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Newswise: New Drug Reduces Stroke Damage in Mice
29-Jun-2020 12:35 PM EDT
New Drug Reduces Stroke Damage in Mice
Health Sciences at the University of Pittsburgh

Mice that received an injection of a new experimental drug, TAT-DP-2, after a stroke had smaller areas of damage, and their long-term neurological function was better than that of untreated animals.

Newswise: Lab-Grown Miniature Human Livers Successfully Transplanted in Rats
28-May-2020 11:00 AM EDT
Lab-Grown Miniature Human Livers Successfully Transplanted in Rats
Health Sciences at the University of Pittsburgh

Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats. In this proof-of-concept experiment, the lab-made organs survived for four days inside their animal hosts.

Newswise:Video Embedded upmc-designs-playbook-for-return-of-youth-high-school-and-collegiate-team-sports
VIDEO
Released: 1-Jun-2020 2:00 PM EDT
UPMC Designs Playbook for Return of Youth, High School and Collegiate Team Sports
Health Sciences at the University of Pittsburgh

A multidisciplinary team of clinicians and researchers led by UPMC Sports Medicine has developed guidelines to assist coaches, athletic trainers and organizers creating a safe environment for youth athletes, fans and staff as they consider a return to play.

Newswise: Study Traces Brain-to-Gut Connections
14-May-2020 8:00 AM EDT
Study Traces Brain-to-Gut Connections
Health Sciences at the University of Pittsburgh

Using rabies virus injected into the stomach of rats, researchers trace the nerves back to the brain and find distinct "fight or flight" and "rest and digest" circuits. These results explain how mental states can affect the gut, and present new ways to treat gastrointestinal problems.

Newswise: Immune System Discovery Paves Way to Lengthen Organ Transplant Survival
Released: 8-May-2020 2:20 PM EDT
Immune System Discovery Paves Way to Lengthen Organ Transplant Survival
Health Sciences at the University of Pittsburgh

A new discovery in mice shows the innate immune system has "memory," previously thought to be a unique feature of the adaptive immune system. Blocking this memory prevented transplanted organs from being rejected, providing a way to more specific drugs that could lengthen organ transplant survival.

Newswise:Video Embedded drug-overdose-epidemic-is-transmitted-from-old-to-young-study-shows
VIDEO
30-Apr-2020 4:15 PM EDT
Drug Overdose Epidemic is Transmitted from Old to Young, Study Shows
Health Sciences at the University of Pittsburgh

The generation a person was born into – Silent Generation, Baby Boomer, Generation X or Millennial – strongly predicts how likely they are to die from a drug overdose, and at what age. Within each generation, there was a steady march toward greater overdose risk at younger ages.

Newswise: Long-Lasting, Low Toxicity Antimicrobial Peptide Fights ‘Superbug’ Lung Infections
27-Apr-2020 9:00 AM EDT
Long-Lasting, Low Toxicity Antimicrobial Peptide Fights ‘Superbug’ Lung Infections
Health Sciences at the University of Pittsburgh

Through serendipity, researchers at the University of Pittsburgh Graduate School of Public Health considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections.

Newswise: UPMC Leads Global Effort to Fast Track Testing of Hydroxychloroquine and other COVID-19 Therapies with ‘Learning While Doing’ Clinical Trial
Released: 9-Apr-2020 11:00 AM EDT
UPMC Leads Global Effort to Fast Track Testing of Hydroxychloroquine and other COVID-19 Therapies with ‘Learning While Doing’ Clinical Trial
Health Sciences at the University of Pittsburgh

Novel 'learning while doing' clinical trial approach called REMAP helps doctors find the optimal trade-off between quickly adopting new therapies during a pandemic, such as the anti-malarial drug hydroxychloroquine, and waiting until they are tested in longer clinical trials. The trial announced today at UPMC, called UPMC-REMAP-COVID19 learns from similar trials enrolling around the world and uses artificial intelligence to quickly arrive at answers.

Newswise:Video Embedded covid-19-vaccine-candidate-shows-promise-in-first-peer-reviewed-research
VIDEO
31-Mar-2020 9:45 AM EDT
COVID-19 Vaccine Candidate Shows Promise in First Peer-Reviewed Research
Health Sciences at the University of Pittsburgh

A potential COVID-19 vaccine, delivered by microscopic needles, produces antibodies specific to the virus when tested in mice. This is the first peer-reviewed paper describing a COVID-19 vaccine candidate. The next step is a human clinical trial.

Newswise: UPMC to Protect Staff Pay During Covid-19 Pandemic Response
Released: 30-Mar-2020 4:45 PM EDT
UPMC to Protect Staff Pay During Covid-19 Pandemic Response
Health Sciences at the University of Pittsburgh

UPMC is implementing a staffing and pay protection program, which will ensure that all staff will continue to be paid at their current rate for normally scheduled hours through May 9, 2020 even if they are assigned to alternative work during their regular hours.

Newswise: Mimicking Cancer’s Evasive Tactics, Microparticles Show Promise Against Transplant Rejection
8-Mar-2020 9:00 PM EDT
Mimicking Cancer’s Evasive Tactics, Microparticles Show Promise Against Transplant Rejection
Health Sciences at the University of Pittsburgh

Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own, while leaving the immune system intact.

Newswise: DARPA Awards $22 Million to Create ‘Smart’ Device for Healing Large Muscle Wounds
Released: 11-Mar-2020 9:00 AM EDT
DARPA Awards $22 Million to Create ‘Smart’ Device for Healing Large Muscle Wounds
Health Sciences at the University of Pittsburgh

Researchers from seven institutions team up to create a device combining artificial intelligence, bioelectronics and regenerative medicine for regrowing muscle tissue, especially after combat injuries.

Newswise: Drug Prices Rose 3x Faster Than Inflation Over Last Decade, Even After  Discounts, Study Shows
27-Feb-2020 12:15 PM EST
Drug Prices Rose 3x Faster Than Inflation Over Last Decade, Even After Discounts, Study Shows
Health Sciences at the University of Pittsburgh

The net cost of prescription drugs – meaning sticker price minus manufacturer discounts – rose over three times faster than the rate of inflation over the course of a decade, according to a study published today in JAMA. It’s the first to report trends in all brand name net drug costs in the U.S.

Newswise: For Weight-Loss Surgery Patients Who Quit Smoking, Relapse is Common
18-Feb-2020 12:25 PM EST
For Weight-Loss Surgery Patients Who Quit Smoking, Relapse is Common
Health Sciences at the University of Pittsburgh

Although 1 in 7 adults smoke cigarettes the year prior to undergoing weight-loss surgery, nearly all successfully quit at least a month before their operation. However, smoking prevalence steadily climbs to pre-surgery levels within seven years, according to new research.

17-Feb-2020 9:20 AM EST
Half of Transgender Youth Have Avoided Disclosing Gender Identity to a Health Care Provider, Study Shows
Health Sciences at the University of Pittsburgh

Researchers surveyed 153 transgender youths receiving gender-affirming care at a specialty clinic, and even in this relatively "out" population, nearly half reported intentionally hiding their gender identity from a health care provider outside the clinic.

Newswise: Finding the Lost Stephen Hawkings
10-Feb-2020 8:00 AM EST
Finding the Lost Stephen Hawkings
Health Sciences at the University of Pittsburgh

During a press briefing Friday at AAAS, Dr. Rory Cooper will discuss how people with disabilities are shut off from STEM careers and why inclusivity matters.

Newswise: Heart Disease Risk Grows as Women Move Through Menopause
Released: 3-Feb-2020 8:30 AM EST
Heart Disease Risk Grows as Women Move Through Menopause
Health Sciences at the University of Pittsburgh

A marker for heart disease risk considerably worsens as women transition through menopause, according to a new analysis from the largest and longest running study of women’s health in midlife. Black women experience this accelerated decline earlier in menopause than their white counterparts.

Newswise: Large Proportion of Reproductive-Age Women Live in Counties Where Catholic Hospitals Hold High Market Share
27-Jan-2020 12:00 PM EST
Large Proportion of Reproductive-Age Women Live in Counties Where Catholic Hospitals Hold High Market Share
Health Sciences at the University of Pittsburgh

Nearly 2 of every 5 women of reproductive age in the U.S. live in counties where Catholic hospitals have a high market share, according to a new analysis. Catholic hospitals do not provide certain reproductive health options.

Newswise:Video Embedded researchers-regrow-damaged-nerves-with-polymer-and-protein
VIDEO
17-Jan-2020 7:00 PM EST
Researchers Regrow Damaged Nerves with Polymer and Protein
Health Sciences at the University of Pittsburgh

University of Pittsburgh researchers have created a biodegradable nerve guide – a polymer tube – filled with growth-promoting protein that can regenerate long sections of damaged nerves, without the need for transplanting stem cells or a donor nerve.

Released: 22-Jan-2020 9:00 AM EST
Decline in Late Stage Cancer Diagnoses After Health Reform Law
Health Sciences at the University of Pittsburgh

Advanced stage cancer diagnoses declined following health insurance expansion in Massachusetts, likely due to increased access to screening and diagnostic services that identified cancers earlier, according to new research.

Released: 21-Jan-2020 11:05 AM EST
Clinical Trial: Vitamin D Supplementation Linked to Potential Improvements in Blood Pressure in Children
Health Sciences at the University of Pittsburgh

Overweight and obese vitamin D-deficient children who took a relatively high dose of vitamin D every day for six months had lower blood pressure and improved insulin sensitivity than their peers who took a lower dose, according to the results of a new clinical trial.

Newswise: Visits to Pediatricians on the Decline
16-Jan-2020 12:00 PM EST
Visits to Pediatricians on the Decline
Health Sciences at the University of Pittsburgh

Commercially insured children in the U.S. are seeing pediatricians less often than they did a decade ago, according to a new analysis led by a pediatrician-scientist at the University of Pittsburgh and UPMC Children’s Hospital of Pittsburgh.

Newswise: Sepsis Associated with 1 in 5 Deaths Globally, Double Previous Estimate
14-Jan-2020 8:00 AM EST
Sepsis Associated with 1 in 5 Deaths Globally, Double Previous Estimate
Health Sciences at the University of Pittsburgh

Twice as many people as previously believed are dying of sepsis worldwide, according to an analysis published today in The Lancet and announced at the Critical Care Reviews annual meeting in Belfast. Among them are a disproportionately high number of children in poor areas.

Newswise: More Interventions Follow Gastric Bypass than Gastric Sleeve, Large Study Shows
13-Jan-2020 12:00 PM EST
More Interventions Follow Gastric Bypass than Gastric Sleeve, Large Study Shows
Health Sciences at the University of Pittsburgh

A study involving tens of thousands of bariatric surgery patients found that gastric bypass patients were significantly more likely than gastric sleeve patients to end up back in the hospital in the years following surgery.

Newswise: UPMC First in the U.S. to Implant Wireless Retinal Device
Released: 13-Jan-2020 3:25 PM EST
UPMC First in the U.S. to Implant Wireless Retinal Device
Health Sciences at the University of Pittsburgh

UPMC is the first center in the U.S. to implant a wireless retinal device to treat advanced age-related macular degeneration.

Newswise: Program Proves Effective in Preventing Dating Violence with Middle School Students
9-Jan-2020 2:40 PM EST
Program Proves Effective in Preventing Dating Violence with Middle School Students
Health Sciences at the University of Pittsburgh

Coaching Boys Into Men, a program that seeks to prevent dating violence and sexual assault, reduces abusive behaviors among middle school male athletes toward their female peers, according to clinical trial results published today in JAMA Pediatrics.

3-Jan-2020 1:40 PM EST
Don’t Wait to Get Concussion Care
Center for Connected Medicine

Early clinical treatment may significantly reduce recovery time following a concussion, according to new research led by the University of Pittsburgh Sports Medicine Concussion Program.

Newswise: Delivering TB Vaccine Intravenously Dramatically Improves Potency, Study Shows
30-Dec-2019 11:20 AM EST
Delivering TB Vaccine Intravenously Dramatically Improves Potency, Study Shows
Health Sciences at the University of Pittsburgh

Worldwide, more people die from tuberculosis than any other infectious disease, even though the vast majority were vaccinated. The vaccine just isn’t that reliable. But a new Nature study finds that simply changing the way the vaccine is administered could dramatically boost its protective power.

Newswise: Progressive Gender Beliefs in Teen Boys May Be Protective Against Violence
Released: 27-Dec-2019 12:15 AM EST
Progressive Gender Beliefs in Teen Boys May Be Protective Against Violence
Health Sciences at the University of Pittsburgh

Teenage boys who witness their peers abusing women and girls are much more likely to bully and fight with others, as well as behave abusively toward their dates, compared to teenage boys who don’t witness such behaviors, according to a new study.

26-Nov-2019 12:05 PM EST
Rural-Urban Flip: How Changing ACA Rules Affected Health Insurance Premium Costs
Health Sciences at the University of Pittsburgh

People in rural areas of the U.S. who receive subsidies to buy health insurance in the Health Insurance Marketplaces pay less in premiums than their counterparts in urban areas, a flip that occurred in 2018 and has been widening since, according to a new analysis.

Newswise:Video Embedded fertility-treatment-not-maternal-age-causes-epigenetic-changes-in-mouse-offspring
VIDEO
25-Nov-2019 12:00 PM EST
Fertility Treatment, Not Maternal Age, Causes Epigenetic Changes in Mouse Offspring
Health Sciences at the University of Pittsburgh

Epigenetic disorders are more common among children born through assisted reproductive technology. A new mouse study suggests that the fertility treatments themselves are to blame, not the age of the mother.

13-Nov-2019 8:00 AM EST
Menopause Isn’t the Only Reason for Low Libido in Older Women
Health Sciences at the University of Pittsburgh

A qualitative study by researchers at the University of Pittsburgh School of Medicine found that women in their 60s report various reasons behind why they lack libido – including sexual dysfunction in their partners.

Released: 14-Nov-2019 1:10 PM EST
Pitt School of Dental Medicine Establishes Opioid-free Prescribing Guidelines
Health Sciences at the University of Pittsburgh

The University of Pittsburgh School of Dental Medicine is the first in the nation to establish opioid-free pain management guidelines for the vast majority of procedures performed in all of its clinics.

Released: 5-Nov-2019 9:00 AM EST
Identical Twin Kidney Transplants Warrant Gene Sequencing, Researchers Say
Center for Connected Medicine

Using U.S. transplant registry data, clinical researchers at the University of Pittsburgh found that kidney transplants between identical twins have high success rates, but also surprisingly high rates of immunosuppressant use.

Newswise: Opioid-Related Gifts from Pharma Companies Linked to Physician Prescribing by Specialty
Released: 30-Oct-2019 9:00 AM EDT
Opioid-Related Gifts from Pharma Companies Linked to Physician Prescribing by Specialty
Center for Connected Medicine

Physicians who received gifts from pharmaceutical companies related to opioid medications were more likely to prescribe opioids to their patients in the following year, according to a new analysis.

Newswise: Bacterial Lifestyle Steers the Evolution of Antibiotic Resistance
Released: 23-Oct-2019 10:00 AM EDT
Bacterial Lifestyle Steers the Evolution of Antibiotic Resistance
Health Sciences at the University of Pittsburgh

How bacteria live – whether as independent cells or in a communal biofilm – determines the course of their evolution, with implications for drug-resistant infections.

7-Oct-2019 10:00 AM EDT
Study Seeks to Guide Maternal Weight Gain in Twin Pregnancies
Center for Connected Medicine

New research led by scientists at the University of Pittsburgh Graduate School of Public Health and published today in the journal Obstetrics & Gynecology is beginning to establish evidence-based guidelines for maternal weight gain while pregnant with twins.

Newswise: Gut Immunity More Developed Before Birth Than Previously Thought
7-Oct-2019 3:00 PM EDT
Gut Immunity More Developed Before Birth Than Previously Thought
Health Sciences at the University of Pittsburgh

The first comprehensive look at the immune system of the fetal gut shows that it is far more developed before birth, and could help develop new maternal vaccines and understand if we are predisposed to autoimmune diseases before birth.

Newswise:Video Embedded blockers-build-heart-muscle-may-help-infants-with-congenital-heart-disease
VIDEO
6-Oct-2019 7:00 PM EDT
β-blockers Build Heart Muscle, May Help Infants with Congenital Heart Disease
Center for Connected Medicine

Surgery can mend congenital heart defects shortly after birth, but those babies will carry a higher risk of heart failure for the rest of their lives. UPMC Children’s Hospital researchers found that β-blockers could supplement surgery to mitigate the lasting effects of congenital heart disease.

4-Oct-2019 9:45 AM EDT
Scientists Sound Alarm on Lack of Market Support for Antibiotics Against Superbugs
Center for Connected Medicine

The health care market is failing to support new antibiotics used to treat some of the world’s most dangerous, drug-resistant “superbugs,” according to a new analysis by University of Pittsburgh School of Medicine infectious disease scientists.

Newswise: Benefits, Challenges to Using Film in Public Health Research
Released: 25-Sep-2019 12:00 AM EDT
Benefits, Challenges to Using Film in Public Health Research
Health Sciences at the University of Pittsburgh

To guide the emerging practice of using video as an integral part of the scientific process, University of Pittsburgh Graduate School of Public Health scientists performed the first review of studies on use of film in public health research.

Newswise: Recent US Pediatric Heart Transplant Waitlist Policy Change Falls Short of Intended Benefits
16-Sep-2019 8:00 AM EDT
Recent US Pediatric Heart Transplant Waitlist Policy Change Falls Short of Intended Benefits
Health Sciences at the University of Pittsburgh

In March 2016, the Organ Procurement and Transplantation Network revised its criteria for prioritizing children awaiting heart transplantation in the U.S. with the intention of reducing the number of deaths on the waitlist, but a new study suggests unintended consequences.

10-Sep-2019 12:00 PM EDT
High Social Support Associated with Less Violence Among Male Teens in Urban Neighborhoods
Health Sciences at the University of Pittsburgh

UPMC Children's Hospital researchers find that the presence of adult social support is linked to less violence among at-risk teen boys.

9-Sep-2019 11:30 AM EDT
Telemedicine Engages Newly Postpartum Women in Cardiovascular Monitoring
Health Sciences at the University of Pittsburgh

America has the highest maternal mortality rate in the developed world. Since cardiovascular disease is the primary cause, researchers have created a blood pressure home-monitoring system to rapidly detect concerning trends in postpartum women before their situation becomes critical.

Newswise: Tweets Indicate Nicotine Dependence, Withdrawal Symptoms of JUUL Users
Released: 9-Sep-2019 10:00 AM EDT
Tweets Indicate Nicotine Dependence, Withdrawal Symptoms of JUUL Users
Health Sciences at the University of Pittsburgh

One out of every five tweets mentioning JUUL indentified for a new analysis also references addiction-related themes.

Newswise:Video Embedded runaway-mitochondria-cause-telomere-damage-in-cells
VIDEO
21-Aug-2019 2:00 PM EDT
Runaway Mitochondria Cause Telomere Damage in Cells
Health Sciences at the University of Pittsburgh

Targeted damage to mitochondria produces a "Chernobyl effect" inside cells, pelting the nucleus with harmful reactive oxygen species and causing chromosomal damage.

Newswise: Medicare Patients with Multiple Sclerosis Bear the Burden of Rising Drug Prices
23-Aug-2019 7:00 PM EDT
Medicare Patients with Multiple Sclerosis Bear the Burden of Rising Drug Prices
Health Sciences at the University of Pittsburgh

In a decade, Medicare recipients saw a sevenfold increase in out of pocket costs for multiple sclerosis drugs. Spending on these drugs by Medicare itself increased by tenfold.

Released: 26-Aug-2019 8:30 AM EDT
Physicians Slow to Use Effective New Antibiotics Against Superbugs
Health Sciences at the University of Pittsburgh

New, more effective antibiotics are being prescribed in only about a quarter of infections by carbapenem-resistant Enterobacteriaceae (CRE), a family of the world’s most intractable drug-resistant bacteria.

19-Aug-2019 8:00 AM EDT
Death Rate of Critically Ill Children Linked to Hospital Preparedness for Pediatric Emergencies
Health Sciences at the University of Pittsburgh

Critically ill children brought to hospital emergency departments that are ill-prepared to care for pediatric emergencies have more than three times the odds of dying compared to those brought to hospitals well-equipped to care for them.

Newswise:Video Embedded texas-cities-increasingly-susceptible-to-large-measles-outbreaks
VIDEO
19-Aug-2019 12:00 PM EDT
Texas Cities Increasingly Susceptible to Large Measles Outbreaks
Health Sciences at the University of Pittsburgh

The growing number of children arriving at Texas schools unvaccinated makes the state increasingly vulnerable to measles outbreaks. A 5% further decrease in vaccination rates that have been on a downward trend since 2003 would increase the size of a potential measles outbreak by up to 4,000%.


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