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6-Mar-2018 11:05 AM EST
Study Shows That Environmental Exposures Such as Air Pollution Are More Determinant of Respiratory Health Than Inherited Genetics
Ontario Institute for Cancer Research

Researchers have found strong evidence that environmental exposures, including air pollution, affect gene expressions associated with respiratory diseases much more than genetic ancestry. The study, published today in Nature Communications, analyzed more than 1.6 million data points from biological specimens, health questionnaires and environmental datasets, making this study one of the largest ever to examine the relationship between gene expression and environmental stimuli. These findings represent a groundbreaking use of big data to uncover the environmental factors that are behind diseases and inform strategies for prevention, an approach that would apply to a number of diseases, including cancer.

Released: 4-Dec-2017 10:00 AM EST
OICR Launches Groundbreaking Cancer Therapeutics Innovation Pipeline to Drive Cutting-Edge Therapies to the Clinic
Ontario Institute for Cancer Research

The Ontario Institute for Cancer Research (OICR) today announced the Cancer Therapeutics Innovation Pipeline (CTIP) initiative and the first 10 projects selected in CTIP’s inaugural round of funding. CTIP aims to support the local translation of Ontario discoveries into therapies with the potential for improving the lives of cancer patients.

Released: 6-Sep-2017 9:00 AM EDT
Innovative Study Brings Next-Generation Genomic Sequencing to More Ontario Cancer Patients
Ontario Institute for Cancer Research

Understanding a cancer’s genetics is key to selecting targeted therapies that are likely to be of the most benefit to a patient. The Ontario Institute for Cancer Research (OICR) today announced a new study, called Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (OCTANE). OCTANE will use next-generation genome sequencing technology to bring a unified molecular profiling approach to five Ontario cancer centres.

15-Aug-2017 12:05 PM EDT
New Data Resource Centre Will Help Better Understand Links Between Birth Defects and Childhood Cancer
Ontario Institute for Cancer Research

Up to $14.8 million over five years, contingent on available funds, was announced today by The National Institutes of Health (NIH) Common Fund’s Gabriella Miller Kids First Pediatric Research Program (Kids First). Researchers in Canada and the United States are using these funds to join together and build a centralized, cloud-based database and discovery portal of genetic and clinical data called the Kids First Data Resource Center (DRC).

Released: 9-Mar-2017 10:05 AM EST
Innovative Technique Greatly Increases Sensitivity of DNA Sequencing
Ontario Institute for Cancer Research

OICR researchers, together with international collaborators, have invented a technique to avoid a major problem with common laboratory techniques and improve the sensitivity of important cancer tests. The findings, published today in the journal Nature Protocols, describe a process by which the sensitivity of DNA sequencing can be improved. The technology, called SiMSen-Seq, could aid in detecting the recurrence of cancers, catching possible disease relapses faster than current methods and improving patient outcomes.

Released: 12-Oct-2016 1:00 PM EDT
New Findings Published Today in Nature Challenge Current View of How Pancreatic Cancer Develops
Ontario Institute for Cancer Research

Researchers in the multidisciplinary PanCuRx research initiative at the Ontario Institute for Cancer Research (OICR) and University Health Network’s Princess Margaret Cancer Centre, led by Dr. Faiyaz Notta and Dr. Steven Gallinger, today published new findings that challenge current beliefs about how and why pancreatic cancer is so aggressive.

Released: 6-Oct-2016 9:00 AM EDT
Reactome Announces Annotation and Release of 10,000th Human Protein
Ontario Institute for Cancer Research

The European Bioinformatics Institute (EMBL-EBI), the New York University School of Medicine and the Ontario Institute for Cancer Research (OICR) today announced a major milestone in the Reactome project: the annotation and release of its 10,000th human protein, making it the most comprehensive open access pathway knowledgebase available to the scientific community.

Released: 17-Aug-2016 10:00 AM EDT
New Retrospective Study Aims to Identify Mutations to Better Diagnose Breast Cancer in the Future
Ontario Institute for Cancer Research

Mr. Peter Goodhand, President of The Ontario Institute for Cancer Research (OICR), today announced a new collaborative research study in partnership with Thermo Fisher Scientific and Queen’s University to help bring more targeted diagnosis and treatment to breast cancer patients in the future.

Released: 14-Jul-2016 11:05 AM EDT
International Team Launches Community Competition to Unravel How Cancer Changes a Cell’s RNA
Ontario Institute for Cancer Research

An open challenge that merges the efforts of the International Cancer Genome Consortium, The Cancer Genome Atlas, and the NCI Cloud Pilots with Sage Bionetworks and the open science DREAM Challenge community

Released: 28-Jun-2016 10:00 AM EDT
Researchers Discover Protein Signatures for Accurate Non-Invasive Diagnosis of Aggressive Prostate Cancer
Ontario Institute for Cancer Research

Researchers at the Ontario Institute for Cancer Research (OICR) and University Health Network (UHN) in Toronto, along with researchers at the Eastern Virginia Medical School, have created protein signatures that accurately diagnose prostate cancer and can distinguish between patients with aggressive versus non-aggressive disease using a simple urine sample.

Released: 1-Jun-2016 9:00 AM EDT
Clinical Trial Launched to Test Use of MRI to Improve Prostate Cancer Diagnosis and Management
Ontario Institute for Cancer Research

The Movember Foundation, the Ontario Institute for Cancer Research (OICR) and Prostate Cancer Canada today announced $3 million in funding for a new Phase III clinical trial to evaluate if magnetic resonance imaging (MRI) can replace the current standard of care to diagnose prostate cancer. The primary objective of the multi-centre trial, called PRECISE, is to determine whether MRI imaging can spare some men from undergoing a biopsy and avoid the possible associated side effects.

2-May-2016 10:00 AM EDT
$2 Million in New Funding From Canadian Institutes of Health Research Will Help Ontario Team Study Metabolic Syndromes
Ontario Institute for Cancer Research

The award will fund the study of the role of both genes and the environment on the development of metabolic syndrome, a cluster of medical conditions that are common in aging adults, including obesity, hypertension, high cholesterol, high blood sugar and insulin resistance.

Released: 17-Apr-2016 2:00 PM EDT
International Cancer Genome Consortium for Medicine (ICGCmed) Launches Today, Will Link Genomics to Clinical Information and Health
Ontario Institute for Cancer Research

The International Cancer Genome Consortium (ICGC) today announced plans to launch the International Cancer Genome Consortium for Medicine (ICGCmed), a new phase in the Consortium’s evolution that will link genomics to clinical information and health.

Released: 1-Mar-2016 9:00 AM EST
International Cancer Genome Consortium Reaches Milestone of 1,000 Authorized Users
Ontario Institute for Cancer Research

The International Cancer Genome Consortium (ICGC) announced today that its Data Access Compliance Office (DACO) authorized its 1,000th user, giving them access to the Consortium’s Controlled Access datasets.

8-Dec-2015 3:05 PM EST
Building the Foundations for Cancer Genomic Analysis for Research and Clinical Diagnostics
Ontario Institute for Cancer Research

A study published in the prestigious journal Nature Communications revealed a high degree of heterogeneity in how cancer genome sequencing is done at different institutions across the globe. This result lays the foundation for the coming era of cancer genomics by creating guidelines and providing new tools for achieving higher quality data, for better diagnosis and precision medicine;

Released: 18-Nov-2015 11:15 AM EST
The International Cancer Genome Consortium Brings More Genomic Health Data to Researchers on the Amazon Web Services Cloud
Ontario Institute for Cancer Research

The International Cancer Genome Consortium (ICGC) announced today that 1,200 encrypted cancer whole genome sequences are now securely available on the Amazon Web Services (AWS) Cloud for access by cancer researchers worldwide.

Released: 16-Nov-2015 4:30 PM EST
International Team Announces Crowdsourcing Competition, Running on Google Cloud Platform, To Understand How Cancers Originate And Evolve
Ontario Institute for Cancer Research

An international consortium of groups from Canada, the United States and the United Kingdom have come together to create an innovative, cloud-based, public challenge to optimize the discovery of genetically distinct groups of cells within cancers that could respond differently to treatment and have different risk of spreading.

3-Sep-2015 11:30 AM EDT
The Ontario Institute for Cancer Research and the Structural Genomics Consortium Develop and Give Away New Drug-Like Molecule to Help Crowd-Source Cancer Research
Ontario Institute for Cancer Research

Researchers from the Ontario Institute for Cancer Research (OICR) and the Structural Genomics Consortium (SGC) at the MaRS Discovery District in Toronto have developed a new drug prototype called OICR-9429 and made it freely available to the research community. Already research conducted by international groups using OICR-9429 has shown it to be effective in stopping cancer cell growth in breast cancer cell lines and a specific subtype of leukemia cells.

Released: 9-Jul-2015 1:00 PM EDT
World-Leading Big Data Researchers Call for Support for More Accessible and More Effective Storage of Data in the Cloud to Facilitate Genomics Research
Ontario Institute for Cancer Research

Today in the journal Nature prominent researchers from Canada, Europe and the U.S. have made a powerful call to major funding agencies, asking them to commit to establishing a global genomic data commons in the cloud that could be easily accessed by authorized researchers worldwide.

Released: 15-Jun-2015 11:00 AM EDT
Researchers Sequence and Assemble First Full Genome of a Living Organism Using Technology the Size of Smartphone
Ontario Institute for Cancer Research

Researchers in Canada and the U.K. have for the first time sequenced and assembled de novo the full genome of a living organism, the bacteria Escherichia Coli, using Oxford Nanopore’s MinIONTM device, a genome sequencer that can fit in the palm of your hand.

Released: 1-Jun-2015 9:00 AM EDT
The Ontario Institute for Cancer Research Invests $4.6 Million to Support Pancreatic Cancer Research
Ontario Institute for Cancer Research

OICR is investing $4.6 million over two years in PanCuRx, an initiative that seeks solutions to the high fatality rate of pancreatic cancer.

Released: 18-May-2015 11:00 AM EDT
Research Community Comes Together to Provide New “Gold Standard” for Genomic Data Analysis
Ontario Institute for Cancer Research

New results provide an important benchmark for researchers, helping to define the most accurate methods for identifying somatic mutations in cancer genomes.


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