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Released: 7-Aug-2020 8:05 PM EDT
Penn Medicine-Led Research Suggests Greater Access to Specific HIV and Tuberculosis Medications is Needed Worldwide
Perelman School of Medicine at the University of Pennsylvania

A specific combination of HIV and TB treatments, difficult to obtain in certain parts of the world, decreased mortality risk for patients with HIV and multidrug-resistant TB

Newswise: Penn’s ‘Enhanced Recovery’ Program Significantly Reduces Post-Op Opioid Use
6-Aug-2020 9:00 AM EDT
Penn’s ‘Enhanced Recovery’ Program Significantly Reduces Post-Op Opioid Use
Perelman School of Medicine at the University of Pennsylvania

Penn Medicine researchers found that when an “Enhanced Recovery After Surgery” protocol was employed—which optimizes patients’ surgical care before, during, and after surgery—the majority of patients did not need opioids for pain management at one, three, and six months after elective spinal and peripheral nerve surgery.

3-Aug-2020 5:00 PM EDT
Perfectly Balanced: The Yin and Yang of Inflammation Controlled By A Single Molecule
Perelman School of Medicine at the University of Pennsylvania

Penn Study Reveals A Molecular Mechanism That Helps The Body Mount Perfectly Balanced Responses to Deadly Infections

Newswise: National Cancer Institute Designates Penn’s Abramson Cancer Center as “Exceptional”
Released: 4-Aug-2020 12:00 PM EDT
National Cancer Institute Designates Penn’s Abramson Cancer Center as “Exceptional”
Perelman School of Medicine at the University of Pennsylvania

The National Cancer Institute (NCI) has once again rated the Abramson Cancer Center of the University of Pennsylvania (ACC) as “exceptional,” the highest possible rating for an NCI-designated comprehensive cancer center.

Newswise: Penn Medicine Receives $4.9 Million Grant to Improve Uptake of Cancer Care Best Practices
Released: 4-Aug-2020 12:05 AM EDT
Penn Medicine Receives $4.9 Million Grant to Improve Uptake of Cancer Care Best Practices
Perelman School of Medicine at the University of Pennsylvania

A new grant awarded to the Perelman School of Medicine at the University of Pennsylvania will help identify methods to improve uptake of state-of-the-science care that can have a significant impact for patients.

Released: 3-Aug-2020 9:30 AM EDT
Penn Researchers Identify New Genetic Cause of a Form of Inherited Neuropathy
Perelman School of Medicine at the University of Pennsylvania

Inherited mutations in a gene that keeps nerve cells intact was shown, for the first time, to be a driver of a neuropathy known as Charcot-Marie-Tooth disease. This finding is detailed in a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania, presenting a clearer picture of the disease’s genetic underpinnings that could inform the development of gene therapies to correct it.

Newswise:Video Embedded cancer-care-in-the-time-of-covid
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Released: 29-Jul-2020 5:00 AM EDT
Cancer Care in the Time of COVID
Perelman School of Medicine at the University of Pennsylvania

The medical community is urgently trying to tell the public that seeking health care is still essential, particularly in cancer care, where early detection is key

Newswise: New machine learning method allows hospitals to share patient data -- privately
Released: 28-Jul-2020 3:50 PM EDT
New machine learning method allows hospitals to share patient data -- privately
Perelman School of Medicine at the University of Pennsylvania

Penn Medicine researchers have shown that federated learning is successful specifically in the context of brain imaging, by being able to analyze magnetic resonance imaging (MRI) scans of brain tumor patients and distinguish healthy brain tissue from cancerous regions.

Released: 27-Jul-2020 9:00 AM EDT
Hospitalized COVID-19 Patients Have Low Risk of Stroke
Perelman School of Medicine at the University of Pennsylvania

New research from Penn Medicine shows a low risk of stroke in patients hospitalized for COVID-19. Notably, the majority of afflicted patients had existing risk factors, such as high blood pressure and diabetes. These findings provide more clarity about the role COVID-19 plays in causing stroke in a diverse population of the United States.

Released: 21-Jul-2020 4:25 PM EDT
U.S. Military Improved Mortality Since World War II, But Some Alarming Exceptions Remain
Perelman School of Medicine at the University of Pennsylvania

Although wound survivability has increased over the last 80 years, the U.S. military’s medical corps suffered some periods of backsliding during conflicts, recent analysis shows

Newswise: Rare Mutation of TP53 Gene Leaves People at Higher Risk for Multiple Cancers
14-Jul-2020 9:00 AM EDT
Rare Mutation of TP53 Gene Leaves People at Higher Risk for Multiple Cancers
Perelman School of Medicine at the University of Pennsylvania

For the first time, researchers detai the potential implications of a specific P53 mutation, including an association with a specific type of Li-Fraumeni syndrome (LFS), an inherited predisposition to a wide range of cancers.

7-Jul-2020 3:55 PM EDT
Access to Nature Requires Attention When Addressing Community Health Needs
Perelman School of Medicine at the University of Pennsylvania

Nature is a tool to address deeply entrenched health disparities; health systems should work to increase nature access, as they have with other social determinants of health

Released: 8-Jul-2020 1:20 PM EDT
Philadelphia Tax on Sweetened Drinks Led to Drop in Sales
Perelman School of Medicine at the University of Pennsylvania

Philadelphia’s tax on sweetened beverages led to a 38.9 percent drop in the volume of taxed beverages sold at small, independent retailers and a significant increase in the price of taxed beverages, according to new research from the Perelman School of Medicine at the University of Pennsylvania. This study builds on previous research that suggests beverage taxes can help reduce purchases of sugary drinks, led by Christina Roberto, PhD, an associate professor of Medical Ethics and Health Policy at Penn, and senior author on this latest paper published in Health Affairs.

7-Jul-2020 11:00 AM EDT
Sensory Neurons Outside the Brain Drive Autistic Social Behaviors, Penn Study Suggests
Perelman School of Medicine at the University of Pennsylvania

A new study from Penn Medicine lends further evidence that the social behaviors tied to autism spectrum disorders (ASD) emerge from abnormal function of sensory neurons outside the brain.

Released: 1-Jul-2020 9:00 AM EDT
Penn Launches Region’s First Center for Translational Neuromodulation
Perelman School of Medicine at the University of Pennsylvania

The Penn Brain Science, Translation, Innovation, and Modulation (brainSTIM) Center brings together a team of leading neuroscientists, neurologists, psychiatrists, psychologists, and engineers at Penn using neuromodulation techniques to research, repair, and enhance human brain function—the first translational center of its kind in the region.

Released: 29-Jun-2020 12:05 PM EDT
The Gut Shields the Liver from Fructose-Induced Damage
Perelman School of Medicine at the University of Pennsylvania

After one consumes food or a beverage containing fructose, the gut helps to shield the liver from damage by breaking down the sugar. However, the consumption of too much fructose can overwhelm the gut, causing fructose to “spill over” into the liver, where it wreaks havoc and causes fatty liver, researchers discovered.

18-Jun-2020 1:05 PM EDT
Critically Ill Patients with COVID-19 Are More Likely to Develop Heart Rhythm Disorders Than Other Hospitalized Patients
Perelman School of Medicine at the University of Pennsylvania

Patients with COVID-19 who were admitted to an intensive care unit were 10 times more likely than other hospitalized COVID-19 patients to suffer cardiac arrest or heart rhythm disorders, according to a new study. .

Released: 22-Jun-2020 8:55 AM EDT
Nuclear Softening Allows Cells to Move Into Dense Tissue, Encouraging Injury Repair
Perelman School of Medicine at the University of Pennsylvania

Using an enzyme inhibitor in meniscus cells, a Penn team was able to soften their nucleus and promote access to previously impassible areas

Released: 18-Jun-2020 1:05 PM EDT
Homeless Patients Are More Likely to be Readmitted to a Hospital Within 30 Days of Discharge
Perelman School of Medicine at the University of Pennsylvania

Patients who are homeless are far more likely than housed individuals to be readmitted to a hospital within 30 or 90 days of their discharge, according to a new multi-center analysis of inpatient data from Florida, Massachusetts and New York.

17-Jun-2020 10:15 AM EDT
10 Percent of Patients Continue to Use Opioids Three to Six Months After Heart Surgery
Perelman School of Medicine at the University of Pennsylvania

Nearly 10 percent of patients who are prescribed opioid medications following heart surgery will continue to use opioids more than 90 days after the procedure, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.

Released: 17-Jun-2020 10:35 AM EDT
Penn’s Center of Excellence in Environmental Toxicology (CEET) Receives $8 Million Grant from the National Institute of Environmental Health Sciences
Perelman School of Medicine at the University of Pennsylvania

The Center of Excellence in Environmental Toxicology (CEET) at the University of Pennsylvania received an $8 million grant, to be distributed over the next five years, from the National Institute of Environmental Health Sciences, a renewal of its P30 Environmental Health Sciences Core Center (EHSCC) grant.

Released: 8-Jun-2020 9:45 AM EDT
Pregnancy Complications in Assisted Reproduction Linked to a Specific Process
Perelman School of Medicine at the University of Pennsylvania

An experimental study from researchers in the Perelman School of Medicine at the University of Pennsylvania links a specific procedure – embryo culture – that is part of the assisted reproduction process (ART) to placental abnormalities, risk for preeclampsia, and abnormal fetal growth. The team, led by Marisa Bartolemei, PhD, a professor of Cell and Developmental Biology, published their findings today in Development.

Released: 28-May-2020 9:00 AM EDT
New Mental Health Platform Provides Support for Healthcare Workers
Perelman School of Medicine at the University of Pennsylvania

A team at Penn Medicine, in collaboration with UnitedHealth Group, created COBALT—a digital platform that offers immediate access to mental health support for health care workers during this critical time.

22-May-2020 12:05 PM EDT
Follow-up Treatments After Opioid Overdose Rare Among Insured Patients
Perelman School of Medicine at the University of Pennsylvania

Of nearly 6,500 commercially insured patients treated in EDs nationwide for an overdose or other opioid-related medical complications, only 16 percent accessed opioid use disorder (OUD) medications or another form of treatment within three months of the ED visit.

Newswise: Taking Inventory of Which Drugs the World Is Using to Treat COVID-19
Released: 27-May-2020 10:30 AM EDT
Taking Inventory of Which Drugs the World Is Using to Treat COVID-19
Perelman School of Medicine at the University of Pennsylvania

New research from the Perelman School of Medicine at the University of Pennsylvania catalogued every use documented in medical literature so far and found physicians have reported on the use of more than 100 different off-label and experimental treatments

Released: 27-May-2020 8:30 AM EDT
New Cancer Immunotherapy Targeting Myeloid Cells Slows Tumor Growth
Perelman School of Medicine at the University of Pennsylvania

Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions. Reporting in Nature Cancer, the researchers showed for the first time in human cells and a mouse model that inhibiting the c-Rel molecule in myeloid cells — as opposed to lymphoid cells that today’s immunotherapies target — blocked the production of immune suppressor cells and significantly shrank tumors.

Released: 20-May-2020 10:35 AM EDT
New Liver Cancer Research Targets Non-Cancer Cells to Blunt Tumor Growth
Perelman School of Medicine at the University of Pennsylvania

“Senotherapy,” a treatment that uses small molecule drugs to target “senescent” cells, or those cells that no longer undergo cell division, blunts liver tumor progression in animal models according to new research from a team led by Celeste Simon, PhD, a professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania and scientific director of the Abramson Family Cancer Research Institute. The study was published in Nature Cell Biology.

Released: 14-May-2020 7:20 AM EDT
Elizabeth Howell, MD, MPP, Named New Chair of Obstetrics and Gynecology at Penn Medicine
Perelman School of Medicine at the University of Pennsylvania

PHILADELPHIA – Elizabeth Howell, MD, MPP, an accomplished researcher of health inequities and a respected women’s health leader, has been named chair of the Department of Obstetrics and Gynecology in the Perelman School of Medicine at the University of Pennsylvania. She will join Penn on Sept. 1, 2020, from her post as a professor of Obstetrics, Gynecology, and Reproductive Science at the Icahn School of Medicine at Mount Sinai.

Released: 13-May-2020 11:55 AM EDT
Reddit Reveals Peaks of Public Interest in COVID-19 Topics
Perelman School of Medicine at the University of Pennsylvania

Online forums can be used by public health officials to quickly identify topics of public interest during the COVID-19 pandemic and to quell misinformation

11-May-2020 8:30 AM EDT
Steep Decline in Organ Transplants Amid COVID-19 Outbreak
Perelman School of Medicine at the University of Pennsylvania

France and the United States have experienced a tremendous reduction in the number of organ donations and transplant procedures since the onset of the COVID-19 pandemic. By early April, transplant centers in both countries were conducting far fewer deceased donor transplants compared to just one month earlier, with the number of procedures dropping by 91 percent in France and 50 percent in the United States.

5-May-2020 10:00 AM EDT
Penn Researchers Discover Key Mechanism of Cytokine Storm in Castleman Disease
Perelman School of Medicine at the University of Pennsylvania

Penn researchers say they know what's going on at the cellular level when patients experience a flare

Released: 5-May-2020 2:45 PM EDT
Financial Incentives Boost Doctor Training in Opioid Treatment Medication
Perelman School of Medicine at the University of Pennsylvania

Offering $750 to emergency medicine physicians exponentially increased those trained to prescribe buprenorphine.

Newswise: Activating an Estrogen Receptor Can Stop Pancreatic Cancer Cells from Growing
Released: 4-May-2020 9:00 AM EDT
Activating an Estrogen Receptor Can Stop Pancreatic Cancer Cells from Growing
Perelman School of Medicine at the University of Pennsylvania

Activating a receptor found on the surface of many normal and cancer tissues has been shown to stop pancreatic cancer from growing, but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy

Released: 20-Apr-2020 8:30 AM EDT
Penn Medicine Launches COVID-19 Convalescent Plasma Study
Perelman School of Medicine at the University of Pennsylvania

Convalescent plasma therapy for COVID-19 patients — an experimental approach of giving a transfusion of plasma collected from a donor who has recovered from COVID-19 to a patient with an active infection — is the focus of a new two-part research initiative at Penn Medicine. Researchers will first collect plasma from people who have recovered from their infection under a donor research protocol. The second part involves conducting clinical trials to test the safety and efficacy of giving that plasma to moderately and severely ill hospitalized patients.

15-Apr-2020 12:20 PM EDT
How Do Commonly Used Blood Pressure Medications Affect Outcomes Among Patients with COVID-19?
Perelman School of Medicine at the University of Pennsylvania

A new international trial will evaluate whether the use of medications to treat high blood pressure affect outcomes among patients who are prescribed the medication and hospitalized with COVID-19. Investigators will examine whether ACEI or ARBs help to mitigate complications or lead to worse outcomes.

Released: 16-Apr-2020 10:00 AM EDT
Penn Medicine Partners with Local Restaurants to Create Healthcare Meal Delivery Platform
Perelman School of Medicine at the University of Pennsylvania

Penn Medicine created a new meal delivery platform for frontline hospital staff called Nourished, to ensure safe and convenient access to local takeout meals during the COVID-19 pandemic. Nourished allows staff to easily order affordable meals from a curated list of local restaurants via text message.

Newswise: Blood Test May Help Doctors Catch Pancreatic Cancer Early
13-Apr-2020 1:55 PM EDT
Blood Test May Help Doctors Catch Pancreatic Cancer Early
Perelman School of Medicine at the University of Pennsylvania

A blood test may be able to detect the most common form of pancreatic cancer while it is still in its early stages while also helping doctors accurately stage a patient’s disease and guide them to the appropriate treatment.

Released: 9-Apr-2020 1:05 PM EDT
Measuring the Risk Among Clinicians Who Intubate Patients with COVID-19
Perelman School of Medicine at the University of Pennsylvania

Penn launched the U.S. component of a global registry that aims to help protect health care providers who intubate patients with COVID-19 and quantify their risk of developing the disease. The intubateCOVID registry tracks exposures and outcomes among providers who perform intubations, with the ultimate goal of reducing the transmission of COVID-19 to these providers.

Newswise: Penn Launches Trial to Evaluate Hydroxychloroquine to Treat, Prevent COVID-19
Released: 6-Apr-2020 9:00 AM EDT
Penn Launches Trial to Evaluate Hydroxychloroquine to Treat, Prevent COVID-19
Perelman School of Medicine at the University of Pennsylvania

A new trial led by the Perelman School of Medicine at the University of Pennsylvania will evaluate whether the drug hydroxychloroquine (HCQ) can benefit people infected with COVID-19, as well as whether taking the drug preventatively may help people avoid infection altogether

Released: 25-Mar-2020 6:05 PM EDT
Penn Establishes Center to Accelerate Coronavirus Research
Perelman School of Medicine at the University of Pennsylvania

Penn Medicine has established a new center to help expand and accelerate research related to the novel coronavirus, SARS-CoV-2, that causes the respiratory illness known as COVID-19.The center aims to advance research to support the development of potential vaccines, diagnostic tools, and therapies

23-Mar-2020 9:00 AM EDT
CAR Macrophages Go Beyond T Cells to Fight Solid Tumors
Perelman School of Medicine at the University of Pennsylvania

Penn Medicine research shows genetically engineering macrophages – an immune cell that eats invaders in the body – could be the key to unlocking cellular therapies that effectively target solid tumors

Released: 23-Mar-2020 11:05 AM EDT
Penn Medicine Announces Appointment of Daniel Yoshor, MD, as Chair of the Department of Neurosurgery
Perelman School of Medicine at the University of Pennsylvania

Daniel Yoshor, MD, has been named chair of the department of Neurosurgery in the Perelman School of Medicine at the University of Pennsylvania and vice president of Clinical Integration and Innovation for the University of Pennsylvania Health System.

Released: 18-Mar-2020 1:05 PM EDT
How “Pioneer” Protein Turns Stem Cells into Organs
Perelman School of Medicine at the University of Pennsylvania

Early on in each cell, a critical protein known as FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The discovery, published in Nature Genetics, helps untangle mysteries of how embryonic stem cells develop into organs.

Released: 17-Mar-2020 2:30 PM EDT
Penn’s Perelman School of Medicine Ranked 3rd Best Medical School in the United States
Perelman School of Medicine at the University of Pennsylvania

The Perelman School of Medicine at the University of Pennsylvania has been ranked #3 among the nation’s medical schools, marking 23 consecutive years the school garnered honors among the top 10 research-oriented medical schools.

12-Mar-2020 4:05 PM EDT
Reducing Kidney Failure Rate Among Patients with Diabetic Kidney Disease
Perelman School of Medicine at the University of Pennsylvania

Now, as part of an effort to reduce the rate of patients with diabetic kidney disease who develop kidney failure, researchers at Penn Medicine are spearheading a collaboration to better understand the progression of DKD and advance research aimed at preserving kidney function in these patients.

6-Mar-2020 9:50 AM EST
Facebook Users Change Their Language Before an Emergency Hospital Visit
Perelman School of Medicine at the University of Pennsylvania

The language in Facebook posts becomes less formal and invokes family more often in the lead-up to an emergency room visit.

9-Mar-2020 8:00 AM EDT
Giving Commonly Used Muscle Relaxant Through Nose Shows Potential to Treat Neurodegenerative Diseases
Perelman School of Medicine at the University of Pennsylvania

Delivering the medication dantrolene through the nose rather than the mouth may help the medication penetrate the brain more effectively, potentially maximizing its therapeutic benefits in the treatment of neurodegenerative diseases, like Alzheimer’s disease.

Newswise: Imaging Can Guide Whether Liquid Biopsy Will Benefit Individual Glioblastoma Patients
24-Feb-2020 9:00 AM EST
Imaging Can Guide Whether Liquid Biopsy Will Benefit Individual Glioblastoma Patients
Perelman School of Medicine at the University of Pennsylvania

New research shows brain imaging may be able to predict when a blood test known as a liquid biopsy would or would not produce clinically actionable information

21-Feb-2020 12:00 AM EST
Targeting Stromal Cells May Help Overcome Treatment Resistance in Glioblastoma
Perelman School of Medicine at the University of Pennsylvania

The deadly brain cancer glioblastoma (GBM) is often resistant to chemotherapy and radiation, but new research shows targeting stromal cells – the cells that serve as the connective tissue of the organs – may be an effective way of overcoming that resistance

Newswise: Blood Test Can Predict Clinical Response to Immunotherapy in Metastatic Non-Small Cell Lung Cancer
24-Feb-2020 9:00 AM EST
Blood Test Can Predict Clinical Response to Immunotherapy in Metastatic Non-Small Cell Lung Cancer
Perelman School of Medicine at the University of Pennsylvania

Non-small cell lung cancer (NSCLC) patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations.


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