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Newswise: Joan W. Conaway elected to the National Academy of Sciences
Released: 27-Apr-2020 5:35 PM EDT
Joan W. Conaway elected to the National Academy of Sciences
Stowers Institute for Medical Research

The Stowers Institute for Medical Research is pleased to announce that Joan Weliky Conaway, PhD, a Stowers Investigator since 2001, has been elected a member of the prestigious National Academy of Sciences (NAS) for her distinguished and continuing achievements in original scientific research. The recognition reflects the exceptional productivity and impact of the research program co-led by Conaway and her lifelong collaborator and husband Ron Conaway, PhD.

Newswise: What’s old is new again
Released: 20-Apr-2020 3:55 PM EDT
What’s old is new again
Stowers Institute for Medical Research

Drug resistance is a major obstacle in cancer treatment—leading to relapse for many patients. In a new study, published online April 20, 2020, in Nature Cell Biology, researchers from the Stowers Institute for Medical Research, Children’s Mercy Kansas City, and The University of Kansas Cancer Center report on a promising new strategy to overcome drug resistance in leukemia, using targeted doses of the widely-used chemotherapy drug doxorubicin.

Newswise:Video Embedded technologies-converge-on-interacting-surfaces-in-protein-complexes
VIDEO
9-Apr-2020 4:00 PM EDT
Technologies Converge on Interacting Surfaces in Protein Complexes
Stowers Institute for Medical Research

Researchers at the Stowers Institute for Medical Research have fine-tuned a method to pinpoint surfaces within large multi-protein complexes that are close to, and likely to be directly interacting with, one another.

Newswise: How the historically misunderstood amyloid helps to store memories
11-Mar-2020 6:05 PM EDT
How the historically misunderstood amyloid helps to store memories
Stowers Institute for Medical Research

For the first time, scientists from the Stowers Institute for Medical Research and collaborators have described the structure of an endogenously sourced, functioning neuronal amyloid at atomic resolution. The amyloid is composed of self-aggregated Orb2, the fruit fly version of the mRNA-binding cytoplasmic polyadenylation element-binding (CPEB) protein, which has been linked to long-term memory storage. The results of this work, published online March 13, 2020, in Science, have some very interesting implications.

Newswise: Zeroing in on how a tumor suppressor protein is cast away
21-Oct-2019 10:05 AM EDT
Zeroing in on how a tumor suppressor protein is cast away
Stowers Institute for Medical Research

Researchers from the Stowers Institute for Medical Research have uncovered new details about several proteins implicated in tumor growth and metastasis, opening a potential avenue for the development of treatments for diseases such as breast cancer.

Newswise: X marks the spot: recombination in structurally distinct chromosomes
Released: 16-Oct-2019 10:05 AM EDT
X marks the spot: recombination in structurally distinct chromosomes
BioMed Valley Discoveries

A recent study from the laboratory of Stowers Investigator Scott Hawley, PhD, has revealed more details about how the synaptonemal complex performs its job, including some surprising subtleties in function.

Newswise: Size Matters: How Cells Pack in Epithelial Tissues
4-Sep-2019 11:00 AM EDT
Size Matters: How Cells Pack in Epithelial Tissues
Stowers Institute for Medical Research

Small-cell clones in proliferating epithelia – tissues that line all body surfaces – organize very differently than their normal-sized counterparts, according to a recent study from the Stowers Institute for Medical Research. Published online September 5, 2019, in Developmental Cell, these findings from the laboratory of Matthew Gibson, PhD, may contribute to a better understanding of how some human diseases progress.

Newswise: EMBO Laboratory Leadership Training Offered at the Stowers Institute
Released: 19-Aug-2019 2:05 PM EDT
EMBO Laboratory Leadership Training Offered at the Stowers Institute
Stowers Institute for Medical Research

This October, the Stowers Institute for Medical Research will host a session of the EMBO Laboratory Leadership for Group Leaders Course at its campus in Kansas City, Missouri.

Newswise: Super-resolution microscopy illuminates associations between chromosomes
Released: 3-Jul-2019 11:45 AM EDT
Super-resolution microscopy illuminates associations between chromosomes
Stowers Institute for Medical Research

KANSAS CITY, MO—Thanks to super-resolution microscopy, scientists have now been able to unambiguously identify physical associations between human chromosomes. The findings have brought to light a new understanding to a curious observation first made more than 50 years ago. The Stowers Institute for Medical Research scientists probed these physical connections between five of the chromosomes in the human karyotype in a report recently published online in the Journal of Cell Biology.

Newswise: More than a protein factory
Released: 24-May-2019 12:05 PM EDT
More than a protein factory
Stowers Institute for Medical Research

Researchers from the Stowers Institute for Medical Research have discovered a new function of ribosomes in human cells that may show the protein-making particle’s role in destroying healthy mRNAs, the messages that decode DNA into protein.

Newswise: New Method of Scoring Protein Interactions Mines Large Data Sets From a Fresh Angle
Released: 8-Mar-2019 11:10 AM EST
New Method of Scoring Protein Interactions Mines Large Data Sets From a Fresh Angle
Stowers Institute for Medical Research

Researchers from the Stowers Institute for Medical Research have created a novel way to define individual protein associations in a quick, efficient, and informative way. These findings, published in the March 8, 2019, issue of Nature Communications, show how the topological scoring (TopS) algorithm, created by Stowers researchers, can – by combining data sets – identify proteins that come together.

Newswise: Scientists have identified a bone marrow backup system
Released: 15-Jan-2019 12:05 PM EST
Scientists have identified a bone marrow backup system
Stowers Institute for Medical Research

New research from the Stowers Institute for Medical Research has identified a backup for an important biological system – the hematopoietic system, whose adult stem cells constantly replenish the body’s blood supply.

Newswise:
Released: 26-Oct-2018 10:20 AM EDT
"Navigator" neurons play critical role in sense of smell
Stowers Institute for Medical Research

Researchers at the Stowers Institute for Medical Research have identified "navigator" neurons that are key to setting up connections in the system responsible for the sense of smell. The new study builds on a breakthrough 2014 report from the laboratory of Stowers Investigator Ron Yu, Ph.D., which showed a critical period in olfactory wiring using mice as a model system.

Newswise: New study probes the ancient past of a body plan code
23-Sep-2018 8:00 PM EDT
New study probes the ancient past of a body plan code
Stowers Institute for Medical Research

Researchers from the Stowers Institute for Medical Research have opened a window on another piece of evolutionary biology. They have found that Hox genes, which are key regulators of the way the bodies of bilaterally symmetrical animals form, also play a role in controlling the radially symmetric body plan of the starlet sea anemone, Nematostella vectensis.

Newswise: New Research Opens Door to Expanding Stem Cells Available for Transplants
Released: 3-Aug-2018 3:05 PM EDT
New Research Opens Door to Expanding Stem Cells Available for Transplants
Stowers Institute for Medical Research

Researchers from the Stowers Institute for Medical Research and collaborators have identified a way to expand blood-forming, adult stem cells from human umbilical cord blood (hUCB).

Newswise: New Model for Predicting Neuroblastoma Outcomes Incorporates Early Developmental Signals
Released: 6-Jul-2018 10:00 AM EDT
New Model for Predicting Neuroblastoma Outcomes Incorporates Early Developmental Signals
Stowers Institute for Medical Research

Motivated by a desire to better understand the molecular circuitry underlying neuroblastoma and limitations of current methods for predicting disease progression and outcome, researchers from the Kulesa Lab at the Stowers Institute for Medical Research and collaborators at the University of Michigan and Oxford University set out to construct a logic-based model incorporating information about developmental signaling pathways implicated in the disease.

Newswise: New Assay Reveals Biophysical Properties That Allow Certain Proteins to Infect Others
29-Jun-2018 4:15 PM EDT
New Assay Reveals Biophysical Properties That Allow Certain Proteins to Infect Others
Stowers Institute for Medical Research

Scientists at the Stowers Institute for Medical Research have identified a physical basis for the spread of corrupted proteins known as prions inside cells. Their research findings are reported in the July 5, 2018, issue of the scientific journal Molecular Cell.

Newswise:Video Embedded scientists-have-captured-the-elusive-cell-that-can-regenerate-an-entire-flatworm
VIDEO
12-Jun-2018 10:30 AM EDT
Scientists Have Captured the Elusive Cell That Can Regenerate an Entire Flatworm
Stowers Institute for Medical Research

Researchers at the Stowers Institute for Medical Research have captured the one cell that is capable of regenerating an entire organism.

Newswise: How Epigenetic Regulation of the Hoxb Gene Cluster Maintains Normal Blood-forming Stem Cells and Inhibits Leukemia
Released: 8-May-2018 12:05 PM EDT
How Epigenetic Regulation of the Hoxb Gene Cluster Maintains Normal Blood-forming Stem Cells and Inhibits Leukemia
Stowers Institute for Medical Research

New research from the Stowers Institute for Medical Research reveals that a DNA regulatory element within the Hoxb cluster globally mediates signals to the majority of Hoxb genes to control their expression in blood-forming stem cells.

Newswise: Alejandro Sanchez Alvarado Elected to the National Academy of Sciences
Released: 1-May-2018 12:05 PM EDT
Alejandro Sanchez Alvarado Elected to the National Academy of Sciences
Stowers Institute for Medical Research

The Stowers Institute for Medical Research is pleased to announce that Alejandro Sánchez Alvarado, Ph.D., a Stowers and Howard Hughes Medical Institute (HHMI) investigator, has been elected a member of the prestigious National Academy of Sciences (NAS) for his distinguished and continuing achievements in original scientific research.

Newswise: Molecular Signature of “Trailblazer” Neural Crest Cells Gives Insight Into Development and Cancer
Released: 18-Dec-2017 4:50 PM EST
Molecular Signature of “Trailblazer” Neural Crest Cells Gives Insight Into Development and Cancer
Stowers Institute for Medical Research

In a study published online in the journal eLife, the researchers identified a molecular signature of approximately 1300 genes differentially expressed in an aggressive subset of migrating neural crest cells termed as “trailblazers” in a vertebrate model system of development. These genes appear to play a critical role in migration and may be part of a broader molecular signature of cell invasion in a number of phenomena.

Newswise: Marriage of Microscopy Techniques Reveals 3D Structure of Critical Protein Complex
Released: 2-Aug-2017 2:35 PM EDT
Marriage of Microscopy Techniques Reveals 3D Structure of Critical Protein Complex
Stowers Institute for Medical Research

Researchers at the Stowers Institute for Medical Research have solved the three-dimensional structure of a complex that is essential for the correct sorting of chromosomes into eggs and sperm during reproductive cell division or meiosis.

Newswise: Cancer Cells May Streamline Their Genomes in Order to Proliferate More Easily
19-Jun-2017 5:05 AM EDT
Cancer Cells May Streamline Their Genomes in Order to Proliferate More Easily
Stowers Institute for Medical Research

Research from the Stowers Institute provides evidence suggesting that cancer cells might streamline their genomes in order to proliferate more easily. The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA. While downsizing might enable these cells to replicate faster, it also seems to render them less able to withstand DNA damage.

Newswise: Selfish Gene Acts as Both Poison and Antidote to Eliminate Competition
Released: 20-Jun-2017 6:05 AM EDT
Selfish Gene Acts as Both Poison and Antidote to Eliminate Competition
Stowers Institute for Medical Research

Researchers from the Stowers Institute for Medical Research in collaboration with Fred Hutchinson Cancer Research Center researchers have identified an unprecedented genetic survival strategy that would be right at home in an Agatha Christie murder mystery novel.

Newswise: Genetic Cross-Talk Key to Cell Balance
31-May-2017 2:00 PM EDT
Genetic Cross-Talk Key to Cell Balance
Stowers Institute for Medical Research

In a study published in the June 5, 2017, issue of the Proceedings of the National Academy of Sciences, Stowers scientists Bony De Kumar, Ph.D., and Robb Krumlauf, Ph.D., provide evidence of direct cross-regulatory feedback, or cross-talk, between Nanog and Hox genes.

Newswise: Polymerases Pause to Help Mediate the Flow of Genetic Information
Released: 17-May-2017 9:00 AM EDT
Polymerases Pause to Help Mediate the Flow of Genetic Information
Stowers Institute for Medical Research

Stop-and-go traffic is typically a source of frustration, an unneccesary hold-up on the path from point A to point B. But when it comes to the molecular machinery that copies our DNA into RNA, a stop right at the beginning of the path may actually be helpful. Recent research from the Stowers Institute for Medical Research shows that this stop prevents another machine from immediately following the first, presumably to better control the traffic and avoid later collisions.

Newswise: Uncovering New Relationships and Organizational Principles in Protein Interaction Networks
6-Mar-2017 2:00 PM EST
Uncovering New Relationships and Organizational Principles in Protein Interaction Networks
Stowers Institute for Medical Research

Proteins, those basic components of cells and tissues, carry out many biological functions by working with partners in networks. The dynamic nature of these networks – where proteins interact with different partners at different times and in different cellular environments – can present a challenge to scientists who study them.

Newswise:Video Embedded possible-key-to-regeneration-found-in-planaria-s-origins
VIDEO
Released: 13-Feb-2017 1:05 PM EST
Possible Key to Regeneration Found in Planaria’s Origins
Stowers Institute for Medical Research

A new report from the Stowers Institute for Medical Research chronicles the embryonic origins of planaria, providing new insight into the animal's remarkable regenerative abilities.

Newswise: New Finding Reveals Battle Behind Gene Expression
Released: 15-Dec-2016 4:05 PM EST
New Finding Reveals Battle Behind Gene Expression
Stowers Institute for Medical Research

The complex process regulating gene expression is often compared to following a recipe. Miss a genetic ingredient, or add it in the wrong order, and you could have a disaster on your hands.

Newswise: Research Points to Orb2 as a Physical Substrate for Memory Strength, Retention
Released: 2-Dec-2016 3:00 PM EST
Research Points to Orb2 as a Physical Substrate for Memory Strength, Retention
Stowers Institute for Medical Research

How do you remember what happened today in the weeks and months that follow? Researchers at the Stowers Institute for Medical Research have answered a piece of that question in a recent study.

Newswise: Shifts in the Microbiome Impact Tissue Repair and Regeneration
Released: 26-Aug-2016 2:05 PM EDT
Shifts in the Microbiome Impact Tissue Repair and Regeneration
Stowers Institute for Medical Research

Researchers at the Stowers Institute have established a definitive link between the makeup of the microbiome, the host immune response, and an organism’s ability to heal itself.

Newswise: Researchers Discover a Key Molecular Signal That Shapes Regeneration in Planarian Stem Cells
9-Aug-2016 4:05 PM EDT
Researchers Discover a Key Molecular Signal That Shapes Regeneration in Planarian Stem Cells
Stowers Institute for Medical Research

Researchers at the Stowers Institute have identified a key molecule that directs stem cells in the planarian flatworm to make copies of themselves.

Newswise: Similarities Unite Three Distinct Gene Mutations of Treacher Collins Syndrome
22-Jul-2016 1:05 PM EDT
Similarities Unite Three Distinct Gene Mutations of Treacher Collins Syndrome
Stowers Institute for Medical Research

Scientists at the Stowers Institute for Medical Research have reported a detailed description of how function-impairing mutations in polr1c and polr1d genes cause Treacher Collins syndrome (TCS), a rare congenital craniofacial development disorder that affects an estimated 1 in 50,000 live births.

Newswise: Robert Krumlauf Elected to the National Academy of Sciences
Released: 4-May-2016 11:05 AM EDT
Robert Krumlauf Elected to the National Academy of Sciences
Stowers Institute for Medical Research

The Stowers Institute for Medical Research is pleased to announce that Scientific Director and Investigator Robert Krumlauf, Ph.D., has been elected a member of the National Academy of Sciences (NAS) for his distinguished and continuing achievements in original scientific research.

Newswise: Researchers Generate Whole-Genome Map of Fruit Fly Genetic Recombination
Released: 17-Mar-2016 2:00 PM EDT
Researchers Generate Whole-Genome Map of Fruit Fly Genetic Recombination
Stowers Institute for Medical Research

For the first time, researchers at the Stowers Institute have mapped where recombination occurs across the whole genome of the fruit fly Drosophila melanogaster after a single round of meiosis.

Newswise: Researchers Use Mouse Model to Study Craniofacial Disorders
Released: 25-Feb-2016 8:00 AM EST
Researchers Use Mouse Model to Study Craniofacial Disorders
Stowers Institute for Medical Research

Researchers from the laboratory of Paul Trainor, Ph.D., at the Stowers Institute of Medical Research have developed an effective and reliable technique for studying high-arched palate using a mouse model. The methodology could expand research into the genetic aspects of this craniofacial abnormality.

Newswise: The Worm Has Turned: New Research Uncovers Processes Driving Planarian Stem Cell Differentiation in Living Tissues
16-Dec-2015 12:05 PM EST
The Worm Has Turned: New Research Uncovers Processes Driving Planarian Stem Cell Differentiation in Living Tissues
Stowers Institute for Medical Research

In two new studies, researchers in the laboratory of Howard Hughes Medical Institute Investigator Alejandro Sánchez Alvarado, Ph.D., at the Stowers Institute for Medical Research explore the intricate processes at work when stem cells differentiate into planarian skin cells.

Newswise: Potential Biochemical Mechanism Underlying Long-Term Memories Identified
2-Dec-2015 4:50 PM EST
Potential Biochemical Mechanism Underlying Long-Term Memories Identified
Stowers Institute for Medical Research

During the holidays, we often remember the past and create new memories. But, why do some memories fade away while others last forever? Scientists at the Stowers Institute for Medical Research have identified a possible biochemical mechanism by which the specialized brain cells known as neurons create and maintain a long-term memory from a fleeting experience.

Newswise: How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Released: 25-Nov-2015 2:05 PM EST
How a Genetic Locus Protects Adult Blood-Forming Stem Cells
Stowers Institute for Medical Research

A particular location in DNA, called the Dlk1-Gtl2 locus, plays a critical role in protecting hematopoietic, or blood-forming, stem cells—a discovery revealing a critical role of metabolic control in adult stem cells, and providing insight for potentially diagnosing and treating cancer, according to researchers from the Stowers Institute for Medical Research.

Newswise: Protein Complex Links Cellular Metabolism to Gene Expression, Offers Potential Therapeutic Target
26-Oct-2015 6:05 AM EDT
Protein Complex Links Cellular Metabolism to Gene Expression, Offers Potential Therapeutic Target
Stowers Institute for Medical Research

Researchers in the Workman Lab at the Stowers Institute for Medical Research have identified a link between cellular metabolism and gene expression, one with potentially far-reaching implications for cancer risk prediction and treatment.

Newswise: Innovative Imaging Technique Reveals New Cellular Secrets
Released: 11-Sep-2015 10:30 AM EDT
Innovative Imaging Technique Reveals New Cellular Secrets
Stowers Institute for Medical Research

A team of researchers from the Stowers Institute for Medical Research and the University of Colorado Boulder has devised a novel optical technique — a combination of structured illumination microscopy (SIM) and single-particle averaging (SPA) — to resolve individual components of SPB duplication in living yeast cells.

Newswise: Orchestrating Hair Cell Regeneration: A Supporting Player’s Close-Up
10-Jul-2015 5:05 PM EDT
Orchestrating Hair Cell Regeneration: A Supporting Player’s Close-Up
Stowers Institute for Medical Research

A new study in Developmental Cell, from Stowers Institute for Medical Research Associate Investigator Tatjana Piotrowski, Ph.D., zeros in on an important component in fish: the support cells that surround centrally-located hair cells in each garlic-shaped sensory organ, or neuromast.

Newswise: Stress Triggers Key Molecule to Halt Transcription of Cell’s Genetic Code
Released: 27-May-2015 3:00 PM EDT
Stress Triggers Key Molecule to Halt Transcription of Cell’s Genetic Code
Stowers Institute for Medical Research

Researchers at the Stowers Institute have shown that a molecule called elongin A assists with transcription.

Newswise: Stowers Investigator Elected to American Academy of Arts and Sciences
22-Apr-2015 10:00 AM EDT
Stowers Investigator Elected to American Academy of Arts and Sciences
Stowers Institute for Medical Research

Sánchez Alvarado, known for his groundbreaking work on the biology of the planaria—a flatworm model organism known for its regenerative abilities, has been elected to the American Academy of Arts and Sciences.

Newswise: New Technique Can Locate Genes’ On-Off Switches
6-Mar-2015 12:00 PM EST
New Technique Can Locate Genes’ On-Off Switches
Stowers Institute for Medical Research

Researchers at the Stowers Institute for Medical Research have developed a high-resolution method that can precisely and reliably map individual transcription factor binding sites in the genome, vastly outperforming standard techniques

Newswise: Researchers Design “Evolutionary Trap” to Thwart Drug Resistance
6-Feb-2015 1:00 PM EST
Researchers Design “Evolutionary Trap” to Thwart Drug Resistance
Stowers Institute for Medical Research

Using theoretical and experimental approaches, researchers at the Stowers Institute for Medical Research have developed a two-pronged strategy that uses an evolving cell population’s adaptive nature against it.

Newswise: Cutting the Ties That Bind
22-Oct-2014 4:00 PM EDT
Cutting the Ties That Bind
Stowers Institute for Medical Research

The development of a new organism from the joining of two single cells is a carefully orchestrated endeavor. But even before sperm meets egg, an equally elaborate set of choreographed steps must occur to ensure successful sexual reproduction. Those steps, known as reproductive cell division or meiosis, split the original number of chromosomes in half so that offspring will inherit half their genetic material from one parent and half from the other.

Newswise: New Insight That “Mega” Cells Control the Growth of Blood-Producing Cells
17-Oct-2014 12:00 PM EDT
New Insight That “Mega” Cells Control the Growth of Blood-Producing Cells
Stowers Institute for Medical Research

While megakaryocytes are best known for producing platelets that heal wounds, these “mega” cells found in bone marrow also play a critical role in regulating stem cells according to new research from the Stowers Institute for Medical Research. In fact, hematopoietic stem cells differentiate to generate megakaryocytes in bone marrow. The Stowers study is the first to show that hematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes).

Newswise: Misfolded Proteins Clump Together in a Surprising Place
14-Oct-2014 4:00 PM EDT
Misfolded Proteins Clump Together in a Surprising Place
Stowers Institute for Medical Research

Scientists at the Stowers Institute for Medical Research have made a surprising finding about the aggregates of misfolded cellular proteins that have been linked to aging-related disorders such as Parkinson’s disease. The researchers report their results in the October 16, 2014 online issue of the journal Cell.

Newswise: How an Ancient Vertebrate Uses Familiar Tools to Build a Strange-Looking Head
11-Sep-2014 1:00 PM EDT
How an Ancient Vertebrate Uses Familiar Tools to Build a Strange-Looking Head
Stowers Institute for Medical Research

Investigator and Scientific Director Robb Krumlauf, Ph.D. and colleagues show that the sea lamprey Petromyzon marinus, a survivor of ancient jawless vertebrates, exhibits a pattern of gene expression that is reminiscent of its jawed cousins, who evolved much, much later.


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