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  • Embargo expired:
    28-Aug-2018 11:00 AM EDT

Article ID: 699440

Researchers Find Elusive Source of Most Abundant Immune Cell

La Jolla Institute for Allergy and Immunology

Neutrophils—short-lived, highly mobile and versatile—outnumber all other immune cells circulating through the blood stream. Now, researchers at La Jolla Institute for Allergy and Immunology identified a progenitor of neutrophils in the bone marrow of mice and humans and tied it to cancer-promoting activities.

Released:
24-Aug-2018 11:35 AM EDT
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  • Embargo expired:
    8-Aug-2018 11:00 AM EDT

Article ID: 698538

Innate Lymphoid Cells (ILCs) form an essential line of defense against enteric bacteria

La Jolla Institute for Allergy and Immunology

Mice deficient in innate lymphoid cells are vulnerable to lethal infection by the bacterial pathogen Yersinia enterocolitica (YE), which causes some forms of food poisoning. Moreover, activation by a cytokine called LIGHT, which is a member of the tumor necrosis factor (TNF) superfamily, is necessary for ILCs to mount an anti-bacterial response.

Released:
6-Aug-2018 11:05 AM EDT
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  • Embargo expired:
    2-Aug-2018 5:00 AM EDT

Article ID: 698247

Maternal Dengue Immunity Protects Against Fetal Damage in Mice Following Zika Virus Infection

La Jolla Institute for Allergy and Immunology

A mouse mother's prior dengue immunity would protects her unborn pups from devastating brain defects such as microencephaly associated with ZIKV. These findings could guide development of more effective flavivirus vaccines and hint at what types of immune responses are maximally protective against fetal brain damage after Zika invasion.

Released:
30-Jul-2018 1:15 PM EDT
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Article ID: 697191

Kimishige Ishizaka, Distinguished Immunologist Who Guided Growth of Nascent La Jolla Institute, Dies

La Jolla Institute for Allergy and Immunology

Dr. Kimishige Ishizaka, discoverer of a novel class of antibodies and the first Scientific Director of the La Jolla Institute for Allergy and Immunology (LJI), has died on July 6 in Yamagata City, Japan. He was 92 years old.

Released:
9-Jul-2018 4:30 PM EDT
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  • Embargo expired:
    20-Jun-2018 12:05 PM EDT

Article ID: 696320

Genetic Deletion of Two Protein-Modifying Enzymes Predisposes Mice to Asthma

La Jolla Institute for Allergy and Immunology

Allergic asthma is a chronic inflammatory disease of the lung and airways driven, at least in part, by, a subgroup of overly active T helper cells. Thus, to devise better treatments, it is essential to determine how this cell population, known as TH2 cells, develops, matures and then crosses the line between protection and tissue damage.

Released:
19-Jun-2018 12:05 PM EDT
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Article ID: 692704

LJI Researchers Are One Step Closer to an Effective Anti-Atherosclerosis Vaccine

La Jolla Institute for Allergy and Immunology

A new paper published in Circulation by researchers at La Jolla Institute for Allergy and Immunology reports successful vaccination of atherosclerotic mice with a small chunk of protein snipped out of "bad cholesterol." Vaccination reduced plaque levels in test mice, and other experiments with human blood samples identified the class of T cells likely responsible for positive outcomes. The paper suggests that a comparable strategy could form the basis of a human vaccine.

Released:
12-Apr-2018 12:05 PM EDT
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  • Embargo expired:
    23-Mar-2018 2:00 PM EDT

Article ID: 691349

Bystander T Cells Can Steal the Show From "Professional" Regulatory Cells in Resolving Inflammation

La Jolla Institute for Allergy and Immunology

A team led by LJI researchers reveals that bystander cell accumulation antagonizes rather than abets cell-killing by specific CTLs, curbing inflammation. This is noteworthy because that chief anti-inflammatory role has been traditionally ascribed to what are called regulatory T cells, or "Tregs", which dampen autoimmune responses. T

Released:
19-Mar-2018 11:05 AM EDT
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Article ID: 691491

Western Diet Depletes Artery-Protecting Immune Cells

La Jolla Institute for Allergy and Immunology

New research from scientists at the La Jolla Institute for Allergy and Immunology shows how a diet high in fat and cholesterol depletes the ranks of artery-protecting immune cells, turning them into promoters of inflammation, which exacerbate atherosclerotic plaque buildup that occurs in cardiovascular disease. The team has also found that high density lipoproteins (HDL)—more commonly known as “good cholesterol”—counteract this process, helping the protective immune cells maintain their identity and keep arteries clear.

Released:
20-Mar-2018 6:05 PM EDT
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Article ID: 689681

Immune Signature Predicts Asthma Susceptibility

La Jolla Institute for Allergy and Immunology

Asthma is a chronic inflammatory disease driven by the interplay of genetics, environmental factors and a diverse cast of immune cells. In their latest study, researchers at La Jolla Institute for Allergy and Immunology (LJI) identified a subset of T cells, whose frequency serves as early childhood immune signature that predicts the risk of developing asthma later on.

Released:
16-Feb-2018 10:05 AM EST
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  • Embargo expired:
    13-Feb-2018 12:00 PM EST

Article ID: 689241

LJI researchers reveal how to undermine immune cell mobilization in allergic inflammation.

La Jolla Institute for Allergy and Immunology

LJI researchers report mechanisms used by a subgroup of ILCs, known as ILC2 cells, to undergo maturation required for them to mount an effective immune response. These discoveries suggest a novel approach to treat inflammatory disease caused by overactive ILC2s.

Released:
9-Feb-2018 11:05 AM EST

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