Latest News from: American Society for Biochemistry and Molecular Biology (ASBMB)

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Article ID: 700580

How Cells Handle a Sticky, Toxic, but Absolutely Essential Molecule

American Society for Biochemistry and Molecular Biology (ASBMB)

A team of researchers at the Lerner Research Institute of the Cleveland Clinic has now solved a long-standing puzzle by identifying the protein that "chaperones" free heme in cells. The findings are published in the Journal of Biological Chemistry.

Released:
14-Sep-2018 2:05 PM EDT

Article ID: 700557

Big Data Studies Scrutinize Links Between Fatty Liver Disease and How Cells Make Energy

American Society for Biochemistry and Molecular Biology (ASBMB)

Three recent studies dig into how nonalcoholic fatty liver disease affects mitochondria in the liver: how mitochondrial energy production stutters and fails as the disease progresses, and how this affects the organ’s use of nutrients to produce energy.

Released:
14-Sep-2018 10:05 AM EDT

Article ID: 700075

Scanning Thousands of Molecules Against an Elusive Cancer Target

American Society for Biochemistry and Molecular Biology (ASBMB)

Researchers at the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health, have developed a system to accelerate the discovery of chemical compounds that inhibit an enzyme implicated in a number of cancers. The set of tools and methods, which the researchers used to test more than 16,000 compounds, is described in a new paper published in the Journal of Biological Chemistry.

Released:
6-Sep-2018 2:05 AM EDT

Article ID: 699619

Scientists Sweep Cellular Neighborhoods Where Zika Hides Out

American Society for Biochemistry and Molecular Biology (ASBMB)

Researchers are reporting the protein/protein interactome of Zika virus and its human host cells with a proteomic approach that gives unprecedented insight into membrane-bound protein interactions. The data reveal a new role for a familiar organelle in viral replication.

Released:
28-Aug-2018 8:45 AM EDT

Article ID: 699468

How to Improve Cell Replacement Therapy for Parkinson's Disease

American Society for Biochemistry and Molecular Biology (ASBMB)

Researchers found a new cell surface marker on stem cells induced to become dopamine neurons, which allow isolation of a more beneficial population of induced neurons for cell replacement therapy. Animals that received a transplant sorted using the new marker fared better than their counterparts with a typical transplant.

Released:
23-Aug-2018 3:30 PM EDT

Article ID: 699121

Obesity Leads to Infertility Through Oxidative Stress in Mice

American Society for Biochemistry and Molecular Biology (ASBMB)

Researchers studying infertility in obese mice have identified a protein suppressed in the egg cell precursors of obese mice that controls antioxidant production and may regulate egg cell maturation.

Released:
16-Aug-2018 2:30 PM EDT

Article ID: 698991

Fat Metabolism Is Linked to Sleep Apnea

American Society for Biochemistry and Molecular Biology (ASBMB)

Researchers studying the link between sleep apnea and heart disease have found a new mechanism: lipid clearance from the blood is slower in people with apnea, predisposing them to heart disease. Fortunately, CPAP treatment seems to improve matters.

Released:
14-Aug-2018 4:05 PM EDT

Article ID: 698959

Inching Closer to a Soft Spot in Antibiotic-Resistant Tuberculosis

American Society for Biochemistry and Molecular Biology (ASBMB)

Researchers comparing several clonal strains of isoniazid-sensitive and resistant tuberculosis bacteria found shared changes to mycobacterial metabolism that bolster the evidence for a new proposed drug target.

Released:
14-Aug-2018 1:05 PM EDT

Article ID: 698462

Molecular & Cellular Proteomics presents draft guidelines for reporting advanced proteomics studies

American Society for Biochemistry and Molecular Biology (ASBMB)

The journal Molecular & Cellular Proteomics has released draft guidelines for reporting studies that use DIA-MS proteomics. The guidelines will help authors report enough information on this new method to make their work interpretable and reproducible.

Released:
2-Aug-2018 10:30 AM EDT

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