Through small, neighborhood classes, researchers at UPMC Children’s Hospital of Pittsburgh and Promundo-US significantly reduced sexual violence among teenage boys living in areas of concentrated disadvantage. The study appears in JAMA.
As the biggest vaccination effort in U.S. history gets underway, several states may not have enough facilities in some areas to administer the COVID-19 vaccine to all residents who want it, according to a new analysis from the University of Pittsburgh School of Pharmacy and the nonprofit West Health.
A group of international collaborators led by researchers from the University of Pittsburgh identified new genetic associations that can predict individual susceptibility to Takayasu arteritis.
Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine learning algorithm to create human liver organoids with blood and bile handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life.
University of Pittsburgh researchers reveal a molecular basis for the deep and fundamental connection between the disruption in circadian rhythms and predisposition to substance abuse.
While most patients are at least somewhat satisfied with their surgery long-term, satisfaction decreased from 85% to 77% three to seven years post-surgery. Most patients also continue to lead sedentary lives, which contributes to weight regain and negatively affects their mental well-being.
The bodies of people with uncontrolled diabetes appear to be the perfect environment for a common type of superbug to thrive unchecked and do its worst damage, according to new research by University of Pittsburgh School of Medicine scientists.
The study showed that health insurance expansions increased early-stage cancer diagnoses, while rates of late-stage cancer decreased.
Researchers from the Pittsburgh Center for Pain Research uncovered additional complexities behind mechanical allodynia – the sensation of pain from innocuous stimuli, such as light touch.
Today in Science, researchers at the University of Pittsburgh School of Medicine describe a new method to extract tiny but extremely powerful SARS-CoV-2 antibody fragments from llamas, which could be fashioned into inhalable therapeutics with the potential to prevent and treat COVID-19.
University of Pittsburgh School of Medicine scientists have discovered the fastest way to identify potent, neutralizing human monoclonal antibodies against SARS-CoV-2, the virus that causes COVID-19. The method – as well as a trio of successful animal studies on an antibody called “Ab1” – are described today in the Proceedings of the National Academy of Sciences. Ab1 is on track for human clinical trials by early next year.
James J. Collins, Ph.D., an innovator in synthetic biology whose ideas have contributed to novel diagnostics and treatments targeting infections and complex diseases, has been awarded the 2020 Dickson Prize in Medicine, the University of Pittsburgh School of Medicine’s highest honor.
A metabolite produced following consumption of dietary soy may decrease a key risk factor for dementia – with the help of the right bacteria, according to a new discovery.
Two physician scientists at the University of Pittsburgh have been elected to the prestigious National Academy of Medicine: Dr. Toren Finkel, director of the Pitt Aging Institute, and Dr. Amy Wagner, professor of physical medicine and neuroscience at Pitt.
Older people who report greater levels of social engagement have more robust gray matter in regions of the brain relevant in dementia, according to new research. The findings matter during the COVID-19 pandemic.
Variations in a gene that regulates dopamine levels in the brain may influence the mobility of elderly and frail adults, according to new research.
In a new study, infectious disease researchers show that HIV viremia isn’t always nonadherence to medication or resistance to the drugs. Instead, the patients are victims of what the scientists have dubbed “repliclones” – large clones of HIV-infected cells that produce infectious virus particles.
The study found the drug can help the most severely injured trauma patients.
New study addresses a mystery first raised in March: Why do some people with COVID-19 develop severe inflammation? The research shows how the molecular structure and sequence of the SARS-CoV-2 spike protein could be behind life-threatening inflammatory conditions MIS-C and cytokine storm.
Researchers have created a machine-learning algorithm that can pick up on subtle signs of osteoarthritis – too abstract to register in the eye of a trained radiologist – on an MRI scan taken years before symptom onset.
People with atrial fibrillation who are exposed to greater levels of pollution have a higher risk of stroke than their peers who live with less pollution.
The slight decline in drug overdose deaths in 2018 coincides with Chinese regulations on the powerful opioid carfentanil, rather than the result of domestic U.S. efforts to curb the opioid epidemic, a University of Pittsburgh Graduate School of Public Health analysis revealed today.
Scientists announced today that they have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 virus, which is the cause of COVID-19.
The $1 million Magee Prize will support a collaborative team whose groundbreaking research in reproductive sciences and women’s health could improve lives globally.
Researchers created a system that uses CRISPR in a new way. Rather than acting on the genome to create permanent change, their system briefly suppresses genes specific to adenovirus antibody production, just long enough for the virus to deliver its gene therapy cargo unimpeded.
The FDA just revoked their EUA for intubation boxes - plastic shields that supposedly protect health care workers from becoming infected with SARS-CoV-2 - due to concerns over aerosol leaks. This study describes a better box, with negative pressure and filtration, that contains airborne virus.
Contrary to earlier observational results, vitamin D supplements do not prevent severe asthma attacks in at-risk children, according to the first placebo-controlled clinical trial to test this relationship.
Hepatocytes – the chief functional cells of the liver – are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply. Researchers demonstrated that large animals with ailing livers can grow a new organ in their lymph nodes from their own hepatocytes.
Men at particular risk for HIV are very likely to consistently take prevention medication during vacations when their odds of contracting the virus are higher, according to a new study.
In the first large, multicenter analysis of its kind, the 40-hospital UPMC health system today reported its findings on clinician-directed retesting of patients for presence of SARS-CoV-2, the virus that causes COVID-19.
New research by neuroscientists at the University of Pittsburgh and UC San Francisco (UCSF) revealed that a simple, earbud-like device developed at UCSF that imperceptibly stimulates a key nerve leading to the brain could significantly improve the wearer’s ability to learn sounds of a new language.
Study finds that men who harbor more harmful attitudes about masculinity – including beliefs about aggression and homophobia – also tend toward bullying, sexual harassment, depression and suicidal thoughts.
Critics of the universal hepatitis C screening argue that it’s wasteful to test pregnant women for a disease that can’t be immediately treated, but results of a small phase I clinical trial suggest otherwise: pregnancy could be an excellent time to diagnose and cure hepatitis C infection.
Study reports 98% sensitivity and 97% specificity in recognizing and characterizing prostate cancer using an artificial intelligence (AI) program.
Devices commonly implanted for chronic pain could expand patient access to prosthetic arms that "feel."
New study on how immune memory can be targeted and improve immunotherapy and prevent cancer recurrence.
Infusing umbilical cord blood – a readily available source of stem cells – safely and effectively treated 44 children born with various non-cancerous genetic disorders, including sickle cell, thalassemia, Hunter syndrome, Krabbe disease, MLD, and an array of immune deficiencies.
The National Institutes of Health has renewed a five-year grant for $5 million for the Alliance for Regenerative Rehabilitation and Training (AR3T) to continue its work expanding scientific knowledge, expertise and methodologies focused on science and regenerative medicine.
Mice that received an injection of a new experimental drug, TAT-DP-2, after a stroke had smaller areas of damage, and their long-term neurological function was better than that of untreated animals.
Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats. In this proof-of-concept experiment, the lab-made organs survived for four days inside their animal hosts.
A multidisciplinary team of clinicians and researchers led by UPMC Sports Medicine has developed guidelines to assist coaches, athletic trainers and organizers creating a safe environment for youth athletes, fans and staff as they consider a return to play.
Using rabies virus injected into the stomach of rats, researchers trace the nerves back to the brain and find distinct "fight or flight" and "rest and digest" circuits. These results explain how mental states can affect the gut, and present new ways to treat gastrointestinal problems.
A new discovery in mice shows the innate immune system has "memory," previously thought to be a unique feature of the adaptive immune system. Blocking this memory prevented transplanted organs from being rejected, providing a way to more specific drugs that could lengthen organ transplant survival.
The generation a person was born into – Silent Generation, Baby Boomer, Generation X or Millennial – strongly predicts how likely they are to die from a drug overdose, and at what age. Within each generation, there was a steady march toward greater overdose risk at younger ages.
Through serendipity, researchers at the University of Pittsburgh Graduate School of Public Health considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections.
Novel 'learning while doing' clinical trial approach called REMAP helps doctors find the optimal trade-off between quickly adopting new therapies during a pandemic, such as the anti-malarial drug hydroxychloroquine, and waiting until they are tested in longer clinical trials. The trial announced today at UPMC, called UPMC-REMAP-COVID19 learns from similar trials enrolling around the world and uses artificial intelligence to quickly arrive at answers.
A potential COVID-19 vaccine, delivered by microscopic needles, produces antibodies specific to the virus when tested in mice. This is the first peer-reviewed paper describing a COVID-19 vaccine candidate. The next step is a human clinical trial.
UPMC is implementing a staffing and pay protection program, which will ensure that all staff will continue to be paid at their current rate for normally scheduled hours through May 9, 2020 even if they are assigned to alternative work during their regular hours.
Inspired by a tactic cancer cells use to evade the immune system, University of Pittsburgh researchers have engineered tiny particles that can trick the body into accepting transplanted tissue as its own, while leaving the immune system intact.
Researchers from seven institutions team up to create a device combining artificial intelligence, bioelectronics and regenerative medicine for regrowing muscle tissue, especially after combat injuries.
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