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Released: 23-Jun-2022 6:00 AM EDT
Scientists Hope to Create a Health ‘Scorecard’ for Dementia Risk
UC Davis Health

An important new study of diverse communities is looking at how brain changes, genetics and other factors contribute to dementia and Alzheimer’s disease. The results could affect millions. Among people 65 and older, about 1 in 9 has Alzheimer’s disease.

Newswise: Roswell Park-Developed Immunotherapy Now Part of Nationwide Study in Kids With Brain Cancer
Released: 7-Jun-2022 2:05 PM EDT
Roswell Park-Developed Immunotherapy Now Part of Nationwide Study in Kids With Brain Cancer
Roswell Park Comprehensive Cancer Center

The immunotherapy SurVaxM is being utilized in a pilot study in children and adolescents with several brain cancer types through a multicenter trial sponsored by the Pediatric Brain Tumor Consortium (PBTC).

Newswise: Trauma Study Aims to Improve Survival for Bleeding Patients
Released: 27-May-2022 2:25 PM EDT
Trauma Study Aims to Improve Survival for Bleeding Patients
Vanderbilt University Medical Center

Emergency Medicine and Trauma Surgery researchers at Vanderbilt University Medical Center (VUMC) are joining Vanderbilt LifeFlight in a Department of Defense (DOD)-funded clinical trial aimed at improving survival with resuscitation techniques used to keep patients alive after a traumatic injury.

Released: 26-May-2022 2:05 PM EDT
Investigational Drug Trial Seeks Male Volunteers with Chronic Kidney Diseases
Saint Louis University Medical Center

Researchers at Saint Louis University School of Medicine are enrolling volunteers in an investigational drug trial for hypogonadal men with chronic kidney disease.

Released: 24-May-2022 11:00 AM EDT
Susan G. Komen Awards Grant to Define and Advance Diagnosis of Inflammatory Breast Cancer
Susan G. Komen

Susan G. Komen awarded a research grant to apply a new, first-of-its-kind tool that seeks to more accurately diagnose inflammatory breast cancer (IBC).

Released: 19-May-2022 2:50 PM EDT
Study tests link between common blood pressure pills and breast cancer
Curtin University

Curtin University researchers will examine if the long-term use of a popular blood pressure medication increased the risk of breast cancer in almost 200,000 women as part of a new project supported by the Federal Government.

Newswise: After Sprint for COVID-19 Vaccines, HVTN Researchers Return to HIV Marathon With Fresh Determination and Knowledge, Launch Clinical Research Registry and Ad Campaign
Released: 18-May-2022 9:55 AM EDT
After Sprint for COVID-19 Vaccines, HVTN Researchers Return to HIV Marathon With Fresh Determination and Knowledge, Launch Clinical Research Registry and Ad Campaign
HIV Vaccine Trials Network

SEATTLE (May 18, 2022) – Building on momentum from the highly successful COVID-19 vaccine clinical trials, the HIV Vaccine Trials Network (HVTN) is launching a new HIV awareness campaign and unveiling a first-of-its-kind national registry that will provide updated HIV information and make it easier to learn about and participate in HIV clinical trials at HelpEndHIV.org.

Newswise: Early Study Finds New Lymphoma Drug Effective
Released: 13-May-2022 10:50 AM EDT
Early Study Finds New Lymphoma Drug Effective
Michigan Medicine - University of Michigan

In early research led by the University of Michigan Health Rogel Cancer Center, the oral medication zanubrutinib was found to help most patients with a slow-growing type of cancer known as marginal zone lymphoma.

Released: 11-May-2022 8:00 AM EDT
First Patients Dosed in Phase 2 Platform Clinical Trial Testing Novel Immunotherapy Combinations in Highly Malignant Ovarian Cancer
Cancer Research Institute (CRI) and Ovarian Cancer Research Alliance (OCRA)

A phase 2 clinical trial testing novel immunotherapy combinations in aggressive ovarian cancer has opened and first patients have begun treatment.

Newswise: Stroke Patient with Brain Injury Fully Recovers After Participating in UTHealth Houston-Led Clinical Trial
Released: 3-May-2022 8:05 AM EDT
Stroke Patient with Brain Injury Fully Recovers After Participating in UTHealth Houston-Led Clinical Trial
University of Texas Health Science Center at Houston

A stroke and subsequent brain injury qualified 65-year-old Linda Carmichael for a national, randomized clinical trial led locally by Sunil A. Sheth, MD, with McGovern Medical School at UTHealth Houston, investigating the safety and efficacy of endovascular thrombectomy plus medical management compared to medical management alone in certain LVO stroke patients.

Released: 27-Apr-2022 11:05 AM EDT
Wake Forest University School of Medicine Researchers Receive $1.7 Million Grant to Study Obesity Medication
Wake Forest School of Medicine

With the support of a $1.7 million grant from the National Institutes of Health, researchers at the School of Medicine will lead the Long-term Effectiveness of the Anti-Obesity medication Phentermine (LEAP) trial, a placebo-controlled, randomized-controlled trial that will enroll 1,000 adults at five sites across the U.S.

Newswise: Immunotherapy Study Offers Hope for Pancreatic Cancer Patients
Released: 27-Apr-2022 11:05 AM EDT
Immunotherapy Study Offers Hope for Pancreatic Cancer Patients
Sylvester Comprehensive Cancer Center

In a research letter to the journal JAMA Oncology, clinical researchers at Sylvester Comprehensive Cancer Center in the University of Miami Miller School of Medicine showed that immunotherapy can be an option for at least one subgroup of pancreatic cancer patients. The study found that patients with inherited BRCA and other similar mutations can achieve complete responses — in some cases going from near death to durable recoveries.

Released: 26-Apr-2022 2:05 PM EDT
Blasting Bladder Cancer
University of New Mexico Comprehensive Cancer Center

Bladder cancer affects nearly 84,000 people in the United States each year, making it the sixth most common cancer. Most people survive it, but unfortunately, many lose their bladders. Neda Hashemi, MD, and her team at The University of New Mexico Comprehensive Cancer Center are now offering several clinical trials, including one that will give people with bladder cancer a chance to fight their disease and keep their bladders.

Released: 25-Apr-2022 1:35 PM EDT
NIH Awards Wake Forest University School of Medicine $4 Million Grant to Study Chronic Pain and Opioid Use Disorder
Wake Forest School of Medicine

Researchers at Wake Forest University School of Medicine have been awarded a five-year, $4 million grant through the National Institutes of Health (NIH) Helping End Addiction Long-term (HEAL) Initiative to study chronic pain and opioid use disorder.

Newswise: Mount Sinai Launches Phase 1 U.S. Trial of NDV-HXP-S, an Egg-Based Investigational COVID-19 Vaccine, in Healthy Adults Previously Immunized Against COVID-19
Released: 21-Mar-2022 2:05 PM EDT
Mount Sinai Launches Phase 1 U.S. Trial of NDV-HXP-S, an Egg-Based Investigational COVID-19 Vaccine, in Healthy Adults Previously Immunized Against COVID-19
Mount Sinai Health System

A team of clinical investigators at the Icahn School of Medicine at Mount Sinai has announced the launch of a Phase 1, open-label, placebo-controlled study to evaluate the safety and immunogenicity of an egg-based COVID-19 vaccine in healthy, vaccinated adults who have never been infected with COVID-19.

Newswise: University of Kentucky's Sanders-Brown Center on Aging Begins 1st Clinical Trial in the World for Newly Discovered Form of Dementia
Released: 17-Mar-2022 1:25 PM EDT
University of Kentucky's Sanders-Brown Center on Aging Begins 1st Clinical Trial in the World for Newly Discovered Form of Dementia
University of Kentucky

Now a couple of years after this discovery, Pete Nelson, the R.C. Durr Foundation Chair in Alzheimer's Disease at the University of Kentucky, is working towards the second part of the dream, with the world’s first clinical trial for LATE officially underway by his colleagues at UK.

Released: 15-Mar-2022 4:55 PM EDT
Enrollment is complete for the largest national clinical trial on approaches for dementia care
University of California, Los Angeles (UCLA), Health Sciences

The Dementia Care Study (D-CARE), a nation-wide clinical trial assessing the effectiveness of different approaches to caring for people with Alzheimer’s disease and other dementias, has reached its recruitment goal by enrolling 2,176 persons living with dementia and their caregivers

Released: 1-Mar-2022 2:30 PM EST
Nationwide Study Led by U of U Health Tests New Treatment for “Brain on Fire” Disease
University of Utah Health

University of Utah Health researchers are leading a five-year, $22-million nationwide clinical trial for NMDA receptor encephalitis––a type of autoimmune encephalitis that prompts the immune system to mistakenly attack the brain, causing confusion, memory loss, seizures, and symptoms similar to bipolar disorder and other psychiatric conditions.

Newswise: SLU Transplant Team Enrolls Participants in National Kidney Study
Released: 22-Feb-2022 2:35 PM EST
SLU Transplant Team Enrolls Participants in National Kidney Study
Saint Louis University

African Americans have an increased risk of kidney failure, and new research shows that some of this risk is related to variations in a gene called apolipoprotein L1 (APOL1). Scientists will address racial disparities in kidney transplant outcomes.

Newswise: Overlook Medical Center chosen as SURVIVE trial site, enrolling patients for new brain tumor vaccine
Released: 22-Feb-2022 8:35 AM EST
Overlook Medical Center chosen as SURVIVE trial site, enrolling patients for new brain tumor vaccine
Atlantic Health System

Experts at Overlook are hoping that SurVaxM, a first-of-its-kind vaccine targeting a protein found in glioblastomas and other cancers, will give patients a better shot at long-term survival and improved function.

Released: 15-Feb-2022 4:05 AM EST
Mutation Matchmaking
University of New Mexico Comprehensive Cancer Center

The UNM Comprehensive Cancer Center has opened the Targeted Agent and Profiling Utilization Registry (TAPURTM) Study, sponsored by the American Society of Clinical Oncology (ASCO). The clinical trial is cancer agnostic. It may help people who have rare cancer mutations and enable them to receive personalized cancer therapy.

Newswise: Trial Evaluating Device to Identify a Concussion Biomarker Begins Recruiting Patients
Released: 9-Feb-2022 1:30 PM EST
Trial Evaluating Device to Identify a Concussion Biomarker Begins Recruiting Patients
University of Texas Health Science Center at Houston

A trial investigating a potential electric biomarker for mild traumatic brain injury is now recruiting teenage and adult patients at The University of Texas Health Science Center at Houston (UTHealth Houston).

Newswise: Roswell Park Opens Phase 2B Randomized Clinical Trial of Promising Brain Cancer Immunotherapy
Released: 4-Feb-2022 11:00 AM EST
Roswell Park Opens Phase 2B Randomized Clinical Trial of Promising Brain Cancer Immunotherapy
Roswell Park Comprehensive Cancer Center

Roswell Park Comprehensive Cancer Center is the first center to treat patients in a newly opened advanced-stage clinical trial utilizing the brain cancer vaccine SurVaxM, offering a new treatment option for patients who are dealing with a rare but deadly form of the disease. The multicenter randomized clinical trial is sponsored by MimiVax LLC, a company spun off from Roswell Park in 2012.

Released: 20-Jan-2022 1:40 PM EST
U of U Health Testing New Male Contraceptive Gel
University of Utah Health

University of Utah Health scientists are testing a new contraceptive gel for men. Based on preliminary research, the scientists believe the hormonal gel decreases a man’s sperm production––reducing his chances of fathering a child––without decreasing his sex drive.

Newswise: The Wistar Institute and Stanford Medicine to Begin Phase 2 Clinical Trial of VK-2019 in Patients with Epstein-Barr Virus (EBV)-Positive Advanced Nasopharyngeal Carcinoma
Released: 5-Jan-2022 9:35 AM EST
The Wistar Institute and Stanford Medicine to Begin Phase 2 Clinical Trial of VK-2019 in Patients with Epstein-Barr Virus (EBV)-Positive Advanced Nasopharyngeal Carcinoma
Wistar Institute

Wistar announces the initiation of a Phase 2 clinical study of VK-2019 in patients with advanced Epstein-Barr Virus (EBV)-positive nasopharyngeal carcinoma (NPC) and lymphoma.

Released: 4-Jan-2022 10:30 AM EST
Penn Medicine-Led Team Receives $8 Million to Build on Success of Hepatitis C Kidney Transplantation Research
Perelman School of Medicine at the University of Pennsylvania

With an $8 million grant from the National Institutes of Health (NIH), the next stage of the THINKER project — called THINKER-NEXT — will aim to provide a comprehensive view of the risks and benefits of transplanting HCV-infected kidneys into non-infected patients.

Newswise: New Alzheimer’s prevention trial in young people
Released: 21-Dec-2021 1:30 PM EST
New Alzheimer’s prevention trial in young people
Washington University in St. Louis

Washington University School of Medicine in St. Louis is launching an international clinical trial aimed at preventing Alzheimer’s disease in people genetically destined to develop the illness at a young age. Unlike most other Alzheimer’s prevention trials, this one will enroll people before the disease has taken hold – up to 25 years before the expected onset of dementia.

Released: 14-Dec-2021 10:35 AM EST
Duke Institute Lands Federal Contract to Make Vaccine Candidates
Duke Health

The National Institute of Allergy and Infectious Diseases awarded researchers at the Duke Human Vaccine Institute a contract that enables it to compete for projects advancing investigational vaccines to production for use in early clinical trials.

Released: 13-Dec-2021 1:25 PM EST
Landmark COVID-19 vaccine trial in sub-Saharan Africa is the first to study the efficacy of mRNA COVID-19 vaccines in people living with HIV
Covid-19 Prevention Network (CoVPN)

A highly anticipated clinical trial in eight sub-Saharan countries is the first to specifically evaluate the efficacy of a COVID-19 vaccine in people living with HIV, including those with poorly controlled infections. It also is the first study to evaluate the efficacy of vaccines – in this case, Moderna mRNA-1273 – against the omicron variant of SARS-CoV-2, the virus that causes COVID-19.

Newswise: Exploring New Cancer Therapies that use a Patient’s Immune System to Fight Tumors
Released: 9-Dec-2021 11:40 AM EST
Exploring New Cancer Therapies that use a Patient’s Immune System to Fight Tumors
Rutgers Cancer Institute of New Jersey

Research underway at Rutgers Cancer Institute of New Jersey will contribute to the development of new cancer treatments that are based on the administration of cancer-fighting immune cells to patients.

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Released: 7-Dec-2021 8:45 AM EST
Researchers to begin human trials for promising new inhaled COVID-19 vaccines designed to combat variants of concern
McMaster University

Human trials are set to begin for two next-generation COVID-19 vaccines developed by a team of scientists at McMaster University.

Newswise:Video Embedded new-tech-gives-kidney-stone-patients-options2
VIDEO
Released: 2-Dec-2021 4:10 PM EST
New tech gives kidney stone patients options
University of Washington School of Medicine

Using high-frequency waves, the new treatment pushes smaller stones from the bottom of the kidney toward the ureter. The procedure allows for an office visit instead of surgery.

Newswise: Fox Chase Cancer Center, The Wistar Institute Announce Opening of Phase 1 Clinical Trial of Anticancer Drug Candidate
Released: 2-Dec-2021 11:20 AM EST
Fox Chase Cancer Center, The Wistar Institute Announce Opening of Phase 1 Clinical Trial of Anticancer Drug Candidate
Wistar Institute

Fox Chase Cancer Center has opened an investigator-initiated, phase 1 clinical trial to evaluate the safety and efficacy of gamitrinib in patients with advanced cancer.

Newswise: Clinical trial to study if mindfulness helps with diabetes-related stress, health
Released: 1-Dec-2021 10:05 AM EST
Clinical trial to study if mindfulness helps with diabetes-related stress, health
Penn State College of Medicine

Researchers at Penn State College of Medicine are seeking volunteers from across the U.S. to participate in a clinical trial examining whether online mindfulness-based stress reduction can reduce stress and average blood sugar levels in those with Type 1 or Type 2 diabetes.

Newswise: Can Ancient Botanical Therapies Help Treat COVID-19?
Released: 12-Nov-2021 3:05 PM EST
Can Ancient Botanical Therapies Help Treat COVID-19?
University of California San Diego Health

A novel study — led by University of California San Diego and UCLA, in collaboration with the La Jolla Institute for Immunology — is assessing whether medicinal mushrooms and Chinese herbs provide therapeutic benefit in treating acute COVID-19 infection.

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Released: 9-Nov-2021 6:05 PM EST
New drug offers hope for pancreatic cancer patients
University of South Australia

A world first drug developed by University of South Australia scientists may provide the critical breakthrough for 500,000 people diagnosed with pancreatic cancer.

Released: 9-Nov-2021 3:35 PM EST
Rutgers Launches IMPOWER HIV Prevention Studies in Newark
Rutgers University-New Brunswick

Rutgers New Jersey Medical School’s Research with a Heart is recruiting participants for the MERCK– IMPOWER studies to assess an HIV prevention oral medication on sexual minority groups.

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Released: 8-Nov-2021 11:40 AM EST
International Alzheimer’s clinical trial to test two drugs in combination
Washington University in St. Louis

Researchers leading the Tau Nex Gen Trial — a worldwide clinical trial aimed at finding treatments for Alzheimer’s disease — are modifying an arm of the trial to target two brain proteins: amyloid and tau. A part of DIAN-TU, the trial originally was announced with a focus on drugs that target tau.

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Released: 28-Oct-2021 1:55 PM EDT
U Vermont Research Leads to First-of-Its-Kind Mesothelioma Clinical Trial
University of Vermont

A promising new therapy for mesothelioma and metastatic cancer, arising from laboratory investigations at the University of Vermont Cancer Center, is about to enter a Phase I clinical trial. he approach, published in PLOS ONE, targets a universal vulnerability in cancer cells that could be exploited therapeutically.

Newswise: USC Norris Comprehensive Cancer Center launches global clinical trial testing potential therapy for aggressive type of breast cancer
Released: 9-Oct-2021 7:05 AM EDT
USC Norris Comprehensive Cancer Center launches global clinical trial testing potential therapy for aggressive type of breast cancer
Keck Medicine of USC

USC Norris Comprehensive Cancer Center launches global clinical trial testing potential therapy for aggressive type of breast cancer.

Released: 8-Oct-2021 3:35 PM EDT
ATR inhibitor RP-3500 demonstrates safety and early clinical benefit
University of Texas M. D. Anderson Cancer Center

Early data from a biomarker-driven Phase I trial of ATR inhibitor RP-3500 shows encouraging results for patients with advanced solid tumors harboring selected molecular alterations

Newswise: Clinical trial investigating use of high-dose vitamin D3 in prevention of cluster headache now recruiting patients
Released: 30-Sep-2021 3:25 PM EDT
Clinical trial investigating use of high-dose vitamin D3 in prevention of cluster headache now recruiting patients
University of Texas Health Science Center at Houston

A clinical trial investigating whether high-dose vitamin D3 supplements combined with a multivitamin could effectively prevent cluster headaches is now recruiting patients at The University of Texas Health Science Center at Houston (UTHealth Houston).

Newswise: University of Miami Urologist Receives Major NIH Grant to Study Regenerative Treatment for Erectile Dysfunction
Released: 27-Sep-2021 12:45 PM EDT
University of Miami Urologist Receives Major NIH Grant to Study Regenerative Treatment for Erectile Dysfunction
University of Miami Health System, Miller School of Medicine

A University of Miami Miller School of Medicine urologist was awarded a significant R01 grant from the National Institutes of Health (NIH) for a first-of-its-kind study for treating erectile dysfunction using a combination of platelet-rich plasma and shockwave therapy.

Released: 31-Aug-2021 8:20 AM EDT
Experimental Phase 2b HIV Vaccine Regimen Provides Insufficient Protection in Preventing HIV
Fred Hutchinson Cancer Research Center

A primary analysis of an experimental HIV vaccine regimen being studied in a high-incidence population of young women in sub-Saharan Africa found the experimental vaccine did not provide sufficient protection against HIV infection.

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Released: 30-Aug-2021 8:05 AM EDT
Putting Patient Care at the Heart of Cancer Trials
University of South Australia

From bench to bedside, the journey towards new cancer therapies is full of challenges. Clinical trials – where new treatments are tested on people – are vital, but with fewer than five percent of cancer patients participating worldwide, it’s a long road to travel.

Released: 27-Aug-2021 2:05 PM EDT
Michigan Medicine to help lead NIH study of extra COVID-19 vaccine dose in people with autoimmune disease
Michigan Medicine - University of Michigan

A Michigan Medicine physician will co-lead a NIH study of antibody response to an additional dose of the COVID-19 vaccine in people with autoimmune disease. The trial will also assess whether pausing immunosuppressive medication improves immune response to the booster shot.

Newswise: Hackensack University Medical Center to Participate in Groundbreaking Clinical Trial for Investigational Alzheimer’s Disease Medication
Released: 25-Aug-2021 2:05 PM EDT
Hackensack University Medical Center to Participate in Groundbreaking Clinical Trial for Investigational Alzheimer’s Disease Medication
Hackensack Meridian Health

Hackensack Meridian Hackensack University Medical Center’s Center for Memory Loss & Brain Health has started enrollment for a clinical trial for ATH-1017, an investigational medication for the treatment of mild to moderate Alzheimer’s disease as of August 3, 2021.

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Released: 25-Aug-2021 8:55 AM EDT
Chula Medicine Announced the Success of Clinical Trials for the “ChulaCov19” Vaccine and Acceleration of the Next Phase of Research
Chulalongkorn University

August 16, 2021 – Chulalongkorn Memorial Hospital, Thai Red Cross Society, and the Vaccine Research Center, Faculty of Medicine, Chulalongkorn University (CVRC) held a press conference on the progress of clinical trials for the Thai “ChulaCov19” mRNA vaccine. The clinical trial (Phase 1) was administered in healthy volunteers who are found to have good immunity after they have been vaccinated. The volunteers’ antibodies have been greatly boosted to prevent the original strain of the virus, and four other variants, namely Alpha, Beta, Gamma, and Delta. Manufacturing and preparation for registration to be used in an emergency are underway.

Newswise: Hackensack University Medical Center to Open Clinical Trial for Medication to Treat Alzheimer’s-Related Agitation
Released: 24-Aug-2021 11:30 AM EDT
Hackensack University Medical Center to Open Clinical Trial for Medication to Treat Alzheimer’s-Related Agitation
Hackensack Meridian Health

Hackensack Meridian Hackensack University Medical Center, Center for Memory Loss and Brain Health will be participating in a multicenter clinical trial to study the safety and efficacy of escitalopram, an antidepressant, for the treatment of agitation related to Alzheimer’s disease. This study is sponsored by the National Institute on Aging. Johns Hopkins University is the principal site and Hackensack University Medical Center will begin enrolling patients in the study starting in September 2021.


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