Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment

Sun et al. discover that myogenic progenitors derived from hPSCs could engraft and mature to become local satellite cells in vivo after transplantation. These engrafted MPCs not only function as satellite cells in muscle regeneration but could also ameliorate disease phenotype in a Duchenne muscular dystrophy (DMD) mouse model.