Latest News from: Cincinnati Children's Hospital Medical Center

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Newswise: Human Pancreas on a Chip Opens New Possibilities for Studying Disease
  • Embargo expired:
    16-Jul-2019 5:00 AM EDT

Article ID: 715634

Human Pancreas on a Chip Opens New Possibilities for Studying Disease

Cincinnati Children's Hospital Medical Center

Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD. It may be feasible to also use the small two-chambered device, which features bioengineered human pancreatic organoids to study the causes of non-CF-related conditions such as type 1 and 2 diabetes, according to researchers who report findings in Nature Communications.

Released:
11-Jul-2019 2:00 PM EDT
Newswise: Scientists Developing Way to Help Premature Babies Breathe Easier

Article ID: 715004

Scientists Developing Way to Help Premature Babies Breathe Easier

Cincinnati Children's Hospital Medical Center

Researchers suggest a possible cell-based therapy to stimulate lung development in fragile premature infants who suffer from a rare condition called Bronchopulmonary Dysplasia (BPD), which in the most severe cases can lead to lifelong breathing problems and even death. Scientists publish their preclinical findings report the American Journal of Respiratory and Critical Care Medicine.

Released:
26-Jun-2019 3:05 PM EDT
Newswise: Researchers Find Cause of Rare, Fatal Disease That Turns Babies’ Lips and Skin Blue

Article ID: 714551

Researchers Find Cause of Rare, Fatal Disease That Turns Babies’ Lips and Skin Blue

Cincinnati Children's Hospital Medical Center

Scientists used a gene editing method called CRISPR/Cas9 to generate mice that mimic a respiratory disorder in newborn infants that turns their lips and skin blue. The new laboratory model allowed researchers to find the ailment’s cause and a potential, desperately needed nanoparticle-based treatment.

Released:
19-Jun-2019 9:00 AM EDT
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Article ID: 714441

3 Signs of Progress Against Sickle Cell Disease

Cincinnati Children's Hospital Medical Center

June 19 is World Sickle Cell Awareness Day. Scientists at Cincinnati Children's have recently made three important steps forward in helping people with sickle cell in the U.S. and in sub-Saharan Africa live longer, better lives.

Released:
19-Jun-2019 8:05 AM EDT
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  • Embargo expired:
    19-Jun-2019 7:00 AM EDT

Article ID: 714471

Scientists Identify Genes Associated with Biliary Atresia Survival

Cincinnati Children's Hospital Medical Center

Scientists at Cincinnati Children’s Hospital Medical Center have identified an expression pattern of 14 genes at the time of diagnosis that predicts two year, transplant-free survival in children with biliary atresia – the most common diagnosis leading to liver transplants in children. The researchers also found that the antioxidant N-acetyl-cysteine (NAC) reduced liver injury and fibrosis (excess fibrous connective tissue) in mice with biliary atresia and increased survival times.

Released:
17-Jun-2019 4:00 PM EDT
Newswise: Scientists Bioengineer Human Liver Disease in the Lab to Find New Treatments
  • Embargo expired:
    30-May-2019 11:00 AM EDT

Article ID: 713376

Scientists Bioengineer Human Liver Disease in the Lab to Find New Treatments

Cincinnati Children's Hospital Medical Center

Scientists successfully bioengineered human liver organoids that faithfully mimic key features of fatal liver disease in the laboratory. This allowed them to uncover underlying disease biology in the organoids and test a potential therapy that in preclinical lab tests reversed an often-fatal childhood condition called Wolman disease.

Released:
23-May-2019 11:00 AM EDT
Newswise: Potential New Target Emerges for Preventing Preterm Birth
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    7-May-2019 11:00 AM EDT

Article ID: 712190

Potential New Target Emerges for Preventing Preterm Birth

Cincinnati Children's Hospital Medical Center

Experts at Cincinnati Children’s report that the systemic inflammatory process that triggers preterm birth begins in an unexpected location that suggests new ways to develop preventative medications.

Released:
2-May-2019 9:00 AM EDT
Newswise: Major Grant Fuels Hunt for Universal Flu Vaccine

Article ID: 712292

Major Grant Fuels Hunt for Universal Flu Vaccine

Cincinnati Children's Hospital Medical Center

Funds from the National Institutes of Health will accelerate the chase for one of medicine’s most elusive goals: a universal influenza vaccine.

Released:
2-May-2019 2:05 PM EDT
Newswise: Shining Light on Rare Nerve Tumors Illuminates a Fresh Path for Fighting Cancer
  • Embargo expired:
    23-Apr-2019 2:00 PM EDT

Article ID: 711672

Shining Light on Rare Nerve Tumors Illuminates a Fresh Path for Fighting Cancer

Cincinnati Children's Hospital Medical Center

Experts use emerging technique to reveal that a protein named “Merlin” may interact with 50 other proteins to trigger the rare condition neurofibromatosis 2 (NF2). But this discovery has implications that go far beyond NF2 itself.

Released:
22-Apr-2019 11:05 AM EDT
Newswise: Overlooked Molecular Machine in Cell Nucleus May Hold Key to Treating Aggressive Leukemia
  • Embargo expired:
    22-Apr-2019 11:00 AM EDT

Article ID: 711477

Overlooked Molecular Machine in Cell Nucleus May Hold Key to Treating Aggressive Leukemia

Cincinnati Children's Hospital Medical Center

Many people fighting a very aggressive form of acute myeloid leukemia (AML) don’t survive more than five years. These very sick patients are often unable to receive the only cure—a bone marrow transplant. Now, an international team of scientists report in Nature Cell Biology on a long-overlooked part of a leukemic cell’s internal machinery, where they may have found a key to treating the aggressive blood cancer.

Released:
18-Apr-2019 11:05 AM EDT

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