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A Cleveland Clinic-led research collaboration between Timothy Chan, MD, PhD, Chair of Cleveland Clinic’s Global Center for Immunotherapy, and Bristol Myers Squibb has published the most comprehensive overview to date of how our immune system reshapes tumor architecture in response to immune checkpoint therapy. The eight-year study, published in Nature Medicine, outlines how cancer immunotherapy induces tumor recognition through neoantigens to reshape the tumor ecosystem.

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Cleveland Clinic researchers have discovered a new bacterium that weakens the immune system in the gut, potentially contributing to certain inflammatory and infectious gut diseases. The team identified the bacterium, Tomasiella immunophila (T. immunophila), which plays a key role in breaking down a crucial immune component of the gut’s multi-faceted protective immune barrier. Identifying this bacterium is the first step to developing new treatments for a variety of inflammatory and infectious gut diseases.

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Friday, September 20, 2024, CLEVELAND: A Cleveland Clinic study showed that in patients with type 2 diabetes, obesity, and chronic kidney disease, bariatric surgery was associated with a significant decrease in the progression of chronic kidney disease compared to those who received GLP-1 diabetes medications. The paper was published in Annals of Surgery.

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CLEVELAND: A clinical trial has demonstrated that the cancer drug pomalidomide is safe and effective in treating hereditary hemorrhagic telangiectasia (HHT), a rare bleeding disorder that impacts more than 1 in 5,000 people worldwide.

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Cleveland Clinic researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease.

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A new Cleveland Clinic study has identified diet-derived molecules called metabolites as main drivers of young-onset colorectal cancer risk, especially those associated with red and processed meat. The NPJ Precision Oncology report, which analyzed metabolite and microbiome datasets, highlighted that one of the best ways a younger (<60 years) adult can prevent colorectal cancer is to discuss their diet with their doctor.

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Cleveland Clinic and Sports Data Labs, Inc. (SDL) are partnering with the goal of creating the largest compilation of sports health data, which will be used to develop new technology-driven tools and services.

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New Cleveland Clinic and Tufts University research shows that elevated levels of the gut microbiome trimethylamine N-oxide (TMAO) pathway led to a higher risk of heart failure independent of other risk factors, according to a study of two large National Institutes of Health cohorts. The study was recently published in the journal Circulation: Heart Failure.

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New Cleveland Clinic research shows that consuming foods with erythritol, a popular artificial sweetener, increases risk of cardiovascular events such as heart attack and stroke. The findings, from a new intervention study in healthy volunteers, show erythritol made platelets (a type of blood cell) more active, which can raise the risk of blood clots.

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31 de julio de 2024, CLEVELAND - Un estudio desarrollado por Cleveland Clinic ha identificado áreas geográficas en Estados Unidos, donde los esfuerzos estratégicos para promover la detección del cáncer colorrectal podrían ayudar a reducir las brechas en la atención médica que afectan a las comunidades hispanas/latinas.

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Cleveland Clinic-led research has identified geographic areas in the United States where strategic efforts to promote colorectal cancer screening could help reduce healthcare gaps affecting Hispanic/Latino communities. The study, published in the American Journal of Public Health, marks a first step toward conducting larger neighborhood-level studies addressing disparities in colorectal cancer screening.

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Walsh University has signed a major multi-year agreement with Cleveland Clinic Mercy Hospital Sports Medicine, strengthening a strong collaboration to enhance the health and wellness of its student scholar athletes.

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A Cleveland Clinic-led study published in eBioMedicine reveals that maternal Zika virus infections can reprogram fetal immune development, leading to long-term consequences in children’s immunity.

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Kent State University and Cleveland Clinic have announced a multiyear partnership in which Cleveland Clinic becomes the official healthcare provider for Kent State Athletics.