Glen Mays studies strategies for organizing and financing public health strategies, preventive services and prevention policy, with a focus on estimating the health and economic effects of these efforts. He is nationally recognized as an expert on the economic implications of the Affordable Care Act. He directs the National Coordinating Center for Public Health Services and Systems Research funded by the Robert Wood Johnson Foundation and based at the University of Kentucky.

As part of this work, he directs the Public Health Practice-Based Research Networks Program, which brings together more than 1000 public health agencies and researchers from around the nation to study innovations in practice. Mays' work also includes the National Longitudinal Survey of Public Health Systems, which since 1998 has followed a nationally representative cohort of U.S. communities to examine the implementation and impact of multi-organizational public health strategies.

He earned a degree in political science from Brown University, a master's in public health and doctorate in health services research from UNC-Chapel Hill, and completed a postdoctoral fellowship in health economics at Harvard Medical School.