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For many people with classical Hodgkin lymphoma, the disease is one of the most curable forms of cancer with standard chemotherapy or chemo plus radiotherapy. But for the 10 to 30 percent of patients whose cancer relapses, or doesn’t respond to initial therapy, secondary treatment often involves harsher chemotherapies followed by an autologous stem cell transplant, which uses a patient’s own stem cells.

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Every day, City of Hope physicians, scientists and researchers are making a difference in the lives of people from around the world who have been diagnosed with cancer

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There are several types of gynecologic cancers that affect the female reproductive system, including endometrial, ovarian, cervical, vaginal and vulvar cancer.

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Max Martin, Hans Zimmer, Jack Antonoff and the Chainsmokers announced as honorees for Songs of Hope XIII — benefiting City of Hope.

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As a nurse coordinator in City of Hope’s Department of Hematology & Hematopoietic Cell Transplantation, Christine Magnus Moore, R.N., B.S.N., has cared for patients going through the most challenging circumstances one can imagine.

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Mona Jung’s father had an attitude of quiet resignation to lung cancer — especially when it came to the side effects of his treatment. When nausea and fatigue overwhelmed him, he said nothing. When hunger eluded him, he played the tough guy. Yet, when Elvis Ngai Kwan went to visit his oncologist he painted a positive picture of his health.

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An international team of researchers led by City of Hope’s Bart Roep, Ph.D., the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes and professor/founding chair of the Department of Diabetes Immunology, has been able to justify an alternative theory about the cause of type 1 diabetes (T1D) through experimental work. The study results were published online today in the journal Nature Medicine.

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A large silver bell hangs on a wooden plaque at the entrance of City of Hope | Antelope Valley’s chemotherapy infusion area.

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City of Hope patient Susan Young has had a remarkable response to a potentially revolutionary new treatment, a combination of the p53 cancer vaccine and a drug that blocks a specific cancer-aiding protein.

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If your monthly breast self-exam happens in the shower — sporadically — and involves a quick once-over of your breasts, you may be missing some important elements of an effective exam. In truth, the best and most thorough breast self-exam you can perform is a multistep process, involving more than just the breasts themselves

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A sudden breast cancer diagnosis will shake even the hardiest soul. But when Linh Quan received her news in the Spring of 2012, it was like being doubly kicked when she was already down.

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Many know Botox as a trendy way to get rid of wrinkles, but the popular drug — made from botulinum neurotoxin (BoNT) — can do more than just fill lines.

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Multicenter, phase II trial suggests autologous transplant should be standard of care for HIV patients with relapsed/treatment-resistant lymphoma.

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While we look to invent new medicines to treat cancer, a parallel approach to repurpose existing medicines may be highly effective. Stress, mediated by adrenaline, has been suspected to promote cancer growth and this research study shows that by blocking adrenaline receptors in breast cancers, they are less successful in spreading to and growing in the brain.

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For many cancer survivors, being hit with the news that cancer has returned can be a devastating blow; a moment that tests the strength and courage of even the toughest of patients.

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Clinical trials that lay the groundwork for novel leukemia and lymphoma treatments will be among the highlights of the annual meeting of the American Society of Hematology (ASH) getting under way this week in Orlando. The trials, presented by researchers and physicians from City of Hope, could ultimately lead to innovative therapeutic approaches that improve survival and quality of life for patients with those and other diseases.

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For people who have battled cancer, every new day is a new adventure. No one knows that better than the cancer doctor, nurse researcher and five cancer patients who will be riding City of Hope’s float at the 127th Tournament of Roses Parade on New Year’s Day.

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With open enrollment for the Covered California health exchange now underway, City of Hope has announced an agreement with Blue Shield of California to participate in the insurer’s Individual and Family Plan products.

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In a clinical trial to be launched at City of Hope in November, researchers Don J. Diamond, Ph.D., Vincent Chung, M.D., and their collaborators will combine an immune-boosting vaccine and a drug that blocks a tumor’s inhibitory signal to more effectively activate a patient’s own immune system to fight his or her cancer.

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Steven T. Rosen, M.D., provost and chief scientific officer for City of Hope, will receive a Lifetime Achievement Award from the Israel Cancer Research Fund (ICRF) on Nov. 18 at a Chicago gala attended by hundreds of supporters of cancer research. The award recognizes Rosen’s longstanding commitment to advancing science and medicine and providing extraordinary patient care.

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Renowned health care leader Glenn D. Steele Jr., M.D., Ph.D., the recent past president and chief executive officer of Geisinger Health System, will join the City of Hope board of directors beginning Jan. 1, 2016.

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The National Institutes of Health has awarded City of Hope a five-year, $4.8 million grant to study the possible role of chemicals in the environment in the development of breast cancer during the menopausal transition in women.

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The National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) has awarded a $2.2 million grant to help City of Hope researchers explore the underlying mechanisms of graft-versus-host disease, the leading cause of long-term sickness and death following transplantation of bone marrow cells from a donor.

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Renowned health care leader Glenn D. Steele Jr., M.D., Ph.D., the recent past president and chief executive officer of Geisinger Health System, will join the City of Hope board of directors beginning Jan. 1, 2016.

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Called “The Miracle of Science with Soul,” the new campaign is the first-ever broad communications program by City of Hope, which pioneered the technology behind cancer treatment game-changers trastuzumab (Herceptin®), bevacizumab (Avastin®) and rituximab (Rituxan®), as well as synthetic human insulin for the treatment of diabetes. The campaign is centered around the real stories of six patients who showcase how City of Hope fuses science and research innovation with compassionate care in order to save lives.

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Nationally renowned breast cancer and ovarian cancer specialist Victoria L. Seewaldt, M.D., has joined City of Hope as the Ruth Ziegler Chair in Population Sciences. An expert in cancer prediction and prevention, Seewaldt will advance the institution’s efforts to ensure its research reflects and represents the diversity within City of Hope’s community.

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The Judy and Bernard Briskin Family Foundation has announced a gift to launch the new Judy and Bernard Briskin Center for Multiple Myeloma Research at City of Hope, the third named center within City of Hope’s new Hematologic Malignancies and Stem Cell Transplantation Institute. The generous gift will enable the institution to further its already considerable accomplishments in the field of myeloma treatment and research.

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Renowned research scientist Debbie C. Thurmond, Ph.D., has joined City of Hope as professor and founding chair of the Department of Molecular and Cellular Endocrinology within the institution’s new Diabetes & Metabolism Research Institute. Thurmond will lead City of Hope’s efforts to develop new diabetes treatments, focusing on potential therapies that can reverse or prevent the onset of the disease.

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A multinational team of physicians and scientists from City of Hope, the San Francisco Bay area and Europe recently reported success of a phase II clinical trial of a novel drug against essential thrombocythemia (ET), one of three myeloproliferative neoplasms (MPNs).

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Physicians in the newly launched Diabetes & Metabolism Research Institute at City of Hope are now providing islet cell transplantation to suitable candidates through a clinical trial that they believe will be the first step in a multipronged effort to permanently cure type 1 diabetes.

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Already pioneers in the use of immunotherapy, City of Hope researchers are now testing the bold approach to cancer treatment against one of medicine’s biggest challenges: brain cancer. This month, they will launch a clinical trial using patients’ own modified T cells to fight advanced brain tumors.

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New research from City of Hope has found that stimulating a specific gene could prompt growth – in adults – of new neurons in this critical region, leading to faster learning and better memories.

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Renowned musician George Winston and 17-year-old girl prepare for emotional introduction to donors who saved their lives.

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New City of Hope study finds that a cancer-prone mutation of the gene RECQ4 causes its corresponding enzyme, RECQ4, to accumulate in the mitochondria. This can cause mitochondrial dysfunction, possibly explaining cancer's "Warburg effect" of preferring lactic acid fermentation over aerobic respiration to generate energy.

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PCNA is a protein essential to DNA repair and replication, and City of Hope researchers are targeting it in neuroblastoma cells in order to halt tumor growth and induce cell death.

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City of Hope researchers found that a microRNA called miR-105 helps cancer metastasize by breaking down the building blocks of blood vessels' barriers, allowing the cancer cells to enter the bloodstream.

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A novel compound, COH-SR4, synthesized at City of Hope can target and treat drug-resistant lung cancers.

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City of Hope researchers found that menopausal hormone therapy use is linked to a lower risk of B-cell non-Hodgkin lymphoma.

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A team of City of Hope researchers, lead by Yani Lu, Ph.D., found that a parent’s age at birth, particularly a father’s age, may affect the adult-onset cancer risk for daughters — especially for breast cancer.