Embargoed until May 22, 2:15 p.m. ET


PRESS CONFERENCE:  May 22, 2017, 4:45 p.m.; Room 148 (Middle Building, Street Level) Walter E. Washington Convention Center 

Session:  B106 Prenatal, Perinatal, and Childhood Exposures in Lung Disease

Abstract Presentation Time: Monday, May 22, 2:15 p.m. ET

Location:  Room 151 B (Middle Building, Street Level), Walter E. Washington Convention Center

Newswise — ATS 2017, WASHINGTON, DC ─ A new study has found that children, especially boys, whose mothers were exposed to higher levels of outdoor particulate air pollution at the same time that they were very stressed were most likely to develop asthma by age six. The study was presented at the 2017 American Thoracic Society International Conference.  


The team, led by senior investigator Rosalind Wright, MD, MPH, co-director of the Institute for Exposomics Research at the Icahn School of Medicine at Mount Sinai, conducted this study because of their overarching interest in understanding how these and other environmental factors interact to produce respiratory health disparities.

“We know from prior research that lower income, ethnically mixed urban populations are more greatly burdened with asthma and other respiratory health problems,” said lead author Alison Lee, MD, MS, of the Icahn School of Medicine at Mount Sinai.  “Given that populations disproportionately exposed to ambient air pollution are also more likely to be exposed to social stressors such as financial strain, discrimination, housing difficulties, and crime or violence, we were particularly interested in combined effects of both factors starting in early development, even in pregnancy.”


Dr. Lee and colleagues looked at the daily exposure of 736 primarily African American and Latina, urban pregnant women to ambient particulate matter, a type of air pollution caused mainly by traffic and industrial emissions.  They also looked at the women’s prenatal stress levels through a survey that gave a “negative life event” score.  The women reported a greater number of negative events characterized as experiencing more stress.  Their full-term infants were followed to the age of six years. 


The researchers found associations between high particulate exposure during the second trimester of pregnancy and increased odds of developing asthma for all children.  Further examination found that boys born to mothers reporting higher levels of prenatal stress, who were also more highly exposed to air pollution, were particularly affected. 


“Our data are the first to show that when they occur together, the effect is multiplied,” said Dr. Lee.  “It isn’t clear at this point why boys are more impacted, but scientists think it may be related to the fact that boys’ lungs mature at a slower rate compared to girls.  This, coupled with male fetuses’ increased risk for specific types of injury, such as oxidative stress, may increase the risk of respiratory disease when co-exposure to ambient air pollution and stress occurs during the prenatal period.”


Dr. Lee concluded:  “Our data suggest that all children born to women experiencing increased levels of air pollution and stress during the prenatal period are particularly at increased risk of developing asthma in early childhood. As we continue efforts to reduce outdoor air pollution, our study suggests that we must also focus on co-exposures such as stress. Prevention is not a matter of eliminating stress but rather, we need to develop strategies to reduce stress to more normative levels – for example, implementing prenatal programs that provide resources to address the more prevalent stressors or to promote better coping strategies, particularly among disadvantaged, high-risk populations.”

Contact for Media:  Alison Lee, MD, MS, [email protected]




Abstract 8941

Prenatal Exposure to Fine Particulate Matter Is Associated with Early Childhood Asthma: Influence of Exposure Timing and Effect Modification by Prenatal Stress and Child Sex

Authors: A. Lee1, Y.-H.M. Chiu2, H.-H.L. Hsu1, I. Kloog3, J. Schwartz4, S. Cohen5, A. Wilson6, B. Coull7, R.O. Wright1, R. Wright1; 1Icahn School of Medicine at Mount Sinai - New York, NY/US, 2Kravis Children's Hospital, Icahn School of Medicine - New York, NY/US, 3Ben-Gurion University of the Negev - Beer Sheva/IL, 4Harvard School of Public Health - Boston, MA/US, 5Carnegie Mellon University - Pittsburgh, PA/US, 6Colorado State University – Fort Collins, CO/US, 7Harvard T.H. Chan School of Public Health - Boston, MA/US


Rationale: Research documents independent effects of prenatal exposure to ambient fine particulate matter (PM2.5) and stress on childhood asthma risk with demonstrated temporal- and sex-specific effects. Stress can also modify effects of ambient pollutants on respiratory outcomes although this has not been examined starting prenatally. We examined associations between prenatal PM2.5 and asthma in early childhood considering both dose and timing of exposure and whether these effects were modified by child sex and prenatal stress.


Methods: Analyses included 736 mothers and their full-term infants (≥37 weeks gestation) followed to age 6 years for the ascertainment of physician-diagnosed asthma. Maternal daily PM2.5 exposure was estimated over gestation using a validated satellite-based spatiotemporal resolved model. Prenatal stress was indexed by a negative life events (NLEs) score with NLEs ≥3 categorized as high stress. Using Bayesian distributed lag interaction models (BDLIMs) adjusted for maternal age, race/ethnicity, education, obesity, and tobacco smoke exposure, we examined sensitive windows for the effects of weekly averaged PM2.5 on child asthma while accounting for effect modification by both sex and prenatal stress.


Results: Mothers were largely minorities (54% Hispanic, 30% African American) with less than 12 years of education (66%), and nonsmokers prenatally (86%). When accounting for a 3-way interaction (PM2.5 x NLEs x sex), BDLIMs demonstrated associations between higher PM2.5 exposure at 13-20 weeks gestation and increased odds of asthma among boys, with the highest magnitude of effect among boys born to mothers reporting high prenatal stress followed by boys born to mothers with low prenatal stress. The estimated cumulative effects of PM2.5 exposure across pregnancy, accounting for sensitive windows determined by BDLIMs, was significant in the former (OR=1.20, 95%CI=1.10-1.34; per IQR increase in PM2.5) and marginally significant in the latter group (OR=1.06, 95%CI=0.94-1.20). No significant associations were found among girls, regardless of prenatal stress level. (Figure 1)


Conclusions: Boys born to women with concurrent prenatal exposure to both high levels of PM2.5 and psychosocial stress were at greatest risk of developing asthma by age 6 years. Employing methods that identify effects of both timing of exposure as well as dose when examining these complex relationships may help elucidate underlying mechanisms.


Stress-stratified associations between prenatal PM2.5 exposure and children’s asthma.