Latest News from: University of Alabama at Birmingham

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Newswise: Likely molecular mechanisms of SARS-CoV-2 pathogenesis are revealed by network biology
Released: 23-Sep-2020 4:00 PM EDT
Likely molecular mechanisms of SARS-CoV-2 pathogenesis are revealed by network biology
University of Alabama at Birmingham

Researchers combined a lung-epithelial cell host interactome with a SARS-CoV-2 interactome. Network biology analysis of this human/SARS-CoV-2 interactome revealed potential molecular mechanisms of pathogenesis for SARS-CoV-2, the virus responsible for the COVID-19 pandemic.

Released: 15-Sep-2020 6:05 PM EDT
Black heart failure patients have worse prognosis even after reaching treatment targets
University of Alabama at Birmingham

A new study published in Circulation by University of Alabama at Birmingham researchers showed that Black heart failure patients have worse prognoses even after achieving biomarker-based treatment goals.

Newswise: Pro-inflammatory lipids precede Type 1 diabetes onset in mouse model and children
Released: 9-Sep-2020 3:20 PM EDT
Pro-inflammatory lipids precede Type 1 diabetes onset in mouse model and children
University of Alabama at Birmingham

Inflammatory lipid signaling may provoke the autoimmune disease Type 1 diabetes. Researchers have identified a proinflammatory lipid profile that precedes development of T1D in a mouse model and in children under age 15 who are at high risk for T1D. These lipids may be therapeutic targets.

Newswise: Study shows high blood pressure awareness and control are declining in America
9-Sep-2020 11:05 AM EDT
Study shows high blood pressure awareness and control are declining in America
University of Alabama at Birmingham

After nearly 15 years on an upward trend, awareness among Americans about their high blood pressure and rates of blood pressure control are now on the decline. many groups, including older adults and Black adults, are less likely than they were in earlier years to control their blood pressure.

Released: 3-Sep-2020 10:30 AM EDT
Cancer health and education providers stress importance of colorectal cancer awareness following death of “Black Panther” actor
University of Alabama at Birmingham

Colorectal cancer is the second-leading cause of cancer-related deaths in men and the third-leading cause of cancer-related deaths in women in the United States. Black people in the United States also have the highest rates of colorectal cancer of any racial or ethnic group, according to the American Cancer Society.

Released: 2-Sep-2020 4:10 PM EDT
Studying an alternative steroid treatment to calm cytokine storms in COVID-19
University of Alabama at Birmingham

Randy Cron, M.D., Ph.D. wrote the first textbook on cytokine storm syndrome in 2019. Cron and UAB's Winn Chatham, M.D., are testing another potential treatment for cytokine storm syndrome in COVID-19: a targeted drug called anakinra.

Newswise: Plasmin could be the link between COVID-19 comorbidities and serious illness
Released: 2-Sep-2020 12:20 PM EDT
Plasmin could be the link between COVID-19 comorbidities and serious illness
University of Alabama at Birmingham

COVID-19 comorbidities feature elevated levels of the extracellular protease plasmin. Plasmin is able to nick proteins at furin sites. This can increase viral infectivity, including SARS and MERS — the two coronaviruses that are related to the COVID-19 virus. COVID-19 has a spike protein furin site.

Newswise: Preclinical study of COVID-19 vaccine candidate shows potent T-cell responses
Released: 25-Aug-2020 12:05 PM EDT
Preclinical study of COVID-19 vaccine candidate shows potent T-cell responses
University of Alabama at Birmingham

Preclinical results for a COVID-19 vaccine candidate appear to distinguish this vaccine candidate from other vaccine candidates. A single nasal dose in mice gave a potent T-cell response at the lung mucus layer, including killer CD8+ T-cells that can recognize and kill virally infected cells.

Released: 24-Aug-2020 4:55 PM EDT
Frequent soft drink consumption may make adolescents more aggressive
University of Alabama at Birmingham

Soft drink consumption is a likely predictor of aggressive behavior, according to a new study from UAB.A study from the University of Alabama at Birmingham has shown that frequent soft drink consumption by adolescents may contribute to aggressive behavior over time.  Previous studies have shown associations between soft drink consumption and mental health problems in adolescents.

Newswise: Is the COVID-19 virus pathogenic because it depletes specific host microRNAs?
Released: 14-Aug-2020 3:05 PM EDT
Is the COVID-19 virus pathogenic because it depletes specific host microRNAs?
University of Alabama at Birmingham

Why is the COVID-19 virus deadly, compared to cold-causing coronaviruses? Analysis current literature and bioinformatic study of seven coronaviruses, suggests that SARS-CoV-2 acts as a microRNA “sponge,” leading to better viral replication and blockage of the host immune response.

Released: 14-Aug-2020 10:05 AM EDT
Why does COVID-19 impair your sense of smell?
University of Alabama at Birmingham

Hyposmia or anosmia, a decreased or complete loss of smell, has been widely reported in patients with COVID-19, often as a symptom noticed early on prior to other symptoms or even as the only symptom present in an otherwise asymptomatic patient.There are still many unknowns regarding COVID-19, but one common occurrence among those infected is smell loss.

Newswise: Free ArtPlay workshops for teachers will share tips for virtual teaching Aug. 11, Aug. 17
Released: 10-Aug-2020 6:45 PM EDT
Free ArtPlay workshops for teachers will share tips for virtual teaching Aug. 11, Aug. 17
University of Alabama at Birmingham

When musical theater and visual arts summer camps went online at the University of Alabama at Birmingham this summer, staff did not know what to expect. The award-winning camps, presented by UAB’s ArtPlay, are always popular, to the point of selling out all available spaces. Despite the teachers’ fears, campers and their parents loved the new virtual camps.

Newswise: Analysis of Ugandan cervical carcinomas, an aid for understudied sub-Saharan women
Released: 10-Aug-2020 4:30 PM EDT
Analysis of Ugandan cervical carcinomas, an aid for understudied sub-Saharan women
University of Alabama at Birmingham

Cervical cancer kills over 300,000 women a year, and 19 of the 20 nations with the highest death rates are sub-Saharan countries. Now an international team has published the first comprehensive genomic study of cervical cancers in sub-Saharan Africa, with a focus on tumors from 212 Ugandans.

Newswise:Video Embedded uab-department-of-pathology-develops-strategy-to-support-guidesafe-entry-testing-process-more-than-200-000-samples
VIDEO
Released: 5-Aug-2020 4:10 PM EDT
UAB Department of Pathology develops strategy to support GuideSafe™ Entry Testing, process more than 200,000 samples
University of Alabama at Birmingham

This strategy will allow for ramping up testing capacity tenfold for the next 20-plus days leading up to the start of school.

Newswise: Phosphoprotein biomarkers to guide cancer therapy are identified
Released: 28-Jul-2020 4:50 PM EDT
Phosphoprotein biomarkers to guide cancer therapy are identified
University of Alabama at Birmingham

Post-translational modification analysis may broadly identify new biomarkers of cancer drivers for a much more precise prediction of patient responses to treatments. A recent study demonstrates this diagnostic alternative for neuroendocrine neoplasms driven by a protein kinase called Cdk5.

Newswise: Novel diabetes drug candidate shows promising properties in human islets and mouse models
23-Jul-2020 12:35 PM EDT
Novel diabetes drug candidate shows promising properties in human islets and mouse models
University of Alabama at Birmingham

Researchers have discovered a new drug candidate that offers a major advance to treat diabetes. Tested on human and mouse pancreatic islets, mouse and rat cell cultures and animal models of Type 1 and Type 2 diabetes, the drug significantly improved four detrimental characteristics of diabetes.

Released: 8-Jul-2020 3:40 PM EDT
Special unit will treat nursing home patients with COVID-19 in Jefferson County
University of Alabama at Birmingham

UAB will establish a special 25-bed unit to treat patients from nursing home facilities who have COVID-19. The unit will isolate nursing home residents who test positive and are asymptomatic or mildly symptomatic, while providing the appropriate level of skilled nursing care that those patients require.

Newswise: Louis Justement and Mary-Ann Bjornsti begin leadership roles at FASEB
Released: 1-Jul-2020 2:50 PM EDT
Louis Justement and Mary-Ann Bjornsti begin leadership roles at FASEB
University of Alabama at Birmingham

Immunologist Louis Justement, Ph.D., begins his term as president of the largest coalition of biological and biomedical research associations in the United States, FASEB.

Newswise:Video Embedded uab-doctor-shares-her-experience-treating-coronavirus-patients-in-new-york
VIDEO
Released: 25-Jun-2020 6:25 PM EDT
UAB doctor shares her experience treating coronavirus patients in New York
University of Alabama at Birmingham

Winter volunteered to treat patients at New York-Presbyterian Weill Cornell Medical Center.

Newswise: The Parkinson’s disease gut has an overabundance of opportunistic pathogens
Released: 18-Jun-2020 4:25 PM EDT
The Parkinson’s disease gut has an overabundance of opportunistic pathogens
University of Alabama at Birmingham

A 2003 hypothesis says Parkinson’s disease is caused by a gut pathogen that could spread to the brain through the nervous system. No evidence was found until now; researchers report for the first time a significant overabundance of a cluster of opportunistic pathogens in the PD gut.

Released: 17-Jun-2020 3:30 PM EDT
Is a summer vacation safe for your family?
University of Alabama at Birmingham

Destinations are opening up for summer vacation, but does that mean it is safe to travel with your family? The most important consideration while traveling during COVID-19 is weighing the risk, says Curry Bordelon III, DNP, assistant professor in the University of Alabama at Birmingham School of Nursing.

Newswise: Genetic rescue of SHANK3 is potential therapy in rare forms of autism spectrum disorder
Released: 15-Jun-2020 3:05 PM EDT
Genetic rescue of SHANK3 is potential therapy in rare forms of autism spectrum disorder
University of Alabama at Birmingham

A mouse study by Craig Powell, M.D., Ph.D., and colleagues suggests that early genetic rescue may be a potential therapy in autism spectrum disorder, or ASD. Powell looked at one gene called SHANK3, whose alteration is seen in about 0.5 percent of ASD patients.

Newswise: Story of jailed 17th-century Iberian “mulatto pilgrim” told in new book by John K. Moore Jr.
Released: 12-Jun-2020 4:05 PM EDT
Story of jailed 17th-century Iberian “mulatto pilgrim” told in new book by John K. Moore Jr.
University of Alabama at Birmingham

The book tells the story of a man jailed for impersonating a priest in 1693 Spain, when he was likely trying to escape racial persecution. It gives readers a fascinating look at a centuries-old legal case against a man on pilgrimage and shows how Iberians of black-African ancestry faced discrimination and mistreatment.

Newswise: “Prescribing Art” course teaches med students to recognize bias and better address racial disparities
Released: 12-Jun-2020 4:05 PM EDT
“Prescribing Art” course teaches med students to recognize bias and better address racial disparities
University of Alabama at Birmingham

Can art help doctors better understand their patients and address racial disparities? An innovative collaboration at the University of Alabama at Birmingham uses art to help medical students hone their observational skills, in order to make more accurate diagnoses. “Prescribing Art: How Observation Enhances Medicine” is a partnership between the School of Medicine, the Abroms-Engel Institute for Visual Arts and the Birmingham Civil Rights Institute.

Newswise: Retinitis Pigmentosa Research Probes Role of the Enzyme DHDDS in This Genetic Disease
Released: 11-Jun-2020 3:45 PM EDT
Retinitis Pigmentosa Research Probes Role of the Enzyme DHDDS in This Genetic Disease
University of Alabama at Birmingham

Researchers who made a knock-in mouse-model of the genetic disorder retinitis pigmentosa 59, or RP59, expected to see retinal degeneration and retinal thinning. They surprisingly found none, calling into question the commonly accepted — though never proved — mechanism for RP59.

Newswise: Springing into action: The urgent COVID-19 research fund at UAB
Released: 11-Jun-2020 2:05 PM EDT
Springing into action: The urgent COVID-19 research fund at UAB
University of Alabama at Birmingham

Researchers faced the same time crunch — create a COVID-19 research proposal in just five days, to compete for emergency COVID-19 funding raised through UAB and generous business donors in Birmingham and Montgomery.

Released: 11-Jun-2020 12:05 PM EDT
Caring for Your Loved Ones with COVID-19 at Home
University of Alabama at Birmingham

UAB expert provides practical ways you can care for your loved ones who have been diagnosed with COVID-19 at home.Much has been reported about some of the most severe cases of COVID-19, but what about those who may be experiencing mild or lesser symptoms and are not in situations where they have to be hospitalized? How can spouses, parents or families take care of their loved ones at home?

Newswise: Complement genes add to sex-based vulnerability in lupus and schizophrenia
Released: 19-May-2020 7:10 AM EDT
Complement genes add to sex-based vulnerability in lupus and schizophrenia
University of Alabama at Birmingham

Variants in a gene of the human immune system cause men and women to have different vulnerabilities to the autoimmune diseases lupus and Sjögren’s syndrome, according to findings published in the journal Nature. The gene variants are a member of the complement system.

Newswise:Video Embedded sculptor-designs-builds-interactive-contraptions-from-everyday-materials-to-simulate-human-connections
VIDEO
Released: 14-May-2020 6:25 PM EDT
Sculptor designs, builds ‘interactive contraptions’ from everyday materials to simulate human connections
University of Alabama at Birmingham

Even in isolation, Stacey Holloway can hold a hand, receive a swift kiss on the cheek or give a high-five. She can offer a nose rub, just like the ones she shares with her mother. She just does them all alone — that is, if you don’t count the kinetic, prosthetic models she created to help.

Newswise: Precision medicine guides choice of better drug therapy in severe heart disease
Released: 14-May-2020 4:45 PM EDT
Precision medicine guides choice of better drug therapy in severe heart disease
University of Alabama at Birmingham

Is personalized medicine cost-effective? Researchers have answered that question for one medical treatment, genotype-guided antiplatelet therapy for acute coronary syndrome patients with PCI. Their study uses pharmacogenomics and economic analysis of real-world clinical data.

Released: 14-May-2020 2:10 PM EDT
Surplus antioxidants are pathogenic for hearts and skeletal muscle
University of Alabama at Birmingham

Oxidative stress can be pathological. Now researchers report that the other end of the redox spectrum, reductive stress, is also pathological. Reductive stress causes pathological heart enlargement and diastolic dysfunction in a mouse model.

Released: 12-May-2020 6:50 AM EDT
Keeping your eyes healthy during the coronavirus pandemic
University of Alabama at Birmingham

Experts from UAB’s School of Optometry and UAB Callahan Eye Hospital and Clinics provide guidance for keeping your eyes safe during the coronavirus pandemic.

Released: 11-May-2020 3:45 PM EDT
How high school seniors can navigate uncertainty during the coronavirus pandemic
University of Alabama at Birmingham

Angela Stowe, Ph.D., has advice for students leaving high school, and those about to start college, on bringing closure to their K-12 experience and preparing to move forward with their lives.For high school seniors bound for college, the COVID-19 pandemic struck at a pivotal time in life — as they finish one chapter and prepare to start a new one.

Newswise: Individualized mosaics of microbial strains transfer from the maternal to the infant gut
Released: 8-May-2020 3:55 PM EDT
Individualized mosaics of microbial strains transfer from the maternal to the infant gut
University of Alabama at Birmingham

A microbiome “fingerprint” method shows that an individualized mosaic of microbial strains is transmitted to the infant gut microbiome from a mother giving vaginal birth. The study analyzed existing metagenomic databases of fecal samples from mother-infant pairs and used a germfree mouse model.

Newswise: Smartphone-based automated contact tracing: Is it possible to balance privacy, accuracy and security?
Released: 7-May-2020 2:25 PM EDT
Smartphone-based automated contact tracing: Is it possible to balance privacy, accuracy and security?
University of Alabama at Birmingham

UAB professor, Nitesh Saxena, Ph.D., explains the context of contact tracing and how it will help the impact of the novel coronavirus pandemic.

Newswise: Grant will fund pilot program to expand opioid use disorder treatment in Alabama
Released: 6-May-2020 11:55 AM EDT
Grant will fund pilot program to expand opioid use disorder treatment in Alabama
University of Alabama at Birmingham

UAB is launching a pilot program aimed at getting more opioid users into treatment, using telemedicine in three rural counties and emploing the Alabama One Health Record®, a statewide health information exchange, to track outcomes in these patients.

Newswise: UAB biotechnology aids hunt for novel COVID-19 DNA vaccine
Released: 4-May-2020 4:55 PM EDT
UAB biotechnology aids hunt for novel COVID-19 DNA vaccine
University of Alabama at Birmingham

The Earle A. Chiles Research Institute is using the protein purification technology from TriAltus Bioscience to purify the spike protein of the COVID-19 virus. The protein will be used to measure the effectiveness of a new DNA vaccine, intended to evoke an immune response against the spike protein.

Newswise: Gender identity plays a role in the amount of pain experienced by individuals with chronic pain
Released: 1-May-2020 4:25 PM EDT
Gender identity plays a role in the amount of pain experienced by individuals with chronic pain
University of Alabama at Birmingham

Gender identity and genetic sex are distinctly variable when it comes to pain tolerance, according to a study published in the Journal of Pain Research.

Newswise:Video Embedded in-one-of-america-s-rare-undergraduate-immunology-programs-students-are-preparing-for-the-next-pandemic2
VIDEO
Released: 30-Apr-2020 1:05 PM EDT
In one of America’s rare undergraduate immunology programs, students are ‘preparing for the next pandemic’
University of Alabama at Birmingham

UAB's Undergraduate Immunology Program, one of a handful of immunology majors available in the United States, gives students real lab experience with more than 100 faculty pursuing cutting-edge research.The entire planet, more or less, is fixated on the greatest pandemic in modern memory. Claire Elliott is already preparing for the next one.

Newswise:Video Embedded coronavirus-may-damage-kidneys-impact-dialysis-supplies
VIDEO
Released: 27-Apr-2020 4:15 PM EDT
Coronavirus may damage kidneys, impact dialysis supplies
University of Alabama at Birmingham

. Ashita Tolwani, a nephrologist at the University of Alabama at Birmingham, explains how COVID-19 is impacting patients and putting a strain on the availability of dialysis supplies..

Newswise: Working behind the scenes: UAB pathologists play key role in fighting coronavirus pandemic
Released: 24-Apr-2020 12:05 PM EDT
Working behind the scenes: UAB pathologists play key role in fighting coronavirus pandemic
University of Alabama at Birmingham

Testing has been a major cause for concern worldwide ever since the pandemic began, but clinicians and researchers with UAB’s Department of Pathology have been working around the clock to make testing available for as many people as possible, making sure accurate results are available in a timely manner.

Newswise: Search for drugs effective against COVID-19 includes UAB and Southern Research
Released: 23-Apr-2020 3:05 PM EDT
Search for drugs effective against COVID-19 includes UAB and Southern Research
University of Alabama at Birmingham

The University of Alabama at Birmingham will join an international effort coordinated by Scripps Research to test drugs for COVID-19. The work centers around ReFRAME, a vast collection of drugs developed for other diseases that are already known to be safe for humans.

Newswise: rep_immuno_lab_ov_550px.jpg
Released: 17-Apr-2020 11:35 AM EDT
In one of America’s rare undergraduate immunology programs, students are ‘preparing for the next pandemic’
University of Alabama at Birmingham

There are only a handful of immunology majors offered at U.S. universities. A report last October by UAB researchers made the case for expanding these programs. Now faculty and students are seeing an explosion of interest.

Newswise: New boron material of high hardness created by plasma chemical vapor deposition
Released: 15-Apr-2020 3:55 PM EDT
New boron material of high hardness created by plasma chemical vapor deposition
University of Alabama at Birmingham

Researchers used microwave-plasma chemical vapor deposition to create thin crystal films of a novel boron-rich boron-carbide material that has 37 percent the hardness of cubic diamond and acts as an insulator. The new material’s properties were predicted from first-principles analysis.

Newswise: Making the Most of Your Groceries During the Coronavirus Pandemic
Released: 14-Apr-2020 4:00 PM EDT
Making the Most of Your Groceries During the Coronavirus Pandemic
University of Alabama at Birmingham

Tara Harman, RDN, has tips on how to stretch your groceries while saving money.

Released: 7-Apr-2020 4:10 PM EDT
UAB among first in the U.S. to offer clinical trial for the treatment of patients with severe COVID-19 using nitric oxide
University of Alabama at Birmingham

iNO has been used for the treatment of failing lungs, but it was also found to have antiviral properties against coronaviruses.The University of Alabama at Birmingham has been selected to begin enrolling patients in an international study assessing the use of inhaled nitric oxide (iNO) to improve outcomes for COVID-19 patients with severely damaged lungs.


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