Research Alert

Enzyme Family Regulates Scarring, Heart Tissue Enlargement, May Prevent Heart Failure


Article title: A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis

Authors: Yuto Nakamura, Shunbun Kita, Yoshimitsu Tanaka, Shiro Fukuda, Yoshinari Obata, Tomonori Okita, Yusuke Kawachi, Yuri Tsugawa-Shimizu, Yuya Fujishima, Hitoshi Nishizawa, Shigeru Miyagawa, Yoshiki Sawa, Atsuko Sehara-Fujisawa, Norikazu Maeda, Iichiro Shimomura

From the authors: "The loss of ADAM12 enhanced focal adhesion- and fibrosis-related signaling pathways in the heart, which may compromise cardiac function. These results provide insights for the development of novel therapeutics that target ADAM12 to treat heart failure."

This study is highlighted as one of January's "best of the best" as part of the American Physiological Society's APSselect program.

 

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