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Newswise: Great Actions Leave a Mark campaign celebrates the Gift of Life through Living Organ Donation
7-Sep-2022 2:00 PM EDT
Great Actions Leave a Mark campaign celebrates the Gift of Life through Living Organ Donation
University Health Network (UHN)

UHN’s Ajmera Transplant Centre and The Centre for Living Organ Donation announce today the launch of a new campaign, Great Actions Leave a Mark, www.greatactions.ca. The campaign showcases through artistic photos and video, the stories and scars (the mark) from 39 living organ donors and transplant recipients across Canada.

Newswise: Anonymous $11 million gift to support and expand neurofibromatosis research at UHN's Krembil Brain Institute
Released: 17-May-2022 1:25 PM EDT
Anonymous $11 million gift to support and expand neurofibromatosis research at UHN's Krembil Brain Institute
University Health Network (UHN)

Anonymous $11M donation will go toward research, care for Neurofibromatosis patients

Newswise:Video Embedded living-donation-opens-new-doors-for-colorectal-cancer-patients-in-need-of-liver-transplants
VIDEO
28-Mar-2022 4:00 PM EDT
Living Donation Opens New Doors for Colorectal Cancer Patients in Need of Liver Transplants
University Health Network (UHN)

A study published in the Journal of the American Medical Association Surgery is the first in North America to demonstrate that living-donor liver transplant is a viable option for patients who have systemically controlled colorectal cancer and liver tumors that cannot be surgically removed.

Newswise: Gilla-Shapiro.png
6-Dec-2021 4:00 AM EST
Boys 10 times more likely to get HPV vaccine in provinces where programs are publicly funded
University Health Network (UHN)

Boys are 10 times more likely to be vaccinated against human papillomavirus (HPV) in provinces where the vaccine is publicly funded than in places where it is not, according to a new study published by a researcher at the Princess Margaret Cancer Centre and colleagues at McGill University, Université de Montréal, and the Jewish General Hospital.

Released: 17-Nov-2021 4:05 PM EST
Connecting the Dots for Health Data
University Health Network (UHN)

The Canadian Distributed Infrastructure for Genomics (CanDIG) is a collaboration of computer scientists, AI specialists, clinicians, and geneticists working together to enable studies needed to address the health challenges faced by Canadians.

Newswise:Video Embedded university-health-network-reported-top-canadian-research-commercialization-institution-for-2nd-year-running
VIDEO
Released: 1-Nov-2021 11:05 AM EDT
University Health Network reported top Canadian research commercialization institution for 2nd year running
University Health Network (UHN)

According to the latest Association of University Technology Managers (AUTM) North American Annual Licensing Survey, the University Health Network (UHN) ranks as the #1 research commercialization institution in Canada for the second year running according to gross licensing revenue from the research it has commercialized.

Newswise:Video Embedded new-study-reveals-heart-patients-orphaned-following-aortic-dissection-repair-despite-ongoing-risk-of-complications-and-death
VIDEO
Released: 27-Oct-2021 11:25 AM EDT
New study reveals heart patients "orphaned" following aortic dissection repair despite ongoing risk of complications and death
University Health Network (UHN)

A new study from the Peter Munk Cardiac Centre reveals that patients who survive an aortic dissection often fail to receive comprehensive post-surgical follow-up care leaving them vulnerable to a lifetime of sustained risk.

Newswise: Discovery of a potential new therapy for inflammatory arthritis
Released: 20-Oct-2021 2:25 PM EDT
Discovery of a potential new therapy for inflammatory arthritis
University Health Network (UHN)

Ankylosing spondylitis is a painful and inflammatory form of axial spondyloarthritis (SpA) which affects 1-2% of Canadians and causes inflammation in the spine, joints, eyes, gut and skin. In a new paper recently published in the journal Science Translational Medicine, researchers at the Schroeder Arthritis Institute at UHN have made a discovery that could lead to new treatments for SpA.

Newswise: World-first: experts at UHN, Sinai Health and SickKids develop plan to save critically ill mother and her baby
Released: 4-Oct-2021 8:25 AM EDT
World-first: experts at UHN, Sinai Health and SickKids develop plan to save critically ill mother and her baby
University Health Network (UHN)

Physicians recommend that patients with pulmonary hypertension avoid pregnancy, given the high risk of death for the mother and baby. However, Candice Cruise was unaware of her condition until she reached 21 weeks of pregnancy.

Newswise: Princess Margaret Cancer Centre researchers refine test to achieve 'ultrasensitive' detection of HPV in the bloodstream
Released: 27-Sep-2021 2:10 PM EDT
Princess Margaret Cancer Centre researchers refine test to achieve 'ultrasensitive' detection of HPV in the bloodstream
University Health Network (UHN)

Princess Margaret Cancer Centre researchers have made new findings which greatly improve detection of the human papillomavirus (HPV) in the bloodstream and could further hone precision treatment of the illness.

Released: 20-Aug-2021 6:00 PM EDT
Former Medical Director at Princess Margaret Cancer Centre to lead new commission on global cancer care
University Health Network (UHN)

Dr. Mary Gospodarowicz, former Medical Director of the Princess Margaret Cancer Centre, will co-chair a new The Lancet Commission on cancer and health systems as it examines and makes recommendations to improve global cancer care and health systems.

11-Aug-2021 2:40 PM EDT
World-first COVID vaccine booster randomized clinical trial in transplant patients proves third shot is very effective
University Health Network (UHN)

The study enrolled 120 transplant patients between May 25th and June 3rd. None of them had COVID previously and all of them had received two doses of the Moderna vaccine. Half of the participants received a third shot of the vaccine (at the 2-month mark after their second dose) and the other half received placebo. The primary outcome was based on antibody level greater than 100 U/ml against the spike protein of the virus. In the placebo group - after three doses (where the third dose was placebo), the response rate was only 18% whereas in the Moderna three-dose group, the response rate was 55%.

10-Aug-2021 5:20 PM EDT
World-First COVID Vaccine Booster Randomized Clinical Trial in Transplant Patients Proves Third Shot Is Very Effective
University Health Network (UHN)

The study enrolled 120 transplant patients between May 25th and June 3rd. None of them had COVID previously and all of them had received two doses of the Moderna vaccine. Half of the participants received a third shot of the vaccine (at the 2-month mark after their second dose) and the other half received placebo. The primary outcome was based on antibody level greater than 100 U/ml against the spike protein of the virus. In the placebo group - after three doses (where the third dose was placebo), the response rate was only 18% whereas in the Moderna three-dose group, the response rate was 55%.

2-Aug-2021 8:00 AM EDT
Princess Margaret Cancer Centre Researchers Discover Key Stem Cell Dormancy Mechanism Which Could Help Unlock Future Cancer Treatments
University Health Network (UHN)

Princess Margaret Cancer Centre researchers have made new findings which provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers.

Released: 13-Jul-2021 4:00 PM EDT
Study Finds Disparity in Pay for Female Ophthalmologists in Ontario, Canada
University Health Network (UHN)

A team led by researchers and clinicians from the Donald K. Johnson Eye Institute, part of the Krembil Research Institute at University Health Network (UHN), studied 22,389 Ontario physicians across three decades and found a significant payment gap between female and male ophthalmologists even after accounting for age, and some practice differences. This disparity was more pronounced among ophthalmologists when compared to other surgical, medical procedural and medical non-procedural specialty groups.

8-Jul-2021 2:05 PM EDT
Concussion calculator predicts recovery time, risk of long-term symptoms
University Health Network (UHN)

The ability to determine who will recover quickly, and who will continue to suffer from symptoms has largely eluded the medical community. Until now.

Released: 4-Jun-2021 12:20 PM EDT
UHN announces first-in-Canada Social Medicine Modular Housing in Parkdale, in partnership with the City and United Way Greater Toronto
University Health Network (UHN)

University Health Network (UHN) and the Gattuso Centre for Social Medicine, in partnership with the City of Toronto and United Way Greater Toronto (UWGT), are creating what is believed to be the first of its kind in Canada, Social Medicine Supportive Housing site in Parkdale, Toronto.

3-Jun-2021 10:00 AM EDT
AI outperforms humans in creating cancer treatments, but do doctors trust it? It depends!
University Health Network (UHN)

The impact of deploying Artificial Intelligence (AI) for radiation cancer therapy in a real-world clinical setting has been tested by Princess Margaret researchers in a unique study involving physicians and their patients.

   
7-May-2021 1:00 PM EDT
Turning a pancreatic cancer cell’s addiction into a death sentence
University Health Network (UHN)

Probing the unique biology of human pancreatic cancer cells in a laboratory has yielded unexpected insights of a weakness that can be used against the cells to kill them. Led by Princess Margaret Cancer Centre Scientist Dr. Marianne Koritzinsky, researchers showed that about half of patient-derived pancreatic cancer cell lines are highly dependent or “addicted” to the protein peroxiredoxin 4 (PRDX4), as a result of the altered metabolic state of the cancer cell. This addiction, which is vital for the cancer cell's survival, makes it a precise, potential target against the cancer.

13-Apr-2021 9:05 PM EDT
Triple Combination Therapy Shows Promise Against a Rare Deadly Asbestos Cancer
University Health Network (UHN)

Combining immune-boosting drugs with radiation and surgery increased the survival and anticancer immune response in mouse models of mesothelioma in preclinical research by Princess Margaret Cancer Centre researchers.

12-Apr-2021 8:05 AM EDT
Deep Learning model developed at UHN to maximize lifespan after liver transplant
University Health Network (UHN)

Researchers from University Health Network have developed and validated an innovative deep learning model to predict a patient’s long-term outcome after receiving a liver transplant.

Released: 12-Apr-2021 3:05 PM EDT
Double-Lung Transplant After COVID-19 Performed in Canada
University Health Network (UHN)

Case done at University Health Network is believed to be a first in Canada on a patient whose lungs were irreparably damaged by COVID-19

4-Mar-2021 6:00 AM EST
Digital solutions including remote monitoring can help chronic pain sufferers manage their pain and reduce the probability of misuse of prescription opioids.
University Health Network (UHN)

For the first time, an app has been shown to reduce key symptoms of chronic pain. A UNH-led study evaluated the impact of Manage My Pain(MMP), a digital health solution on chronic pain patients.

   
Released: 26-Feb-2021 2:40 PM EST
Ontario network goes national, to improve care for all Spinal Cord Injury patients – regardless of where they live
University Health Network (UHN)

An Ontario network of Spinal Cord Injury (SCI) rehabilitation sites and patient partners, committed to raising the standard of SCI rehabilitation care, is expanding across Canada, to ensure equitable, optimal care for all patients, regardless of where they live.

24-Feb-2021 10:00 AM EST
A Canadian success story: world-first to treat Fabry disease with gene therapy
University Health Network (UHN)

Results of a world-first Canadian pilot study on patients treated with gene therapy for Fabry disease show that the treatment is working and safe.

19-Feb-2021 10:00 AM EST
Turbocharging the killing power of immune cells against cancer
University Health Network (UHN)

Creating “super soldiers” of specific white blood cells to boost an anti-tumour response has been shown in a series of elegant experiments by Princess Margaret researchers.

18-Feb-2021 6:00 AM EST
UHN launches study to explore how Apple Watch can help with early identification of worsening heart failure
University Health Network (UHN)

Dr. Heather Ross launches a clinical study, with Apple to test if remote monitoring with Apple Watch can help with early identification of worsening heart failure. Data collected using an Apple Watch will be compared to data routinely collected from rigorous physical tests patients normally undergo.

16-Feb-2021 5:00 AM EST
New classification of leukemia subtypes reveals potential of personalized treatment using existing drugs
University Health Network (UHN)

Using advanced RNA sequencing, scientists have identified two unique subtypes of a prominent mutation present in many patients with Acute Myeloid Leukemia (AML) – called NPM1 – that could help predict survival and improve treatment response for patients whose leukemic cells bear the mutation.

12-Feb-2021 5:00 AM EST
Promising new approach to stop growth of brain cancer cells
University Health Network (UHN)

Stand Up to Cancer Canada Dream Team is combining strengths of Princess Margaret, SickKids, University of Toronto researchers, and other unique partnerships, to accelerate new cures for hard-to-treat cancers, such as glioblastoma.

4-Feb-2021 2:30 PM EST
Peginterferon-lambda shows strong antiviral action to accelerate clearance of COVID-19
University Health Network (UHN)

A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients – patients who do not need to be hospitalized. This could become an important intervention to treat infected patients and help curb community spread, while COVID-19 vaccines are rolled out this year.

Released: 4-Feb-2021 6:00 AM EST
Maad’ookiing Mshkiki — Sharing Medicine: Connecting Indigenous Communities with Culturally Relevant COVID-19 Vaccine Information
University Health Network (UHN)

Unpacking biomedicine, traditional knowledges and healing practices though oral storytelling and visualizations to support First Nations, Inuit and Métis in making informed choices.

Released: 2-Feb-2021 6:00 AM EST
Test for early detection of heart problems reduces risk of heart damage from chemotherapy
University Health Network (UHN)

Results of a multi-centre, international, clinical trial co-led by Peter Munk Cardiac Centre (PMCC) cardiologist Dr. Dinesh Thavendiranathan point to the benefit of using a more sensitive test to detect heart function issues early, so cancer patients don’t have to fight heart failure too.

Released: 12-Jan-2021 8:05 AM EST
High levels of distress and burnout identified among clinicians at leading cardiac centre
University Health Network (UHN)

More than half the clinicians surveyed at the Peter Munk Cardiac Centre reported burnout and high levels of distress according to a series of studies published today in the Canadian Medical Association Journal Open (CMAJ-OPEN). In these studies carried out before the COVID-19 pandemic, 78% of nurses, 73% of allied health staff and 65% of physicians described experiencing burnout.

Released: 7-Jan-2021 3:45 PM EST
Cancer Cells Hibernate Like Bears to Evade Harsh Chemotherapy
University Health Network (UHN)

Princess Margaret Scientist Dr. Catherine O’Brien and team discovered that cancer cells hijack an evolutionary conserved program to survive chemotherapy. Furthermore, the researchers show that novel therapeutic strategies aimed at specifically targeting cancer cells in this slow-dividing state can prevent cancer regrowth.

Released: 7-Jan-2021 2:40 PM EST
COVID-19 Accelerates Cancer Virtual Care with Quality, Convenience and Cost Savings
University Health Network (UHN)

Research led by Princess Margaret Radiation Oncologist Dr. Alejandro Berlin showed that virtual care can be implemented rapidly and safely across a highly-specialized and high-volume cancer centre. Eighty (80) per cent of patients reported they were either very satisfied or satisfied with it, citing convenience as a main factor, with 72 per cent of physicians reporting similar satisfaction with it.

6-Jan-2021 5:00 AM EST
Common drug may protect hearts from damage caused by breast cancer chemotherapy
University Health Network (UHN)

New research from UHN’s Peter Munk Cardiac Centre (PMCC) shows statins, commonly prescribed to lower cholesterol and reduce the risk of heart disease and stroke, may also protect the heart from damaging side-effects of early breast cancer treatment.

22-Dec-2020 12:00 PM EST
International Trials of Blood Thinners in Critically Ill COVID-19 Patients Pause Due to Futility
University Health Network (UHN)

Three clinical trial platforms working together to test the effects of full doses of anticoagulants (blood thinners) in COVID-19 patients have paused enrollment for one group of patients. Among critically ill COVID-19 patients requiring intensive care unit (ICU) support, full dose anticoagulation drugs did not improve outcomes. Enrollment continues for moderately ill hospitalized COVID-19 patients in the trials.

Released: 14-Dec-2020 12:45 PM EST
First doses of COVID-19 vaccine in Canada given by University Health Network
University Health Network (UHN)

University Health Network (UHN) today gave the first COVID-19 vaccine in Canada. This landmark event signals a potential turning point in the pandemic and underlines the value of science and worldwide cooperation.

25-Nov-2020 10:30 AM EST
Mapping out the mystery of blood stem cells
University Health Network (UHN)

Princess Margaret scientists have revealed how stem cells are able to generate new blood cells throughout our life by looking at vast, uncharted regions of our genetic material that hold important clues to subtle biological changes in these cells.

10-Nov-2020 11:00 AM EST
Canadian discovery: a potential game-changer to reverse alcohol intoxication
University Health Network (UHN)

In a study published today in Scientific Reports, a Nature Research Journal, a team of researchers led by Dr. Joseph Fisher presents a proof of concept of a simple method that could become a game-changer in rescue therapy for severe alcohol intoxication, as well as just “sobering up.”

Released: 21-Oct-2020 12:55 PM EDT
Genome archeologists discover a path to activate the immune response against cancer
University Health Network (UHN)

Ancient embedded elements in our DNA from generations past can activate a powerful immune response to kill cancer cells like an infection.

14-Oct-2020 11:00 AM EDT
Scientists Voice Concerns, Call for Transparency and Reproducibility in AI Research
University Health Network (UHN)

In an article published in Nature on October 14, 2020, scientists at Princess Margaret Cancer Centre, University of Toronto, Stanford University, Johns Hopkins, Harvard School of Public Health, Massachusetts Institute of Technology, and others, challenge scientific journals to hold computational researchers to higher standards of transparency, and call for their colleagues to share their code, models and computational environments in publications.

Released: 9-Oct-2020 8:10 AM EDT
‘Incredibly generous’ $25 million donation to create the Schroeder Arthritis Institute at UHN, consolidating research, education and patient care under one global brand
University Health Network (UHN)

One in five Canadian adults is currently living with arthritis, a disease causing inflammation of the joints, which can result in chronic, debilitating pain, reduced mobility and premature disability. Arthritis is the leading cause of disability globally. To address this growing crisis, the Schroeder Arthritis Institute, launched with a $25 million donation by philanthropists Walter and Maria Schroeder, will help UHN’s innovative arthritis program become a world-class hub for innovation in research, education and patient care.

   
Released: 18-Sep-2020 12:55 PM EDT
UHN features Apple Watch in a new study to advance remote management of heart failure
University Health Network (UHN)

The Ted Rogers Centre for Heart Research, at the Peter Munk Cardiac Centre (University Health Network) are collaborating with Apple, Inc., to give heart failure patients even more control over their health, and usher in a new era of remote monitoring possibilities.

25-Aug-2020 11:00 AM EDT
International cardiology trial shows potential benefit of using personalized medicine in blood thinner therapy selection
University Health Network (UHN)

An international, first-of-its-kind cardiology trial used personalized genetic testing to reduce by 34 per cent the number of serious adverse events following balloon angioplasty, a treatment for the most common form of heart disease.

Released: 21-Aug-2020 11:45 AM EDT
Developing precise medicines for triple negative breast cancer
University Health Network (UHN)

Taking advantage of a cancer cell’s altered metabolism that drives its runaway growth, Princess Margaret researchers are zeroing in on these molecular changes to help them develop more precise drug targets for one of the most deadly breast cancers.

Released: 3-Aug-2020 1:00 PM EDT
A blood test could predict who benefits from immunotherapy
University Health Network (UHN)

A test which detects changing levels of tumour fragments in the blood may be an easy, non-invasive and quick way to predict who will benefit from immunotherapy, a treatment option for advanced cancers.

Released: 9-Jul-2020 5:00 AM EDT
Medical Cannabis put to the test in first ever real-world evidence clinical trial led by UHN
University Health Network (UHN)

Medical cannabis is finally being put under the microscope, in a first-of-its-kind real world evidence study led by Dr. Hance Clarke, Toronto General Hospital. In the Medical Cannabis Real-World Evidence trial patients using the online portal created by Medical Cannabis by Shoppers, will know exactly what is in their product and its effectiveness.

22-Jan-2020 5:55 PM EST
New Drug Target for Prostate Cancer Found in the Non-Coding Genome
University Health Network (UHN)

Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design.

Released: 12-Nov-2019 5:30 AM EST
‘It’s not about just surviving. It’s about seeing my patients living normally’
University Health Network (UHN)

Dr. Eugene Chang was 25, recently engaged and halfway through a physical medicine and rehabilitation residency in Vancouver when he started feeling sick. Fatigue, dizziness and nausea took over his normally active lifestyle. Suddenly his bike to work was not so easy.


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