EMBARGOED UNTIL December 21, 2021, 12:00 AM ET

Newswise — Charlottesville, VA (December 21, 2021).  Researchers in Japan have evaluated hemodynamic factors that may help identify sites where aneurysms are likely to form. Detailed findings of this study are described in the article “Computational fluid dynamic analysis of the initiation of cerebral aneurysms” by Soichiro Fujimura et al., published today in the Journal of Neurosurgery (https://thejns.org/doi/10.3171/2021.8.JNS211452).

Unruptured aneurysms are most often found incidentally during screening for other diseases or health check-ups. Predicting locations where aneurysms are more likely to form can help with screening and prevention. Together with a group of engineers and physicians from multiple Japanese institutions, Dr. Soichiro Fujimura sought to find an association between hemodynamic factors and sites of aneurysm formation.

The researchers examined angiographic images from 10 cases in which new aneurysms were found during follow-up imaging after treatment for another pre-existing aneurysm elsewhere. Using earlier images obtained of vessel wall sites before the new aneurysms had formed, along with images of 34 aneurysm-free control sites in a separate set of patients, the researchers created 3D software models to evaluate the hemodynamic forces acting on the vessel walls. Their results showed that the aneurysm formation sites were associated with regions of high tensile forces and large total pressure loss. The authors conclude that forces “caused by blood flow collision or the existence of secondary flow” at arterial bifurcations as well as arterial sidewalls are linked to aneurysm formation. The identification of these regions may lead to improved predictions of the locations where aneurysms may form.

When asked about the study, Dr. Yuichi Murayama said, “Observation of the new aneurysm formation process is extremely rare and precise imaging analysis was challenging. This study may be useful as a screening method for the healthy person who has strong family history of brain aneurysms and for identifying places on cerebral arteries at risk for developing aneurysms in the future.”


Fujimura S, Tanaka K, Takao H, Okudaira T, Koseki H, Hasebe A, Suzuki T, Uchiyama Y, Ishibashi T, Otani K, Karagiozov K, Fukudome K, Hayakawa M, Yamamoto M, Murayama Y. Computational fluid dynamic analysis of the initiation of cerebral aneurysms.  Journal of Neurosurgery, published online, ahead of print, December 21, 2021; DOI: 10.3171/2021.8.JNS211452.

Disclosure:  Co-authors T. Suzuki and K. Otani are full-time employees of Siemens Healthcare. Siemens STAR-CCM+ (v10.06.010) software was used for the volumetric grid generation and computation fluid dynamics analysis in this study.

Funding:  Dr. Fujimura was supported by JSPS KAKENHI grant number JP20J30001.


For additional information, please contact: Gillian Shasby, Director of Publications, Journal of Neurosurgery Publishing Group, One Morton Drive, Suite 200, Charlottesville, VA 22903. Email: [email protected]; Phone: 434-924-5555.

For 77 years, the Journal of Neurosurgery has been recognized by neurosurgeons and other medical specialists the world over for its authoritative clinical articles, cutting-edge laboratory research papers, renowned case reports, expert technical notes, and more. Each article is rigorously peer reviewed. The Journal of Neurosurgery is published monthly by the JNS Publishing Group, the scholarly journal division of the American Association of Neurological Surgeons. Other peer-reviewed journals published by the JNS Publishing Group each month include Neurosurgical Focus, the Journal of Neurosurgery: Spine, and the Journal of Neurosurgery: Pediatrics. All four journals can be accessed at www.thejns.org.

Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with more than 10,000 members worldwide. Fellows of the AANS are certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons (Neurosurgery) of Canada or the Mexican Council of Neurological Surgery, AC. Neurological surgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the entire nervous system including the brain, spinal column, spinal cord, and peripheral nerves. For more information, visit www.AANS.org.

Journal Link: Journal of Neurosurgery