Latest News from: La Jolla Institute for Immunology

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  • Embargo expired:
    15-Nov-2018 11:00 AM EST

Article ID: 703806

DICE: Immune cell atlas goes live

La Jolla Institute for Immunology

For more than four years, a team of LJI scientists led by Associate Professor Pandurangan Vijayanand, M.D., Ph.D., has been undertaking a massive immunoprofiling effort, detailing how variations in DNA sequence impact gene activity in different types of immune cells.

Released:
12-Nov-2018 12:05 PM EST
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  • Embargo expired:
    14-Nov-2018 11:00 AM EST

Article ID: 703686

Maternally-Acquired Zika Immunity Can Increase Dengue Disease Severity in Mouse Pups

La Jolla Institute for Immunology

In this study, La Jolla Institute for Immunology (LJI) investigator Sujan Shresta, Ph.D., who studies both dengue and Zika viruses, explored awhether maternal immunity to Zika virus, which is structurally and genetically similar to dengue, might trigger a severe response to dengue infection in offspring.

Released:
8-Nov-2018 5:05 PM EST
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Article ID: 703903

Global immunoprofiling effort reveals multifunctional T cell response during Zika infection

La Jolla Institute for Immunology

The latest study by researchers at the La Jolla Institute for Immunology (LJI) and their collaborators provide the first in-depth characterization of the body’s cytotoxic T cell response to Zika, which plays an important role in providing protective immunity against Zika.

Released:
13-Nov-2018 11:05 AM EST
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  • Embargo expired:
    31-Oct-2018 5:00 AM EDT

Article ID: 702886

LJI investigators discover how protein pair controls cellular calcium signals

La Jolla Institute for Immunology

Two studies recently published by La Jolla Institute for Immunology (LJI) investigators Patrick Hogan, PhD, and Aparna Gudlur, PhD, report how a calcium-sensing protein called STIM1 signals that it's time to initiate calcium retrieval and then relays that message to its partner, the calcium channel ORAI.

Released:
26-Oct-2018 1:35 PM EDT
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Article ID: 702437

La Jolla Institute Receives $ 4.5 Mill Cancer Moonshot Award

La Jolla Institute for Immunology

Researchers at La Jolla Institute for Immunology (LJI) and UC San Diego have been awarded $ 4.5 million as part of the National Cancer Institute’s Cancer Moonshot initiative. The funding will support research to develop new and improved immunotherapeutic treatment options for patients with head and neck cancer.

Released:
18-Oct-2018 1:05 PM EDT
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  • Embargo expired:
    28-Aug-2018 11:00 AM EDT

Article ID: 699440

Researchers Find Elusive Source of Most Abundant Immune Cell

La Jolla Institute for Immunology

Neutrophils—short-lived, highly mobile and versatile—outnumber all other immune cells circulating through the blood stream. Now, researchers at La Jolla Institute for Allergy and Immunology identified a progenitor of neutrophils in the bone marrow of mice and humans and tied it to cancer-promoting activities.

Released:
24-Aug-2018 11:35 AM EDT
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  • Embargo expired:
    8-Aug-2018 11:00 AM EDT

Article ID: 698538

Innate Lymphoid Cells (ILCs) form an essential line of defense against enteric bacteria

La Jolla Institute for Immunology

Mice deficient in innate lymphoid cells are vulnerable to lethal infection by the bacterial pathogen Yersinia enterocolitica (YE), which causes some forms of food poisoning. Moreover, activation by a cytokine called LIGHT, which is a member of the tumor necrosis factor (TNF) superfamily, is necessary for ILCs to mount an anti-bacterial response.

Released:
6-Aug-2018 11:05 AM EDT
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  • Embargo expired:
    2-Aug-2018 5:00 AM EDT

Article ID: 698247

Maternal Dengue Immunity Protects Against Fetal Damage in Mice Following Zika Virus Infection

La Jolla Institute for Immunology

A mouse mother's prior dengue immunity would protects her unborn pups from devastating brain defects such as microencephaly associated with ZIKV. These findings could guide development of more effective flavivirus vaccines and hint at what types of immune responses are maximally protective against fetal brain damage after Zika invasion.

Released:
30-Jul-2018 1:15 PM EDT
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Article ID: 697191

Kimishige Ishizaka, Distinguished Immunologist Who Guided Growth of Nascent La Jolla Institute, Dies

La Jolla Institute for Immunology

Dr. Kimishige Ishizaka, discoverer of a novel class of antibodies and the first Scientific Director of the La Jolla Institute for Allergy and Immunology (LJI), has died on July 6 in Yamagata City, Japan. He was 92 years old.

Released:
9-Jul-2018 4:30 PM EDT
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  • Embargo expired:
    20-Jun-2018 12:05 PM EDT

Article ID: 696320

Genetic Deletion of Two Protein-Modifying Enzymes Predisposes Mice to Asthma

La Jolla Institute for Immunology

Allergic asthma is a chronic inflammatory disease of the lung and airways driven, at least in part, by, a subgroup of overly active T helper cells. Thus, to devise better treatments, it is essential to determine how this cell population, known as TH2 cells, develops, matures and then crosses the line between protection and tissue damage.

Released:
19-Jun-2018 12:05 PM EDT

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