Penn Medicine researchers found that when an “Enhanced Recovery After Surgery” protocol was employed—which optimizes patients’ surgical care before, during, and after surgery—the majority of patients did not need opioids for pain management at one, three, and six months after elective spinal and peripheral nerve surgery.
The National Cancer Institute (NCI) has once again rated the Abramson Cancer Center of the University of Pennsylvania (ACC) as “exceptional,” the highest possible rating for an NCI-designated comprehensive cancer center.
A new grant awarded to the Perelman School of Medicine at the University of Pennsylvania will help identify methods to improve uptake of state-of-the-science care that can have a significant impact for patients.
Inherited mutations in a gene that keeps nerve cells intact was shown, for the first time, to be a driver of a neuropathy known as Charcot-Marie-Tooth disease. This finding is detailed in a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania, presenting a clearer picture of the disease’s genetic underpinnings that could inform the development of gene therapies to correct it.
Penn Medicine researchers have shown that federated learning is successful specifically in the context of brain imaging, by being able to analyze magnetic resonance imaging (MRI) scans of brain tumor patients and distinguish healthy brain tissue from cancerous regions.
New research from Penn Medicine shows a low risk of stroke in patients hospitalized for COVID-19. Notably, the majority of afflicted patients had existing risk factors, such as high blood pressure and diabetes. These findings provide more clarity about the role COVID-19 plays in causing stroke in a diverse population of the United States.
For the first time, researchers detai the potential implications of a specific P53 mutation, including an association with a specific type of Li-Fraumeni syndrome (LFS), an inherited predisposition to a wide range of cancers.
Philadelphia’s tax on sweetened beverages led to a 38.9 percent drop in the volume of taxed beverages sold at small, independent retailers and a significant increase in the price of taxed beverages, according to new research from the Perelman School of Medicine at the University of Pennsylvania. This study builds on previous research that suggests beverage taxes can help reduce purchases of sugary drinks, led by Christina Roberto, PhD, an associate professor of Medical Ethics and Health Policy at Penn, and senior author on this latest paper published in Health Affairs.
The Penn Brain Science, Translation, Innovation, and Modulation (brainSTIM) Center brings together a team of leading neuroscientists, neurologists, psychiatrists, psychologists, and engineers at Penn using neuromodulation techniques to research, repair, and enhance human brain function—the first translational center of its kind in the region.
After one consumes food or a beverage containing fructose, the gut helps to shield the liver from damage by breaking down the sugar. However, the consumption of too much fructose can overwhelm the gut, causing fructose to “spill over” into the liver, where it wreaks havoc and causes fatty liver, researchers discovered.
Patients with COVID-19 who were admitted to an intensive care unit were 10 times more likely than other hospitalized COVID-19 patients to suffer cardiac arrest or heart rhythm disorders, according to a new study. .
Patients who are homeless are far more likely than housed individuals to be readmitted to a hospital within 30 or 90 days of their discharge, according to a new multi-center analysis of inpatient data from Florida, Massachusetts and New York.
Nearly 10 percent of patients who are prescribed opioid medications following heart surgery will continue to use opioids more than 90 days after the procedure, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.
The Center of Excellence in Environmental Toxicology (CEET) at the University of Pennsylvania received an $8 million grant, to be distributed over the next five years, from the National Institute of Environmental Health Sciences, a renewal of its P30 Environmental Health Sciences Core Center (EHSCC) grant.
An experimental study from researchers in the Perelman School of Medicine at the University of Pennsylvania links a specific procedure – embryo culture – that is part of the assisted reproduction process (ART) to placental abnormalities, risk for preeclampsia, and abnormal fetal growth. The team, led by Marisa Bartolemei, PhD, a professor of Cell and Developmental Biology, published their findings today in Development.
A team at Penn Medicine, in collaboration with UnitedHealth Group, created COBALT—a digital platform that offers immediate access to mental health support for health care workers during this critical time.
Of nearly 6,500 commercially insured patients treated in EDs nationwide for an overdose or other opioid-related medical complications, only 16 percent accessed opioid use disorder (OUD) medications or another form of treatment within three months of the ED visit.
New research from the Perelman School of Medicine at the University of Pennsylvania catalogued every use documented in medical literature so far and found physicians have reported on the use of more than 100 different off-label and experimental treatments
Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions. Reporting in Nature Cancer, the researchers showed for the first time in human cells and a mouse model that inhibiting the c-Rel molecule in myeloid cells — as opposed to lymphoid cells that today’s immunotherapies target — blocked the production of immune suppressor cells and significantly shrank tumors.
“Senotherapy,” a treatment that uses small molecule drugs to target “senescent” cells, or those cells that no longer undergo cell division, blunts liver tumor progression in animal models according to new research from a team led by Celeste Simon, PhD, a professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania and scientific director of the Abramson Family Cancer Research Institute. The study was published in Nature Cell Biology.
PHILADELPHIA – Elizabeth Howell, MD, MPP, an accomplished researcher of health inequities and a respected women’s health leader, has been named chair of the Department of Obstetrics and Gynecology in the Perelman School of Medicine at the University of Pennsylvania. She will join Penn on Sept. 1, 2020, from her post as a professor of Obstetrics, Gynecology, and Reproductive Science at the Icahn School of Medicine at Mount Sinai.
France and the United States have experienced a tremendous reduction in the number of organ donations and transplant procedures since the onset of the COVID-19 pandemic. By early April, transplant centers in both countries were conducting far fewer deceased donor transplants compared to just one month earlier, with the number of procedures dropping by 91 percent in France and 50 percent in the United States.
Activating a receptor found on the surface of many normal and cancer tissues has been shown to stop pancreatic cancer from growing, but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy
Convalescent plasma therapy for COVID-19 patients — an experimental approach of giving a transfusion of plasma collected from a donor who has recovered from COVID-19 to a patient with an active infection — is the focus of a new two-part research initiative at Penn Medicine. Researchers will first collect plasma from people who have recovered from their infection under a donor research protocol. The second part involves conducting clinical trials to test the safety and efficacy of giving that plasma to moderately and severely ill hospitalized patients.
A new international trial will evaluate whether the use of medications to treat high blood pressure affect outcomes among patients who are prescribed the medication and hospitalized with COVID-19. Investigators will examine whether ACEI or ARBs help to mitigate complications or lead to worse outcomes.
Penn Medicine created a new meal delivery platform for frontline hospital staff called Nourished, to ensure safe and convenient access to local takeout meals during the COVID-19 pandemic. Nourished allows staff to easily order affordable meals from a curated list of local restaurants via text message.
A blood test may be able to detect the most common form of pancreatic cancer while it is still in its early stages while also helping doctors accurately stage a patient’s disease and guide them to the appropriate treatment.
Penn launched the U.S. component of a global registry that aims to help protect health care providers who intubate patients with COVID-19 and quantify their risk of developing the disease. The intubateCOVID registry tracks exposures and outcomes among providers who perform intubations, with the ultimate goal of reducing the transmission of COVID-19 to these providers.
A new trial led by the Perelman School of Medicine at the University of Pennsylvania will evaluate whether the drug hydroxychloroquine (HCQ) can benefit people infected with COVID-19, as well as whether taking the drug preventatively may help people avoid infection altogether
Penn Medicine has established a new center to help expand and accelerate research related to the novel coronavirus, SARS-CoV-2, that causes the respiratory illness known as COVID-19.The center aims to advance research to support the development of potential vaccines, diagnostic tools, and therapies
Daniel Yoshor, MD, has been named chair of the department of Neurosurgery in the Perelman School of Medicine at the University of Pennsylvania and vice president of Clinical Integration and Innovation for the University of Pennsylvania Health System.
Early on in each cell, a critical protein known as FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The discovery, published in Nature Genetics, helps untangle mysteries of how embryonic stem cells develop into organs.
The Perelman School of Medicine at the University of Pennsylvania has been ranked #3 among the nation’s medical schools, marking 23 consecutive years the school garnered honors among the top 10 research-oriented medical schools.
Now, as part of an effort to reduce the rate of patients with diabetic kidney disease who develop kidney failure, researchers at Penn Medicine are spearheading a collaboration to better understand the progression of DKD and advance research aimed at preserving kidney function in these patients.
Delivering the medication dantrolene through the nose rather than the mouth may help the medication penetrate the brain more effectively, potentially maximizing its therapeutic benefits in the treatment of neurodegenerative diseases, like Alzheimer’s disease.
The deadly brain cancer glioblastoma (GBM) is often resistant to chemotherapy and radiation, but new research shows targeting stromal cells – the cells that serve as the connective tissue of the organs – may be an effective way of overcoming that resistance
Non-small cell lung cancer (NSCLC) patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations.