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31-Oct-2016 11:00 AM EDT
1-in-4 Older Adults Has Not Discussed Advance Care Planning
University of California, San Francisco (UCSF)

More than one in four older adults have not engaged in planning for end-of-life care or directives, despite significant public efforts to encourage the practice. This is especially true for African Americans, Latinos and those with less education and income, according to a study by researchers at UC San Francisco.

20-Oct-2016 2:05 AM EDT
Researchers Use CRISPR to Accelerate Search for HIV Cure
University of California, San Francisco (UCSF)

Researchers at UC San Francisco and the academically affiliated Gladstone Institutes have used a newly developed gene-editing system to find gene mutations that make human immune cells resistant to HIV infection.

20-Oct-2016 2:00 AM EDT
Electronic Records Help Link Genes to Age-Related Hearing Loss
University of California, San Francisco (UCSF)

A study of patient electronic medical records and genome sequences from adults with age-related hearing impairment by researchers at UC San Francisco and Kaiser Permanente Northern California, identified two genetic variations linked to the hearing disorder.

17-Oct-2016 3:50 PM EDT
Gene Links Risk of Psychiatric Disease to Reduced Synapse Numbers
University of California, San Francisco (UCSF)

New research led by UC San Francisco scientists has revealed that mutations in a gene linked with brain development may dispose people to multiple forms of psychiatric disease by changing the way brain cells communicate.

5-Oct-2016 5:30 PM EDT
Human Neurons Continue to Migrate After Birth, Research Finds
University of California, San Francisco (UCSF)

Researchers at UC San Francisco have discovered a previously unknown mass migration of inhibitory neurons into the brain’s frontal cortex during the first few months after birth, revealing a stage of brain development that had previously gone unrecognized. The authors hypothesize that this late-stage migration may play a role in establishing fundamentally human cognitive abilities and that its disruption could underlie a number of neurodevelopmental diseases.

8-Sep-2016 11:00 AM EDT
Newborn Gut Microbiome Predicts Later Allergy and Asthma, Study Finds
University of California, San Francisco (UCSF)

The microbes living in a baby’s gut during its first month of life may directly impact the developing immune system, leading to a higher risk of allergies and asthma later in childhood. The findings highlight the importance of developing early interventions to improve microbial health in young infants.

22-Aug-2016 6:05 PM EDT
Calorie-Burning ‘Good’ Fat Can Be Protected, Says Study
University of California, San Francisco (UCSF)

Preventing cells of beige fat — a calorie-burning tissue that can help to ward off obesity and diabetes — from digesting their own mitochondria traps them in a beneficial, energy-burning state. In mice, this successfully protected against obesity and pre-diabetic symptoms, raising hopes for future applications in human patients.

Released: 17-Aug-2016 7:05 PM EDT
Concussion Rates Rising Significantly in Adolescents
University of California, San Francisco (UCSF)

The number of Americans diagnosed with concussions is growing, most significantly in adolescents, according to researchers at UC San Francisco. They recommend that adolescents be prioritized for ongoing work in concussion education, diagnosis, treatment and prevention.

12-Aug-2016 11:05 AM EDT
Researchers Develop Safer Opioid Painkiller From Scratch
University of California, San Francisco (UCSF)

An international team of researchers has developed a new opioid drug candidate that blocks pain without triggering the dangerous side effects of current prescription painkillers. Their secret? Starting from scratch — with computational techniques that let them explore more than four trillion different chemical interactions.

Newswise: Gene Variant Explains Differences in Diabetes Drug Response
Released: 16-Aug-2016 12:25 PM EDT
Gene Variant Explains Differences in Diabetes Drug Response
University of California, San Francisco (UCSF)

A large international study of metformin, the world’s most commonly used type 2 diabetes drug, reveals genetic differences among patients that may explain why some respond much better to the drug than others.

Released: 6-Jun-2016 6:05 PM EDT
Tarantula Toxins Offer Key Insights Into Neuroscience of Pain
University of California, San Francisco (UCSF)

Researchers have identified a pair of tarantula toxins that target a previously unknown pain pathway in sensory nerves.

Newswise: Researchers Convert Cirrhosis-Causing Cells to Healthy Liver Cells in Mice
27-May-2016 6:00 PM EDT
Researchers Convert Cirrhosis-Causing Cells to Healthy Liver Cells in Mice
University of California, San Francisco (UCSF)

UCSF researchers that it is possible to generate healthy new liver cells in the livers of living mice by converting the very cells that drive liver disease, thereby reducing liver damage and improving liver function at the same time.

4-Mar-2016 2:05 PM EST
Artemisinin Combination Therapy Prevents Malaria in Pregnancy
University of California, San Francisco (UCSF)

Pregnant women can be protected from malaria, a major cause of prematurity, low birth weight and death in infants in Africa, with dihydroartemisinin-piperaquine (DP), an artemisinin combination therapy that is already widely used to treat malaria in adults, according to a study by researchers at UC San Francisco and in Uganda.

23-Feb-2016 6:05 PM EST
Homeless People Suffer Geriatric Conditions Decades Early, UCSF Study Shows
University of California, San Francisco (UCSF)

Homeless people in their fifties have more geriatric conditions than those living in homes who are decades older, according to researchers at UC San Francisco who are following 350 people who are homeless and aged 50 and over, in Oakland.

18-Feb-2016 1:05 PM EST
Gene Linking Sleep and Seasonal Affective Disorder Found
University of California, San Francisco (UCSF)

A newly discovered human gene mutation appears to contribute both to unusual sleep patterns and to heightened rates of seasonal depression, according to new research from UC San Francisco.

10-Feb-2016 4:05 PM EST
Gene Signature Could Lead to a New Way of Diagnosing Lyme
University of California, San Francisco (UCSF)

Researchers at UC San Francisco and Johns Hopkins may have found a new way to diagnose Lyme disease, based on a distinctive gene “signature” they discovered in white blood cells of patients infected with the tick-borne bacteria.

22-Jan-2016 1:05 PM EST
Drug Provides Better Kidney Transplant Survival Rates Than Current Standard of Care
University of California, San Francisco (UCSF)

For the first time, an immunosuppressive agent has shown better organ survival in kidney transplant recipients than a calcineurin inhibitor, the current standard of care, according to a worldwide study led by UC San Francisco and Emory University investigators.

21-Jan-2016 7:05 PM EST
Brain Structure Governing Emotion Is Passed Down from Mother to Daughter, says UCSF Study
University of California, San Francisco (UCSF)

A study of 35 families led by a UC San Francisco psychiatric researcher showed for the first time that the structure of the brain circuitry known as the corticolimbic system is more likely to be passed down from mothers to daughters than from mothers to sons or from fathers to children of either gender.

Released: 26-Jan-2016 3:05 PM EST
Brain’s Wiring Connected to Sensory Processing Disorder
University of California, San Francisco (UCSF)

Researchers at UC San Francisco have found that boys and girls with sensory processing disorder (SPD) have altered pathways for brain connectivity when compared to typically developing children, and the difference predicts challenges with auditory and tactile processing.

Released: 26-Jan-2016 1:05 PM EST
For Breast Cancer Patients, Never Too Late to Quit Smoking
University of California, San Francisco (UCSF)

Documenting that it’s never too late to quit smoking, a large study of breast cancer survivors has found that those who quit smoking after their diagnosis had a 33 percent lower risk of death as a result of breast cancer than those who continued to smoke.

22-Jan-2016 4:05 PM EST
Regular Caffeine Consumption Does Not Result in Extra Heartbeats, Study Shows
University of California, San Francisco (UCSF)

Contrary to current clinical belief, regular caffeine consumption does not lead to extra heartbeats, which, while common, can lead in rare cases to heart- or stroke-related morbidity and mortality, according to UC San Francisco researchers.

14-Jan-2016 8:05 PM EST
Study Shows Surge in Use of CTs in Patients with Minor Injuries
University of California, San Francisco (UCSF)

Twice as many patients with non-serious injuries, such as fractures or neck strain, are undergoing CT scans in emergency departments at California hospitals, according to a UCSF-led study, which tracked the use of the imaging from 2005 to 2013.

12-Jan-2016 3:00 PM EST
E-Cigarettes, As Used, Aren’t Helping Smokers Quit, Study Shows
University of California, San Francisco (UCSF)

Electronic cigarettes are widely promoted and used to help smokers quit traditional cigarettes, but a new analysis from UC San Francisco found that adult smokers who use e-cigarettes are actually 28 percent less likely to stop smoking cigarettes.

Released: 11-Jan-2016 1:05 PM EST
Health Tips to Make This Year’s Super Bowl Party Memorable
University of California, San Francisco (UCSF)

To make your Super Bowl party a touchdown, here are some health tips from UCSF.

4-Jan-2016 8:05 PM EST
Genetic Traffic Signal Orchestrates Early Embryonic Development
University of California, San Francisco (UCSF)

New research by UC San Francisco stem cell biologists has revealed that a DNA-binding protein called Foxd3 acts like a genetic traffic signal, holding that ball of undifferentiated cells in a state of readiness for its great transformation in the third week of development.

Released: 5-Jan-2016 4:05 PM EST
Cannabis-Based Drug Reduces Seizures in Children with Treatment Resistant Epilepsy
University of California, San Francisco (UCSF)

Children and young adults with severe forms of epilepsy that does not respond to standard antiepileptic drugs have fewer seizures when treated with purified cannabinoid, according to a multi-center study led by researchers from UCSF Benioff Children’s Hospital San Francisco.

28-Dec-2015 2:30 PM EST
Mind of Blue: Emotional Expression Affects the Brain’s Creativity Network
University of California, San Francisco (UCSF)

The workings of neural circuits associated with creativity are significantly altered when artists are actively attempting to express emotions, according to a new brain-scanning study of jazz pianists.

11-Dec-2015 5:05 PM EST
Diversity in Medical Research Is a Long Way Off, Study Shows
University of California, San Francisco (UCSF)

Despite Congressional mandates aimed at diversifying clinical research, little has changed in the last 30 years in both the numbers of studies that include minorities and the diversity of scientists being funded, according to a new analysis by researchers at UCSF.

2-Dec-2015 4:05 PM EST
‘Purity’ Of Tumor Samples May Significantly Bias Genomic Analyses
University of California, San Francisco (UCSF)

A new study by UC San Francisco scientists shows that the proportion of normal cells, especially immune cells, intermixed with cancerous cells in a given tissue sample may significantly skew the results of genetic analyses and other tests performed both by researchers and by physicians selecting precision therapies.

Released: 2-Dec-2015 12:00 PM EST
Affordable Care Act Will Spur California Health Care Workforce to Develop New Leadership, Flexibility and People Skills
University of California, San Francisco (UCSF)

As health care shifts away from a fee-for-service model as a result of the Affordable Care Act (ACA), health care workers in California will be called upon to develop new skills and fill new roles, according to a study led by UC San Francisco researchers.

24-Nov-2015 3:05 PM EST
Immunotherapy for Type 1 Diabetes Deemed Safe in First U.S. Trial
University of California, San Francisco (UCSF)

In the first U.S. safety trial of a new form of immunotherapy for type 1 diabetes (T1D), led by UC San Francisco scientists and physicians, patients experienced no serious adverse reactions after receiving infusions of as many as 2.6 billion cells that had been specially selected to protect the body’s ability to produce insulin.

Released: 23-Nov-2015 3:05 PM EST
Expensive Drugs That Cure Hepatitis C Are Worth the Cost, Even at Early Stages of Liver Fibrosis
University of California, San Francisco (UCSF)

It is worthwhile to give patients expensive new drugs that can cure their hepatitis C much earlier than some insurers are now willing to pay for them, according to a UC San Francisco study that models the effects of treating the disease early versus late in its development.

18-Nov-2015 4:05 PM EST
Sensory Illusion Causes Cells to Self-Destruct
University of California, San Francisco (UCSF)

Magic tricks work because they take advantage of the brain’s sensory assumptions, tricking audiences into seeing phantoms or overlooking sleights of hand. Now a team of UC San Francisco researchers has discovered that even brainless single-celled yeast have sensory biases that can be hacked by a carefully engineered illusion, a finding that could be used to develop new approaches to fighting diseases such as cancer.

Released: 18-Nov-2015 4:05 PM EST
Gunshot Survivors in High-Crime Community Face Elevated Risk of Early Death, Study Shows
University of California, San Francisco (UCSF)

One in 20 survivors of gunshot violence in an urban area with high crime died within five years, mainly by homicide, according to the results of a study that tracked patients after they had been discharged from the hospital that treated them.

Released: 17-Nov-2015 7:05 PM EST
Working Up a Sweat May Protect Men From Lethal Prostate Cancer
University of California, San Francisco (UCSF)

A study that tracked tens of thousands of midlife and older men for more than 20 years has found that vigorous exercise and other healthy lifestyle habits may cut their chances of developing a lethal type of prostate cancer by up to 68 percent.

9-Nov-2015 7:05 PM EST
Melanoma’s Genetic Trajectories Are Charted in New Study
University of California, San Francisco (UCSF)

An international team of scientists led by UC San Francisco researchers has mapped out the genetic trajectories taken by melanoma as it evolves from early skin lesions, known as precursors, to malignant skin cancer, which can be lethal when it invades other tissues in the body.

Released: 9-Nov-2015 4:05 PM EST
Researchers Shed Pharmacological Light On Formerly “Dark” Cellular Receptors
University of California, San Francisco (UCSF)

Scientists at the University of North Carolina School of Medicine (UNC) and University of California, San Francisco (UCSF) have created a general tool to probe the activity of these orphan receptors, illuminating their roles in behavior and making them accessible for drug discovery

6-Nov-2015 1:05 PM EST
Patients with Severe Mental Illness Rarely Tested for Diabetes, Despite High Risk, Study Shows
University of California, San Francisco (UCSF)

Although adults with serious psychiatric disorders are at high risk for diabetes, a large study led by UC San Francisco reveals that low-income patients on Medicaid are rarely screened for it.

Released: 6-Nov-2015 1:05 PM EST
New Look at PrEP Study Points to Efficacy for Transgender Women
University of California, San Francisco (UCSF)

In a new look at the groundbreaking iPrEx trial for people at high risk of HIV infection, UCSF researchers have identified strong evidence of efficacy for transgender women when PrEP, a two-drug antiretroviral used to prevent HIV, is used consistently.

4-Nov-2015 7:00 PM EST
Eye Drops Could Clear Up Cataracts Using Newly Identified Chemical
University of California, San Francisco (UCSF)

A chemical that could potentially be used in eye drops to reverse cataracts, the leading cause of blindness, has been identified by a team of scientists from UC San Francisco (UCSF), the University of Michigan (U-M), and Washington University in St. Louis (WUSTL).

Released: 4-Nov-2015 6:05 PM EST
New Mood Disorders Program Aims to Advance Treatments, Erase Stigma
University of California, San Francisco (UCSF)

A gift of $20 million from the Ray and Dagmar Dolby Family Fund to the Department of Psychiatry at UC San Francisco will support research on mood disorders.

Released: 3-Nov-2015 1:05 PM EST
Artificial Kidney Research Advances Through UCSF Collaboration
University of California, San Francisco (UCSF)

Development of a surgically implantable, artificial kidney — a promising alternative to kidney transplantation or dialysis for people with end-stage kidney disease — has received a $6 million boost, thanks to a new grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), one of the National Institutes of Health, to researchers led by UC San Francisco bioengineer Shuvo Roy, PhD, and Vanderbilt University nephrologist William Fissell, MD.

29-Oct-2015 5:05 PM EDT
Does Healthier Food Help Low-Income People Control Their Diabetes?
University of California, San Francisco (UCSF)

To determine whether healthy food could help low-income people better control their diabetes, a pilot study by UC San Francisco and Feeding America tracked nearly 700 people at food banks in California, Texas and Ohio over two years.

28-Oct-2015 2:05 PM EDT
Molecular Switch Generates Calorie-Burning Brown Fat
University of California, San Francisco (UCSF)

A research team led by UC San Francisco scientists has identified a molecular switch capable of converting unhealthy white fat into healthy, energy-burning brown fat in mice.

21-Oct-2015 12:05 PM EDT
Obese Children’s Health Rapidly Improves with Sugar Reduction Unrelated to Calories
University of California, San Francisco (UCSF)

Reducing consumption of added sugar, even without reducing calories or losing weight, has the power to reverse a cluster of chronic metabolic diseases, including high cholesterol and blood pressure, in children in as little as 10 days, according to a study by researchers at UC San Francisco and Touro University California.

16-Oct-2015 3:05 PM EDT
Determining Accurate Life Expectancy of Older Adults Requires Provider, Patient Discussion
University of California, San Francisco (UCSF)

Health care providers must have detailed discussions with their older adult patients to better determine their true life expectancy, as older adults do not accurately predict their own prognosis, a key factor in making decisions about future health interventions, according to researchers at UC San Francisco and San Francisco Veterans Affairs Medical Center.

12-Oct-2015 10:00 AM EDT
Doctors Call on Hospitals to Oppose the Overuse of Antibiotics in Animal Agriculture
University of California, San Francisco (UCSF)

To help stop the spread of antibiotic resistance, UC San Francisco scientists are urging hospitals around the country to stop buying meat from animals that were given antibiotics for growth promotion.

5-Oct-2015 7:05 PM EDT
Gay and Bisexual Men Report Higher Rates of Both Indoor Tanning and Skin Cancer than Heterosexual Men
University of California, San Francisco (UCSF)

Gay and bisexual men were up to six times more likely than heterosexual men to take part in indoor tanning, and twice as likely to report a history of skin cancer, including nonmelanoma and melanoma, according to a study led by UC San Francisco researchers.

5-Oct-2015 7:05 PM EDT
Online Advertising Can Deliver Targeted Cancer Prevention Messages, UCSF Study Finds
University of California, San Francisco (UCSF)

Online advertising based on Google search terms is a potentially effective way to deliver targeted cancer prevention education, according to a study led by Eleni Linos, MD, DrPH, an assistant professor of dermatology at UC San Francisco.

5-Oct-2015 2:05 PM EDT
Chest CT Scans Often Can Be Avoided in Blunt Trauma ER Cases, Study Finds
University of California, San Francisco (UCSF)

Use of computed tomography (CT) scans of the chest for hospital emergency-room patients with blunt trauma could be reduced by more than one-third without compromising detection of major injury, concludes a new study led by a UC San Francisco physician.


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