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Opioid Dependence Found to Permanently Change Brains of Rats

University of California San Diego Health

Approximately one-quarter of patients who are prescribed opioids for chronic pain misuse them, with five to 10 percent developing an opioid use disorder or addiction. In a new study, UC San Diego researchers found that opioid dependence produced permanent changes in the brains of rats.

Channels: Addiction, All Journal News, Drugs and Drug Abuse, Mental Health, Neuro, Pain, Psychology and Psychiatry, Substance Abuse, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), PNAS, Staff Picks,

Released:
24-Jan-2020 1:05 PM EST
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Liver Fibrosis 'Off Switch' Discovered in Mice

University of California San Diego Health

UC San Diego School of Medicine researchers identified several genetic switches, or transcription factors, that determine whether or not liver cells produce collagen — providing a new therapeutic target for liver fibrosis.

Channels: Cell Biology, Digestive Disorders, Genetics, Liver Disease, All Journal News,

Released:
23-Jan-2020 1:45 PM EST
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Newswise: Zika Virus’ Key into Brain Cells ID’d, Leveraged to Block Infection and Kill Cancer Cells
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    16-Jan-2020 11:00 AM EST

Zika Virus’ Key into Brain Cells ID’d, Leveraged to Block Infection and Kill Cancer Cells

University of California San Diego Health

Two different UC San Diego research teams identified the same molecule — αvβ5 integrin — as Zika virus’ key to brain cell entry. They found ways to take advantage of the integrin to both block Zika virus from infecting cells and turn it into something good: a way to shrink brain cancer stem cells.

Channels: Cancer, Cell Biology, Children's Health, Healthcare, Infectious Diseases, OBGYN, Stem Cells, Vaccines, Zika Virus, National Institutes of Health (NIH), Cell (journal), All Journal News,

Released:
14-Jan-2020 3:35 PM EST
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Newswise: Researchers Identify Gene with Functional Role in Aging of Eye

Researchers Identify Gene with Functional Role in Aging of Eye

University of California San Diego Health

Researchers say a gene known to be a biomarker of age plays a key role in age-associated functional and anatomical aging in mouse retinas, a finding that has direct relevance to age-related eye diseases.

Channels: Aging, Genetics, Vision, All Journal News,

Released:
15-Jan-2020 1:15 PM EST
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Newswise: In Mice, Alcohol Dependence Results in Brain-Wide Remodeling of Functional Architecture
Released:
14-Jan-2020 4:50 PM EST
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Newswise: Unfruitful: Eating More Produce Will Not Cure, Stop Prostate Cancer

Unfruitful: Eating More Produce Will Not Cure, Stop Prostate Cancer

University of California San Diego Health

University of California San Diego School of Medicine researchers report that patients with prostate cancer assigned to eat seven or more servings of vegetables and fruits daily saw no extra protection from the increased consumption of micronutrients, running contrary to current thought.

Channels: Cancer, Clinical Trials, Exercise and Fitness, Health Food, Healthcare, Men's Health, Nutrition, National Institutes of Health (NIH), JAMA, All Journal News,

Released:
14-Jan-2020 12:30 PM EST
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Newswise: How Marijuana Accelerates Growth of HPV-related Head and Neck Cancer Identified
Released:
13-Jan-2020 11:55 AM EST
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Newswise: Taking One for the Team: How Bacteria Self-Destruct to Fight Viral Infections
  • Embargo expired:
    10-Jan-2020 11:00 AM EST

Taking One for the Team: How Bacteria Self-Destruct to Fight Viral Infections

University of California San Diego Health

UC San Diego School of Medicine researchers have discovered how a new immune system works to protect bacteria from phages, viruses that infect bacteria — new information that could be leveraged to improve treatment of multidrug-resistant bacterial infections by refining phage therapy.

Channels: Drug Resistance, Immunology, Infectious Diseases, Pharmaceuticals, National Institutes of Health (NIH), All Journal News,

Released:
8-Jan-2020 4:05 PM EST
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Newswise: Lonely in a Crowd: Overcoming Loneliness with Acceptance and Wisdom
  • Embargo expired:
    10-Jan-2020 3:00 AM EST
Released:
8-Jan-2020 2:35 PM EST
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Newswise: The Birds and the Bats: Evolving to Fly May Have Had Big Effect on Gut Microbiome
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    7-Jan-2020 6:00 AM EST

The Birds and the Bats: Evolving to Fly May Have Had Big Effect on Gut Microbiome

University of California San Diego Health

UC San Diego researchers studied nearly 900 vertebrate species and found that bats have unusual gut microbiomes that more closely resemble those of birds than other mammals, raising questions about how evolutionary pressures change the gut microbiome

Channels: Birds, Microbiome, Nature, Wildlife, All Journal News,

Released:
3-Jan-2020 2:25 PM EST
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