of doxorubicin-induced cardiotoxicity identifies a cardioprotective therapy

Magdy et al. use a rs2229774 doxorubicin-induced cardiotoxicity patient-specific model to functionally validate the role of this SNP in RARG as predictive of patients experiencing toxicity. They go on to demonstrate that RARG agonists attenuate cardiotoxicity in human and mouse models.