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A clinical trial from Keck Medicine of USC will test the feasibility of treating non-small cell lung cancer with immunotherapy provided at home.

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A clinical trial from Keck Medicine of USC aims to provide a surgical solution for patients with a form of advanced pancreatic cancer previously considered inoperable.

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The Phase 3 CELLEBRATE trial to test a regenerative stem cell-based therapy in treating patients with stress urinary incontinence is continuing to recruit additional subjects after changing its study protocol to include only patients who have already tried surgery.

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Samara Rahman, 74, enrolled in a clinical trial at UCLA Health that was evaluating an “off-the-shelf” vaccine that is given after surgery to prevent or delay the cancer from coming back in high-risk patients.

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A medication that appeared to stabilize the function and shape of red blood cells in an earlier study for patients with sickle cell disease is now part of a Phase III clinical trial that is open for enrollment at UTHealth Houston.

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For years, researchers and clinicians at University of Michigan have sent recycled, or reconditioned, pacemakers to low- and middle-income countries for compassionate use cases in 2010 through the “My Heart Your Heart” program. Currently, the U-M team is leading an international clinical trial that is testing the impact of sending reconditioned pacemakers abroad for standard use. If successful, the trial could greatly increase access to pacemaker treatment for patients who otherwise would not receive it.

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Hackensack Meridian Neuroscience Institute at Jersey Shore University Medical Center’s ALS Center is the first ALS care provider in the United States to offer patients a new interventional clinical study.

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Researchers with Sylvester Comprehensive Cancer Center have received funding to better understand how personalized nutrition and exercise programs can improve quality of life after cancer treatment.

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UT Southwestern Medical Center is leading three multicenter clinical trials funded by the National Institute on Drug Abuse (NIDA) focused on potential treatments for methamphetamine or cocaine addiction.

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George T. Grossberg, M.D., and colleagues were instrumental in developing the first and only Food and Drug Administration (FDA) approved treatment for agitation associated with Alzheimer's dementia.

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UNC Health is the only academic healthcare system in North Carolina and the South participating in the randomized trial, which aims to assess the safety and efficacy of a combination immunotherapy for newly diagnosed glioblastoma patients.

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$3.12 million NIH study to look at acupuncture as a treatment for stable angina

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Chronic inflammation of the skin, or Hidradenitis Suppurativa (HS), disproportionately affects women and people of color. It can be debilitating, negatively impacting suffers’ quality of life, physical function, work productivity, and the social and emotional wellbeing.

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Researchers at Saint Louis University (SLU) are enrolling participants in a clinical trial to increase youth sport coaches' knowledge of musculoskeletal injuries and how to prevent them. Principal investigator Oluwatoyosi Owoeye, Ph.D., assistant professor of physical therapy at SLU, says this is the first study of its kind.

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Researchers are working to improve outcomes for Black women with breast cancer – including through increased participation in clinical trials, which helps find better ways to prevent, diagnose and treat cancer.

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The Trauma and Transfusion Medicine Research Center (TTMRC) in the Department of Surgery at the University of Pittsburgh School of Medicine is launching a $34 million, federally funded clinical trial to simultaneously test multiple interventions for life-threatening bleeding in at least 1,000 traumatically injured children across 20 U.S. pediatric trauma centers.

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Researchers from UChicago will lead the next phase of the Illinois Precision Medicine Consortium (IPMC)'s participation in the National Institutes of Health's All of Us Research Program.

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Wits Bone Research Lab the only unit of its kind to show that a bone-forming protein can block growth of human squamous cell

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The Speech Accessibility Project is almost halfway through its first phase of gathering voice recordings from people with Parkinson’s. Project participant and Parkinson's advocate Ethan Henderson can comment.

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$9 million grant awarded to researchers with UC San Diego School of Medicine supports new study of semaglutide for liver disease.

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Researchers at RUSH are seeking volunteers to explore how a change in diet may improve brain health after a stroke. The study, called NOURISH — short for Nutrition Effects on Brain Outcomes and Recovery in Stroke After Hospitalization — aims to prevent cognitive and memory decline that is common in stroke survivors.

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The Food and Drug Administration announced yesterday the approval of HEPZATO Kit to treat ocular melanoma that has spread to the liver. HEPZATO uses a hepatic delivery system to inject the chemotherapy drug melphalan into the liver, a procedure referred to as percutaneous hepatic perfusion (PHP). Moffitt Cancer Center’s Jonathan S. Zager, M.D., was the lead international principal investigator on the multinational FOCUS phase 3 clinical trial to test the procedure, which is manufactured by Delcath Systems, Inc.

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A clinical trial evaluating the role of statins in the risk of recurrent intracerebral hemorrhage (ICH) in patients presenting with ICH, has opened for enrollment at UTHealth Houston.

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Following up on positive results from preliminary research, scientists at University of Utah Health are evaluating whether an eight-week program based on positive psychology techniques can improve the mood and well-being of people who have had a stroke and those who care for them.

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Two clinical trials that will evaluate drugs, biologics, medical devices, and other therapies for long COVID that are sponsored by the National Institutes of Health (NIH) will launch at UTHealth Houston.

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Today, the National Institutes of Health launched and is opening enrollment for phase 2 clinical trials that will evaluate at least four potential treatments for long COVID, with additional clinical trials to test at least seven more treatments expected in the coming months. Treatments will include drugs, biologics, medical devices and other therapies.

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Clinical testing is underway for a potentially groundbreaking new treatment for cystic fibrosis.

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Overlook Medical Center in NJ, is the 1st site in the nation to dose a patient in the Phase IIb RESTORE Trial for newly-diagnosed glioblastoma tumors. Researchers will see whether using NanO2 TM, a drug by NuvOx Pharma to infuse oxygen into hypoxic tissues, can boost traditional radiation and chemo.

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A 2022 outbreak of mpox (formerly monkeypox) sickened more than 30,000 people and caused 38 deaths in the United States. It highlighted the lack of an approved vaccine for those under 18 years old.

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A new clinical trial run by Howard University, the University of Illinois Chicago and the University of Miami Miller School of Medicine will partner with community organizations and sites to bring life-saving care closer to a highly vulnerable population – Black people with opioid use disorder.

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A study involving UCLA Jonsson Comprehensive Cancer Center researchers found when ribociclib, a targeted therapy drug, is added to hormone therapy there are significant survival benefits for patients with early hormone-receptor (HR) positive/HER2 negative breast cancer.

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A pneumonia trial – the largest ever led by the University of Bristol – will investigate whether aspirin can reduce the risk of a heart attack or stroke in patients who are admitted to hospital with pneumonia.

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The Society for Clinical Trials (SCT) is pleased to announce that the prestigious David Sackett Trial of the Year Award will be presented to The Chronic Hypertension and Pregnancy (CHAP) Trial.

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UCLA Health investigators are leading a new, six-city trial of injectable buprenorphine for treatment of methamphetamine use disorder in adults who also use opioids.

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UC Davis Health researchers have dosed the second participant in their clinical trial looking to identify a potential cure for HIV utilizing CART-cell therapy.

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The National Institutes of Health trial to evaluate the mpox (previously known as monkeypox) vaccine JYNNEOS has now entered the next stage and is studying the immune responses to and the safety of the vaccine in adolescents. The George Washington University is one of 18 clinical trial sites across the United States that have launched this stage testing the JYNNEOS vaccine.

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The immuno-oncology (IO) clinical trial landscape is shifting in new directions. While the number of total clinical trials is down, there are healthy signs of innovation.

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Keck Medicine of USC has launched a Phase 2 clinical trial investigating the effectiveness of a new outpatient, nonsurgical endoscopic procedure in stabilizing blood glucose levels for patients.

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Keck Medicine of USC has launched a clinical trial to study the effect of a novel hormone replacement therapy on postmenopausal cardiovascular disease and cognitive decline.

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A novel compound that has the potential to starve the bacteria that causes tuberculosis – the world’s leading infectious killer after SARS-CoV2 – is entering human clinical trials.

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The UNM Cancer Center will be one of a few sites in the country participating in a clinical trial to expand the application of theranostic treatment to patients with prostate cancer. This type of treatment is currently used at the cancer center for neuroendocrine tumors. The treatment is a two-part process that first injects the molecule attached to a gallium-68 radioactive isotope that can be imaged to illuminate the cancer cells, which makes them easier to see under Positron Emission Tomography, or PET scans.

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Delray Medical Center is the first hospital in Florida to treat an Alzheimer’s disease patient using non-invasive focused ultrasound technology as part of a groundbreaking study being conducted in collaboration with FAU’s Institute for Human Health and Disease Intervention (I-Health). In the FDA-approved clinical trial, focused ultrasound technology is used to disrupt the blood-brain barrier in participating Alzheimer’s patients.

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The Vanderbilt Memory and Alzheimer’s Center is recruiting individuals age 50 and older to participate in a study researching early drivers of Alzheimer’s disease.