Importance of Reproducibility in Science; Dieldrin and Disrupted DNA Methylome; Novel Ach’ase Reactivators; and More Featured in June 2019 Toxicological Sciences
Issue Also Contains Papers on Developmental Neurotoxicity Screening and Sex Effects in Ozone-Mediated Airway Dysfunction.
Newswise — In the June 2019 issue of Toxicological Sciences, his final as Editor-in-Chief, Gary W. Miller reflects on the importance of reproducibility in science—the same topic of his first editorial in 2014. The issue also contains featured papers on dieldrin exposure and dopamine gene DNA methylation; using microelectrode arrays to study chemical effects in cortical neuron networks; sex effects in ozone-mediated airway dysfunction; and ach’ase reactivators and reduced hippocampal organophosphate toxicity. Additionally, there are open access articles on an improved acute fish toxicity assay and on calcium storage and OP-diisopropyl fluorophosphate-based toxicity.
Highlights of Toxicological Sciences Volume 169, Issue 2 include:
- Editorial: Reproducibility Revisited: Reflections of an Editor
- Editor’s Highlight: Developmental Dieldrin Exposure Alters DNA Methylation at Genes Related to Dopaminergic Neuron Development and Parkinson’s Disease in Mouse Midbrain
- Editor’s Highlight: Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays
- Editor’s Highlight: Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses
- Editor’s Highlight: Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus
- Open Access: Repeatability and Reproducibility of the RTgill-W1 Cell Line Assay for Predicting Fish Acute Toxicity
- Open Access: Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness
Toxicological Sciences is the official journal of the Society of Toxicology (SOT), a professional and scholarly organization of more than 7,800 scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the United States and abroad.