The Broad Institute of MIT and Harvard announces the appointments of Chief Operating Officer Samantha Singer and Chief Communications Officer Clare Midgley to its senior leadership team. They join Chief Development Officer Justine Levin-Allerhand who was recruited to the Broad last year.
The Broad Institute today announced that the United States Patent and Trademark Office has issued the first patent for an engineered CRISPR-Cas9 system that is enabling scientists to modify genes and better understand the biology of living cells and organisms.
AstraZeneca and the Broad Institute in Cambridge, Massachusetts today announce a collaboration to identify new chemical compounds targeting bacterial and viral infections that could speed the development of new antibacterial and antiviral drugs.
Melanoma - the deadliest and most aggressive form of skin cancer - has long been linked to time spent in the sun. Now a team led by scientists from the Broad Institute and Dana-Farber Cancer Institute has sequenced the whole genomes of 25 metastatic melanoma tumors, confirming the role of chronic sun exposure and revealing new genetic changes important in tumor formation.
Neuroscientist and former head of the NIMH will be the Center’s new director
New space will adjoin existing building, consolidating operations and fueling scientific collaborations
The true power of genomic research lies in its ability to help scientists understand biological processes, particularly those that – when altered – can lead to disease. This power is demonstrated dramatically in a pair of papers published today in the journal Nature. In the first, a global team of researchers describes 95 different variations across the genome that contribute in different degrees to alterations in blood cholesterol and triglyceride levels in multiple human populations. In the second report, close examination of just one of these common variants not only reveals the involvement of an unexpected genetic pathway in lipid metabolism but also provides a blueprint for using genomic findings to unravel biological connections between lipid levels and coronary heart disease.
Large-scale study reveals DNA segments missing or duplicated in tumors, uncovers novel cancer genes and genetic abnormalities shared across cancers.
Mexican business leader Carlos Slim Helú today announced the launch of a major research project in genomic medicine that will help accelerate progress in public health in Mexico and around the world.
Fossils may provide tantalizing clues to human history but they also lack some vital information, such as revealing which pieces of human DNA have been favored by evolution because they confer beneficial traits — resistance to infection or the ability to digest milk, for example. Now, researchers describe a method for pinpointing these preferred regions that offers greater precision and resolution than ever before, and the possibility of deeply understanding both our genetic past and present.
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation. When the gene is missing from the donor’s genome but present in the recipient’s, transplants have a greater risk of a serious side-effect known as graft-versus-host disease, in which immune cells from the donor attack tissues in the recipient.
New molecule neutralizes key protein, once thought to be “undruggable,” with roles in leukemia and other cancers
An international team of researchers has decoded the genome of the domestic horse Equus caballus, revealing a genome structure with remarkable similarities to humans and more than one million genetic differences across a variety of horse breeds. In addition to shedding light on a key part of the mammalian branch of the evolutionary tree, the work also provides a critical starting point for mapping disease genes in horses.
In one of the first studies of its kind, an international team of researchers has uncovered a single-letter change in the genetic code that is associated with autism. The finding, published in the October 8 issue of the journal Nature, implicates a neuronal gene not previously tied to the disorder and more broadly, underscores a role for common DNA variation.
In a study published in the September 24th issue of Nature, an international team describes how they harnessed modern genomic technology to explore the ancient history of India, the world’s second most populous nation.
An international research team has decoded the genome of the notorious organism that triggered the Irish potato famine in the mid-19th century and now threatens this season’s tomato and potato crops across much of the US. The study reveals an unusually large genome size — more than twice that of closely related species — and an extraordinary genome structure, which together appear to enable the rapid evolution of genes, particularly those involved in plant infection.
Scientists have deciphered a key molecular circuit that enables the body to distinguish viruses from bacteria and other microbes, providing a deep view of how immune cells in mammals fend off different pathogens.
The Multiple Myeloma Research Foundation (MMRF) and the Broad Institute of MIT and Harvard launch a collaboration to systematically uncover the molecular changes underlying multiple myeloma by whole genome sequencing of individual patient tumors. The MMRF will provide initial resources and valuable multiple myeloma tumor samples.
Researchers have uncovered a vast new class of previously unrecognized mammalian genes that do not encode proteins, but instead function as long RNA molecules, and seem to play critical roles in both health and disease, including cancer, immune signaling and stem cell biology.
Scientists today announced the results of the largest genomic study to date of lung adenocarcinoma, the most common form of lung cancer. The researchers pinpointed a variety of genetic alterations in patient tumors, more than doubling the number of genes linked to the disease. Importantly, the work highlights key molecular defects in lung tumors that are often found in other forms of cancer, a convergence that could open important avenues for treatment.
Scientists have reached a critical milestone in the study of liver cancer that lays the groundwork for predicting the illness's path, whether toward cure or recurrence. The findings were made possible by a large-scale method for revealing genes' activity, which the researchers show can be applied to tissues that have been chemically preserved instead of frozen.
Researchers at the Broad Institute of Harvard and MIT received a grant from the National Institutes of Health (NIH) to map the epigenomes of a variety of medically important cell types, including human embryonic stem cells. The work aims to transform the understanding of an exquisite control system "” a code of so-called "epigenetic" cues that specify when and where in the body genes are made active.
Los Angeles-based philanthropists Eli and Edythe Broad announced today that they have increased their total gift to the Broad Institute of Harvard and MIT to $600 million. Adding to their previous gifts totaling $200 million, the Broads today gave an endowment of $400 million to convert the Institute, which had been launched as a 10-year "venture" experiment, into a permanent biomedical research organization aimed at transforming medicine.
Researchers at the Broad Institute of Harvard and MIT have been chosen to receive a six-year, ~ $86M grant from the National Institutes of Health (NIH) to identify and develop molecular tools known as "small molecules", which can probe the proteins, signaling pathways and cellular processes that are crucial to human health and disease.
On September 4, a major announcement will be made about the future of the Broad Institute of MIT and Harvard, followed by media availability and teleconference.
Researchers are collecting vast amounts of genomic data, but ways to visualize these data in an integrated manner have lagged behind the ability to generate them. Now, Broad Institute researchers have developed a novel and freely available visualization tool that helps users integrate and analyze different types of genomic data, and gives them the flexibility to zoom in on a specific region of interest or to pan out for a broad, whole genome view.
Researchers at the Broad Institute of Harvard and MIT have received a grant to support novel, integrative research aimed at finding ways to encourage the human body to replenish the cells that are missing in type 1 diabetes. Awarded by the Juvenile Diabetes Research Foundation (JDRF), the $3M grant will fund work that knits together two interdisciplinary fields, genome biology and chemical biology, to address a fundamental question in human biology: can existing cells be coaxed to regenerate ones that are lost or damaged by disease?
An international team of researchers has created the most comprehensive "parts list" to date for mitochondria, a compendium that includes nearly 1,100 proteins. By mining this critical resource, the researchers have already gained deep insights into the biological roles and evolutionary histories of several key proteins. In addition, this careful cataloging has identified a mutation in a novel protein-coding gene as the cause behind one devastating mitochondrial disease.
Recent research has shown that adult mouse and human cells can be transformed, or "reprogrammed" into a primitive, stem-cell state, but the process is inefficient and poorly understood. Now, thanks to the application of powerful new integrative genomic tools, scientists have uncovered significant new information about the molecular changes that underlie the direct reprogramming process.
Using new techniques for rapidly scanning the human genome, researchers have associated levels of cholesterol and triglycerides, two fats in the blood, to 18 genetic variants, six of which represent new DNA regions never before associated with the traits. The findings help explain some of the variability in cholesterol and triglyceride levels that arises from genes.
In a groundbreaking study published November 28 in the advance online edition of Nature, an international research team has for the first time measured which of the malaria parasite's genes are turned on or off during actual infection in humans, not in cell cultures, unearthing surprising behaviors and opening a window on the most critical aspects of parasite biology.
In one of the first large-scale comparisons of multiple animal genomes, scientists have analyzed the genomes of twelve species of the fruit fly Drosophila, ten of which had not been previously sequenced, to reveal insights on the evolution of genes and genomes and to discern the functional elements encoded in animal DNA.
Comprehensive analysis of DNA from human lung tumors uncovers more than 50 common genetic abnormalities, less than half involve known cancer genes; Work highlights role of key lung cancer gene.
Using a new "genome-scanning" method, a team of scientists has identified the first robust link between genes and stature in humans. A single letter change in a gene called HMGA2 enables people who carry it to gain as much as a centimeter in height. The work provides insights into how genes hardwire growth in humans and suggests that finding additional height-related genes may be feasible.
By using a new kind of genomic technology, a new study unveils a special code "” not within DNA, but within the so-called "chromatin" proteins surrounding it "” that could unlock the mysterious developmental choices made by mammalian cells, allowing them to assume roles as diverse as liver cells and neurons.
Scientists announce the discovery of three unsuspected regions of human DNA that contain clear genetic risk factors for type 2 diabetes, and another that is associated with elevated blood triglycerides. The study is among the first to apply a suite of genomic resources to clinical research.
Scientists create genome-scale map of genetic variation for malaria parasite; initial use unlocks genes involved in drug resistance.
A research team led by scientists at the Broad Institute of MIT and Harvard announced today the development of a new kind of genetic "roadmap" that can connect human diseases with potential drugs to treat them, as well as predict how new drugs work in human cells. Called the "Connectivity Map," the new tool and its uses are described in the September 29 issue of Science and in separate publications in the September 28 immediate early edition of Cancer Cell.
Researchers announce a major upgrade to ChemBank, a publicly available database that provides the analytic tools for drug discovery.
New study suggests that the last common ancestor shared between chimps and humans may be ~1 million years more recent than previous estimates. Additional findings reveal a particularly young age of one of the human sex chromosomes and point to a complex process of speciation, with possible interbreeding during speciation.
A grant from the National Heart, Lung, and Blood Institute (NHLBI) funds groundbreaking genomic studies aimed at identifying the genetic variations that underlie common human diseases.
Scientists uncover signatures near crucial developmental genes; analysis provides framework for understanding cells' unusual plasticity.
A unique public-private partnership led by researchers at the Broad Institute of MIT and Harvard creates RNAi-based inhibitors for nearly every human and mouse gene. This RNAi-based gene inhibitor library is freely available to researchers worldwide.
Aspergilli studies offer new insights into sexual reproduction, evolution and disease.
Analysis unlocks genetic variation among dog breeds; evolutionary conservation with human reveals regulatory controls of key genes.
Largest gift of its kind to two universities for collaborative research endeavor.
Several new publications validate and mine HapMap resource.
Comparison of the chimpanzee and human genomes reveals extraordinary similarities, significant differences and new paths for biomedical research.
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