NIBIB-supported researchers have developed a smart nanoprobe designed to infiltrate prostate tumors and send back a signal using an optical imaging technique known as Raman spectroscopy.
To mark the 10-year anniversary of the NIBIB-led Concept to Clinic: Commercializing Innovation (C3i) program, we feature three innovators who participated in the program at the early stages of their biomedical technologies.
While pacemakers have been instrumental in treating many patients with heart rhythm disorders, their bulky design and dependence on wires can limit their usefulness and poses a risk of heart damage or infection. Researchers have cut the cords, shrunk the size, and expanded the capabilities of current designs.
A multidisciplinary group of NIH-funded scientists have successfully captured real-time, high-resolution images of the developing mouse placenta during the course of pregnancy.
Researchers at The Pennsylvania State University have developed a new synergistic approach to revascularization that could rapidly grow organized blood vessels in live rats.
If left to their own devices, bacteria on our teeth or wounded skin can encase themselves in a slimy scaffolding, turning into what is called biofilm. These bacteria wreak havoc on our tissue and, being shielded from antibiotic medication by the slime, are difficult to dislodge.
In honor of International Women’s Day, we’re featuring Rebecca Richards-Kortum, Ph.D., a professor of bioengineering at Rice University who has been solving women’s health challenges globally for the past two decades.
What if bacteria—which love to grow deep inside tumors—could guide cancer therapies directly to their target? A team of NIH-funded researchers has engineered a bacterial strain to “light up” tumors so that reprogrammed T cells, drawn like a moth to a flame, can find and destroy them. Their preclinical treatment could potentially be effective against any solid tumor type.
The lungs are one of the most difficult organs for physicians to navigate with a conventional bronchoscope. To overcome these limitations, a team of NIH-funded researchers built a compact robotic system that can autonomously steer a flexible needle around these anatomical obstacles within the lungs of live animals.
A collaborative team of NIH-funded researchers is developing a way to obtain DNA shed from brain tumors using focused ultrasound. Their first-in-human study could be an important step towards improving the way brain tumors are diagnosed.
The qualities of flowing blood, or hemodynamics, hold important insights into vascular diseases, but technological limitations have largely kept measurements of these properties out of reach in the clinic. Now, there may be a potential solution on the horizon.
A new RADx Tech fellowship aims to increase diversity among biotechnology innovators. Fellows who recently completed the six-month program share their perspectives on how the fellowship helped them advance their technologies.
An automated tool captures circulating tumor cells in children with central nervous system cancers. The tool could make it easier to identify tumors that don't respond to treatment.
Frequent insulin injections are an unpleasant, albeit necessary reality for many patients with type 1 diabetes. However, new technology could create a different reality for these patients by treating the disease in one fell swoop.
A beating heart makes for a formidable surgical arena, but a new robotic catheter could someday equip surgeons to operate in the cardiac environment with greater ease.
What if a clinician could 3D print something through your skin, constructing an implant or replacement organ underneath layers of tissue? The world of medicine would be transformed: a host of surgical procedures, which come with a variety of risks, could be performed without ever lifting a scalpel.
The federal government has expanded the Home Test to Treat program, an entirely virtual community health program that offers free COVID-19 health services: at-home rapid tests, telehealth sessions and at-home treatments, to eligible participants nationwide.
Researchers have designed a lightweight helmet with tiny LEGO-size sensors that scan the brain while a person moves. The helmet is the first of its kind to accurately record magnetic fields generated by brain activity while people are in motion, reports a new research paper published in NeuroImage.
Artificially causing – or inducing – labor is becoming increasingly common, yet this practice comes with risks and its level of success is difficult to foresee. But now, new research may offer a way to help predict outcomes and improve the process.Researchers at the University of Arkansas for Medical Sciences (UAMS) have devised a non-invasive method of accurately measuring the electrical activity of uterine muscles.
Introducing medical devices — commonly made of materials such as titanium, silicone, or collagen — into our bodies can elicit a host of different immune responses. While some responses can harm our bodies, others can help heal them. Researchers have not fully grasped the rhyme or reason behind the body’s reactions, but a new study fills in a critical piece of the puzzle.
Navigating the labyrinthine vasculature of the brain with standard surgical instruments can be incredibly challenging, even for the steadiest of hands. But with some robotic assistance, brain surgeons could potentially operate with far greater ease.
There is no cure or FDA-approved therapy for acute respiratory distress syndrome, which has a high rate of mortality. Inflammation plays a major role in developing ARDS. Researchers at Ohio State University developed therapeutic nanocarriers using mice skin cells, which reduced inflammation in their lungs.
Two participants in an NIBIB training program that aims to diversify the biomedical workforce share their stories of how the program influenced their career paths.
Dendritic cells are key orchestrators of the immune response, but most vaccination strategies don’t effectively target them. NIBIB-funded researchers have developed biodegradable nanoparticles that are designed to deliver mRNA cargo to dendritic cells in the spleen.
The National Institutes of Health will advance the development of home-based and point-of-care health technologies with awards to six technology research and development centers around the country.
NIH's Rapid Acceleration of Diagnostics Technology (RADx® Tech) Fetal Monitoring Challenge calls on scientists, engineers, and clinicians around the country to submit their innovative approaches and compete for prizes and additional resources to support technology development and clinical impact.
By now, most people have used an at-home test to find out if they have COVID-19. Rapid antigen tests are a fast and convenient way for people to test themselves for SARS-CoV-2, the virus that causes COVID-19. They’re a popular alternative to the polymerase chain reaction (PCR) tests that require a laboratory to process the results.
The National Institutes of Health and the higher education non-profit VentureWell have selected 10 winners and five honorable mentions of the Design by Biomedical Undergraduate Teams (DEBUT) Challenge, who are set to receive prizes totaling $145,000.
Researchers from Washington University in St. Louis have used ultrasound to nudge rodents into an energy-conserving state that mirrors a natural, hibernation-like survival mechanism known as torpor. The technique could help buy precious time for patients in critical care.
Nanozymes—artificial enzymes that can carry out pre-determined chemical reactions—could selectively activate a cancer drug within a tumor while minimizing damage to healthy tissue in a mouse model of triple negative breast cancer.
NIH's RADx Tech committed resources in early 2022 for increased accessibility of COVID-19 home tests. The RADx Tech Accessibility Program subsequently invited collaboration from advocacy organizations to contribute to design insights and is a first step that will help manufacturers address the gap in accessible test availability.
For most of our tissues and cells, a lack of oxygen, or hypoxia, is bad news. However, cancer cells can thrive in these conditions, rendering tumors less susceptible to anti-cancer treatments including radiation. Now, new research may offer a way to break through cancer’s hypoxia-induced defenses.
This fully wireless ultrasound patch, which can capture detailed medical information and wirelessly transmit the data to a smart device, could represent a major step forward in at-home health care technology.
This interview with Maryellen Giger, PhD, delves into the creation of the MIDRC imaging repository, how its data can be used to develop and evaluate AI algorithms, ways that bias can be introduced—and potentially mitigated—in medical imaging models, and what the future may hold.
Researchers have shown that an automated cancer diagnostic method, which pairs cutting-edge ultrasound techniques with artificial intelligence, can accurately diagnose thyroid cancer, of which there are more than 40,000 new cases every year.
Tissue engineering research has shown that a skin cell type could be a new therapeutic target to accelerate the healing of burns and possibly other wounds.
Researchers from Rice University have created drug-filled microparticles that can be engineered to degrade and release their therapeutic cargo days or weeks after administration. By combining multiple microparticles with different degradation times into a single injection, the researchers could develop a drug formulation that delivers many doses over time.
NIH-funded researchers developed an online tool that can analyze self-collected, at-home videos with a smartphone. When deployed in a nationwide study, the tool could predict physical health and osteoarthritis of the knee or hip.
Researchers at Carnegie Mellon University are developing lipid nanoparticles that are designed to carry mRNA specifically to the pancreas. Their study in mice could pave the way for novel therapies for intractable pancreatic diseases, such as diabetes and cancer.
Bioengineers from Columbia University are developing a pipeline to systematically evaluate how bacterial treatments might synergize with existing anti-cancer therapies in preclinical models.
After years of research, an NIH-funded team has developed a wearable cardiac ultrasound imager that can non-invasively capture real-time images of the human heart. The prototype patch, which is about the size of a postage stamp, can be worn during exercise, providing valuable cardiac information when the heart is under stress.
NIBIB has established the Center for Biomedical Engineering Technology Acceleration—BETA Center, a new intramural research program to solve a range of medicine’s most pressing problems. The BETA Center will serve the wider NIH intramural research program as a biotechnology resource and catalyst for NIH research discoveries.
Using state-of-the-art imaging technology, NIH-funded researchers have found the secret behind the glassfrog’s ability to become transparent, an effective form of camouflage. Future research may provide insights into disorders related to blood clotting or stroke in humans.
NIH, in collaboration with the Administration for Strategic Preparedness and Response at HHS, has launched the Home Test to Treat program, an entirely virtual community health intervention that will provide free COVID-19 health services—at-home rapid tests, telehealth sessions and at-home treatments—in selected communities.
NIBIB-funded researchers are developing a new method to treat pancreatic cancer. In their study, they combined an injectable radioactive gel with systemic chemotherapy in multiple mouse models of the disease. The treatment resulted in tumor regression in all evaluated models, an unprecedented result for this genetically diverse and aggressive type of cancer.
NIBIB-funded researchers are fine-tuning a wearable, cuffless blood pressure monitor. Made of graphene, one of the thinnest materials in the world, the device is worn on the underside of the wrist and can measure blood pressure with comparable accuracy to a standard blood pressure cuff.
Reporting a positive or negative test result just became easier through a new website from the National Institutes of Health. MakeMyTestCount.org, developed through NIH’s Rapid Acceleration of Diagnostics (RADx®) Tech program, allows users to anonymously report the results of any brand of at-home COVID-19 test.
The National Institutes of Health has awarded research funding for seven pilot projects developing early stage, yet groundbreaking neuro-technologies. The innovative projects would enable new medical devices to diagnose and treat both acute and chronic disorders, from neuropathic pain to mental illness.
When it blasts off from the Kennedy Space Center in Florida, Artemis I will carry two anthropomorphic mannequins strapped into its crew module. The mannequins are part of a project aided by a team of Duke University bioengineers with support from NIBIB.
Researchers have found that AI models could accurately predict self-reported race in several types of medical images, suggesting that race information could be unknowingly incorporated into image analysis models.
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