First Peek at RNA Binding and Translation in Single Cells May Inform Drug and Vaccine Design

UC San Diego School of Medicine researchers have developed a new approach — called Surveying Targets by APOBEC-Mediated Profiling (STAMP) — to measure what has until now been largely invisible: how RNA-binding proteins and ribosomes interact with RNA molecules within individual cells. This information is important for the development of new drugs that target translation, as well as the development of RNA vaccines that depend on the translation of synthetic mRNAs.