Among adults with normal kidney function, exposure to higher concentrations of components of air pollution was linked with higher risks of later developing chronic kidney disease.
The results of numerous high-impact clinical trials that could affect kidney-related medical care will be presented in-person and online at ASN Kidney Week 2022 November 3–November 6.
• In a population-level study of 1,105 adults with stable glomerular disease (a type of autoimmune kidney disease), a first dose of a COVID-19 vaccine was not associated with relapse risk; however, receiving a subsequent vaccine dose was associated with a 2-fold higher relative risk of relapse. • Importantly, the increase in absolute risk associated with vaccination was low (1–5% depending on type of glomerular disease), and most vaccine-associated disease flares were mild.
Scientists have generated a polygenic risk score for pediatric steroid sensitive nephrotic syndrome, a kidney disease in children.
Researchers have developed and validated an artificial intelligence–based algorithm to predict hospitalized patients’ risk of major adverse kidney events after discharge.
In an analysis of data from the Framingham Heart Study, albuminuria (a marker of kidney disease) was associated with signs of silent stroke, and patients with albuminuria had a higher risk of developing mild cognitive impairment or dementia.
Investigators recently developed and validated an artificial intelligence–based model that can help clinicians predict which patients in the intensive care unit are most likely to develop acute kidney injury.
A recent analysis indicates that dapagliflozin is a cost-effective treatment in patients with chronic kidney disease in addition to standard of care.
● The Congressional Kidney Caucus recognizes the 50th anniversary of the Medicare End-Stage Renal Disease (ESRD) Program. ● Kidney health leaders join the Congressional Kidney Caucus in calling for greater emphasis on intervening earlier and increasing disease awareness, increasing access to transplantation, and accelerating innovation in kidney health in the future of the ESRD Program.
● Among individuals with varying levels of chronic kidney disease who were not on dialysis, the prevalence of individual symptoms ranged from 24% (chest pain) to 83% (fatigue), and 98% of participants reported at least one symptom. ● Patients categorized as having a “Worse symptom score and worsening trajectory” of symptoms had higher risks of later needing dialysis and of dying before dialysis initiation.
The American Society of Nephrology (ASN) will hold Kidney Week, the world’s premier kidney meeting, in Orlando, FL, November 3–6, 2022. The results of scientific studies and high-impact clinical trials that will advance kidney-related research and medical care will be presented in-person and online.
In 2019, two Canadian provinces passed deemed consent legislation, where adults are automatically presumed to consent to organ donation upon their death unless they registered to opt out.
Today, advocates of the American Society of Nephrology (ASN) and 21 other kidney health professional and patient organizations are meeting with their congressional delegations, calling on them to protect living donors and improve access to transplantation
In an analysis from The Netherlands, the proportion of employed stable kidney transplant recipients was 56%.
New clinical equations that estimate individuals’ kidney function have eliminated an adjustment for Black race. This study examined the impact of using these new race-free equations on the accumulation of waiting time for kidney transplantation before a patient needs dialysis.
Washington, DC (September 16, 2022) —The American Society of Nephrology (ASN) is honored to announce its donation of $25,000 to the onePulse Foundation as a part of ASN’s pledge to bring its values to Florida. ASN encourages others to contribute to this campaign and support the Foundation’s mission to create and support a memorial that opens hearts, a museum that opens minds, educational programs that open eyes, and legacy scholarships that open doors.
The five-year innovative pilot program offers financial support for trainees entering the field of nephrology, focusing on individuals historically underrepresented in medicine.
Kidney transplant recipients experience immune-insufficiency during acute COVID-19.
The KidneyCure Diversity, Equity, Inclusion, and Justice Research Scholar Grant, which was established with a $1 million donation from Otsuka and Visterra that the American Society of Nephrology (ASN) will match, will be awarded every other year beginning in 2023.
In a choice-based study of patients who were waiting for or had received a kidney transplant, the average respondent would accept a kidney today with 6.5 years of expected survival of the transplanted organ to avoid waiting 2 additional years for a kidney with 11 years of expected survival.
In an analysis of data on Medicare beneficiaries starting dialysis in 2008–2015, overall Medicare expenditures for in-center hemodialysis were 11% more than for home-based peritoneal dialysis, and this difference did not change significantly over time as more patients initiated peritoneal dialysis.
Among healthy middle-aged adults in northern Europe, women tended to have lower kidney function than men, but men’s kidney function subsequently declined at a faster rate during aging.
Results from relevant studies indicate that gender-affirming hormone therapy may increase blood levels of creatinine (indicating potential kidney dysfunction or simply a change in lean muscle mass) in transgender men but does not significantly impact blood levels of creatinine in transgender women.
• Among US adults with kidney failure receiving dialysis, risk for SARS-CoV-2 infection during the Omicron-dominant period was higher among patients without vaccination and with 1–2 doses compared with 3 doses of mRNA vaccines. • Irrespective of vaccine doses, risk for infection was higher among patients with low circulating levels of anti–SARS-CoV-2 antibodies.
Today, the US Department of Health and Human Services (HHS) and the American Society of Nephrology (ASN) announced a new prize competition from the Kidney Innovation Accelerator (KidneyX) that seeks to further the development of a fully functional bioartificial kidney.
The American Society of Nephrology (ASN) supports efforts by Congress to improve the US transplant system. Today, the Senate Finance Committee will conduct an oversight hearing, A System in Need of Repair: Addressing Organizational Failures of the U.S.’s Organ Procurement and Transplantation Network (OPTN).
Among adults in Stockholm, Sweden with low kidney function suggestive of chronic kidney disease in 2009–2017, women were less likely than men to receive a diagnostic code related to kidney disease, be referred to a nephrologist, have their kidney function monitored, and receive guideline-recommended medications.
Among older adults with advanced chronic kidney disease, mental and physical health-related quality of life worsened in the year before they started dialysis treatment, but their quality of life stabilized after dialysis was initiated.
• Kidney transplant recipients typically take the immunosuppressant drug tacrolimus to prevent rejection, and some patients experience large fluctuations in blood levels of tacrolimus even when the dose is unchanged. • In a recent study, pediatric kidney transplant recipients with such variability had higher risks of developing antibodies against the transplanted kidney, putting them at risk of rejection.
Compared with atorvastatin, rosuvastatin was associated with an 8% higher risk of hematuria (blood in the urine), a 17% higher risk of proteinuria (protein in the urine), and a 15% higher risk of developing kidney failure requiring replacement therapy such as dialysis or transplantation.
In an analysis of 1997–2017 data on U.S. patients requiring dialysis, exposure to a hurricane was associated with a higher risk of death.
New research indicates that the polycystin-2 protein in cells’ endoplasmic reticulum is important for maintaining kidney health, and its lack can contribute to autosomal dominant polycystic kidney disease.
KidneyCure (the ASN Foundation) is honored to continue its support of investigators committed to advancing kidney health. Building on decades of success, KidneyCure makes it possible to improve knowledge and treatment by identifying and funding high-impact projects.
In an analysis of data on US patients with autosomal dominant polycystic kidney disease, patient outcomes such as age of onset of kidney failure and access to kidney transplantation were strongly associated with race and ethnicity.
A recent study examined how uncertainty surrounding the evolving COVID-19 pandemic influenced shared decision-making between clinicians, older patients with chronic kidney disease, and their care partners.
In a study of individuals on hemodialysis who tested positive for SARS-CoV-2, most had a mild course of COVID-19, but 39%were hospitalized and 13% died.
• Although clinical trials have linked diabetes medications called sodium glucose transport-2 inhibitors to higher bone fracture risks, a large study found no additional risks when the medications were compared with diabetes drugs not associated with fractures. • The findings applied to older adults with normal kidney function as well as to those with mild or moderate kidney disease.
The American Society of Nephrology (ASN) is calling on kidney health professionals to take action to address the impact of climate change on the 850 million people—including more than 37 million Americans—living with kidney diseases across the world who are uniquely vulnerable to the effects of climate change.
2011 changes in policies and recommendations related to the use of erythropoietin-stimulating agents were associated with lower hemoglobin levels and lower risks of major adverse cardiovascular events, mortality, and stroke among adults receiving hemodialysis, but with a higher risk of heart attack.
In hospitalized patients with COVID-19, the SGLT2 inhibitor dapagliflozin was well tolerated regardless of kidney function, but did not significantly lower patients’ risk of organ failure, kidney problems, or death compared with placebo.
• Researchers have developed and validated a new instrument to measure CKD- and transplant-related knowledge in a racially, ethnically, and linguistically diverse group of patients with moderate to severe chronic kidney disease.
Today advocates of the American Society of Nephrology (ASN) and American Association of Kidney Patients (AAKP) will meet with their Congressional delegations to ask for new policies to improve kidney health for 37 million Americans living with kidney diseases.
• There’s a push to transition dialysis care in the United States from in-center to home-based dialysis (including peritoneal dialysis), but a new review has identified several cost considerations that limit the use of peritoneal dialysis. • Addressing these barriers may help to incentivize a switch to peritoneal dialysis.
As we observe World Kidney Day 2022 and recognize all the incredible advances in our field, we must pause and remember members of the kidney community in war-torn countries. This year’s World Kidney Day theme, “Kidney Health for All,” underscores harsh inequities that currently exist around the world. Global attention is currently on the war in Ukraine; many other countries—such as Afghanistan, Cameroon, Ethiopia, Iraq, Libya, Sudan, Syria, and Yemen—are also in conflict.
• Compared with individuals on dialysis who were not vaccinated against COVID-19, those who had received 2 mRNA vaccine doses were 69% and 83% less likely to become infected or experience severe disease, respectively. • There were no significant differences in vaccine effectiveness among age groups, mode of dialysis, or vaccine type.
• In an observational study involving several New York City hospitals, palliative care was used more frequently for hospitalized patients with acute kidney injury (AKI) and COVID-19 than historically reported in AKI. • Despite high mortality associated with AKI, consultation for palliative care occurred late in the hospital course and was not associated with reduced initiation of life sustaining interventions.
• Several factors not included in prior prediction models were important for atherosclerotic cardiovascular disease prediction among patients with chronic kidney disease. • Adding these factors could aid clinicians and patients with decisions related to heart disease prevention.
• Results from a study from France suggest that both individual and herd vaccine-induced immunity protect against severe forms of COVID-19 in patients on dialysis. • A U.S. study found that antibody responses following COVID-19 vaccination wane over time across vaccine types in patients on dialysis.
• Interviews of adults with chronic kidney disease and their caregivers who had previously been involved in kidney disease–related research identified various factors that supported their involvement or created challenges to participation.
• Among veterans with acute kidney injury (AKI) at some point between 2008 to 2017, 6% died in-hospital and 28% died within 1 year. In contrast, in-hospital and one-year mortality was 0.8% and 14%, respectively, among non-AKI hospitalizations. • In veterans hospitalized with AKI, in-hospital and one-year mortality rates remained stable throughout the study period.
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