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Newswise: Rare inherited enzyme disorder yields insight into fibrosis

Article ID: 715918

Rare inherited enzyme disorder yields insight into fibrosis

St. Jude Children's Research Hospital

St. Jude investigators have discovered an association between a deficiency in the enzyme neuraminidase 1 and the build-up of connective tissue in organs such as the muscle, kidney, liver, heart and lungs.

Released:
17-Jul-2019 2:00 PM EDT
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Newswise: Pathway discovered that prevents buildup of Alzheimer’s protein
  • Embargo expired:
    27-Jun-2019 11:00 AM EDT

Article ID: 714823

Pathway discovered that prevents buildup of Alzheimer’s protein

St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital scientists have discovered a pathway that functions like a car wash to prevent the buildup of a toxic protein associated with Alzheimer’s disease. The report appeared online today in the journal Cell.

Released:
24-Jun-2019 12:05 PM EDT
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Newswise: Researchers discover key genetic trigger that compromises cancer immunotherapy
  • Embargo expired:
    17-Jun-2019 11:00 AM EDT

Article ID: 714431

Researchers discover key genetic trigger that compromises cancer immunotherapy

St. Jude Children's Research Hospital

An international research team has discovered a gene that triggers a process called “exhaustion” in the immune T cells used to battle cancer in immunotherapy. The gene, called Tox, launches a process that remodels the cells’ machinery to weaken their ability to attack cancer cells, as well as infections. The discovery, published in advance online in the journal Nature, could lead to diagnostic tests to detect T cell exhaustion, and the researchers hope their basic findings will also result in techniques to prevent exhaustion.

Released:
17-Jun-2019 10:05 AM EDT
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Newswise: Martine Roussel,  Ph.D., of St. Jude Elected to the National Academy of Sciences

Article ID: 712528

Martine Roussel, Ph.D., of St. Jude Elected to the National Academy of Sciences

St. Jude Children's Research Hospital

Martine Roussel, Ph.D., a member of the Department of Tumor Cell Biology and co-leader of the Cancer Biology Program at St. Jude Children’s Research Hospital, was elected to the National Academy of Sciences. Roussel is one of 100 new members and 25 foreign associates recognized this year by the renowned society of scholars for their distinguished and continuing achievements in original research.

Released:
7-May-2019 4:05 PM EDT
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Newswise: St. Jude Physician-Scientist Receives AACR Award

Article ID: 712522

St. Jude Physician-Scientist Receives AACR Award

St. Jude Children's Research Hospital

The American Association for Cancer Research has named Esther Obeng, M.D., Ph.D., of St. Jude Children’s Research Hospital recipient of the 2019 Gertrude B. Elion Cancer Research Award.

Released:
7-May-2019 4:05 PM EDT
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Newswise: Charles Mullighan named St. Jude Comprehensive Cancer Center Deputy Director

Article ID: 712018

Charles Mullighan named St. Jude Comprehensive Cancer Center Deputy Director

St. Jude Children's Research Hospital

Dr. Mullighan will help guide precision medicine, preclinical and other strategic research initiatives within the cancer center

Released:
26-Apr-2019 5:05 PM EDT
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Cancer

Newswise: AACR: Genetic study identifies a risk factor for stroke among cancer survivors
  • Embargo expired:
    2-Apr-2019 9:00 AM EDT

Article ID: 710582

AACR: Genetic study identifies a risk factor for stroke among cancer survivors

St. Jude Children's Research Hospital

Research at St. Jude Children’s Research Hospital has identified a genomic risk factor associated with stroke in childhood cancer survivors. The findings were announced today at a press conference as part of the American Association for Cancer Research annual meeting in Atlanta. This investigation draws on whole genome sequencing and other data gathered longitudinally through the St. Jude Lifetime Cohort (SJLIFE) study.

Released:
1-Apr-2019 4:30 PM EDT
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Newswise: Genomic analysis offers roadmap for diagnosis and treatment of a high-risk leukemia
  • Embargo expired:
    29-Mar-2019 12:00 PM EDT

Article ID: 710387

Genomic analysis offers roadmap for diagnosis and treatment of a high-risk leukemia

St. Jude Children's Research Hospital

Acute erythroid leukemia (AEL) is a high-risk cancer with a dismal prognosis, uncertain genetic basis and controversy surrounding the diagnosis. That is changing, thanks to research led by St. Jude Children’s Research Hospital that appears today in the journal Nature Genetics. The researchers completed the largest, most comprehensive genomic analysis yet of AEL and identified six age-related subgroups with distinct mutations and patterns of gene expression as well as treatment outcomes.

Released:
28-Mar-2019 1:05 PM EDT
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Newswise: American Association for Cancer Research honors Cancer Control and Survivorship Program

Article ID: 710381

American Association for Cancer Research honors Cancer Control and Survivorship Program

St. Jude Children's Research Hospital

The American Association for Cancer Research (AACR) has announced that the 13th annual AACR Team Science Award will be presented to the Cancer Control and Survivorship Program at St. Jude Children’s Research Hospital. The Cancer Control and Survivorship Program is a multidisciplinary research program of the St. Jude Comprehensive Cancer Center, which strives to improve the quality of life of individuals surviving childhood cancer. Leslie L. Robison, PhD, chair of the Department of Epidemiology & Cancer Control, and Melissa Hudson, MD, director of the Division of Cancer Survivorship, lead the program.

Released:
28-Mar-2019 12:05 PM EDT
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Newswise: Genetic Variations in a Fourth Gene Linked to Elevated Leukemia Risk in Hispanic Children

Article ID: 708066

Genetic Variations in a Fourth Gene Linked to Elevated Leukemia Risk in Hispanic Children

St. Jude Children's Research Hospital

St. Jude Children’s Research Hospital scientists have completed one of the largest studies yet designed to advance understanding of why Hispanic children are more likely to develop leukemia and less likely to survive

Released:
14-Feb-2019 9:00 AM EST
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