Small Molecule Exploits Achilles’ Heel of AML, Kills Cancer CellsCincinnati Children's Hospital Medical Center
Blocking the protein UBE2N with novel small molecule kills AML cells, according to study in Science Translational Medicine.
Blocking the protein UBE2N with novel small molecule kills AML cells, according to study in Science Translational Medicine.
Cincinnati Children’s Hospital Medical Center is celebrating the completion of a new Critical Care Building, a $600 million investment that involved three years of construction on the hospital’s main campus in Avondale.
A study published in the journal Pediatrics shows the combination of two early reading programs had positive effects on preschool students entering kindergarten in Cincinnati Public Schools over a three-year period.
Researchers at Cincinnati Children’s Hospital Medical Center have developed a new framework for different factors influencing how a child’s brain is “wired” to learn to read before kindergarten.
The Cardio-Renal Pediatric Dialysis Emergency Machine (CARPEDIEM) is a new system for patients with acute kidney injury or kidney failure requiring dialysis. This ground-breaking technology is intended to provide continuous renal replacement therapy (CRRT) to patients weighing between 5 and 20 pounds.
A study published in the journal Pediatrics expands validation evidence for a new screening tool that directly engages preschool-age children during clinic visits to assess their early literacy skills. The tool, which is the first of its kind, has the potential to identify reading difficulties as early as possible, target interventions and empower families to help their child at home, according to researchers at Cincinnati Children’s Hospital Medical Center.
Cincinnati Children’s Hospital Medical Center and TriHealth are announcing the expansion of the special delivery unit at the Cincinnati Children’s Fetal Care Center.
Cincinnati Children’s Hospital Medical Center today named Visael “Bobby” Rodriguez as its vice president of diversity, inclusion and community relations.
Tina L. Cheng, MD, MPH, will be the new chair of the Department of Pediatrics at the University of Cincinnati College of Medicine, the new chief medical officer at Cincinnati Children’s Hospital Medical Center, and director of the Cincinnati Children’s Research Foundation.
The combination of higher exposure to air pollution and pre-existing health disparities is contributing to higher mortality among minority populations during the COVID-19 pandemic, according to experts at Cincinnati Children's.
A study published online April 20, 2020, in Nature Immunology, led by researchers at Cincinnati Children's reports a possible new approach for treating myelodysplastic syndrome (MDS), which often can lead to leukemia.
New research data in the journal PLoS Pathogens suggests that reactivated HSV in trigeminal nerves of laboratory mice kills off at least a portion of sensory neurons. The findings provide additional evidence that as humans get older, the long-term consequences of HSV infection in the nervous system can accumulate and cause neurological damage.
The continuing epidemic of pre-term birth includes this stark reality: tiny, fragile babies are born with underdeveloped lungs and prone to lifelong respiratory infections and related chronic illnesses. Cincinnati Children’s researchers report in Immunology the discovery of a complex biological process could in the development of cost effective treatments to help babies develop lifelong pulmonary resistance to respiratory infections.
A new study suggests that significant early childhood exposure to traffic-related air pollution (TRAP) is associated with structural changes in the brain at the age of 12. The Cincinnati Children’s Hospital Medical Center study found that children with higher levels of TRAP exposure at birth had reductions at age 12 in gray matter volume and cortical thickness as compared to children with lower levels of exposure.
Report led by experts at Cincinnati Children's, published today in Pediatrics, urges pediatricians to increase support for parents of children with chronic conditions.
Scientists describe in Nature Immunology an entirely new molecular process in mice that triggers T cell-driven inflammation and causes different auto-immune diseases. In a study published online Dec. 17, researchers report their data have implications for Multiple Sclerosis, Type 1 diabetes and Inflammatory Bowel Disease. It also will help efforts to find better treatments for autoimmune disease, still an urgent need in medicine.
The Influenza IMPRINT Cohort study will explore the emerging idea that a person’s very first influenza virus exposure impacts the magnitude, durability and breadth of their immune response to all future flu exposures.
Although KJ Upshaw’s official job title at Cincinnati Children’s is floor tech in Environmental Services, he refers to himself simply as the housekeeper. For two little boys in the medical center’s Bone Marrow Transplant unit, KJ is much more. He’s a cherished friend who helped make their lives in the hospital brighter and more fulfilling.
A study in Nature shows stem cell therapy helps hearts recover from a heart attack, although not for the biological reasons originally proposed two decades ago that today are the basis of ongoing clinical trials. The study reports that injecting living or even dead heart stem cells into the injured hearts of mice triggers an acute inflammatory process, which in turn generates a wound healing-like response to enhance the mechanical properties of the injured area.
After decades of little or no progress, biomedical researchers are finally making some headway at detecting and treating sepsis, a deadly medical complication that sends a surge of pathogenic infection through the body and remains a major public health problem. They report data in Science Translational Medicine.
Bariatric surgery can be a life-changer for severely obese teens. However, some recipients may develop nutritional deficiencies years after treatment. Also, one of the two primary forms of bariatric surgery, gastric bypass, appears to cause more nutritional disruption than the other, vertical sleeve gastrectomy, according to study led by experts at Cincinnati Children’s published online Nov. 8, 2019 in the journal Clinical Gastroenterology and Hepatology.
A study led by experts at Cincinnati Children's reports new details about a rare lung complication affecting children with systemic JIA. The complications appear related to how some patients react to treatments called "biologics."
In a finding that could help lead to new therapies for immune diseases like multiple sclerosis and IBD, scientists report in the Journal of Experimental Medicine identifying a gene and family of proteins critical to the formation of mature and fully functioning T cells in the immune system.
Young adult women with a documented history of being maltreated as children report higher levels of pain than women not maltreated in childhood, according to a new study.
Cincinnati Children's will use a $28M federal grant to serve as the data coordinating center for the Rare Diseases Clinical Research Network. The network includes 20 groups of medical centers searching for improved treatments for hundreds of rare diseases.
The mehealth web portal for ADHD can support a physician’s selection of behavioral medications, appropriate dosing and testing of other interventions.
Three new studies by scientists at Cincinnati Children’s, in collaboration with researchers at the University of Cincinnati, highlight the relationship between air pollution and mental health in children.
Building upon the initial five-year plan, LungMAP 2 includes research on normal lung development in early adulthood and abnormal development in selected rare lung diseases.
Targeting the protein Eyes Absent 3 (EYA3) may help prevent vascular remodeling in pulmonary arterial hypertension (PAH), according to new study from Cincinnati Children's.
Researchers used a powerful new computer-assisted technology called single-cell transcriptomics that measures thousands of individual cells simultaneously to map cell types and molecular cascades that drive the growth of SHH-medulloblastoma. In a study published Aug. 29 by the journal Cancer Cell
In a study based on mouse models, scientists at Cincinnati Children's reveal that NK cell transplants may help reduce the risk of severe bleeding during childbirth caused by placental accreta.
Clinical trials are a critical tool for getting new treatments to people who need them, but research shows that difficulty finding the right volunteer subjects can undermine the effectiveness of these studies. Researchers designed and tested a new computerized solution that used artificial intelligence (AI) to effectively identify eligible subjects from Electronic Health Records (EHRs), allowing busy clinical staff to focus their limited time on evaluating the highest quality candidates
Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD. It may be feasible to also use the small two-chambered device, which features bioengineered human pancreatic organoids to study the causes of non-CF-related conditions such as type 1 and 2 diabetes, according to researchers who report findings in Nature Communications.
Researchers suggest a possible cell-based therapy to stimulate lung development in fragile premature infants who suffer from a rare condition called Bronchopulmonary Dysplasia (BPD), which in the most severe cases can lead to lifelong breathing problems and even death. Scientists publish their preclinical findings report the American Journal of Respiratory and Critical Care Medicine.
Scientists used a gene editing method called CRISPR/Cas9 to generate mice that mimic a respiratory disorder in newborn infants that turns their lips and skin blue. The new laboratory model allowed researchers to find the ailment’s cause and a potential, desperately needed nanoparticle-based treatment.
June 19 is World Sickle Cell Awareness Day. Scientists at Cincinnati Children's have recently made three important steps forward in helping people with sickle cell in the U.S. and in sub-Saharan Africa live longer, better lives.
Scientists at Cincinnati Children’s Hospital Medical Center have identified an expression pattern of 14 genes at the time of diagnosis that predicts two year, transplant-free survival in children with biliary atresia – the most common diagnosis leading to liver transplants in children. The researchers also found that the antioxidant N-acetyl-cysteine (NAC) reduced liver injury and fibrosis (excess fibrous connective tissue) in mice with biliary atresia and increased survival times.
Scientists successfully bioengineered human liver organoids that faithfully mimic key features of fatal liver disease in the laboratory. This allowed them to uncover underlying disease biology in the organoids and test a potential therapy that in preclinical lab tests reversed an often-fatal childhood condition called Wolman disease.
Experts at Cincinnati Children’s report that the systemic inflammatory process that triggers preterm birth begins in an unexpected location that suggests new ways to develop preventative medications.
Experts use emerging technique to reveal that a protein named “Merlin” may interact with 50 other proteins to trigger the rare condition neurofibromatosis 2 (NF2). But this discovery has implications that go far beyond NF2 itself.
Many people fighting a very aggressive form of acute myeloid leukemia (AML) don’t survive more than five years. These very sick patients are often unable to receive the only cure—a bone marrow transplant. Now, an international team of scientists report in Nature Cell Biology on a long-overlooked part of a leukemic cell’s internal machinery, where they may have found a key to treating the aggressive blood cancer.
Cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer allowed scientists to discover a molecular driver of the highly aggressive, deadly, and treatment-resistant brain cancer, glioblastoma. Published in Cell Stem Cell, the findings present an opportunity to find out if new therapeutic approaches can stop glioblastoma at its earliest stages of initial formation or recurrence.
New study uses single-cell RNA sequencing technology to find a target for treating EoE. Findings also raise questions about the dietary supplement butyrate.
Scientists discovered a light-dependent molecular pathway that regulates how blood vessels develop in the eye. The findings in Nature Cell Biology suggest it may be possible to use light therapy to help premature infants whose eyes are still developing avoid vision problems. The novel molecular process helps ensure blood-vessel development in the eye is appropriately balanced to prepare it for visual function.
A pilot study of 45 middle school kids shows that more than a third of those screened had abnormal levels of blood sugar or high cholesterol. Two had blood sugar levels (HbA1c) in the diabetes range.
From fathers to children, the delivery of hereditary information requires the careful packing of DNA in sperm. But just how nature packages this DNA to prepare offspring isn’t clear. Using new technology to reveal the 3D organization of DNA in maturing male reproductive cells, scientists revealed a crucial period in development that helps explain how fathers pass on genetic information to future generations.
Record number makes Valentine’s Day a little sweeter for patients and families
A Phase 1 clinical trial of investigational vaccines intended to protect against Zaire ebolavirus (Ebola) has begun in the United States at Cincinnati Children’s Hospital Medical Center. The study is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID).
After over a decade of preclinical research and development, a new gene therapy treatment for Sickle Cell Anemia (SCA) is reversing disease symptoms in two adults and showing early potential for transportability to resource-challenged parts of the world where SCA is most common.