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Released: 16-Apr-2018 8:45 AM EDT
Researchers Propose New Definition of Alzheimer’s Disease

Researchers announce new definition of Alzheimer’s disease.

Released: 18-Dec-2017 8:00 AM EST
Alzheimer’s Clinical Trials Get A Prevention Makeover

From trial-ready registries to genotyping parties, the field has developed new techniques and meds to stem a tide of failed trials. Alzforum’s 13-part series sums up the state of the art as presented at a recent conference.

Released: 11-Dec-2017 8:00 AM EST
Clinical Trials on Alzheimer’s Disease: Shifting the Focus to Prevention

This past decade, Alzheimer’s science has undergone a paradigm shift toward the disease’s early, silent phase. For trials, this means change at every level: new participants, new screening tools, new outcome measurements. What’s the progress?

Released: 12-Jul-2017 8:05 AM EDT
Direct-To-Consumer Genetic Testing Can Be a Trip Down the Rabbit Hole

Anyone can learn whether they carry mutations known to cause Alzheimer’s, frontotemporal dementia, and other fatal neurodegenerative diseases.

Released: 19-Jun-2017 11:05 AM EDT
A Single Microglial Protein Controls Suite of Alzheimer’s Risk Genes

The discovery hints that microglia, rather than neurons, may control much of a person’s genetic susceptibility to Alzheimer’s disease.

Released: 15-Jun-2017 2:05 PM EDT
More Support for Amyloid Hypothesis in Alzheimer's: Protective APP Mutation Lowers Aβ in Blood

A new study shows that people with a protective Aβ mutation have less of the peptide in their blood all through their lives, likely explaining why they do not get Alzheimer's. It suggests ways to prevent the disease in the vast majority of people who don’t have the mutation.

Released: 5-Jun-2017 8:05 AM EDT
Robert Terry, Co-Founder of U.S. Alzheimer’s Research Dies at 93

A founder of U.S. Alzheimer’s research, Robert D. Terry, has died at 93. He first showed what plaques and tangles look like in the electron microscope, and linked failing cognition to withering synapses in the brain.

Released: 1-Jun-2017 1:05 PM EDT
Gel-Like Drops of Protein and RNA Make a Splash in Neurodegenerative Diseases

At a meeting in Leuven, Belgium, a coherent picture began to emerge for how fluid pockets of proteins and RNAs contribute to health and disease.

Released: 11-Sep-2016 6:05 PM EDT
How Do You Tell a Cognitively Normal Person They Will Likely Get Alzheimer’s in the Next Few Years?

As researchers seek cognitively normal people on the way to Alzheimer’s to fill clinical prevention trials, they face the delicate task of disclosing a highly elevated, but not certain, risk of developing the disease to thousands of people. Scientists look to cancer research for cues as they recruit for the first of such trials.

Released: 18-Aug-2016 12:05 PM EDT
Eight Years Old and Growing Fast: DIAN Is Becoming an Alzheimer’s Movement

The Dominantly Inherited Alzheimer’s Network is churning out serial data on how Alzheimer’s disease develops in a given person over many years, and at the same time transforming how therapeutic trials are being done on this disease.

Released: 18-Aug-2016 12:05 PM EDT
New Insights into Microglia Help Researchers Understand Neurodegenerative Disease

Alzforum reports some of the major highlights from the recent Keystone symposium on the role of microglia in neurodegenerative disease.

Released: 15-Aug-2016 9:05 AM EDT
Coming to a Center Near You: GAP and EPAD to Revamp Alzheimer’s Trials

In the past year, the Global Alzheimer’s Platform and the European Prevention of Alzheimer’s Dementia have moved quickly, and jointly, to pave the way toward more, faster, cheaper trials. Will they be better, too?

Released: 11-Jul-2016 12:05 PM EDT
Brexit Could Threaten Neurodegenerative Disease Research in Europe

Neurodegenerative disease researchers in the U.K. fear the Brexit will curtail their access to EU funds and complicate international collaborations. Analysts agree that a U.K. exit is likely to harm big science across the continent.

Released: 23-May-2016 5:05 PM EDT
Fresh Insights Into Sleep, Brain Cleansing, and Memory

Researchers are making progress in understanding exactly how sleep helps the brain lay down memories and remove waste products. The findings may have implications for diseases in which sleep and memory are impaired. Alzforum reports.

Released: 26-Apr-2016 1:05 PM EDT
Drug Trials in Frontotemporal Dementia: Can Industry, Academia, Families and Regulators Get on One Page?

In Washington, D.C., stakeholders in frontotemporal dementia came together to apply lessons learned from setbacks of Alzheimer’s drug development to the emerging field of therapy evaluation in FTD.

Released: 21-Apr-2016 1:05 PM EDT
NIH Summit Sets Priorities for Research on the Non-Alzheimer’s Dementias

Last month, scientists gathered to powwow about where we are with FTD, DLB, and cerebrovascular disorders and how best to target research dollars to them. Researchers articulated funding priorities for each of these diseases, which will inform the next bypass budget, and, hopefully, the next funding allocation.

Released: 18-Feb-2016 4:05 PM EST
Coming MOOC Opens Learning on Lesser-Known Dementia Variants to All

A free, open online course on rare forms of dementia aims to spread knowledge while harnessing social learning.

Released: 15-Feb-2016 11:05 AM EST
Cancer Drug Benefit for Alzheimer’s Disease Looks Questionable

Studies report no reduction in the amyloid-β peptide or the plaques it forms. Hints of efficacy came from four people free of the ApoE4 risk gene for AD, and one patient who was on it for nearly two years. Meanwhile, scientists uncovered a new mechanism of action for bexarotene. Researchers wonder what’s going on.

Released: 9-Feb-2016 11:05 AM EST
ROCK’N the Tau? Vasospasm Drug Shows Promise in Models of Dementia

Inhibiting the Rho kinases ROCK1 and ROCK2 with fasudil, a drug approved in China and Japan, stimulates tau autophagy in cell culture and flies.

Released: 1-Feb-2016 10:05 AM EST
Will Death in French Drug Trial Lead to Tighter Phase 1 Rules?

While regulators are trying to figure out what went wrong, independent chemists have dug into the mechanism of what may have been a "dirty" drug.

Released: 22-Jan-2016 11:05 AM EST
Howard Feldman to Breathe New Life Into Alzheimer’s Network

The University of California San Diego’s incoming Alzheimer’s research czar talked with Alzforum about where he wants to take the embattled Alzheimer’s Disease Cooperative Study and neurodegeneration research in the region.

Released: 15-Jan-2016 4:05 PM EST
ALS Meeting Upbeat on New Treatment Ideas and Experiments

While no cure is in sight, ALS experts see reason to feel hopeful about research progress and possible new treatments.

Released: 22-Dec-2015 3:05 PM EST
Dementia with Lewy Bodies: Is the Research Ready for Clinical Trials

The most complicated of the age-relating dementing diseases just got a little clearer. Marked by degeneration of both the mind and the body, dementia with Lewy bodies combines aspects of both Alzheimer’s and Parkinson’s. DLB has for years languished in the shadows of its eponymous cousins when it came to recognition and research funding, but a recent, once-in-a-decade international conference showcased progress in better defining what DLB is and setting the stage for therapy trials.

Released: 7-Dec-2015 10:05 AM EST
New Mice Help Scientists Understand ALS and Frontotemporal Dementia

Scientists have made several kinds of mice in the hope of mimicking ALS and frontotemporal dementia, diseases caused by mutations in the C9ORF72 gene. Early results indicate that the mutated genes generate unusual RNAs and proteins, but that losing the normal C9ORF72 gene does not kill neurons.

Released: 11-Sep-2015 2:05 PM EDT
How Do You Communicate Alzheimer’s Risk in the Age of Prevention?

Researchers conducting clinical trials of drugs that might prevent AD are exploring how best to inform participants of their increased risk for the disease, and studying how they cope with this information. Alzforum reports in a two-part series.

Released: 6-Aug-2015 4:05 PM EDT
100 DIAN Family Members Gather for Their First International Meeting

A sense of shared purpose energized a day of exchange between families with autosomal-dominant AD and researchers engaged in the Dominantly Inherited Alzheimer Network.

Released: 17-Apr-2015 11:05 AM EDT
$100M IDEAS: CMS Blesses Study to Evaluate Amyloid Scans in Clinical Practice

The Centers for Medicare & Medicaid Services has given the nod to an 18,500-patient study to see whether amyloid scans prove their worth in the clinic. Researchers hope the study will eventually convince CMS and private insurance companies to cover the technology.

Released: 19-Mar-2015 11:00 AM EDT
Neuroinflammation Emerges as a Key Player in Neurodegenerative Disease at Keystone Meeting

At the Keystone symposium “Neuroinflammation in Diseases of the Central Nervous System,” researchers bridged the gap between inflammation and neurobiology to uncover how the two influence neurodegenerative disease. Read Alzforum’s seven-part series for the highlights.

Released: 19-Feb-2015 4:00 PM EST
More Needed Than Ever, Brain Banks Are Modernizing But Face Funding Crunch

Brain banks enable crucial advances in neurodegenerative disease research, but dwindling public support around the world now threatens to cripple these institutions. Alzforum reports on the challenges and achievements of brain banks in a three-part series.

Released: 18-Feb-2015 5:30 PM EST
Comprehensive Series Explores Tau PET in Alzheimer’s and Frontotemporal Dementia Research

Scientists are developing PET tracers to detect neurofibrillary tangles in the brain, one of the hallmarks of Alzheimer's disease. Alzforum reviews the state of the research.

Released: 17-Sep-2014 10:00 AM EDT
Neuroscientists Get Busy in the CRISPR Kitchen—What Will They Cook Up?

Molecular biologists are wielding a hot new gene editing tool called CRISPR to mutate, slice, and hopefully repair virtually any spot in the genome of any animal. Neuroscientists are finally taking advantage of the new technique, with an eye toward potential therapies for genetic diseases.

Released: 7-Jul-2014 8:00 AM EDT
Preimplantation Genetic Diagnosis Can Stop Inherited Disease in a Family

Many families with a history of Alzheimer’s or related diseases remain unaware they can use preimplantation genetic diagnosis to avoid passing on disease genes to their children. In a two-part series, Alzforum covers the pros and cons of PGD.

Released: 17-Jun-2014 11:25 AM EDT
Brain Training—Plain Gaming, or a New Vein for Preclinical Research?

While scientists debate whether computer games benefit cognition, some are finding new uses for gaming data—in clinical trial research. In a two-part series, Alzforum reports on the data behind the games.

Released: 30-Apr-2014 11:00 AM EDT
Joint Conference Explores the Frontiers of Alzheimer’s and Parkinson’s Research

Catch up on the latest in Alzheimer’s and Parkinson’s. Alzforum series delivers the highlights of new findings presented at a joint Keystone meeting.

Released: 6-Mar-2013 3:00 PM EST
Conference Explores Frontiers in Alzheimer’s, Lou Gehrig’s Diseases

At the Keystone Symposium “New Frontiers in Neurodegenerative Disease Research,” held 4-7 February in Santa Fe, New Mexico, researchers explored the processes that lead to a variety of diseases, including Alzheimer’s and Lou Gehrig’s disease (amyotrophic lateral sclerosis, ALS). Several presenters described damage that genes undergo as people age, pointing to DNA breaks as a potential step on the way to disease. Others discussed a new component of the protein tangles that characterize Alzheimer's disease. Researchers also reported progress in understanding how two proteins, TDP-43 and FUS, cause ALS. See Alzforum’s four-part series

Released: 14-Feb-2013 12:00 PM EST
Combination Drug Trials: Time to Open a New Front in AD?

Scientists are getting serious about tackling Alzheimer's disease with multiple drugs. Going after one target at a time has not proven successful, and some researchers believe that new drugs may not work well alone. Instead, they want to develop combination therapies. It worked for AIDS and cancer—why not Alzheimer’s?

Released: 7-Feb-2013 10:30 AM EST
Meeting Probes Latest in Alzheimer’s Disease Imaging Research

At the 7th Human Amyloid Imaging conference held in Miami, Florida, 250 experts discussed the hottest topics in Alzheimer’s brain imaging. What’s in store for 2013? Read about new compounds that image tau—one of the disease’s toxic proteins, ground rules for scanning patients for plaques, and a plan to unify scan measures.

Released: 16-Jan-2013 6:00 PM EST
Exploring Deep Brain Stimulation for Parkinson's, Alzheimer's Diseases

Electrodes implanted inside the brain are helping patients with Parkinson's disease. Called deep brain stimulation, the treatment often gives patients control over their movements that cannot be achieved with currently approved drugs. But the surgery is delicate and the treatment does not work for everyone. Alzforum explores the procedure and its potential use for Alzheimer's disease.

Released: 3-Jan-2013 1:45 PM EST
A New Year’s Recap: The Twelve Trends of Alzheimer’s

Planning to cover dementia research this year? Before the 12 Days of Christmas are over, bone up on the most compelling research trends of 2012 by reading Alzforum’s roundup. It covers everything from surprising gene discoveries to drug trial results and points out some of the big stories to watch for in 2013.

Released: 30-Nov-2012 10:35 AM EST
Repeated Knocks to the Head Leads to Newly Recognized Brain Disease

Take a look inside the brains of many soldiers, football players, and boxers, and you’ll find shrinking structures and massive, spreading pathology. Scientists now realize the pattern looks different from any known neurodegenerative disease. A fledgling scientific field has sprung up around these findings and is hurrying to identify, study, and prevent this newly described disease. Special coverage from Alzforum, a respected news source on Alzheimer’s and related diseases, details their latest efforts.

Released: 20-Nov-2012 1:55 PM EST
Alzheimer’s Drug Trials: Scientists Learn From The Old, Bring On The New

Potential Alzheimer’s disease drugs have performed poorly in clinical trials with no sign of any new approvals on the horizon. Have scientists reached a therapeutic dead end? Not according to the 5th Clinical Trials in Alzheimer’s Disease conference, held 29-31 October in Monaco. Researchers revealed benefit from new data, suggesting some of those therapies may still prove useful. To read about the latest trial trends, check out the seven-part series from the Alzheimer Research Forum Alzforum, a well-respected news source on Alzheimer’s and related diseases.

Released: 16-Oct-2012 6:00 PM EDT
Alzheimer's Disease Prevention Trials Just Made a Leap Forward

Two pharma companies have agreed to donate three investigational drugs to test in people who are destined by genetics to develop early-onset Alzheimer's disease.

Released: 5-Oct-2012 1:00 PM EDT
Tau Drug Heads into Phase 3 Trials in Frontotemporal Dementia, Alzheimer’s

A small company with roots in Singapore and Scotland plans to test a relatively unknown compound in clinical trials for a type of dementia that strongly affects behavior.

Released: 5-Oct-2012 1:00 PM EDT
Large European Initiative Tackles Dementia Prevention

Against a backdrop of failed clinical trials and looming epidemic, people are wondering if anything can be done to stop or slow down Alzheimer’s disease. A large European initiative has begun to test if lifestyle interventions can prevent dementia.

Released: 5-Oct-2012 1:00 PM EDT
Industry Group Lobbies for Insurance Coverage for Amyloid Tracers

The FDA recently approved a positron emission tomography tracer for imaging amyloid plaques in the brain. But who will pay for these expensive scans, and who will they benefit? The lobbying has begun...

Released: 5-Oct-2012 1:00 PM EDT
Mice With Lou Gehrig’s Disease Not Quite What the Doctors Ordered

You’ve heard the tale before: Scientists can treat diseases like Alzheimer’s and Lou Gehrig’s in mice, but when those same drugs get to human trials, they fail. Can researchers come up with mice that better mimic the patient? In the case of Lou Gehrig’s, some of the latest mice have a problem: they die not because of their spinal nerve disease, but due to blockage of their gut, reports Alzforum, the leading news source on Alzheimer’s and related disease research.

Released: 29-Feb-2012 3:30 PM EST
Scanning for Plaques: A New Frontier in Alzheimer’s Disease

New compounds that visualize Alzheimer's-related plaques on brain scans of living people may soon be available to doctors. Clinician researchers are grappling with whether to scan healthy people, how to reliably read scans, and how to reveal plaque status. A nine-part series by the Alzforum reports the field’s latest progress in tackling these issues.

Released: 3-Feb-2012 2:00 PM EST
Alzheimer's Disease: Tau Spreads in the Brain, Not Between People

Tau, the protein that tangles together in Alzheimer's, spreads from cell to cell in the mouse brain, perhaps explaining disease progression in humans, suggests a new study. "Alzheimer's disease seems to spread like an infection from brain cell to brain cell...." says The New York Times, but experts assure Alzforum that the disease is not contagious.

Released: 16-Dec-2011 3:30 PM EST
Has the Time Come for Dementia Screening in Primary Care?

Having primary care doctors routinely screen patients for dementia at annual check up visits—just like they do for high blood pressure or cholesterol—could identify people in need of dementia care and reassure those who are healthy. That’s what dementia experts argued at a meeting held last month, as reported on Alzforum (

Released: 7-Dec-2011 1:00 PM EST
On Alzforum, Researchers Debate How to Conduct Alzheimer’s Trials

Candidate drugs for Alzheimer’s disease have so far been tested in patients who have dementia; by that time, the disease may be too far along to do much about it. In a recent opinion piece, scientists laid out the case for testing drugs at an earlier stage, in patients who have yet to show clinical symptoms. The proposal has sparked ongoing debate on Alzforum.

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