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Released: 6-Aug-2020 8:55 AM EDT
Algorithm Created By “Deep Learning” Identifies Potential Therapeutic Targets Throughout Genome
Children's Hospital of Philadelphia

A team of researchers have developed an algorithm through machine learning that helps predict sites of DNA methylation – a process that can change the activity of DNA without changing its overall structure – and could identify disease-causing mechanisms that would otherwise be missed by conventional screening methods.

Released: 4-Aug-2020 3:30 PM EDT
Experts from Across the U.S. Issue Back-To-School Safety Guidelines for Pediatric Solid Organ Transplant Recipients
Children's Hospital of Philadelphia

As school districts look ahead to a very different school year, pediatric infectious disease experts from across the United States convened to outline back-to-school safety guidelines for solid organ transplant (SOT) recipients. The group, led by Kevin J. Downes, MD, attending physician in the Division of Pediatric Infectious Diseases at Children’s Hospital of Philadelphia (CHOP), published their recommendations today in the Journal of the Pediatric Infectious Diseases Society.

Released: 3-Aug-2020 11:20 AM EDT
Caregiver-Reported Child Sleep Problems Associated with Impaired Academic and Psychosocial Functioning in Middle Childhood
Children's Hospital of Philadelphia

Whether children have ongoing sleep problems from birth through childhood or do not develop sleep problems until they begin school, a new study by researchers at Children’s Hospital of Philadelphia (CHOP) has found that sleep disturbances at any age are associated with diminished well-being by the time the children are 10 or 11 years old. The findings, which were published in The Journal of Child Psychology and Psychiatry, suggest health care providers should screen children for sleep problems at every age and intervene early when a sleep problem is identified.

Released: 31-Jul-2020 10:20 AM EDT
Youth with Diabetes Who are Involved in the Decision to Start Continuous Glucose Monitoring are More Likely to Continue Using It
Children's Hospital of Philadelphia

In a new study published in Diabetes Care, researchers at Children’s Hospital of Philadelphia (CHOP) have found that youth who are involved with the decision to start CGM are more likely to continue using the monitoring technology more than two months after starting. The findings suggest that children and adolescents who do not have a role in the decision are less likely to be satisfied with the device and use the device consistently.

Released: 30-Jul-2020 3:25 PM EDT
CHOP Researchers Identify Lab Profiles that Differentiate MIS-C from COVID-19 in Children
Children's Hospital of Philadelphia

Researchers from Children’s Hospital of Philadelphia (CHOP) report important data that differentiate MIS-C from severe COVID-19 in children and suggest that MIS-C is a post-infectious syndrome related to COVID-19 but distinct from KD. The findings were published today in The Journal of Clinical Investigation.

Released: 28-Jul-2020 9:40 AM EDT
CHOP Spine Surgeons Outline Framework for Prioritizing Procedures as Elective Surgeries Resume
Children's Hospital of Philadelphia

As hospitals resume elective procedures, including pediatric spine surgeries, surgeons from Children’s Hospital of Philadelphia (CHOP) have outlined a framework for prioritizing pediatric spine surgeries amid the pandemic. The recommendations were published recently in The Journal of Bone and Joint Surgery.

Released: 28-Jul-2020 8:25 AM EDT
Therapy Helps Children with Food Allergies Manage Severe Anxiety
Children's Hospital of Philadelphia

Children’s Hospital of Philadelphia (CHOP) has launched the Food Allergy Bravery (FAB) Clinic to help children with a phobia of anaphylaxis. This revolutionary clinic, housed within the Food Allergy Center, is the first in the world to bring together psychologists and food allergy experts to treat food allergic children with severe phobia of anaphylaxis.

21-Jul-2020 10:55 AM EDT
New Computational Model by CHOP Researchers Identifies Noncoding Mutations Across Five Pediatric Cancers
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a new computational algorithm that has, for the first time, identified a spectrum of mutations in the noncoding portion of the human genome across five major pediatric cancers. The study, which was published today in Science Advances, used the algorithm to analyze more than 500 pediatric cancer patients’ mutations and gene expression profiles to develop a comprehensive list of potentially cancer-causing mutations.

Released: 15-Jul-2020 10:40 AM EDT
States Slow to Implement Stay-at-Home Orders Saw Higher Rates of COVID-19 Deaths
Children's Hospital of Philadelphia

As the COVID-19 pandemic spread across the United States, governments at the state and local levels issued emergency declarations and shut down schools. With no treatment and no vaccine, this was seen as the best way to stop the spread of the SARS-CoV-2 virus. Researchers from Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania’s Perelman School of Medicine have conducted one of the first studies to measure the efficacy of social distancing in the early days of the COVID-19 pandemic. They found that states that were slow to implement such orders saw higher COVID-19 death rates.

Released: 8-Jul-2020 2:55 PM EDT
CHOP-Pioneered Spatial Mapping Method Pinpoints Potential New Therapeutic Targets in Lupus
Children's Hospital of Philadelphia

A team of researchers from Children’s Hospital of Philadelphia (CHOP) used a new method of pinpointing potential disease-causing changes in the genome to identify two new potential therapeutic targets for lupus, while also paving the way for more accurately identifying disease-causing variations in other autoimmune disorders.

Released: 1-Jul-2020 11:00 AM EDT
CHOP’s Center for Applied Genomics Receives Funding to Study Risk of Disease Specifically in African Americans
Children's Hospital of Philadelphia

The National Institutes of Health (NIH) announced today that researchers from Children’s Hospital of Philadelphia (CHOP) are among the recipients of a multi-million dollar grant that focuses on the use of genomics to improve risk assessment for diverse populations and integrate the findings into clinical care.

Released: 22-Jun-2020 9:45 AM EDT
CHOP Study Finds Remote Monitoring Effectively Detects Seizures in At-Risk Newborns
Children's Hospital of Philadelphia

A team of researchers from Children’s Hospital of Philadelphia (CHOP) has demonstrated how to easily and effectively monitor for seizures in newborn infants, catching more instances than typical methods and improving the quality of care for infants in hospitals that lack the on-site resources to detect these seizures.

Released: 15-Jun-2020 9:35 AM EDT
COVID-19 Associated with Dramatic Decline in Use of Emergency Department by Pediatric Asthma Patients
Children's Hospital of Philadelphia

The number of patients visiting the emergency department (ED) for asthma treatment dropped by 76% in the first month of the COVID-19 pandemic, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The proportion of ED visits that led to a patient being hospitalized also decreased over this period, suggesting the decrease in overall visits was not solely due to patients avoiding the hospital due to the pandemic or delays in care for less serious asthma events.

9-Jun-2020 8:05 AM EDT
Telemedicine Proven Effective Means of Monitoring Patients in Large Pediatric Neurology Network
Children's Hospital of Philadelphia

As the COVID-19 pandemic sent entire communities into lockdown, doctors quickly adopted telehealth strategies without knowing whether they would be effective or feasible. Now, a new study from the Division of Neurology at Children’s Hospital of Philadelphia (CHOP) shows that for pediatric neurology care, the transition was very successful even in a short period of time and may provide guidance on the future of pediatric care after the pandemic subsides.

Released: 8-Jun-2020 4:45 PM EDT
Scientists Identify Targets for COVID-19 Vaccine Using Cancer Immunotherapy Tools
Children's Hospital of Philadelphia

Cancer researchers at Children’s Hospital of Philadelphia (CHOP) have harnessed tools used for the development of cancer immunotherapies and adapted them to identify regions of the SARS-CoV-2 virus to target with a vaccine, employing the same approach used to elicit an immune response against cancer cells to stimulate an immune response against the virus. Using this strategy, the researchers believe a resulting vaccine would provide protection across the human population and drive a long-term immune response.

Released: 4-Jun-2020 2:10 PM EDT
Universal Preoperative COVID-19 Screening Improves Safety by Identifying Otherwise Asymptomatic Pediatric Surgical Patients
Children's Hospital of Philadelphia

Universally screening pediatric patients for COVID-19 before they undergo surgical procedures has allowed hospitals to improve safety by identifying all patients who test positive for the virus, half of whom have no symptoms, according to new research led by Children’s Hospital of Philadelphia (CHOP). The study, which analyzed universal screening procedures at CHOP and two other major children’s hospitals, found that screening patients for COVID-19 allowed hospitals to ensure patients and physicians were not exposed to the virus.

Newswise: Study Shows Vision and Balance Issues are Common in Elementary School-age Children with a Concussion
2-Jun-2020 12:15 PM EDT
Study Shows Vision and Balance Issues are Common in Elementary School-age Children with a Concussion
Children's Hospital of Philadelphia

In a new study, researchers at Children’s Hospital of Philadelphia (CHOP) have performed the most comprehensive characterization of elementary school-age concussions to date, revealing an opportunity to improve outcomes for this age group through more consistent visio-vestibular assessments at the initial health care visit.

Released: 28-May-2020 11:05 AM EDT
Study Shows Uptick in At-Home Pediatric Fractures During COVID-19 Pandemic
Children's Hospital of Philadelphia

COVID-19 social distancing measures, including the closure of schools and parks and the indefinite cancellation of team sports, have led to a nearly 60% decrease overall in pediatric fractures but an increase in the proportion of fractures sustained at home, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The findings, published in the Journal of Pediatric Orthopaedics, suggest a need for increased awareness of at-home safety measures.

18-May-2020 4:25 PM EDT
Study Finds Parent-Led Discussion about Mutual Strengths Benefits Parent-Teen Communication
Children's Hospital of Philadelphia

A primary care-based intervention to promote parent-teen communication led to less distress and increased positive emotions among adolescents, as well as improved communication for many teens, according to a new study by researchers at the Center for Parent and Teen Communication at Children’s Hospital of Philadelphia (CHOP). The findings, which were published today in The Journal of Pediatrics, highlight the potential impact of engaging parents in the primary care setting to improve parent-teen communication, which could lead to better adolescent health outcomes.

Released: 1-May-2020 11:05 AM EDT
Children in Rural Communities at Risk for Poor Lawnmower Injury Outcomes
Children's Hospital of Philadelphia

Children in rural communities are 1.7 times more likely to undergo an amputation after a lawnmower injury than children in urban communities, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The researchers also found that although lawnmower injuries are prevalent throughout the United States, children in Southern and Midwestern states account for more than 80% of pediatric lawnmower injuries.

Released: 28-Apr-2020 4:25 PM EDT
Cardioprotective Drug Prevents Severe Cardiac Events in Children Undergoing Chemotherapy for Acute Myeloid Leukemia
Children's Hospital of Philadelphia

The cardioprotective drug dexrazoxane preserved cardiac function in pediatric patients undergoing chemotherapy for acute myeloid leukemia (AML) without compromising overall patient survival and potentially improving it, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The results suggest dexrazoxane should be considered for cardioprotection in all pediatric patients undergoing standard chemotherapy for AML.

17-Apr-2020 4:55 PM EDT
Pulse Oximetry Monitoring Overused in Infants with Bronchiolitis
Children's Hospital of Philadelphia

Monitoring blood oxygen levels with continuous pulse oximetry is being overused in infants with bronchiolitis who do not require supplemental oxygen, according to a study by researchers at Children’s Hospital of Philadelphia (CHOP). The researchers found the use of continuous pulse oximetry occurred frequently and varied widely among hospitals in their sample, despite national recommendations advising against the practice.

Released: 16-Apr-2020 11:40 AM EDT
Researchers Get Important Glimpse Into Microbiome Development in Early Life
Children's Hospital of Philadelphia

A team of researchers at Children’s Hospital of Philadelphia (CHOP) has characterized how the gut microbiome develops in the first hours of infancy, providing a critical baseline for how changes in this environment can impact health and disease later in life.

Released: 9-Apr-2020 2:20 PM EDT
Researchers Reveal Important Genetic Mechanism Behind Inflammatory Bowel Disease
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic pathway associated with this variation is involved in other immune disorders, suggesting the mechanism they identified could serve as an important therapeutic target.

Released: 8-Apr-2020 3:15 PM EDT
New Tool Improves Ability to Gather Useful Genetic Information Obtained from Blood and Skin Tissues
Children's Hospital of Philadelphia

Hoping to refine the usefulness of RNA sequencing, a team of researchers reviewed a database of RNA sequencing results in non-clinically-accessible tissues from organs like the brain and heart. This helped them identify differences between tissues that were well expressed to help identify when clinically-accessible tissues like blood and skin samples are most useful and when they are not.

Released: 23-Mar-2020 2:05 PM EDT
CHOP Researchers Develop Method for Measuring Quality of Life Across Lifespan for Individuals on Autism Spectrum
Children's Hospital of Philadelphia

A new study led by researchers at Children’s Hospital of Philadelphia (CHOP) shows that a set of simple questionnaires can help clinicians and families better evaluate the quality of life of people diagnosed with autism spectrum disorder (ASD). The newly-developed tool is designed for children, adolescents, and adults on the autism spectrum, and early findings show where clinicians can learn more about how to support the needs of autistic individuals by directly asking them these critical questions.

16-Mar-2020 2:35 PM EDT
Most Mass Shootings Occur Closest to Hospitals without Verification to Treat Trauma
Children's Hospital of Philadelphia

In an analysis of 2019 mass shootings and hospital locations, researchers at Children’s Hospital of Philadelphia (CHOP) found that the closest hospital to more than 70% of mass shootings was a non-trauma center, where sudden, high casualty loads were more likely to overwhelm capacity and trauma-specific care options may have been limited. They also found that in more than half of mass shooting events, the nearest pediatric trauma center was more than 10 miles away.

Released: 10-Mar-2020 9:00 AM EDT
CHOP Study Demonstrates How to Collect True Impact Incidents from Head Impact Sensors in Youth Sports
Children's Hospital of Philadelphia

An increased awareness of concussion risks in young athletes has prompted researchers to use a variety of head impact sensors to measure frequency and severity of impacts during sports. A new study from Children’s Hospital of Philadelphia (CHOP) shows these head sensors can record a large number of false positive impacts during real game play. The CHOP team’s study emphasizes that an extra step to video-confirm the sensor data is essential for research and for use of this data in injury prevention strategies for player safety.

Newswise: Novel Sepsis Treatment Enhances Bacterial Capture by Neutrophil “Traps”
Released: 5-Mar-2020 9:35 AM EST
Novel Sepsis Treatment Enhances Bacterial Capture by Neutrophil “Traps”
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a novel treatment for sepsis – one of the leading causes of hospital death – that enhances the body’s bacteria-capturing neutrophil extracellular traps (NETs) so that they more effectively capture infectious bacteria, resist degradation, and improve sepsis outcomes and survival.

Released: 5-Mar-2020 9:10 AM EST
Children with Food Protein-Induced Enterocolitis More Likely to Have Other Allergies
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) have found that children with a rare food allergy known as food protein-induced enterocolitis syndrome, or FPIES, have a significantly higher chance of being diagnosed with other allergic conditions, including eczema, traditional food allergy and asthma. But the researchers also found that FPIES did not directly cause those other allergies.

Released: 27-Feb-2020 1:40 PM EST
New Algorithm Tracks Pediatric Sepsis Epidemiology Using Clinical Data
Children's Hospital of Philadelphia

Researchers at Children’s Hospital of Philadelphia (CHOP) have developed a novel computational algorithm to track the epidemiology of pediatric sepsis, allowing for the collection of more accurate data about outcomes and incidence of the condition over time, which is essential to the improvement of care.

Newswise: CHOP Researchers Develop Novel Approach to Capture Hard-to-View Portion of Colon in 3-D for the First Time
24-Feb-2020 4:50 PM EST
CHOP Researchers Develop Novel Approach to Capture Hard-to-View Portion of Colon in 3-D for the First Time
Children's Hospital of Philadelphia

In a groundbreaking discovery, researchers at Children’s Hospital of Philadelphia (CHOP) developed a new imaging method that allows scientists to view the enteric nervous system (ENS) – a key part of the human colon – in three dimensions by making other colon cells that normally block it invisible. The ENS has previously only been visible in thin tissue slices that provide limited clinical information.

Newswise: Roberts Individualized Medical Genetics Center Outlines Framework for Centralized Approach to Genetic and Genomic Testing
20-Feb-2020 4:30 PM EST
Roberts Individualized Medical Genetics Center Outlines Framework for Centralized Approach to Genetic and Genomic Testing
Children's Hospital of Philadelphia

In a special report published today in the journal Pediatrics, Roberts Individualized Medical Genetics Center researchers, physicians, and genetic and financial counselors describe the success of the model, their plans to build on that success for the future, and the important lessons learned from their first four years in operation.

Newswise: New Computational Tools Identify Alternative Splicing Changes in Aggressive Cancers
12-Feb-2020 10:15 AM EST
New Computational Tools Identify Alternative Splicing Changes in Aggressive Cancers
Children's Hospital of Philadelphia

A multi-institutional group of researchers led by Children’s Hospital of Philadelphia (CHOP) has linked a strong cancer driver gene to changes in proteins that regulate alternative splicing. The researchers created new computational tools and biological model systems for the study. This collaborative research, led by Yi Xing, PhD, at CHOP and Owen Witte, MD, at the University of California, Los Angeles (UCLA), was published today in the Proceedings of the National Academy of Sciences.

Released: 11-Feb-2020 9:00 AM EST
Teens with a History of ADHD Need Stronger Monitoring of Health Risks
Children's Hospital of Philadelphia

Adolescents with a history of attention-deficit/hyperactivity disorder (ADHD) are at an increased risk for a multitude of adverse outcomes, including sexually-transmitted infections (STIs), mental health conditions, and car accidents. Researchers from Children’s Hospital of Philadelphia (CHOP) wanted to better understand how primary care doctors addressed these risks with patients as they transitioned from childhood to young adulthood. They found that although doctors generally discuss depression, substance abuse, and suicide risk with patients who have a history of ADHD, they rarely discuss safe driving with them and most of the time they do not monitor patients for risky sexual behavior.

Released: 5-Feb-2020 1:25 PM EST
Seed Funds Awarded to Four Proposals to Develop Medical Devices for Children
Children's Hospital of Philadelphia

The Pennsylvania Pediatric Medical Device Consortium (PPDC) has announced its latest round of seed grants to companies developing medical devices for children. The Consortium chose four projects from eight finalists in a competition to receive seed grants of $50,000 each.

Released: 5-Feb-2020 12:10 PM EST
Family and Environmental Risk Factors are Linked to Poor Sleep in Young Children
Children's Hospital of Philadelphia

Poor sleep habits and sleep disorders are very common in early childhood, especially in children exposed to multiple family and environmental risks like parental depression and poverty, say researchers from Children’s Hospital of Philadelphia (CHOP) in a study recently published in the journal Sleep.

22-Jan-2020 5:00 PM EST
Benefits of Fetal Surgery for Spina Bifida Persist in School-Age Children
Children's Hospital of Philadelphia

In a follow-up to the landmark 2011 study that demonstrated prenatal surgery for spina bifida has measurable benefits over surgery after birth for one of the most disabling neural tube defects, researchers have published new findings. These findings show significant physical and emotional benefits a decade later in school-age children who received corrective surgery in the womb for myelomeningocele, the most severe form of spina bifida.

Released: 14-Jan-2020 1:45 PM EST
Reduced Inhaler Use is Safe for Infants with Bronchiolitis
Children's Hospital of Philadelphia

Bronchiolitis, a lung infection that is one of the most common reasons for hospitalizations in young children, is most prevalent during the winter months and is usually treated with albuterol delivered via inhalers, despite evidence showing no benefit in most patients. A multidisciplinary team of researchers from Children’s Hospital of Philadelphia (CHOP) redesigned the hospital’s standard treatment for the infection and reduced albuterol use without compromising care.

Released: 14-Jan-2020 9:00 AM EST
Large Study of Subtle, Rare Genetic Differences Reveals Several New Clinically Relevant Targets for Variety of Diseases
Children's Hospital of Philadelphia

A large, multicenter study led by researchers at Children’s Hospital of Philadelphia (CHOP) compared the genomic data of more than 100,000 people of European ancestry and discovered how relatively rare, albeit recurrent, genetic variations can influence a variety of common diseases. In addition, existing drugs could be repurposed to target these conditions – ranging from autoimmune diseases to neuropsychological diseases and even cancer – now that the genetic underpinnings of these conditions are known.

Released: 7-Jan-2020 4:30 PM EST
Genetic Differences Help Distinguish Type 1 Diabetes in Children from “Type 1.5” Diabetes in Adults
Children's Hospital of Philadelphia

A multi-center team of researchers led by Children’s Hospital of Philadelphia (CHOP) has discovered a genetic signature that could help distinguish an adult-onset form of diabetes sharing many type 1 diabetes (T1D) characteristics from pediatric-onset T1D, opening the door to potentially more straightforward diagnostic tests for the adult condition and improving responses by ensuring patients receive the most appropriate treatment.

Released: 4-Dec-2019 4:05 PM EST
Scientists Detail how Chromosomes Reorganize after Cell Division
Children's Hospital of Philadelphia

Researchers have discovered key mechanisms and structural details of a fundamental biological process—how a cell nucleus and its chromosomal material reorganizes itself after cell division. The new findings in chromosomal architecture and function may offer important insights into human health and disease.

Newswise: Teens with Heart Disease Improve Exercise Capacity in Large Clinical Trial
Released: 17-Nov-2019 10:45 AM EST
Teens with Heart Disease Improve Exercise Capacity in Large Clinical Trial
Children's Hospital of Philadelphia

The largest-ever clinical trial of a medication for pediatric cardiology patients found that an oral drug significantly improved exercise capacity in adolescent patients with severe, congenital single-ventricle heart defects. A study leader says the physiologic benefits represent a milestone in pediatric cardiology.

12-Nov-2019 2:30 PM EST
Revised Criteria Lead to More Accurate Screening for Eye Disease in Premature Infants
Children's Hospital of Philadelphia

A multicenter group of 41 hospitals led by researchers at Children’s Hospital of Philadelphia (CHOP) has confirmed that an improved method for predicting retinopathy of prematurity (ROP), a leading cause of blindness in children, was able to reduce the number of babies having invasive diagnostic examinations by nearly a third, while raising disease detection up to 100 percent.

Newswise: Early Spinal Patterns May Predict Scoliosis in Teen Years
Released: 13-Nov-2019 3:30 PM EST
Early Spinal Patterns May Predict Scoliosis in Teen Years
Children's Hospital of Philadelphia

A pediatric researcher has identified patterns of spinal curvature in younger children that may be likely to develop into scoliosis by adolescence. Accurately predicting scoliosis, a common, abnormal curvature of the spine, may set the stage for the first-ever methods to prevent the potentially disabling condition.

Newswise: Stephan Grupp, MD, PhD, Elected to the National Academy of Medicine
Released: 21-Oct-2019 3:45 PM EDT
Stephan Grupp, MD, PhD, Elected to the National Academy of Medicine
Children's Hospital of Philadelphia

Stephan Grupp, MD, PhD, Chief of the Cell Therapy and Transplant Section in the Division of Oncology and Director of the Cancer Immunotherapy Program at Children’s Hospital of Philadelphia, has been elected into the National Academy of Medicine (NAM), effective Oct. 1, 2019.

Newswise: Children's Hospital of Philadelphia Offers Help and Cure for Picky Eaters
Released: 21-Oct-2019 2:30 PM EDT
Children's Hospital of Philadelphia Offers Help and Cure for Picky Eaters
Children's Hospital of Philadelphia

Families dealing with the stress and frustration of their child’s overly picky eating habits may have a new addition to their parental toolbox. Pediatric researchers describe a brief group cognitive-behavioral therapy program that provides parents with specific techniques to improve their child’s mealtime behaviors and expand the range of foods their children will eat.

Newswise: Beverly Davidson, PhD, Elected to the National Academy of Medicine
Released: 21-Oct-2019 12:05 PM EDT
Beverly Davidson, PhD, Elected to the National Academy of Medicine
Children's Hospital of Philadelphia

Beverly L. Davidson, PhD, director of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics at Children’s Hospital of Philadelphia, has been elected to the National Academy of Medicine. She is being recognized for her role in developing innovative therapies for fatal, inherited brain disorders.

Newswise: Subtle Mitochondrial DNA Mutations Alter Expression of Nuclear Genes, with Profound Clinical Effects
Released: 15-Oct-2019 4:40 PM EDT
Subtle Mitochondrial DNA Mutations Alter Expression of Nuclear Genes, with Profound Clinical Effects
Children's Hospital of Philadelphia

Subtle changes in the DNA of mitochondria, the tiny power plants in cells, can have profound consequences for a patient’s health. Research on biological mechanisms suggests that relatively minor changes in mitochondrial energy flow and metabolism could offer significant future benefits to patients with complex diseases.


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