Research Alert

Xie and colleagues propose a regulatory mechanism of hepatic bile acid metabolism in colitis pathogenesis. They find that the hepatic CYP8B1-cholic acid metabolic axis impairs Lgr5+ intestinal stem cell renewal by repressing PPARĪ±, thus exacerbating intestinal injury. Hepatic FXR activation or CYP8B1 knockout restores damaged epithelial barrier and alleviates colitis.

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