Research Alert

Article title: SUMO2 regulates vascular endothelial function and oxidative stress in mice

Authors: Young-Rae Kim, Julia S. Jacobs, Qiuxia Li, Ravinder Reddy Gaddam, Ajit Vikram, Jing Liu, Modar Kassan, Kaikobad Irani, Santosh Kumar

From the authors: “Using multiple complementary approaches, we show that hyper-SUMO2ylation impairs vascular endothelial function and increases vascular oxidative stress, whereas endogenous SUMO2 is essential for maintenance of normal physiological function of the vascular endothelium.”

This study is highlighted as one of December's "best of the best" as part of the American Physiological Society's APSselect program.