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Newswise: Researchers Identify New Therapeutic Target for Colorectal Cancer
  • Embargo expired:
    27-Dec-2019 9:00 AM EST

Researchers Identify New Therapeutic Target for Colorectal Cancer

The Rockefeller University Press

Researchers at the University of Toronto have identified a key protein that supports the growth of many colorectal cancers. The study, which will be published December 27 in the Journal of Cell Biology, reveals that a protein called Importin-11 transports the cancer-causing protein βcatenin into the nucleus of colon cancer cells, where it can drive cell proliferation. Inhibiting this transport step could block the growth of most colorectal cancers caused by elevated βcatenin levels.

Channels: Cancer, Cell Biology, Digestive Disorders, Genetics, All Journal News, Grant Funded News,

Released:
19-Dec-2019 8:05 AM EST
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Newswise: Researchers discover how Zika virus remodels its host cell to boost viral production
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    23-Dec-2019 9:00 AM EST

Researchers discover how Zika virus remodels its host cell to boost viral production

The Rockefeller University Press

Researchers in China have discovered how a Zika virus protein reshapes its host cell to aid viral replication. The study, which will be published December 23 in the Journal of Cell Biology, reveals that the viral protein NS1 converts an interior cellular compartment called the endoplasmic reticulum (ER) into a protective region where the virus can survive and replicate. Blocking this process could be a novel therapeutic strategy to treat patients infected with Zika or similar viral pathogens, such as the yellow fever and dengue viruses.

Channels: All Journal News, Cell Biology, Microbiome, Zika Virus, Grant Funded News,

Released:
16-Dec-2019 10:15 AM EST
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Newswise: Researchers discover a new way in which insulin interacts with its receptor
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    14-Nov-2019 9:00 AM EST

Researchers discover a new way in which insulin interacts with its receptor

The Rockefeller University Press

The biological actions of insulin are mediated by its receptor—the insulin receptor—which is localized on the cell surface. In a new study, researchers from Germany, Canada, and Finland show how insulin interacts with its receptor at a second binding site. The scientists hope that these new details concerning insulin–receptor interactions will ultimately expand the current models of insulin binding to its receptor and pave the way towards new approaches to structure-based drug design.

Channels: All Journal News, Cell Biology, Diabetes, Grant Funded News,

Released:
7-Nov-2019 12:00 PM EST
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Newswise: David Eisner Named Editor-in-Chief of the Journal of General Physiology (JGP)

David Eisner Named Editor-in-Chief of the Journal of General Physiology (JGP)

The Rockefeller University Press

David Eisner has been selected to serve as the eighth editor-in-chief of the Journal of General Physiology (JGP), effective January 1, 2020. Eisner, the British Heart Foundation Professor of Cardiac Physiology at the University of Manchester, succeeds Sharona Gordon, who has led the journal since 2014.

Channels: Heart Disease, Psychology and Psychiatry,

Released:
22-Oct-2019 12:30 PM EDT
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Newswise: Researchers Identify New Therapeutic Target for Pulmonary Fibrosis
  • Embargo expired:
    10-Oct-2019 9:00 AM EDT

Researchers Identify New Therapeutic Target for Pulmonary Fibrosis

The Rockefeller University Press

Researchers in Japan have identified a genetic mutation that causes a severe lung disease called idiopathic pulmonary fibrosis (IPF) by killing the cells lining the lung’s airways. The study, which will be published October 10 in the Journal of Experimental Medicine (JEM), suggests that protecting these cells by inhibiting a cell death pathway called necroptosis could be a new therapeutic approach to treating IPF.

Channels: Cell Biology, Genetics, Respiratory Diseases and Disorders, Journal of Experimental Medicine, All Journal News, Grant Funded News,

Released:
7-Oct-2019 9:00 AM EDT
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  • Embargo expired:
    17-Sep-2019 9:00 AM EDT

Cancer cells turn to cannibalism to survive chemotherapy, study suggests

The Rockefeller University Press

Researchers from the Tulane University School of Medicine have discovered that some cancer cells survive chemotherapy by eating their neighboring tumor cells. The study, which will be published September 17 in the Journal of Cell Biology, suggests that this act of cannibalism provides these cancer cells with the energy they need to stay alive and initiate tumor relapse after the course of treatment is completed.

Channels: All Journal News, Cancer, Cell Biology, Women's Health, Grant Funded News,

Released:
10-Sep-2019 10:00 AM EDT
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Newswise: Birth defects associated with Zika virus infection may depend on mother’s immune response, study suggests
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    14-Aug-2019 9:00 AM EDT

Birth defects associated with Zika virus infection may depend on mother’s immune response, study suggests

The Rockefeller University Press

New research led by scientists at The Rockefeller University in New York may help explain why Zika virus infection causes birth defects in some children but not others. The study, which will be published August 14 in the Journal of Experimental Medicine, suggests that the risk of developing an abnormally small head (microcephaly) depends on the types of antibody produced by pregnant mothers in response to Zika infection.

Channels: All Journal News, Immunology, Infectious Diseases, OBGYN, Women's Health, Zika Virus, Journal of Experimental Medicine, Grant Funded News,

Released:
7-Aug-2019 8:05 AM EDT
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Newswise: Researchers find genetic cause for fatal response to Hepatitis A
  • Embargo expired:
    18-Jun-2019 9:00 AM EDT

Researchers find genetic cause for fatal response to Hepatitis A

The Rockefeller University Press

Researchers have identified a genetic mutation that caused an 11-year-old girl to suffer a fatal reaction to infection with the Hepatitis A virus (HAV). The study, which will be published June 18 in the Journal of Experimental Medicine, reveals that mutations in the IL18BP gene causes the body’s immune system to attack and kill healthy liver cells, and suggests that targeting this pathway could prevent the deaths of patients suffering rapid liver failure in response to viral infection.

Channels: All Journal News, Genetics, Liver Disease, Immunology, Infectious Diseases, Journal of Experimental Medicine, Grant Funded News,

Released:
12-Jun-2019 9:00 AM EDT
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Newswise: Researchers identify human protein that aids development of malaria parasite
  • Embargo expired:
    12-Jun-2019 9:00 AM EDT

Researchers identify human protein that aids development of malaria parasite

The Rockefeller University Press

Researchers in Japan have discovered that the Plasmodium parasites responsible for malaria rely on a human liver cell protein for their development into a form capable of infecting red blood cells and causing disease. The study, which will be published June 12 in the Journal of Experimental Medicine, suggests that targeting this human protein, known as CXCR4, could be a way to block the parasite’s life cycle and prevent the development of malaria.

Channels: All Journal News, Climate Science, Infectious Diseases, Public Health, Journal of Experimental Medicine, Grant Funded News,

Released:
5-Jun-2019 10:05 AM EDT
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Newswise: Researchers identify new roles for common oncogene MYC
  • Embargo expired:
    29-May-2019 9:00 AM EDT

Researchers identify new roles for common oncogene MYC

The Rockefeller University Press

Cancer researchers have discovered surprising new functions for a protein called MYC, a powerful oncogene that is estimated to drive the development of almost half a million new cancer cases in the US every year. The study, which will be published May 29 in the Journal of Experimental Medicine, shows that MYC affects the efficiency and quality of protein production in lymphoma cells, fueling their rapid growth and altering their susceptibility to immunotherapy.

Channels: All Journal News, Cancer, Immunology, Journal of Experimental Medicine, Grant Funded News,

Released:
22-May-2019 9:25 AM EDT
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