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Newswise: Experimental COVID-19 Vaccine Offers Long-term Protection Against Severe Disease
Released: 1-Dec-2022 2:30 PM EST
Experimental COVID-19 Vaccine Offers Long-term Protection Against Severe Disease
University of North Carolina School of Medicine

SARS-CoV-2 vaccines protected infant rhesus macaques against 1 severe lung disease after high dose challenge one year after vaccination.

Newswise:Video Embedded scientists-elucidate-how-dreadd-technology-highjacks-neuronal-activity
VIDEO
Released: 30-Nov-2022 1:05 PM EST
Scientists Elucidate How DREADD Technology Highjacks Neuronal Activity
University of North Carolina School of Medicine

Reported in Nature, UNC School of Medicine scientists used cryogenic electron microscopy to determine the detailed, high-resolution structures of four designer receptors bound to three drug-like but inert compounds, a major advance in chemogenetics research.

Newswise: Scientists Link Rare Genetic Phenomenon to Neuron Function, Schizophrenia
Released: 30-Nov-2022 11:45 AM EST
Scientists Link Rare Genetic Phenomenon to Neuron Function, Schizophrenia
University of North Carolina School of Medicine

UNC School of Medicine's Jin Szatkiewicz, PhD, and colleagues conducted one of the first and the largest investigations of tandem repeats in schizophrenia, elucidating their contribution to the development of this devastating disease.

Newswise: Multiple Stressors Contributed to Physician Burnout During First Wave of COVID-19 in the U.S.
Released: 10-Nov-2022 12:25 PM EST
Multiple Stressors Contributed to Physician Burnout During First Wave of COVID-19 in the U.S.
University of North Carolina School of Medicine

Front-line physicians who cared for COVID-19 patients during the first wave of the pandemic in New York City and New Orleans reported multiple factors that contributed to their occupational stress during this extraordinarily trying time in their careers.

Newswise: Scientists Reveal Role of Key Brain Protein in Childhood Movement Disorder
Released: 3-Nov-2022 2:50 PM EDT
Scientists Reveal Role of Key Brain Protein in Childhood Movement Disorder
University of North Carolina School of Medicine

Scientists in the U.S. and UK illuminated the molecular events underlying an inherited movement and neurodegenerative disorder known as ARSACS – Autosomal recessive spastic ataxia of Charlevoix-Saguenay, named for two Quebec valleys where the first cases were found.

Newswise: Scientists Discover Protein Partners that Could Heal Heart Muscle
Released: 6-Oct-2022 4:40 PM EDT
Scientists Discover Protein Partners that Could Heal Heart Muscle
University of North Carolina School of Medicine

Scientists at the UNC School of Medicine have made a significant advance in the promising field of cellular reprogramming and organ regeneration, and the discovery could play a major role in future medicines to heal damaged hearts.

Released: 29-Sep-2022 12:05 PM EDT
UNC-led Initiative Set to Gain Insights to Improve Posttraumatic Outcomes
University of North Carolina School of Medicine

Led By Sam McLean, MD, MPH, director of the UNC Institute for Trauma Recovery, researchers have established an $8-million initiative funded through the U.S. Department of Defense to overcome this lack of understanding.

Newswise: Can Scientists Take the Trip out of Psychedelics, Leaving only the Anti-depressant Effect?
28-Sep-2022 9:40 AM EDT
Can Scientists Take the Trip out of Psychedelics, Leaving only the Anti-depressant Effect?
University of North Carolina School of Medicine

Published in Nature, this research in animal models show it’s possible to create a compound that hits the same exact target as psychedelic drugs hit – the 5-HT2A serotonin receptors on the surface of specific neurons – but does not cause the same psychedelic effects when given to mice.

Newswise: Majority of Clinicians in U.S. Safety Net Practices Report ‘Moral Distress’ During COVID-19 Pandemic
Released: 26-Aug-2022 8:05 AM EDT
Majority of Clinicians in U.S. Safety Net Practices Report ‘Moral Distress’ During COVID-19 Pandemic
University of North Carolina School of Medicine

UNC School of Medicine’s Donald Pathman, MD, MPH, found that most healthcare providers experienced either mild or intense levels of moral distress during the first year of the pandemic due to issues related to patient care and their workplaces.

Newswise: Scientists Discover Surprise Anticancer Properties of Common Lab Molecule
Released: 23-Aug-2022 2:15 PM EDT
Scientists Discover Surprise Anticancer Properties of Common Lab Molecule
University of North Carolina School of Medicine

UNC School of Medicine scientists discovered that a molecule called EdU, which is commonly used in laboratory experiments to label DNA, is in fact recognized by human cells as DNA damage, triggering a runaway process of DNA repair that is eventually fatal to affected cells, including cancer cells.

Newswise: Scientists Create New Map of the Developing Cerebral Cortex
Released: 18-Aug-2022 12:30 PM EDT
Scientists Create New Map of the Developing Cerebral Cortex
University of North Carolina School of Medicine

Scientists at the UNC School of Medicine have mapped the surface of the cortex of the young human brain with unprecedented resolution, revealing the development of key functional regions from two months before birth to two years after.

Released: 8-Aug-2022 12:30 PM EDT
Scientists Create Long-acting Injectable Drug Delivery System for Tuberculosis
University of North Carolina School of Medicine

Research in animal models showed the potential of delivering a TB drug with one injection that lasts at least four months, in lieu of the current standard treatment requiring constant adherence to a daily drug regimen.

Newswise: Scientists Reveal Potential Role of Genetic Variants on Psychedelics’ Therapeutic Effects
Released: 27-Jul-2022 3:00 PM EDT
Scientists Reveal Potential Role of Genetic Variants on Psychedelics’ Therapeutic Effects
University of North Carolina School of Medicine

UNC School of Medicine researchers report that common genetic variations in one serotonin receptor could be a reason why people with psychiatric conditions, such as depression, respond differently to psychedelic treatments.

Released: 26-Jul-2022 4:05 PM EDT
Specific Brain Responses to Traumatic Stress Linked to PTSD Risk
University of North Carolina School of Medicine

Results from the largest prospective study of its kind indicate that in the initial days and weeks after experiencing trauma, individuals facing potentially threatening situations who had less activity in their hippocampus developed more severe posttraumatic stress disorder (PTSD) symptoms.

Released: 25-Jul-2022 3:15 PM EDT
Researchers Reveal Brain Changes, Differences in Children with ADHD
University of North Carolina School of Medicine

UNC scientists conducted a study to image the neural activity analogues to cognitive flexibility and discover differences in the brain activity of children with ADHD and those without.

Released: 19-Jul-2022 4:15 PM EDT
Scientists Reveal Genetic Architecture Underlying Alcohol, Cigarette Abuse
University of North Carolina School of Medicine

UNC School of Medicine researchers are beginning to parse the underlying genetic differences in people who abuse substances. The more they learn, the better chance they will be able to create therapies to help the millions of people who struggle with addiction.

Released: 5-Jul-2022 12:30 PM EDT
Fourth-generation Vaping Devices Increase Risk to Immune Cells
University of North Carolina Health Care System

Users of fourth-generation nicotine-salt-containing devices, such as Juul and disposable devices, display a unique mix of cellular biomarkers indicative of immune suppression.

Newswise: Scientists Discover Key to Hepatitis A Virus Replication, Show Drug Effectiveness
30-Jun-2022 3:30 PM EDT
Scientists Discover Key to Hepatitis A Virus Replication, Show Drug Effectiveness
University of North Carolina School of Medicine

UNC School of Medicine scientists discovered that hepatitis A viral replication requires specific interactions between a human protein and a group of enzymes, and they used a molecule to stop replication at this key interactive step, making it impossible for the virus to infect liver cells.

Newswise: Covid-19 Pandemic Increases Employment Disruptions Due to Childcare Insecurity
Released: 13-Jun-2022 9:05 AM EDT
Covid-19 Pandemic Increases Employment Disruptions Due to Childcare Insecurity
University of North Carolina School of Medicine

A study published in JAMA Pediatrics shows how frequently childcare insecurity during the COVID-19 pandemic occurred and the effect it had on parental job loss.

   
Newswise: Study Confirms Pathogenesis of EV-D68 Virus Causing Polio-like Paralyzing Illness in Children
Released: 26-May-2022 10:00 AM EDT
Study Confirms Pathogenesis of EV-D68 Virus Causing Polio-like Paralyzing Illness in Children
University of North Carolina School of Medicine

A case report published in the New England Journal of Medicine provides evidence that enterovirus D68 directly infects spinal cord neurons and that a corresponding robust immune response is present – a direct causation to the polio-like paralyzing illness, acute flaccid myelitis (AFM). Matthew Vogt, MD, PhD, assistant professor of pediatrics and microbiology & immunology at the UNC School of Medicine is the lead author of the study.

Newswise:Video Embedded visual-system-brain-development-implicated-in-infants-who-develop-autism
VIDEO
24-May-2022 2:05 PM EDT
Visual System Brain Development Implicated in Infants who Develop Autism
University of North Carolina School of Medicine

For the first time, scientists have found that brain differences in the visual brain systems of infants who later are diagnosed with autism are associated with inherited genetic factors.

Newswise: Scientists Use Machine Learning Models to Help Identify Long COVID Patients
Released: 17-May-2022 2:10 PM EDT
Scientists Use Machine Learning Models to Help Identify Long COVID Patients
University of North Carolina School of Medicine

Clinical scientists used machine learning models to explore de-identified electronic health record data in the National COVID Cohort Collaborative (N3C) to help discern characteristics of people with long COVID and factors that may help identify such patients using data from medical records.

Newswise: Researchers Reveal Moral Distress Impact, Actions to Support Doctors During Pandemic
Released: 16-May-2022 3:15 PM EDT
Researchers Reveal Moral Distress Impact, Actions to Support Doctors During Pandemic
University of North Carolina School of Medicine

During the COVID-19 pandemic, healthcare organizations, leaders, researchers, and practitioners have attempted on the fly to deal with the inherent stresses, strains, and struggles related to an unprecedented healthcare crisis in modern times.

Newswise: Can Spurring Neuron Growth in Adulthood Improve Cognitive Health, Mood?
Released: 16-May-2022 2:55 PM EDT
Can Spurring Neuron Growth in Adulthood Improve Cognitive Health, Mood?
University of North Carolina School of Medicine

UNC-Chapel Hill scientists boosted electrical activity between cells in the hypothalamus and the hippocampus to create new neurons – an important process called neurogenesis -- in animal models.

Released: 11-May-2022 1:15 PM EDT
Scientists Detect Common Fungicide in Pregnant Women and Children
University of North Carolina School of Medicine

For the first time, UNC-Chapel Hill scientists have measured the concentration of a biomarker of the commonly used fungicide azoxystrobin in the urine of pregnant women and children. They also documented maternal transfer of the chemical to mouse embryos and weaning-age mice.

   
Newswise: Gene Therapy Could Treat Pitt-Hopkins Syndrome, Proof-of-Concept Study Suggests
Released: 10-May-2022 12:30 PM EDT
Gene Therapy Could Treat Pitt-Hopkins Syndrome, Proof-of-Concept Study Suggests
University of North Carolina School of Medicine

University of North Carolina School of Medicine scientists, who report their results in the journal eLife, devised an experimental, gene-therapy-like technique to restore the normal activity of the gene deficient in people with Pitt-Hopkins syndrome.

Newswise: UNC Blood Clot Expert Working with NASA to Study Blood Flow, Clot Formation in Zero Gravity
Released: 3-May-2022 11:15 AM EDT
UNC Blood Clot Expert Working with NASA to Study Blood Flow, Clot Formation in Zero Gravity
University of North Carolina School of Medicine

In the ultimate use of telemedicine, Stephan Moll, MD, worked with NASA to treat a U.S. astronaut’s blood clot during a mission on the International Space Station. That led to a study on how blood flows in zero gravity, and if astronauts are at greater risk of developing blood clots in space.

Newswise: Scientists Detail Brain Dynamics Implicated in Neurological Conditions
Released: 2-May-2022 10:05 AM EDT
Scientists Detail Brain Dynamics Implicated in Neurological Conditions
University of North Carolina School of Medicine

This research in mice provides evidence for how dynamics in the default mode network of the brain are altered by activating the locus coeruleus region – a small nucleus in the brainstem that releases norepinephrine. It also suggests new targets for treatment to restore DMN function.

Newswise: Scientists Implicate Non-Cardiac Genes in Congenital Heart Disease
Released: 27-Apr-2022 3:15 PM EDT
Scientists Implicate Non-Cardiac Genes in Congenital Heart Disease
University of North Carolina School of Medicine

UNC-Chapel Hill, Princeton, and Boston Children’s Hospital researchers show how three transcription factors inside the embryonic heart recruit the protein subunit CHD4 for their role known roles in heart health and disease.

Newswise: UNC Landmark Study Paves the Way for Universal Obstetric Ultrasound
Released: 26-Apr-2022 2:00 PM EDT
UNC Landmark Study Paves the Way for Universal Obstetric Ultrasound
University of North Carolina School of Medicine

Establishing accurate gestational age with ultrasound early is essential to delivering high-quality care. Yet, the high cost for equipment and the need for trained sonographers limits its use in low-resource settings. A new study introduces a novel opportunity to democratize obstetric ultrasound.

Newswise: Study Shows Important Change in B-Cells in Women with PPD
Released: 8-Apr-2022 2:05 PM EDT
Study Shows Important Change in B-Cells in Women with PPD
University of North Carolina School of Medicine

A study published in Molecular Psychiatry is the first to look at multiple levels of biology within women with postpartum depression (PPD) to see how women with the condition differ from those without it.

Newswise: Scientists Unravel Biological Mechanisms for Severe COVID
Released: 7-Apr-2022 12:35 PM EDT
Scientists Unravel Biological Mechanisms for Severe COVID
University of North Carolina School of Medicine

This research illustrates the importance of a well-known cytokine called interleukin-13 in protecting cells against SARS-CoV-2, which helps explain the mystery of why people with allergic asthma fair better against COVID despite having a chronic lung condition.

Newswise: Scientists Identify Overgrowth of Key Brain Structure in Babies Who Later Develop Autism
24-Mar-2022 2:40 PM EDT
Scientists Identify Overgrowth of Key Brain Structure in Babies Who Later Develop Autism
University of North Carolina School of Medicine

Scientists have known the amygdala is abnormally large in school-age children with autism, but now, for the first time, researchers from the Infant Brain Imaging Study (IBIS) Network, used magnetic resonance imaging (MRI) to demonstrate that the amygdala grows too rapidly in infancy.

Newswise: UNC Health to Implement New Software to Support Cancer Care, Create Comprehensive Treatments
Released: 14-Mar-2022 2:15 PM EDT
UNC Health to Implement New Software to Support Cancer Care, Create Comprehensive Treatments
University of North Carolina Health Care System

This fall UNC Health is implementing a new software called Oncology Clinical Pathways that will facilitate a common high quality, evidence-based care standard across the entire UNC Health system of hospitals in North Carolina, ensuring that each patient receives the most up-to-date course of recommended cancer treatment.

Newswise: Scientists Map Entire Human Gut at Single Cell Resolution
Released: 18-Feb-2022 3:00 PM EST
Scientists Map Entire Human Gut at Single Cell Resolution
University of North Carolina School of Medicine

For the first time, scientists used entire human GI tracts from three organ donors to show how cell types differ across all regions of the intestines, to shed light on cellular functions, and to show gene expression differences between these cells and between individuals.

Released: 14-Feb-2022 12:05 PM EST
Study Shows Pandemic Has Adversely Affected Clinicians in Safety-Net Practices
University of North Carolina School of Medicine

In a recent article in the official journal of the U.S. Surgeon General, Public Health Reports, UNC Family Medicine's Donald Pathman, MD, MPH, UNC Social Medicine’s Jeffrey Sonis, MD, MPH, and colleagues assess how the pandemic has affected clinicians in outpatient, safety-net practices.

Newswise: Unexpected Insights on the Importance of Lymphatic Vessels in the Heart
Released: 13-Jan-2022 10:15 AM EST
Unexpected Insights on the Importance of Lymphatic Vessels in the Heart
University of North Carolina School of Medicine

Deleting VE-cadherin from the lymphatic vessels in newborn and adult lab mice caused the lymphatic vessels in the heart to regress and eventually disappear. This discovery could have important implications for immune function related to the heart.

Released: 15-Dec-2021 12:15 PM EST
Scientists Unveil Drug Discovery Tool to Screen More Than 11 Billion Compounds
University of North Carolina Health Care System

Scientists created a way to identify the best combinations of chemical building blocks to serve as seeds that can grow into a hierarchy of molecules with the best predicted ability to bind to the receptor targets. This allowed them to test 11 billion compounds, the largest drug screen to date.

Newswise: UNC-Led CORVASEQ Surveillance Program Detects Omicron Variant in North Carolina
Released: 15-Dec-2021 10:35 AM EST
UNC-Led CORVASEQ Surveillance Program Detects Omicron Variant in North Carolina
University of North Carolina School of Medicine

The Coronavirus Variant Sequencing (CORVASEQ) Surveillance Program, led by a team of UNC researchers, has detected the Omicron SARS-CoV-2 variant in North Carolina. Together, members of the program have sequenced more than 10,000 samples from COVID-19 positive patients to track the spread and development of the virus across the state.

Newswise: Lorenzo-press-release-image_smallest-300x292.jpg
Released: 29-Nov-2021 4:05 PM EST
Scientists Discover Biological Mechanisms Caused by Deficits in High-risk Autism Gene
University of North Carolina School of Medicine

Scientists demonstrated that rare variants in the ANK2 gene, consistently found in individuals with autism spectrum disorder (ASD), can alter architecture and organization of neurons, potentially contributing to autism

Newswise: DOD_DEVICE-IMAGE-289x300.png
Released: 26-Oct-2021 1:45 PM EDT
DOD Funds $4.3-million Initiative to Improve Sleep, Clearance of the Brain
University of North Carolina School of Medicine

The U.S. Department of Defense is funding the first human trial of a device to speed up and enhance the natural system of brain cleansing that occurs when we sleep.

   
22-Oct-2021 11:45 AM EDT
Gene Therapy Shows Early Promise as Angelman Syndrome Treatment
University of North Carolina School of Medicine

Scientists publish encouraging early tests of a gene therapy strategy against Angelman syndrome, a neurodevelopmental disorder that features poor muscle control and balance, hard-to-treat epilepsy, and intellectual disabilities.

Newswise:Video Embedded scientists-show-how-crucial-proteins-change-shape-inside-cells
VIDEO
Released: 20-Oct-2021 1:05 PM EDT
Scientists Show How Crucial Proteins Change Shape Inside Cells
University of North Carolina School of Medicine

Scientists can now pinpoint and track proteins that are in a desired shape in real time inside living cells. The scientists demonstrated the technique in, essentially, movies that track the active version of an important signaling protein – a molecule, in this case, important for cell growth.

Newswise: berkowitz-proposes-innovative-methodological-approach-to-studies-that-address-health-related-social-needs-image2-214x300.jpeg
18-Oct-2021 11:45 AM EDT
Adding SNAP Benefits for Older Adults in Medicare, Medicaid Can Reduce Hospital Visits, Healthcare Costs
University of North Carolina School of Medicine

A study published in Annals of Internal Medicine shows that participation in the Supplemental Nutrition Assistance Program (SNAP) by older adults dually enrolled in Medicare and Medicaid is associated with fewer hospital visits and lower healthcare costs. But millions of Americans do not take advantage of the program.

Released: 13-Oct-2021 10:00 AM EDT
UNC Partners with SECU Foundation to Increase Behavioral Health Care Access to Children through Telepsychiatry
University of North Carolina School of Medicine

The COVID-19 pandemic has turned an existing child and adolescent behavioral health crisis into an overwhelming epidemic affecting families across the nation, and especially in North Carolina. To address this urgent need, leaders in the UNC Department of Psychiatry are leading a pilot program funded in part by a $1.97 million grant from the SECU Foundation to the UNC Health Foundation.

Newswise: Malaria Parasite Evolving to Evade Rapid Diagnostics in Africa
Released: 28-Sep-2021 4:05 PM EDT
Malaria Parasite Evolving to Evade Rapid Diagnostics in Africa
University of North Carolina School of Medicine

This research, published in Nature Microbiology, showed that two genetic mutations to the parasite Plasmodium falciparum -- the most common cause of malaria cases and deaths -- allow it to escape detection from rapid tests.

21-Sep-2021 5:05 PM EDT
Therapy Using Dual Immune System Cells Effectively Controls Neuroblastoma
University of North Carolina School of Medicine

A newly developed immunotherapy that simultaneously uses modified immune-fighting cells to home in on and attack two antigens, or foreign substances, on cancer cells was highly effective in mice implanted with human neuroblastoma tissue.

Newswise: Scientists Pinpoint Problem Protein in Mucus
Released: 22-Sep-2021 3:15 PM EDT
Scientists Pinpoint Problem Protein in Mucus
University of North Carolina School of Medicine

This discovery, published in the Proceedings of the National Academy of Sciences (PNAS), suggest that MUC5AC could become a target of better therapeutics to untangle the super thick and sticky mucus that plays a role in health problems for millions of people suffering from pulmonary conditions.

Released: 25-Aug-2021 2:30 PM EDT
New Study Gives Insight into How Often COVID-19 Spreads through Households
University of North Carolina School of Medicine

A new study out in the Clinical Infectious Diseases journal demonstrates how quickly COVID-19 can spread through a household, and provides insight into how and why communities of color have suffered disproportionately from the pandemic.

11-Aug-2021 3:05 PM EDT
SuperSNAP Helps Food Insecure Households Afford Healthy Foods
University of North Carolina School of Medicine

Researchers at the University of North Carolina at Chapel Hill studied the effects of SuperSNAP, which is run through Reinvestment Partners out of Durham, NC, to see if the additional funds translated into the purchase of more healthful foods, setting the stage for better health outcomes.


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