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Released: 21-Jan-2016 2:05 PM EST
Computational Analysis of Breast Cancer Finds That Many Cell Types Correlate with Patient Survival and Genomic Features
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

A study by researchers at Norris Cotton Cancer Center has shown that a very sensitive computational method can be used to reveal the human immune system’s effect on cancer. The Dartmouth study was the first to perform an in-depth computational examination of how immune activity translates to prognosis in breast cancer.

Released: 15-Oct-2015 2:05 PM EDT
Higher Volume Mammography Facilities Better for Screening
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Women who visit mammography facilities with higher total interpretive volumes are more likely to benefit from screening, according to a new study published in the Journal of Medical Screening. Research shows such facilities are significantly more likely to diagnose invasive tumors with good prognoses.

Released: 15-Oct-2015 2:05 PM EDT
Vitamin D, Calcium Intake Does Not Reduce Colorectal Polyps
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

A large, randomized study at 11 U.S. hospitals including Dartmouth-Hitchcock Medical Center found that vitamin D and calcium supplements fail to protect against developing colorectal cancer.

Released: 16-Sep-2015 10:05 AM EDT
Genetic Risk Score for Telomere Length Predictive of Lung Adenocarcinoma
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

An unprecedented large study provides compelling evidence that long telomere length increases the risk of lung adenocarcinoma

Released: 16-Sep-2015 10:05 AM EDT
Dartmouth Research Finds Some Gene Chromosomes More Risk Associated with Disease
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth’s Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk-associated with disease than protective.

Released: 16-Sep-2015 10:05 AM EDT
Subtle Variations in Expression of Imprinted Genes to Explain Newborn Health Outcomes
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

In the first and largest studies to examine subtle variation of imprinted gene expression and control, investigators from Dartmouth’s Norris Cotton Cancer Center, report in two papers published recently in Epigenetics on a subgroup of imprinted genes expressed in the placenta

Released: 16-Sep-2015 10:05 AM EDT
Dartmouth Investigators Study Impact of Shift in Testing Guidelines for Assessing HER2 Status in Breast Cancer Patients
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Accurately determining HER2 status in patients with breast cancer is a critical prognostic and predictive factor and identifies patients who may benefit from treatment with anti-HER2 therapies.

Released: 9-Jul-2015 2:05 PM EDT
MRI, Near Infrared Spectral Tomography Increases Specificity in Breast Cancer Imaging
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Norris Cotton Cancer Center investigators demonstrated that a dual breast exam using MRI and Near Infrared Spectral Tomography (NIRST) is feasible and more accurate than MRI alone.

Released: 25-Jun-2015 10:05 AM EDT
E2F4 Signature Can Predicts Progression of Bladder Cancer
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Investigators from Dartmouth’s Norris Cotton Cancer Center harnessed genomic data to discover that the previously identified E2F4 signature in breast cancer can be utilized to predict prognosis and response to therapy in bladder cancer.

Released: 27-May-2015 10:05 AM EDT
Dartmouth Research Finds Common Cancer Drug Increases Collagen in Melanoma
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Collagen is the most abundant protein in the human body, and investigators are uncertain how its presence affects the behavior of melanoma cells.

Newswise: Dartmouth Researchers Use Implantable Micro-Device to Monitor Oxygen in Glioma to Improve Treatment Outcomes
Released: 21-May-2015 1:05 PM EDT
Dartmouth Researchers Use Implantable Micro-Device to Monitor Oxygen in Glioma to Improve Treatment Outcomes
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Monitoring oxygen levels in human tumors growing in a mouse brain using EPR oximetry with implantable resonators provides opportunities to evaluate and optimize various strategies being developed to improve oxygen levels in the glioma.

Released: 14-May-2015 2:05 PM EDT
Dartmouth Researchers Engineer Micro-Factory to Attack Tumors
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

A team of Dartmouth investigators have engineered therapeutic cells encapsulated in nanoporous capsules to secrete antitumor molecules from within the tumor.

Released: 12-May-2015 11:05 AM EDT
Dartmouth Team Devises Use of Food Dye, Near Infrared Light to Aid in Breast Resection
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Dartmouth team focuses on coming up with a practical solution that both preserves the surgical practice of inking the margins of breast cancer tumors, and allows quality imaging post-inking.

Released: 1-May-2015 9:00 AM EDT
Teens Who Mix Energy Drinks with Alcohol More Likely to Have Alcohol Use Disorder
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Norris Cotton Cancer Center investigators found teens aged 15-17 years old who had ever mixed alcohol with energy drinks were four times more likely to meet the criteria for alcohol use disorder.

Released: 16-Apr-2015 2:05 PM EDT
Research Finds No Correlation between Regulatory T Cells and Survival in Glioblastoma
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Using a novel methodology of epigenetic quantitative analysis, investigators found no correlation between regulatory T cells and survival in the tumor microenvironment or blood, even when adjusting for well-known prognostic factors.

Released: 15-Apr-2015 11:05 AM EDT
Early Use of Palliative Care in Cancer Improves Patients' Lives, Outcomes for Caregivers
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

A new randomized clinical trial has noted significant improvement in several measures among those who began palliative care early.

Released: 14-Apr-2015 2:05 PM EDT
Reconceptualizing Stress in Cancer Treatment
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Dartmouth investigators point to the shortcomings of using the word stress in a medical or scientific context and encourage bodymind therapies to treat trauma in patients with cancer.

Released: 13-Apr-2015 2:05 PM EDT
Nanoparticles at Specific Temperature Stimulate Antitumor Response
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Dartmouth researchers identified the precise temperature that results in a distinct body-wide antitumor immune response that resists metastatic disease.

Released: 9-Apr-2015 2:05 PM EDT
Specific Cells in Female Reproductive Tract Display Susceptibility to HIV Infection
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Dartmouth study finds some portions of the female reproductive tract are more likely to be infected by HIV, particularly the ectocervix compared to the endometrium.

Newswise: Investigators Discover Mechanism Responsible for Tumor Invasion in Brain Cancer
Released: 8-Apr-2015 3:05 PM EDT
Investigators Discover Mechanism Responsible for Tumor Invasion in Brain Cancer
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

A neuro-oncology research team at Dartmouth's Norris Cotton Cancer Center recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

Released: 7-Apr-2015 2:05 PM EDT
Research Finds Cells Respond to Stress by Folding and Unfolding Their Genomes
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Uncovering cellular response to stress may provide leverage to determine how to trick undesirable cells, such as cancer or damaged cells, into dying instead of recovering from stress.

Released: 6-Apr-2015 2:05 PM EDT
Dartmouth Investigators Identify Mechanism that Drives Melanoma to Metastasize
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

The significance of this work is its descriptions of alternative mechanisms by which tumors move and settle in new locations.

Newswise: Dartmouth Investigators Develop Antibacterial Enzymes to Combat Drug-Resistant Bacterial Pathogens
Released: 2-Apr-2015 1:05 PM EDT
Dartmouth Investigators Develop Antibacterial Enzymes to Combat Drug-Resistant Bacterial Pathogens
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

By engineering antibacterial enzymes, Dartmouth investigators led by Karl Griswold, PhD are using novel strategies to target the prevalent drug-resistant bacterium Staphylococcus aureus.

Released: 1-Apr-2015 3:05 PM EDT
"Firefly" Mechanism Makes Cancer Studies More Efficient, Less Expensive
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

The mechanism that makes fireflies glow through a process called bioluminescence can be used to study tumor response to therapy as well, researchers have found.

Released: 31-Mar-2015 2:05 PM EDT
Facilitated Intervention Can Improve Quality of Life for Breast Cancer Survivors
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Taking the focus off pain management and specific post-treatment symptoms, Norris Cotton Cancer Center researchers establish a new paradigm for working with breast cancer survivors

Released: 30-Mar-2015 3:05 PM EDT
Marketing of Energy Drinks Placed on TV Channels that Appeal to Teens
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Though the Academy of Pediatrics advises against the consumption of energy drinks by teens, research finds that manufacturers market the bulk of their products on TV channels that likely appeal to teens.

Newswise: Norris Cotton Cancer Center at Dartmouth Redesignated As NCI
Released: 26-Mar-2015 12:05 PM EDT
Norris Cotton Cancer Center at Dartmouth Redesignated As NCI "Comprehensive Cancer Center"
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

The National Cancer Institute (NCI) has renewed its Cancer Center Support Grant to Norris Cotton Cancer Center (NCCC) at Dartmouth, continuing NCCC's designation as a Comprehensive Cancer Center.

Newswise: Researchers Use Nanoparticles to Selectively Target Tumor Cells in Two Cancer Models
Released: 25-Mar-2015 3:05 PM EDT
Researchers Use Nanoparticles to Selectively Target Tumor Cells in Two Cancer Models
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Dartmouth team uses nanomaterials to pursue a systematic study of variables in xenograft models of both breast and ovarian human cancer.

Newswise: Immunomagnetic Assay On-a-Chip Captures, Analyzes Circulating Tumor Cells
Released: 24-Mar-2015 4:05 PM EDT
Immunomagnetic Assay On-a-Chip Captures, Analyzes Circulating Tumor Cells
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Dartmouth bioengineers demonstrate a novel system that couples nano-engineered particles and microfluidic chips for capturing and manipulating circulating tumor cells.

Newswise: Researchers Discover Mechanism to Control Multiple Processes of Cell Growth, Division
Released: 23-Mar-2015 3:05 PM EDT
Researchers Discover Mechanism to Control Multiple Processes of Cell Growth, Division
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Investigators from Dartmouth's Norris Cotton Cancer Center find that the protein Pom1 possesses the ability to modify different sets of proteins to coordinate the processes of cell growth and division.

Released: 20-Mar-2015 3:05 PM EDT
Dartmouth Investigators Make Photodynamic Therapy for Pancreatic Cancer Simpler, Cheaper
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Research finds the values measured with dynamic contrast enhanced computer tomography strongly correlated with fluorescence intensity measured directly from the pancreatic tissue.

Released: 19-Mar-2015 3:05 PM EDT
Two Distinct Populations of CD4 T Cells Play Different Roles in Immune System
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Utilizing a novel transgenic mouse model, Edward Usherwood, PhD of Dartmouth's Norris Cotton Cancer Center and collaborators found that CD4 T cells divide into two different populations that each has a different job.

Released: 18-Mar-2015 1:05 PM EDT
mHealth App Ideal for Breast Cancer Risk Assessment, Prevention
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Elissa Ozanne, PhD from Dartmouth's Norris Cotton Cancer Center and colleagues concluded that mobile health devices are acceptable to older, diverse, and low income women.

Released: 17-Mar-2015 10:05 AM EDT
Doctors Don't Always Agree on Breast Biopsies; Say Women with Aytpia or DCIS Should Seek Second Opinions
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

While doctors almost always agree on a pathological diagnosis of invasive breast cancer, there is room for improvement when diagnosing atypia (or atypical ductal hyperplasia-ADH) and DCIS (ductal carcinoma in-situ).

Released: 16-Mar-2015 2:05 PM EDT
Dartmouth Investigators Identify Window of Vulnerability for STIs to Infect Human Female Reproductive Tract
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

The benefits of these findings are directly applicable to other reproductive challenges including gynecological cancers such as cervical cancer.

Released: 5-Mar-2015 2:05 PM EST
Fast Food Commercials to Kids 'Deceptive' by Industry Self-Regulation Standards
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Fast food ads aimed at kids fail to de-emphasize toy premiums, and fail to emphasize healthy menu items, investigators at Dartmouth-Hitchcock's Norris Cotton Cancer Center have found.

2-Mar-2015 3:05 PM EST
U.S. Spends More on Cancer Care, Saves Fewer Lives than Western Europe
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Such findings have raised questions about the additional value of U.S. cancer care derived from the additional spending, in comparison to the situation in other high-income countries.

Newswise:Video Embedded cherenkov-effect-improves-radiation-therapy-for-patients-with-cancer
VIDEO
Released: 25-Feb-2015 10:00 AM EST
Cherenkov Effect Improves Radiation Therapy for Patients with Cancer
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

The complex parts of the blue light known as the Cherenkov Effect can be measured and used in dosimetry to make therapies safer and more effective.

Released: 20-Feb-2015 9:30 AM EST
Dartmouth Investigators Discover Key Indicator for Successful Treatment of Infertile Couples
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Study determines if follicle stimulating hormone and estrogen at the upper limits of normal could predict treatment success as measured in live birth rates.

Newswise:Video Embedded structure-based-design-used-as-tool-for-engineering-deimmunized-biotherapeutics
VIDEO
Released: 13-Feb-2015 1:00 PM EST
Structure-Based Design Used as Tool for Engineering Deimmunized Biotherapeutics
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

While methods for identifying immunogenic hotspots, or epitopes, are evolving rapidly, technologies to redesign the hotspots while maintaining biotherapeutic activity and stability are far less developed.

Released: 13-Feb-2015 9:25 AM EST
Google-Style Ranking Used to Describe Gene Connectivity
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Coining the term "Gene Rank" (GR), Eugene Demidenko, PhD, captured a new characterization of gene connectivity by using a computer algorithm to compare tissues across or within organisms at great speed with a simple laptop computer.

Released: 10-Feb-2015 10:05 AM EST
Investigators at Dartmouth Identify Key Pathways Underlying Different Subsets of Systemic Sclerosis
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Sorting out patients with systemic sclerosis (SSc) according to their shared biology, researchers discovered how disease heterogeneity can be defined, allowing for targeted selection of patients for clinical trials.

Released: 9-Feb-2015 2:15 PM EST
Dartmouth Physician-Scientists Examine Efficacy of Radiation Therapy in 'Good-Risk' DCIS Patients
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

A collaborative national clinical trials group discovered that radiation therapy in addition to chemotherapy was even more effective at preventing recurrence of ductal carcinoma in situ (DCIS) than previously thought.

Released: 4-Feb-2015 2:00 PM EST
Dartmouth Investigators Find Pilot ACOs Miss Opportunities to Curb Cardiovascular Spending
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

In a study of 10 large health systems, researchers at Dartmouth and the University of Michigan found that implementation of pilot accountable care organizations (ACOs) did not limit spending on discretionary or non-discretionary cardiovascular treatment for patients.

Released: 4-Feb-2015 12:00 PM EST
Dartmouth Investigators Push for Substantive Study of Body-Mind Therapy Approaches
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Dartmouth investigators note the lack of hypothesized scientific models for the mechanisms of action responsible for outcomes in Somatic Experiencing(SE) trauma therapy and other body-mind therapies.

Released: 4-Feb-2015 8:55 AM EST
Dartmouth Investigators Develop Groundbreaking Technique to Measure Oxygen in Deep-Sited Tumor and Brain
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

A novel Electron Paramagnetic Resonance (EPR) oximetry technique will help clinicians directly measure oxygen and schedule treatments at times of high oxygen levels in cancer and stroke patients to improve outcomes, The EPR team at Dartmouth's Geisel School of Medicine has found.

Released: 3-Feb-2015 4:00 PM EST
Dartmouth Researchers Reprogram Tumor's Cells to Attack Itself
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Inserting a specific strain of bacteria into the microenvironment of aggressive ovarian cancer transforms the behavior of tumor cells from suppression to immunostimulation, researchers at Norris Cotton Cancer Center and the Geisel School of Medicine at Dartmouth have found.

Released: 3-Feb-2015 2:10 PM EST
Dartmouth Cancer Investigators Help National Cancer Institute Present Statistics in More Understandable Ways
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

Three papers in the survival monograph published by the Journal of the National Cancer Institute, co-authored by Dartmouth's Norris Cotton Cancer Center investigators Steven Woloshin, MD, MS, and Lisa Schwartz, MD, MS, aim to help doctors, patients, and policymakers better understand cancer prognosis and survival.

Released: 2-Feb-2015 10:00 AM EST
Dartmouth Researchers Discover New Mechanism of Acquired Resistance to Breast Cancer Drugs
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

In the search for new approaches to treat ERBB2 positive breast cancers that have become drug-resistant, Dartmouth investigator Manabu Kurokawa, PhD, led a team in discovery of a novel cancer resistance mechanism.

Released: 28-Jan-2015 1:05 PM EST
Dartmouth Investigators Conduct Systematic Testing of Deimmunized Biotherapeutic Agents
Norris Cotton Cancer Center Dartmouth-Hitchcock Medical Center

By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, researchers have established a novel testing platform.


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