) Using a simple camera and water tank, investigators from Dartmouth-Hitchcock’s Norris Cotton Cancer Center demonstrated that induced Cherenkov light can be imaged and used to confirm that the complex spatial dose distribution imparted in dynamic treatment plans is being delivered correctly.
Researchers report on the use of denoising autoencoders (DAs) to effectively extract key biological principles from gene expression data and summarize them into constructed features with convenient properties.
While not superior to capecitabine, eribulin is an active and well-tolerated therapy in women with metastatic breast cancer (MBC) receiving this therapy as a first, second, or third line chemotherapy regimen.
By implementing a “best practice alert” function in the electronic medical record, pathologists at Dartmouth-Hitchcock significantly reduced physicians’ orders for two-unit transfusions for non-bleeding patients.
Cancer fighting chimeric antigen receptor (CAR) T cells, developed in the Sentman laboratory of Dartmouth’s Norris Cotton Cancer Center, are taking the next step into a Phase I clinical trial beginning early in 2015.
Substantial improvements were seen in control of hypertension and cholesterol, and smoking cessation, according to a study in the January 13 issue of JAMA.
Partnering with head and neck surgeons, pathologists at Dartmouth Hitchcock Medical Center's Norris Cotton Cancer Center developed a new use for an old test to determine if a patient's cancer is recurring, or if the biopsy shows benign inflammation of mucosal tissues.
By looking at the expression levels of downstream genes of the regulators in breast cancer, investigators have identified a gene signature in E2F4 that is predictive of estrogen receptor positive (ER+) breast cancer.
By developing cell lines that grow readily in culture, investigators have created a fast-track research tool that remains applicable to many scientists who use mouse melanoma as a model system.
Researchers at the Norris Cotton Cancer Center and University of Hawaii Cancer Center find that one-third of Hawaiian adolescents have tried e-cigarettes, half of whom have never used another tobacco product.
Apheresis, the simple process of drawing blood, becomes a powerful therapeutic in extracorporeal photopherisis (ECP) according to clinicians and scientists who met at the NIH State of the Science Symposium in Therapeutic Apheresis.
The fruits and vegetables provided at school deliver an important dietary boost to low income adolescents, according to Meghan Longacre, PhD and Madeline Dalton, PhD of Dartmouth Hitchcock’s Norris Cotton Cancer Center and The Hood Center for Children and Families
Supplemental ultrasound screening for all U.S. women with dense breasts would substantially increase healthcare costs with little improvement in overall health, according to senior author Anna Tosteson, ScD, at Dartmouth Hitchcock’s Norris Cotton Cancer Center and The Dartmouth Institute for Health Policy and Clinical Practice.
A team of researchers at Dartmouth College and University of Pittsburgh found respondents who had smoked water pipe tobacco but not smoked cigarettes were at increased risk of cigarette smoking two years later as recently published online in JAMA Pediatrics.
Dartmouth researchers have developed a fluorescence imaging technique that can more accurately identify receptors for targeted cancer therapies without a tissue biopsy.
Dartmouth researchers say lung cancer screening in the National Lung Screening Trial (NLST) meets a commonly accepted standard for cost effectiveness as reported in the Nov. 6 issue of the New England Journal of Medicine. This relatively new screening test uses annual low-dose CT scans to spot lung tumors early in individuals facing the highest risks of lung cancer due to age and smoking history.
Study suggests it may be possible to use Diffuse Optical Spectroscopic Tomographic imaging (DOST) to predict which patients will best respond to chemotherapy used to shrink breast cancer tumors before surgery.
Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility in genome-wide association studies (GWAS).
A leading Dartmouth researcher, working with The Melanoma Genetics Consortium, GenoMEL, an international research consortium, co-authored a paper published today in the Journal of the National Cancer Institute that proves longer telomeres increase the risk of melanoma.
Dartmouth researchers have found that the genetic mutation BRAFV600E , frequently found in metastatic melanoma, not only secretes a protein that promotes the growth of melanoma tumor cells, but can also modify the network of normal cells around the tumor to support the disease’s progression. Targeting this mutation with Vemurafenib reduces this interaction, and suggests possible new treatment options for melanoma therapy. They report on their findings in “BRAFV600E melanoma cells secrete factors that activate stromal fibroblasts and enhance tumourigenicity,” which was recently published in British Journal of Cancer.
Dartmouth researchers have found that African American women are 55 percent less likely to receive breast reconstruction after mastectomy regardless of where they received their care. They report on their findings in “The influence of race/ethnicity and place of service on breast reconstruction for Medicare beneficiaries with mastectomy,” recently published in SpringerPlus.
An ortho-oncology team at Dartmouth-Hitchcock Norris Cotton Cancer Center successfully adapted a shoulder surgical aid (the Spider Limb Positioner) to conduct a left hip disarticulation on a melanoma patient as described in a case report published online in Medical Devices.
Dartmouth researchers explored the type and number of connections in transcription factor networks (TFNs) to evaluate the role assortativity plays on robustness in a study published in PLOS Computational Biology in August. The study found that the assortativity signature contributes to a network’s resilience against mutations.
Model allows researcher to remove false positive findings that plague modern research when many dozens of factors and their interactions are suggested to play a role in causing complex diseases.
Dartmouth researchers identify enzyme that may help break down chemoresistance in cancer cell that overexpress Myeloid Cell Leukema-1 (Mcl-1).
Researchers at Dartmouth-Hitchcock Norris Cotton Cancer Center are exploring ways to wake up the immune system so it recognizes and attacks invading cancer cells. One pioneering approach uses nanoparticles to jumpstart the body’s ability to fight tumors
From the litter box to the laboratory, a microscopic organism native to cats shows promise in treating cancer. Dartmouth researchers’ mutated strain of T. gondii reprograms the natural power of the immune system to kill cells.
Available evidence suggests that paroxetine and fluoxetine can improve depressive symptoms but may be less well-tolerated. Unfortunately, the most promising agent, Mianserin, is not available in the U.S.
Dartmouth researchers have found that early exposure to the ultraviolet radiation lamps used for indoor tanning is related to an increased risk of developing basal cell carcinomas (BCC) at a young age. Their findings are reported in “Early-Onset Basal Cell Carcinoma and Indoor Tanning: A Population-Based Study,” a study that will be published in the July 2014 issue of Pediatrics. Since indoor tanning has become increasingly popular among adolescents and young adults, this research calls attention to the importance of counseling young people about the risk of indoor tanning.
Researchers retested tumor samples from a large group of women and found that 22 out of 530 women had their tumor type incorrectly classified, which precluded them from effective treatment options.
Dartmouth researchers have found that reducing carbohydrate intake could reduce the risk of breast cancer recurrence among women whose tumor tissue is positive for the IGF-1 receptor.
Dartmouth researchers have found that those caring for patients with advanced cancer experienced reduced depression and felt less burdened by caregiving tasks when palliative support services were offered soon after the patient’s diagnosis. They presented their findings at the American Society of Clinical Oncologist (ASCO) annual meeting in Chicago on June 3, 2014.
New research confirms a vulnerability to lung cancer can be inherited and implicates the BRCA2 gene as harboring one of the involved genetic mutations. An international consortium of scientists including investigators at the Institute for Cancer Research in London, the International Agency for Research on Cancer in Lyon, the National Cancer Institute in Bethesda, Harvard, and Dartmouth used integrated results from the 1000 Genomes Project with genetics studies of lung cancer to complete the investigation published on June 1, 2014 in Nature Genetics.
The American College of Radiology has awarded a three-year term of accreditation to Norris Cotton Cancer Center’s Radiation Oncology department after a complete review and on-site surveys of its professional and technical practices and facilities in Lebanon, New Hampshire and St. Johnsbury, Vermont.
Using next generation DNA sequencing, Dartmouth scientists have identified potentially actionable mutations in cancers of the appendix. When specific mutations for a cancer type are identified, patients can be treated with chemotherapy or other targeted agents that work on those mutations.
Researchers at Dartmouth’s Norris Cotton Cancer Center have published results from a study Cell Reports that discovers a new mechanism that distinguishes normal blood stem cells from blood cancers.
While parents may think tweens (aged 10-14) need less adult supervision when they are not in school, Dartmouth researchers found that certain coached extracurricular activities can help prevent tween smoking and drinking.
Dartmouth will serve as a Lead Academic Participating Site in the National Cancer Institute’s new National Clinical Trials Network , designed to improve speed and efficiency of cancer clinical trials.
Dartmouth researchers have found that the anxiety experienced with a false-positive mammogram is temporary and does not negatively impact a woman’s overall well-being. Their findings are reported in “Consequences of False-Positive Screening Mammograms,” which was published online in the April 21, 2014 JAMA Internal Medicine
Researchers from the Geisel School of Medicine at Dartmouth will present a scientific poster on Wednesday, April 9, 2014 at the American Association of Cancer Researchers conference in San Diego, CA. Their study suggests that manipulation of drug dosage and schedules may improve anti-tumor effects of PI3K-inhibitors to target breast cancer tumors. These findings have implications for the optimal strategy to use such drugs in patients, and lay the groundwork for future development of anti-cancer therapeutics.
Binge drinking by teenagers and young adults is strongly associated with liking, owning, and correctly identifying music that references alcohol by brand name according to a study by the University of Pittsburgh and Dartmouth-Hitchcock Norris Cotton Cancer Center.
Researchers from the Geisel School of Medicine at Dartmouth will present a scientific poster on Tuesday, April 8, 2014 at the American Association of Cancer Researchers conference in San Diego, CA. The research identifies a potential characteristic for predicting outcome in a deadly form of brain cancer known as glioblastoma multiforme.
Researchers at the Geisel School of Medicine at Dartmouth have found that the body’s immune system response was enhanced when they disrupted VISTA, a protein that prevents the immune system from overreacting. Understanding how checkpoint regulators like VISTA function is important to cancer researchers, who hope to use the immune system to attack tumors.
In a presentation exploring the promise of magnetic nanoparticle (mNP) hyperthermia in breast cancer treatment, Dartmouth researcher P. Jack Hoopes, DMV, PhD, will review preclinical studies conducted at Norris Cotton Cancer Center and discuss plans for early-phase clinical studies in humans at AACR annual meeting on Sunday 4/6/14.
Variations in a woman’s genome may contribute to her risk of developing ovarian cancer. Researchers using data collected by the Ovarian Cancer Association Consortium have discovered uncommon variants in new regions of the genome that influence ovarian cancer risk, and will present their findings on April 6, 2014 at the American Association for Cancer Research Annual Meeting in San Diego, CA.
New study finds teenagers and young adults are exposed to direct mail and web coupons from tobacco manufacturers. This exposure translates into increased nicotine use among youth.
Smokers turn to e-cigs to ease nicotine withdrawal, or to avoid harmful chemicals in tobacco smoke. But many use e-cigs in public spaces and regular cigarettes everywhere else. Quitting half-way won’t help. And we don’t know that smokeless vapor is safe.
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